| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Roser Mir, Avelina Tortosa, Fina Martinez-Soler, August Vidal, Enric Condom, Alba P\\xc3\\xa9rez-Perarnau, Tatiana Ruiz-Larroya, Joan Gil, Pepita Gim\\xc3\\xa9nez-Bonaf\\xc3\\xa. Mdm2 antagonists induce apoptosis and synergize with cisplatin overcoming chemoresistance in TP53 wild-type ovarian cancer cells. International journal of cancer. vol 132. issue 7. 2013-04-04. PMID:22961628.' |
defective signaling in this pathway compromises p53 function, and thus cisplatin does not induce apoptosis. |
2013-04-04 |
2023-08-12 |
Not clear |
| b' Roser Mir, Avelina Tortosa, Fina Martinez-Soler, August Vidal, Enric Condom, Alba P\\xc3\\xa9rez-Perarnau, Tatiana Ruiz-Larroya, Joan Gil, Pepita Gim\\xc3\\xa9nez-Bonaf\\xc3\\xa. Mdm2 antagonists induce apoptosis and synergize with cisplatin overcoming chemoresistance in TP53 wild-type ovarian cancer cells. International journal of cancer. vol 132. issue 7. 2013-04-04. PMID:22961628.' |
a new group of nongenotoxic small molecules called nutlins have been developed to inhibit p53-mdm2 binding, inducing apoptosis in chemoresistant tumors through the activation of the p53 pathway. |
2013-04-04 |
2023-08-12 |
Not clear |
| b' Roser Mir, Avelina Tortosa, Fina Martinez-Soler, August Vidal, Enric Condom, Alba P\\xc3\\xa9rez-Perarnau, Tatiana Ruiz-Larroya, Joan Gil, Pepita Gim\\xc3\\xa9nez-Bonaf\\xc3\\xa. Mdm2 antagonists induce apoptosis and synergize with cisplatin overcoming chemoresistance in TP53 wild-type ovarian cancer cells. International journal of cancer. vol 132. issue 7. 2013-04-04. PMID:22961628.' |
the wild-type p53 cisplatin-resistant ovarian cancer cell-line a2780cis was used to test the effect of nutlin-3a (nut3a) on apoptosis response. |
2013-04-04 |
2023-08-12 |
Not clear |
| Chariya Hahnvajanawong, Supaluk Ketnimit, Kovit Pattanapanyasat, Natthinee Anantachoke, Banchob Sripa, Khosit Pinmai, Wunchana Seubwai, Vichai Reutraku. Involvement of p53 and nuclear factor-kappaB signaling pathway for the induction of G1-phase cell cycle arrest of cholangiocarcinoma cell lines by isomorellin. Biological & pharmaceutical bulletin. vol 35. issue 11. 2013-04-04. PMID:22972485. |
our research suggests that isomorellin induces cell cycle arrest and apoptosis in cca cell lines through p53 and the nf-κb-signaling pathway. |
2013-04-04 |
2023-08-12 |
human |
| G Nilufer Yonguc, Yavuz Dodurga, Ayse Kurtulus, Bora Boz, Kemalettin Aca. Caspase 1, caspase 3, TNF-alpha, p53, and Hif1-alpha gene expression status of the brain tissues and hippocampal neuron loss in short-term dichlorvos exposed rats. Molecular biology reports. vol 39. issue 12. 2013-04-04. PMID:23053939. |
the aim of this study was to examine caspase 1, caspase-3 and also cell apoptosis related genes as p53, tumor necrosis factor-alpha, hypoxia inducible factor 1-alpha expressions in hippocampus, cerebellum, cortex, and to estimate total hippocampal neuron number in ddvp treated rats. |
2013-04-04 |
2023-08-12 |
human |
| Rahul Kumar, Kausar M Ansari, Bhushan P Chaudhari, Alok Dhawan, Premendra D Dwivedi, Swatantra K Jain, Mukul Da. Topical application of ochratoxin A causes DNA damage and tumor initiation in mouse skin. PloS one. vol 7. issue 10. 2013-04-04. PMID:23071775. |
the oxidative stress was further emphasized by the suppression of nrf2 translocation to nucleus following a single topical application of ota (80 µg/mouse) after 24 h. ota (80 µg/mouse) application for 12-72 h caused significant enhancement in- (a) reactive oxygen species generation, (b) activation of erk1/2, p38 and jnk mapks, (c) cell cycle arrest at g0/g1 phase (37-67%), (d) induction of apoptosis (2.0-11.0 fold), (e) expression of p53, p21/waf1, (f) bax/bcl-2 ratio, (g) cytochrome c level, (h) activities of caspase 9 (1.2-1.8 fold) and 3 (1.7-2.2 fold) as well as poly adp ribose polymerase cleavage. |
2013-04-04 |
2023-08-12 |
mouse |
| Juxiang Huang, Lin Wang, Minghu Jiang, Hong Lin, Lianxiu Qi, Haizhen Dia. PTHLH coupling upstream negative regulation of fatty acid biosynthesis and Wnt receptor signal to downstream peptidase activity-induced apoptosis network in human hepatocellular carcinoma by systems-theoretical analysis. Journal of receptor and signal transduction research. vol 32. issue 5. 2013-04-03. PMID:22799769. |
we proposed pthlh-activated network that upstream included the regulation of apoptosis, signal transduction resulting in induction of apoptosis, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, negative regulation of centriole replication, negative regulation of fatty acid biosynthesis, negative regulation of wnt receptor signaling pathway, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism, apoptosis, induction of apoptosis, and negative regulation of phosphorylation. |
2013-04-03 |
2023-08-12 |
human |
| Miguel Mendivil-Perez, Carlos Velez-Pardo, Marlene Jimenez-Del-Ri. TPEN induces apoptosis independently of zinc chelator activity in a model of acute lymphoblastic leukemia and ex vivo acute leukemia cells through oxidative stress and mitochondria caspase-3- and AIF-dependent pathways. Oxidative medicine and cellular longevity. vol 2012. 2013-04-03. PMID:23320127. |
we found that tpen induces apoptosis in both types of cells by a molecular oxidative stress pathway involving o(2)(•-) > h(2)o(2) >> nf-κb (jnk/c-jun) >p53> loss ΔΨ(m)> caspase-3, aif > chromatin condensation/dna fragmentation. |
2013-04-03 |
2023-08-12 |
Not clear |
| S Sadagopan, M V Veettil, S Chakraborty, N Sharma-Walia, N Paudel, V Bottero, B Chandra. Angiogenin functionally interacts with p53 and regulates p53-mediated apoptosis and cell survival. Oncogene. vol 31. issue 46. 2013-04-02. PMID:22266868. |
angiogenin functionally interacts with p53 and regulates p53-mediated apoptosis and cell survival. |
2013-04-02 |
2023-08-12 |
mouse |
| C Dudgeon, R Peng, P Wang, A Sebastiani, J Yu, L Zhan. Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth. Oncogene. vol 31. issue 46. 2013-04-02. PMID:22286758. |
in this study, we found that sorafenib kills cancer cells by activating puma (p53-upregulated modulator of apoptosis), a p53 target and a bh3-only bcl-2 family protein. |
2013-04-02 |
2023-08-12 |
Not clear |
| Shiwang Li, Jing He, Shuai Li, Guoqing Cao, Shaotao Tang, Qiangsong Tong, Harish C Josh. Noscapine induced apoptosis via downregulation of survivin in human neuroblastoma cells having wild type or null p53. PloS one. vol 7. issue 7. 2013-04-02. PMID:22848370. |
noscapine induced apoptosis via downregulation of survivin in human neuroblastoma cells having wild type or null p53. |
2013-04-02 |
2023-08-12 |
human |
| Himanshu Vashistha, Pravin C Singhal, Ashwani Malhotra, Mohammad Husain, Peter Mathieson, Moin A Saleem, Cyril Kuriakose, Surya Seshan, Anna Wilk, Luis Delvalle, Francesca Peruzzi, Marco Giorgio, Pier Giuseppe Pelicci, Oliver Smithies, Hyung-Suk Kim, Masao Kakoki, Krzysztof Reiss, Leonard G Megg. Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney. American journal of physiology. Renal physiology. vol 303. issue 12. 2013-04-02. PMID:23019230. |
experiments with cultured podocytes revealed previously unrecognized cross talk between p66 and the redox-sensitive transcription factor p53 that controls hyperglycemia-induced ros metabolism, transcription of p53 target genes (angiotensinogen, angiotensin ii type-1 receptor, and bax), angiotensin ii generation, and apoptosis. |
2013-04-02 |
2023-08-12 |
mouse |
| Mi-Yeon Cho, Su-Young Park, Sumin Park, Yong Rok Lee, Mi-Kyoung Kwak, Jung-Ae Ki. Effects of geranyl-phloroacetophenone on the induction of apoptosis and chemosensitization of adriamycin-resistant MCF-7 human breast cancer cells. Archives of pharmacal research. vol 35. issue 5. 2013-03-28. PMID:22644859. |
in adriamycin-resistant mcf-7 human breast cancer (mcf-7/adr) cells, which express a mutant form of p53, 3-gap induced significant apoptosis, which was accompanied by no change in p53 transcriptional activity, but an increase in bax expression, cyt c release, and activation of caspase-9, 7, and 3. |
2013-03-28 |
2023-08-12 |
human |
| Benyuan Deng, Fei Liu, Yonggang Wei, Limei Luo, Xi Chen, Lvnan Yan, Bo L. Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of hepatocellular carcinoma in a Chinese population. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 1. 2013-03-28. PMID:23065572. |
p73, a p53 homolog, has some p53-like activities and plays an important role in modulating cell cycle, apoptosis, and dna repair. |
2013-03-28 |
2023-08-12 |
Not clear |
| Anat Achiron, Anna Feldman, David Magalashvili, Mark Dolev, Michael Gurevic. Suppressed RNA-polymerase 1 pathway is associated with benign multiple sclerosis. PloS one. vol 7. issue 10. 2013-03-28. PMID:23077530. |
the most significant under-expressed pathway operating in bms was the pol-1 pathway (p = 4.0*10(-5)) known while suppressed to activate p53 dependent apoptosis and to suppress nfκb induced inflammation. |
2013-03-28 |
2023-08-12 |
Not clear |
| Mingrong Cheng, Bing He, Tao Wan, Weiping Zhu, Jiang Han, Bingbing Zha, Houxiang Chen, Fengxiao Yang, Qing Li, Wei Wang, Hongzhi Xu, Tao Y. 5-Fluorouracil nanoparticles inhibit hepatocellular carcinoma via activation of the p53 pathway in the orthotopic transplant mouse model. PloS one. vol 7. issue 10. 2013-03-28. PMID:23077553. |
analysis of apoptosis pathways indicated that gc/5-fu upregulates p53 expression at both protein and mrna levels. |
2013-03-28 |
2023-08-12 |
mouse |
| Chiu-Yuan Chen, Kun-Chieh Chen, Tsung-Ying Yang, Hsiang-Chun Liu, Shih-Lan Hs. Gallic Acid Induces a Reactive Oxygen Species-Provoked c-Jun NH2-Terminal Kinase-Dependent Apoptosis in Lung Fibroblasts. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-03-28. PMID:23533505. |
inhibition of jnk using pharmacologic inhibitor (sp600125) and genetic knockdown (jnk specific sirna) significantly inhibited p53 accumulation, reduced puma and fas expression, and abolished apoptosis induced by gallic acid. |
2013-03-28 |
2023-08-12 |
mouse |
| Chiu-Yuan Chen, Kun-Chieh Chen, Tsung-Ying Yang, Hsiang-Chun Liu, Shih-Lan Hs. Gallic Acid Induces a Reactive Oxygen Species-Provoked c-Jun NH2-Terminal Kinase-Dependent Apoptosis in Lung Fibroblasts. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-03-28. PMID:23533505. |
these observations imply that gallic acid-mediated hydrogen peroxide formation acts as an initiator of jnk signaling pathways, leading to p53 activation and apoptosis in mouse lung fibroblasts. |
2013-03-28 |
2023-08-12 |
mouse |
| Hong-Rui Liu, Lin-Yi Meng, Zhi-Yan Lin, Yang Shen, Yun-Qiu Yu, Yi-Zhun Zh. Cochinchina momordica seed extract induces apoptosis and cell cycle arrest in human gastric cancer cells via PARP and p53 signal pathways. Nutrition and cancer. vol 64. issue 7. 2013-03-27. PMID:23020228. |
cochinchina momordica seed extract induces apoptosis and cell cycle arrest in human gastric cancer cells via parp and p53 signal pathways. |
2013-03-27 |
2023-08-12 |
human |
| Z Korwek, T Sewastianik, A Bielak-Zmijewska, G Mosieniak, O Alster, M Moreno-Villanueva, M Moreno-Villaneuva, A Burkle, E Sikor. Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells. DNA repair. vol 11. issue 11. 2013-03-27. PMID:23058634. |
pretreatment of resting t cells with ku 55933 blocked phosphorylation of atm, h2ax and p53, which, in turn, prevented puma expression, caspase activation and apoptosis. |
2013-03-27 |
2023-08-12 |
human |