| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Catarina M Henriques, Madalena C Carneiro, Inês M Tenente, António Jacinto, Miguel Godinho Ferreir. Telomerase is required for zebrafish lifespan. PLoS genetics. vol 9. issue 1. 2013-05-30. PMID:23349637. |
cell proliferation, but not apoptosis, is rescued in tp53(-/-)tert(-/-) mutants, underscoring p53 as mediator of telomerase deficiency and consequent telomere instability. |
2013-05-30 |
2023-08-12 |
mouse |
| Marie-Jo Halaby, Anne Hakem, Li Li, Samah El Ghamrasni, Shriram Venkatesan, Prakash M Hande, Otto Sanchez, Razqallah Hake. Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis. PLoS genetics. vol 9. issue 1. 2013-05-30. PMID:23382699. |
in contrast, loss of p53 fully rescued the increased apoptosis and reduced number of thymocytes and splenocytes in rnf8(-/-) mice. |
2013-05-30 |
2023-08-12 |
mouse |
| Jeyran Shahbazi, Richard Lock, Tao Li. Tumor Protein 53-Induced Nuclear Protein 1 Enhances p53 Function and Represses Tumorigenesis. Frontiers in genetics. vol 4. 2013-05-30. PMID:23717325. |
this enhances p53 protein stability and its transcriptional activity, leading to transcriptional activation of p53-target genes such as p21 and pig3, cell growth arrest and apoptosis upon dna damage stress. |
2013-05-30 |
2023-08-12 |
Not clear |
| Megan E Culbreth, Joshua A Harrill, Theresa M Freudenrich, William R Mundy, Timothy J Shafe. Comparison of chemical-induced changes in proliferation and apoptosis in human and mouse neuroprogenitor cells. Neurotoxicology. vol 33. issue 6. 2013-05-28. PMID:22634143. |
high-content screening of markers for proliferation (brdu incorporation) and apoptosis (activated caspase 3 and p53) was used to assess the effect of chemicals in both cell lines. |
2013-05-28 |
2023-08-12 |
mouse |
| Chung-Hsin Yeh, Yu-Yen Yang, Ya-Fang Huang, Kuan-Chih Chow, Ming-Feng Che. Induction of apoptosis in human Hep3B hepatoma cells by norcantharidin through a p53 independent pathway via TRAIL/DR5 signal transduction. Chinese journal of integrative medicine. vol 18. issue 9. 2013-05-28. PMID:22936321. |
induction of apoptosis in human hep3b hepatoma cells by norcantharidin through a p53 independent pathway via trail/dr5 signal transduction. |
2013-05-28 |
2023-08-12 |
human |
| Yang Xu, Chunsun Li, Qing Tian, Yanqin Li, Zhen Yang, Zhixin Liang, Liangan Che. Suppression of lung cancer metastasis-related protein 1 promotes apoptosis in lung cancer cells. International journal of molecular medicine. vol 30. issue 6. 2013-05-28. PMID:23076562. |
in conclusion, lcmr1 suppresses apoptosis in lung cancer cells and this effect is associated with multiple apoptosis-related proteins, including p53, bax and mcl-1. |
2013-05-28 |
2023-08-12 |
human |
| Boban M Erovic, Luke Harris, Mina Jamali, David P Goldstein, Jonathan C Irish, Sylvia L Asa, Ozgur Met. Biomarkers of parathyroid carcinoma. Endocrine pathology. vol 23. issue 4. 2013-05-23. PMID:23001705. |
we constructed a tissue microarray of parathyroid carcinomas from 10 patients as well as parathyroid adenomas from 25 patients and stained the slides for 34 proteins involved in angiogenesis (platelet-derived growth factor receptor (pdgfr)-α, pdgfr-β, vascular endothelial growth factor receptor-2 (vegfr-2), and epidermal growth factor receptor (egfr)), inflammation (cyclooxygenase (cox)-1 and cox-2), cell adhesion (matrix metalloproteinase (mmp)-1, cd9, and keratin 7), cell cycle (cdc2p34, cyclin d1, retinoblastoma (rb), p27, p21, parafibromin, bmi-1, 14-3-3σ, and p53), and apoptosis (bcl-2a, mcl-1, bcl-xl, and glutathione-s-transferase-isoenzyme π (gst-π)) along with some markers of the sonic hedgehog (smo, shh, gli-1, gli-2, gli-3, and patched), mtor (akt, mammalian target of rapamycin (mtor), and forkhead box o (foxo)-1), and wnt (wisp-1, wisp-2, and β-catenin) signal transduction pathways. |
2013-05-23 |
2023-08-12 |
Not clear |
| Imad Shams, Assaf Malik, Irena Manov, Alma Joel, Mark Band, Aaron Aviv. Transcription pattern of p53-targeted DNA repair genes in the hypoxia-tolerant subterranean mole rat Spalax. Journal of molecular biology. vol 425. issue 7. 2013-05-23. PMID:23318952. |
the tumor suppressor gene p53 induces growth arrest and/or apoptosis in response to dna damage/hypoxia. |
2013-05-23 |
2023-08-12 |
mouse |
| Masaki Kawamata, Takahiro Ochiy. Two distinct knockout approaches highlight a critical role for p53 in rat development. Scientific reports. vol 2. 2013-05-22. PMID:23230510. |
the p53-null escs were resistant to apoptosis and differentiation, and exhibited severe chromosome instabilities in the chimera-contributed cells, suggesting an essential role for p53 in maintaining esc quality and genomic integrity. |
2013-05-22 |
2023-08-12 |
mouse |
| Carlos Rotman, Larry Fischel, Gabriela Cortez, Hisham Greiss, Nasiruddin Rana, John Rinehart, Carolyn B Coula. A search to identify genetic risk factors for endometriosis. American journal of reproductive immunology (New York, N.Y. : 1989). vol 69. issue 1. 2013-05-17. PMID:23167810. |
to search for molecular markers of endometriosis the following polymorphisms: p53 codon 72 pro (apoptosis), tnf alpha-308 (inflammation), vegf-1164aa (angiogenesis), and sod2 (oxidative stress) were investigated. |
2013-05-17 |
2023-08-12 |
Not clear |
| G Sarek, L Ma, J Enbäck, A Järviluoma, P Moreau, J Haas, A Gessain, P J Koskinen, P Laakkonen, P M Ojal. Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas. Oncogene. vol 32. issue 9. 2013-05-16. PMID:22469985. |
we have reported that p53 reactivation by an inhibitor of the p53-mdm2 interaction, nutlin-3, induces selective and massive apoptosis in pel cells leading to efficient anti-tumor activity in a subcutaneous xenograft model for pel. |
2013-05-16 |
2023-08-12 |
Not clear |
| Na Zhang, Li-Yan Zhang, Yan Zhang, Qing Ji, Jin-Hong Wang, Rui-Zhe Qi, Jing Xu, Wei-Ping Yuan, Tao Cheng, Ying-Dai Ga. [Effects of DAPT on biological activity of hematopoietic stem cells in mice]. Zhongguo shi yan xue ye xue za zhi. vol 20. issue 3. 2013-05-16. PMID:22739182. |
the results indicated that the mrna expression of the cell cycle related-genes cdk1, cdk2, cdk4, cdk6, p27 in lin(-) c-kit(+)sca-1(+) marked cells increased (p < 0.05), the expression of p18, p21 decreased (p < 0.05), the expression of the apoptosis related-genes bcl-2, bcl-xl, bax, p53, puma in lin(-) c-kit(+)sca-1(+) marked cells increased (p < 0.05), the expression of bim decreased (p < 0.05), the expression of mcl-1 had not changed (p > 0.05) after treatment with dapt 1 µmol/l for 5 d. the changes of cell cycle of lin(-)c-kit(+)sca-1(+) marked cells in bone marrow had no statistical significance after treatment with dapt 1 µmol/l for 5 d, cd34(-)lin(-)c-kit(+)sca-1(+) marked cells in bone marrow at g(0) phase decreased and at g(1) phase increased after treatment with dapt 1 µmol/l for 5 d (p < 0.05); the apoptotic fractions of lin(-) c-kit(+) sca-1(+) marked cells and cd34(-)lin(-)c-kit(+)sca-1(+) marked cells in bone marrow increased after treatment with dapt 1 µmol/l for 5 d (p < 0.05). |
2013-05-16 |
2023-08-12 |
mouse |
| Samy A F Morad, James P Madigan, Jonathan C Levin, Noha Abdelmageed, Ramin Karimi, Daniel W Rosenberg, Mark Kester, Sriram S Shanmugavelandy, Myles C Cabo. Tamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53. Biochemical pharmacology. vol 85. issue 8. 2013-05-16. PMID:23353700. |
at the molecular level, the regimen, but not single agents, induced time-dependent upregulation of tumor suppressor protein p53; however, introduction of a p53 inhibitor staved neither mmp nor apoptosis. |
2013-05-16 |
2023-08-12 |
human |
| Xueying Wang, Baojie L. Genetic studies of bone diseases: evidence for involvement of DNA damage response proteins in bone remodeling. International journal of biomedical science : IJBS. vol 3. issue 4. 2013-05-16. PMID:23675047. |
dna damage response is triggered by double stranded dna breaks, single stranded dna breaks as well as other types of lesions, which recruit and activate ser/thr kinases such as atm to the damaged sites, where atm activates p53 to promote apoptosis, cell cycle arrest, and dna repair. |
2013-05-16 |
2023-08-12 |
mouse |
| Paul Chan, Yen-Cheng Chen, Li-Jen Lin, Tzu-Hurng Cheng, Kazunori Anzai, Yin-Han Chen, Zhong-Min Liu, Jaung-Geng Lin, Hong-Jye Hon. Tanshinone IIA Attenuates H₂O₂ -induced injury in human umbilical vein endothelial cells. The American journal of Chinese medicine. vol 40. issue 6. 2013-05-14. PMID:23227799. |
our results show that huvecs incubated with 200 μm h(2)o(2) had significantly decreased the viability of endothelial cells, which was accompanied with apparent cell apoptosis, the activation of caspase-3 and the upregulation of p53 expression, which was known to play a key role in h(2)o(2) -induced cell apoptosis. |
2013-05-14 |
2023-08-12 |
human |
| Ariele Viacava Follis, Jerry E Chipuk, John C Fisher, Mi-Kyung Yun, Christy R Grace, Amanda Nourse, Katherine Baran, Li Ou, Lie Min, Stephen W White, Douglas R Green, Richard W Kriwack. PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nature chemical biology. vol 9. issue 3. 2013-05-14. PMID:23340338. |
puma binding induces partial unfolding within bcl-xl to disrupt p53 binding and promote apoptosis. |
2013-05-14 |
2023-08-12 |
Not clear |
| Ariele Viacava Follis, Jerry E Chipuk, John C Fisher, Mi-Kyung Yun, Christy R Grace, Amanda Nourse, Katherine Baran, Li Ou, Lie Min, Stephen W White, Douglas R Green, Richard W Kriwack. PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nature chemical biology. vol 9. issue 3. 2013-05-14. PMID:23340338. |
puma, unique among bh3-only proteins, disrupts the interaction between cytosolic p53 and bcl-xl, allowing p53 to promote apoptosis via direct activation of the bcl-2 effector molecules bax and bak. |
2013-05-14 |
2023-08-12 |
Not clear |
| Ariele Viacava Follis, Jerry E Chipuk, John C Fisher, Mi-Kyung Yun, Christy R Grace, Amanda Nourse, Katherine Baran, Li Ou, Lie Min, Stephen W White, Douglas R Green, Richard W Kriwack. PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nature chemical biology. vol 9. issue 3. 2013-05-14. PMID:23340338. |
our data suggest that puma-induced partial unfolding of bcl-xl disrupts interactions between cytosolic p53 and bcl-xl, releasing the bound p53 to initiate apoptosis. |
2013-05-14 |
2023-08-12 |
Not clear |
| Jian-Qing Yu, Wei Bao, Jia-Chuan Le. Emodin regulates apoptotic pathway in human liver cancer cells. Phytotherapy research : PTR. vol 27. issue 2. 2013-05-13. PMID:22565822. |
furthermore, emodin increased the protein level of p53 and decreased the protein level of nf-κb/p65 in hepg2 cells, which indicated these two regulators might play a role in emodin-induced apoptosis. |
2013-05-13 |
2023-08-12 |
human |
| Katia Varani, Fabrizio Vincenzi, Martina Targa, Beatrice Paradiso, Annapaola Parrilli, Milena Fini, Giovanni Lanza, Pier Andrea Bore. The stimulation of A(3) adenosine receptors reduces bone-residing breast cancer in a rat preclinical model. European journal of cancer (Oxford, England : 1990). vol 49. issue 2. 2013-05-10. PMID:22770890. |
a(3)ars were expressed in mrmt-1 cells and their activation reduced nf-kb, increased p53 expression and apoptosis, inhibited tumour cell proliferation and migration. |
2013-05-10 |
2023-08-12 |
human |