| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chaoyi Cui, Guang Liu, Ying Huang, Xinwu Lu, Min Lu, Xintian Huang, Weimin Li, Mier Jian. MicroRNA profiling in great saphenous vein tissues of patients with chronic venous insufficiency. The Tohoku journal of experimental medicine. vol 228. issue 4. 2013-04-16. PMID:23132275. |
functional annotation of target genes of differentially expressed mirnas via bioinformatics approaches revealed that these predicted targets were significantly enriched and involved in several key signaling pathways important for cvi, including mitogen-activated protein kinase pathways, pathways in cancer, apoptosis, and cell cycle, and p53 signaling pathways. |
2013-04-16 |
2023-08-12 |
Not clear |
| Wei-jun Pang, Yan Xiong, Yu Wang, Qiang Tong, Gong-she Yan. Sirt1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes. Experimental cell research. vol 319. issue 5. 2013-04-16. PMID:23313858. |
we also find that hyperacetylated p53 is the major effect of sirt1 knockdown by overexpression of a mutated p53, whereas sirt1 overexpression prevents camptothecin-induced apoptosis through p53 deacetylation in preadipocytes. |
2013-04-16 |
2023-08-12 |
Not clear |
| Kun Liu, Liang Shao, Li Wang, Yanping Ding, Guanhua Su, Jue Wang, Yuhua Liao, Zhaohui Wan. Induction of cardiomyocyte apoptosis by anti-cardiac myosin heavy chain antibodies in patients with acute myocardial infarction. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 30. issue 5. 2013-04-12. PMID:21063838. |
the expression of apoptosis related p53 and bcl-2 protein and the second messenger calcium were detected respectively by western blotting, patch clamp and confocal calcium imaging. |
2013-04-12 |
2023-08-12 |
rat |
| Wentao Dai, Huajie Chen, Rian Yu, Lingfei He, Bing Chen, Xuemin Che. Effects of cadmium on telomerase activity, expressions of TERT, c-myc and P53, and apoptosis of rat hepatocytes. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 30. issue 6. 2013-04-12. PMID:21181359. |
effects of cadmium on telomerase activity, expressions of tert, c-myc and p53, and apoptosis of rat hepatocytes. |
2013-04-12 |
2023-08-12 |
rat |
| Wentao Dai, Huajie Chen, Rian Yu, Lingfei He, Bing Chen, Xuemin Che. Effects of cadmium on telomerase activity, expressions of TERT, c-myc and P53, and apoptosis of rat hepatocytes. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 30. issue 6. 2013-04-12. PMID:21181359. |
this study investigated the effect of cadmium on the telomerase activity, the expression of tert, c-myc and p53 and the apoptosis of rat hepatocytes. |
2013-04-12 |
2023-08-12 |
rat |
| Wentao Dai, Huajie Chen, Rian Yu, Lingfei He, Bing Chen, Xuemin Che. Effects of cadmium on telomerase activity, expressions of TERT, c-myc and P53, and apoptosis of rat hepatocytes. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 30. issue 6. 2013-04-12. PMID:21181359. |
our study herein suggested that cadmium may contribute to the carcinogenesis by activating telomerase, and overexpressing the mrnas of tert, c-myc and p53, and causing apoptosis of normal cells. |
2013-04-12 |
2023-08-12 |
rat |
| A R M Ruhul Amin, V S Thakur, K Gupta, M K Agarwal, D N Wald, D M Shin, M L Agarwa. N-(phosphonacetyl)-L-aspartate induces TAp73-dependent apoptosis by modulating multiple Bcl-2 proteins: potential for cancer therapy. Oncogene. vol 32. issue 7. 2013-04-12. PMID:22430213. |
in the complete absence of p53, cells treated with n-(phosphonacetyl)-l-aspartate (pala) continue to synthesize dna slowly and eventually progress through s-phase, suffering severe dna damage that in turn triggers apoptosis, whereas cells with functional p53 undergo growth arrest. |
2013-04-12 |
2023-08-12 |
human |
| A R M Ruhul Amin, V S Thakur, K Gupta, M K Agarwal, D N Wald, D M Shin, M L Agarwa. N-(phosphonacetyl)-L-aspartate induces TAp73-dependent apoptosis by modulating multiple Bcl-2 proteins: potential for cancer therapy. Oncogene. vol 32. issue 7. 2013-04-12. PMID:22430213. |
we found that treatment of cells lacking p53 with pala induced tap73, noxa and bim and inactivation of these proteins with dominant-negative plasmids or small interfering rnas significantly inhibited apoptosis, suggesting that pala-induced apoptosis was mediated via tap73-dependent expression of noxa and bim. |
2013-04-12 |
2023-08-12 |
human |
| A R M Ruhul Amin, V S Thakur, K Gupta, M K Agarwal, D N Wald, D M Shin, M L Agarwa. N-(phosphonacetyl)-L-aspartate induces TAp73-dependent apoptosis by modulating multiple Bcl-2 proteins: potential for cancer therapy. Oncogene. vol 32. issue 7. 2013-04-12. PMID:22430213. |
moreover, expression of p53 in these cells protected them from pala-induced apoptosis by activating p21, sustaining the expression of Δnp73 and inhibiting the induction of noxa and bim. |
2013-04-12 |
2023-08-12 |
human |
| A R M Ruhul Amin, V S Thakur, K Gupta, M K Agarwal, D N Wald, D M Shin, M L Agarwa. N-(phosphonacetyl)-L-aspartate induces TAp73-dependent apoptosis by modulating multiple Bcl-2 proteins: potential for cancer therapy. Oncogene. vol 32. issue 7. 2013-04-12. PMID:22430213. |
taken together, our study identifies novel but opposing roles for the p53 and tap73 in the induction of noxa and bim and regulation of apoptosis. |
2013-04-12 |
2023-08-12 |
human |
| H G Campbell, R Mehta, A A Neumann, C Rubio, M Baird, T L Slatter, A W Braithwait. Activation of p53 following ionizing radiation, but not other stressors, is dependent on the proline-rich domain (PRD). Oncogene. vol 32. issue 7. 2013-04-12. PMID:22484427. |
in response to cellular stressors p53 can induce apoptosis, cell cycle arrest or senescence as well as aid in dna repair. |
2013-04-12 |
2023-08-12 |
mouse |
| H G Campbell, R Mehta, A A Neumann, C Rubio, M Baird, T L Slatter, A W Braithwait. Activation of p53 following ionizing radiation, but not other stressors, is dependent on the proline-rich domain (PRD). Oncogene. vol 32. issue 7. 2013-04-12. PMID:22484427. |
the proline-rich domain (prd) of p53 (residues 58-101) has been reported to be essential for the induction of apoptosis. |
2013-04-12 |
2023-08-12 |
mouse |
| Tobias Brandt, Fiona M Townsley, Daniel P Teufel, Stefan M V Freund, Dmitry B Veprintse. Molecular basis for modulation of the p53 target selectivity by KLF4. PloS one. vol 7. issue 10. 2013-04-12. PMID:23118962. |
the tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, dna repair and metabolism. |
2013-04-12 |
2023-08-12 |
Not clear |
| Wan-Chi Lin, Yu-Chi Chuang, Yung-Sheng Chang, Ming-Derg Lai, Yen-Ni Teng, Ih-Jen Su, Clay C C Wang, Kuan-Han Lee, Jui-Hsiang Hun. Endoplasmic reticulum stress stimulates p53 expression through NF-κB activation. PloS one. vol 7. issue 7. 2013-04-11. PMID:22859938. |
a previous study has indicated that one major apoptotic regulator, p53, is significantly increased in response to er stress, and participates in er stress-induced apoptosis. |
2013-04-11 |
2023-08-12 |
Not clear |
| Karandeep Singh Nandra, Mark Agiu. The differences between typical and atypical antipsychotics: the effects on neurogenesis. Psychiatria Danubina. vol 24 Suppl 1. 2013-04-10. PMID:22945197. |
haloperidol, of the typical antipsychotics, causes neuron apoptosis by a free radical induced mechanism, involving bcl-xs, p53, cytochrome c translocation and caspase 3 activation. |
2013-04-10 |
2023-08-12 |
Not clear |
| Chit Fang Cheok, David P Lan. Seeking synergy in p53 transcriptional activation for cancer therapy. Discovery medicine. vol 14. issue 77. 2013-04-10. PMID:23114582. |
given that a large proportion of cancers, including hematological malignancies, retain the expression of the wildtype p53 allele, reactivating wildtype p53 in these cancers could lead to selective apoptosis and is regarded as a potential therapeutic strategy. |
2013-04-10 |
2023-08-12 |
mouse |
| Chit Fang Cheok, David P Lan. Seeking synergy in p53 transcriptional activation for cancer therapy. Discovery medicine. vol 14. issue 77. 2013-04-10. PMID:23114582. |
our previous results show that cdk inhibition synergizes with nutlin in p53 activation and p53-dependent apoptosis, converting a cell cycle arrest response to apoptosis. |
2013-04-10 |
2023-08-12 |
mouse |
| Jinfeng Shen, Ellen H van den Bogaard, Evelyn N Kouwenhoven, Vladimir J N Bykov, Tuula Rinne, Qiang Zhang, Geuranne S Tjabringa, Christian Gilissen, Simon J van Heeringen, Joost Schalkwijk, Hans van Bokhoven, Klas G Wiman, Huiqing Zho. APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 6. 2013-04-09. PMID:23355676. |
treatment of these patient keratinocytes with the mutant p53-targeting compound apr-246/prima-1(met) (p53 reactivation and induction of massive apoptosis) that has been successfully tested in a phase i/ii clinical trial in cancer patients partially but consistently rescued morphological features and gene expression during epidermal stratification in both 2d and 3d models. |
2013-04-09 |
2023-08-12 |
human |
| Daisuke Hibi, Aki Kijima, Yuta Suzuki, Yuji Ishii, Meilan Jin, Yoshiko Sugita-Konishi, Tokuma Yanai, Akiyoshi Nishikawa, Takashi Umemur. Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice. Toxicology. vol 304. 2013-04-08. PMID:23261758. |
in the present study, to investigate the effects of p53 knockout on ota-induced mutagenicity, apoptosis, and karyomegaly in renal tubular cells, p53-proficient and p53-deficient gpt delta mice were given 1 and 5mg/kg of ota for 4 weeks. |
2013-04-08 |
2023-08-12 |
mouse |
| b' Roser Mir, Avelina Tortosa, Fina Martinez-Soler, August Vidal, Enric Condom, Alba P\\xc3\\xa9rez-Perarnau, Tatiana Ruiz-Larroya, Joan Gil, Pepita Gim\\xc3\\xa9nez-Bonaf\\xc3\\xa. Mdm2 antagonists induce apoptosis and synergize with cisplatin overcoming chemoresistance in TP53 wild-type ovarian cancer cells. International journal of cancer. vol 132. issue 7. 2013-04-04. PMID:22961628.' |
cisplatin is a genotoxic drug that leads cells to apoptosis through the activation of the p53 pathway. |
2013-04-04 |
2023-08-12 |
Not clear |