| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel Menendez, Maria Shatz, Michael A Resnic. Interactions between the tumor suppressor p53 and immune responses. Current opinion in oncology. vol 25. issue 1. 2013-05-10. PMID:23150340. |
the p53 tumor suppressor is a master regulator of antitumor defenses through its control of growth arrest, senescence and apoptosis. |
2013-05-10 |
2023-08-12 |
Not clear |
| Sheetal Bhan, Alice Chuang, Sandeep S Negi, Chad A Glazer, Joseph A Califan. MAGEA4 induces growth in normal oral keratinocytes by inhibiting growth arrest and apoptosis. Oncology reports. vol 28. issue 4. 2013-05-09. PMID:22842486. |
our results indicate that magea4 promotes growth by preventing cell cycle arrest and by inhibiting apoptosis mediated by the p53 transcriptional targets. |
2013-05-09 |
2023-08-12 |
Not clear |
| Tuo Wang, Yan Xue, Maode Wang, Qiang Su. Silencing of the hTERT gene through RNA interference induces apoptosis via bax/bcl-2 in human glioma cells. Oncology reports. vol 28. issue 4. 2013-05-09. PMID:22895663. |
we found that the silencing of the htert gene in t98g cells significantly decreased cell proliferation and telomerase activity, increased the number of cells in g1 phase and decreased the number of cells in s phase, and induced apoptosis via decreasing the protein level of bcl-2 and c-myc and increasing the protein levels of bax and p53. |
2013-05-09 |
2023-08-12 |
human |
| Najat Abbassi, Hakima Chicha, El Mostapha Rakib, Abdellah Hannioui, Mdaghri Alaoui, Abdelouahed Hajjaji, Detlef Geffken, Cinzia Aiello, Rosaria Gangemi, Camillo Rosano, Maurizio Vial. Synthesis, antiproliferative and apoptotic activities of N-(6(4)-indazolyl)-benzenesulfonamide derivatives as potential anticancer agents. European journal of medicinal chemistry. vol 57. 2013-05-09. PMID:23072738. |
moreover, these indazoles were able to trigger apoptosis through the upregulation of the typical apoptosis markers p53 and bax. |
2013-05-09 |
2023-08-12 |
human |
| Fan Zhang, Yang Li, Zhongshu Tang, Anil Kumar, Chunsik Lee, Liping Zhang, Chaoyong Zhu, Anne Klotzsche-von Ameln, Bin Wang, Zhiqin Gao, Shizhuang Zhang, Harald F Langer, Xu Hou, Lasse Jensen, Wenxin Ma, Wai Wong, Triantafyllos Chavakis, Yizhi Liu, Yihai Cao, Xuri L. Proliferative and survival effects of PUMA promote angiogenesis. Cell reports. vol 2. issue 5. 2013-05-09. PMID:23122957. |
the p53 upregulated modulator of apoptosis (puma) is known as an essential apoptosis inducer. |
2013-05-09 |
2023-08-12 |
Not clear |
| Jinshun Lin, Xiuli Jin, Yiwen Bu, Deliang Cao, Nannan Zhang, Shangfu Li, Qinsheng Sun, Chunyan Tan, Chunmei Gao, Yuyang Jian. Efficient synthesis of RITA and its analogues: derivation of analogues with improved antiproliferative activity via modulation of p53/miR-34a pathway. Organic & biomolecular chemistry. vol 10. issue 48. 2013-05-09. PMID:23151607. |
compound 1f markedly activated p53 in hct116 cells at 100 nm, triggering apoptosis. |
2013-05-09 |
2023-08-12 |
Not clear |
| Zhi-Chao Feng, Matthew Riopel, Jinming Li, Lisa Donnelly, Rennian Wan. Downregulation of Fas activity rescues early onset of diabetes in c-Kit(Wv/+) mice. American journal of physiology. Endocrinology and metabolism. vol 304. issue 6. 2013-05-09. PMID:23269409. |
we observed that islets in c-kit(wv/+) mice showed a significant increase in β-cell apoptosis along with upregulated p53 and fas expression. |
2013-05-09 |
2023-08-12 |
mouse |
| Erik Oliemuller, Rafael Peláez, Saray Garasa, María J Pajares, Jackeline Agorreta, Rubén Pío, Luis M Montuenga, Alvaro Teijeira, Susana Llanos, Ana Rouzau. Phosphorylated tubulin adaptor protein CRMP-2 as prognostic marker and candidate therapeutic target for NSCLC. International journal of cancer. vol 132. issue 9. 2013-05-07. PMID:23023514. |
finally, here we demonstrate that crmp-2 phosphorylation impairment, or silencing induces p53 expression and promotes apoptosis through caspase 3 activation. |
2013-05-07 |
2023-08-12 |
Not clear |
| Janey L Wiggs, Alex W Hewitt, Bao Jian Fan, Dan Yi Wang, Dayse R Figueiredo Sena, Colm O'Brien, Anthony Realini, Jamie E Craig, David P Dimasi, David A Mackey, Jonathan L Haines, Louis R Pasqual. The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma. PloS one. vol 7. issue 9. 2013-05-07. PMID:23049825. |
while p53 modulates apoptosis, gene association studies between p53 variants and glaucoma have been inconsistent. |
2013-05-07 |
2023-08-12 |
Not clear |
| Janey L Wiggs, Alex W Hewitt, Bao Jian Fan, Dan Yi Wang, Dayse R Figueiredo Sena, Colm O'Brien, Anthony Realini, Jamie E Craig, David P Dimasi, David A Mackey, Jonathan L Haines, Louis R Pasqual. The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma. PloS one. vol 7. issue 9. 2013-05-07. PMID:23049825. |
in this study we evaluate the association between a p53 variant functionally known to influence apoptosis (codon 72 pro/arg) and the subset of primary open angle glaucoma (poag) patients with early loss of central visual field. |
2013-05-07 |
2023-08-12 |
Not clear |
| Veronica Veschi, Marialaura Petroni, Beatrice Cardinali, Carlo Dominici, Isabella Screpanti, Luigi Frati, Armando Bartolazzi, Alberto Gulino, Giuseppe Giannin. Galectin-3 impairment of MYCN-dependent apoptosis-sensitive phenotype is antagonized by nutlin-3 in neuroblastoma cells. PloS one. vol 7. issue 11. 2013-05-07. PMID:23152863. |
in mycn primed neuroblastoma cells, further activation of both hipk2 and p53 by nutlin-3 leads to massive apoptosis in vitro and to tumor shrinkage and impairment of metastasis in xenograft models. |
2013-05-07 |
2023-08-12 |
human |
| Daniela Montariello, Annaelena Troiano, Maria Malanga, Viola Calabrò, Piera Quesad. p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells. Biochemical pharmacology. vol 85. issue 7. 2013-05-07. PMID:23376119. |
specifically, in mcf7, (i) pj34 in combination with tpt causes a g2/m cell cycle arrest followed by massive apoptosis; (ii) pj34 addition reverts tpt-dependent parp-1 automodification and triggers caspase-dependent parp-1 proteolysis; (iii) tpt, used as a single agent, stimulates p53 expression while in combination with pj34 increases p53, tap63α and tap63γ protein levels with a concomitant reduction of mdm2 protein. |
2013-05-07 |
2023-08-12 |
Not clear |
| Mohammad Reza Ahmadianpour, Parviz Abdolmaleki, Seyed Javad Mowla, Saman Hosseinkhan. Gamma radiation alters cell cycle and induces apoptosis in p53 mutant E6.1 Jurkat cells. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. vol 71. issue 1. 2013-05-06. PMID:23079488. |
gamma radiation alters cell cycle and induces apoptosis in p53 mutant e6.1 jurkat cells. |
2013-05-06 |
2023-08-12 |
human |
| Mohammad Reza Ahmadianpour, Parviz Abdolmaleki, Seyed Javad Mowla, Saman Hosseinkhan. Gamma radiation alters cell cycle and induces apoptosis in p53 mutant E6.1 Jurkat cells. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. vol 71. issue 1. 2013-05-06. PMID:23079488. |
exposure of human p53 mutant jurkat cells to gamma radiation resulted in apoptosis, which was detected by luminometric and flow cytometric analysis. |
2013-05-06 |
2023-08-12 |
human |
| b' Mojca Tajnik, Mojca Stra\\xc5\\xbei\\xc5\\xa1ar, Metka Volav\\xc5\\xa1ek, Emanuela Bo\\xc5\\xa1tjan\\xc4\\x8di\\xc4\\x8d, Damjan Glava\\xc4\\x8. BBC3 is down-regulated with increased tumor size independently of p53 expression in head and neck cancer. Cancer biomarkers : section A of Disease markers. vol 11. issue 5. 2013-05-06. PMID:23220852.' |
in order to confirm the model of bbc3-mediated apoptosis, we used immunohistochemistry to determine the expression of apoptotic proteins p53, p63, bcl-2 and bax. |
2013-05-06 |
2023-08-12 |
Not clear |
| b' Mojca Tajnik, Mojca Stra\\xc5\\xbei\\xc5\\xa1ar, Metka Volav\\xc5\\xa1ek, Emanuela Bo\\xc5\\xa1tjan\\xc4\\x8di\\xc4\\x8d, Damjan Glava\\xc4\\x8. BBC3 is down-regulated with increased tumor size independently of p53 expression in head and neck cancer. Cancer biomarkers : section A of Disease markers. vol 11. issue 5. 2013-05-06. PMID:23220852.' |
through protein expression analysis combined with publicly available cdna microarray datasets of apoptotic factors, we confirmed the model of bbc3-mediated apoptosis, which can be activated with or without p53. |
2013-05-06 |
2023-08-12 |
Not clear |
| M Li, M Yu, C Liu, H Zhu, X He, S Peng, J Hu. miR-34c works downstream of p53 leading to dairy goat male germline stem-cell (mGSCs) apoptosis. Cell proliferation. vol 46. issue 2. 2013-05-06. PMID:23510477. |
mir-34c works downstream of p53 leading to dairy goat male germline stem-cell (mgscs) apoptosis. |
2013-05-06 |
2023-08-12 |
mouse |
| M Li, M Yu, C Liu, H Zhu, X He, S Peng, J Hu. miR-34c works downstream of p53 leading to dairy goat male germline stem-cell (mGSCs) apoptosis. Cell proliferation. vol 46. issue 2. 2013-05-06. PMID:23510477. |
the purpose of this study was to investigate the effects of mir-34c on apoptosis and proliferation of dairy goat male germline stem cells (mgscs), as well as to determine the relationship between p53 and mir-34c in this species. |
2013-05-06 |
2023-08-12 |
mouse |
| Franziska Wachter, Michaela Grunert, Cristina Blaj, David M Weinstock, Irmela Jeremias, Harald Ehrhard. Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling. Cell communication and signaling : CCS. vol 11. issue 1. 2013-05-06. PMID:23594441. |
impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling. |
2013-05-06 |
2023-08-12 |
human |
| Franziska Wachter, Michaela Grunert, Cristina Blaj, David M Weinstock, Irmela Jeremias, Harald Ehrhard. Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling. Cell communication and signaling : CCS. vol 11. issue 1. 2013-05-06. PMID:23594441. |
using several molecular approaches, we studied the impact of different p53 variants on extrinsic and intrinsic apoptosis signaling. |
2013-05-06 |
2023-08-12 |
human |