| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Cattelani, Giovanna Ferrari-Amorotti, Sara Galavotti, Raffaella Defferrari, Barbara Tanno, Samantha Cialfi, Jenny Vergalli, Valentina Fragliasso, Clara Guerzoni, Gloria Manzotti, Angela Rachele Soliera, Chiara Menin, Roberta Bertorelle, Heather P McDowell, Alessandro Inserra, Maria Luisa Belli, Luigi Varesio, Deborah Tweddle, Gian Paolo Tonini, Pierluigi Altavista, Carlo Dominici, Giuseppe Raschellà, Bruno Calabrett. The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform. Neoplasia (New York, N.Y.). vol 14. issue 7. 2013-03-18. PMID:22904680. |
moreover, the lower apoptosis and the enhanced accelerated senescence by the p53-72p isoform in response to dna damage suggest that patients with neuroblastoma with the p53-72 pro/pro genotype may benefit from therapeutic protocols that do not rely only on cytotoxic drugs that function, in part, through p53 activation. |
2013-03-18 |
2023-08-12 |
human |
| Mohammed Shafi Sofi, M K Sateesh, Mohsin Bashir, G Harish, T R Lakshmeesha, S Vedashree, A B Vedamurth. Cytotoxic and pro-apoptotic effects of Abrus precatorius L. on human metastatic breast cancer cell line, MDA-MB-231. Cytotechnology. vol 65. issue 3. 2013-03-18. PMID:23081723. |
the up-regulation of p21 and p53 may be the molecular mechanisms by which a. precatorius extract which induces apoptosis. |
2013-03-18 |
2023-08-12 |
human |
| Antonella Papa, Carlos Cordon-Cardo, Rosa Bernardi, Pier Paolo Pandolf. Compound In Vivo Inactivation of Pml and p53 Uncovers a Functional Interaction in Angiosarcoma Suppression. Genes & cancer. vol 3. issue 9-10. 2013-03-17. PMID:23486996. |
it has been shown that pml favors both p53 accumulation and transcriptional activity; in turn, pml expression is directly regulated by p53, and this reciprocal regulation contributes to p53-mediated apoptosis and senescence. |
2013-03-17 |
2023-08-12 |
Not clear |
| Zhikun Ma, Guoliang Yao, Bo Zhou, Yonggang Fan, Shegan Gao, Xiaoshan Fen. The Chk1 inhibitor AZD7762 sensitises p53 mutant breast cancer cells to radiation in vitro and in vivo. Molecular medicine reports. vol 6. issue 4. 2013-03-14. PMID:22825736. |
in the present study, we aimed to demonstrate for the first time, that azd7762 not only promotes radiation-induced apoptosis and mitotic catastrophe of p53 mutant t47d breast cancer cells in vitro, but also delays their xenograft growth in response to radiation in vivo. |
2013-03-14 |
2023-08-12 |
Not clear |
| Zhikun Ma, Guoliang Yao, Bo Zhou, Yonggang Fan, Shegan Gao, Xiaoshan Fen. The Chk1 inhibitor AZD7762 sensitises p53 mutant breast cancer cells to radiation in vitro and in vivo. Molecular medicine reports. vol 6. issue 4. 2013-03-14. PMID:22825736. |
these results suggest that azd7762 may effectively abrogate radiation-induced g2/m arrest and inhibit radiation damage repair in conferring radiosensitivity on p53 mutant t47d breast cancer cells, by promoting radiation-induced apoptosis and mitotic catastrophe. |
2013-03-14 |
2023-08-12 |
Not clear |
| Peng Sun, Hong Yu, Wen-Qing Zhang, Ming Hu, Rui L. Lentivirus-mediated siRNA targeting VEGF inhibits gastric cancer growth in vivo. Oncology reports. vol 28. issue 5. 2013-03-14. PMID:22895814. |
furthermore, the expression of vegf, sirtuin 1 (sirt1), survivin and bcl-2 was downregulated, whereas the expression of p53 and p21 was upregulated in the tumor cells, indicating that vegf sirna induced apoptosis in gastric cancer cells by inhibiting sirt1 expression, leading to p53 transcriptional upregulation and the activation of downstream p21, while suppressing bcl-2 and survivin expression. |
2013-03-14 |
2023-08-12 |
mouse |
| Ge Zhang, Yan Liu, Liwei Yu, Lina Su. GFP/HPV-16E6 fusion protein induces apoptosis in MCF-7 and 293T cells using a transient expression system. Oncology reports. vol 28. issue 5. 2013-03-14. PMID:22922869. |
furthermore, we observed significant apoptosis induced by gfp-16e6, which proved to be dependent on p53 expression. |
2013-03-14 |
2023-08-12 |
human |
| Houda Alachkar, Zhiliang Xie, Guido Marcucci, Kenneth K Cha. Determination of cellular uptake and intracellular levels of Cenersen (Aezea(®), EL625), a p53 antisense oligonucleotide in acute myeloid leukemia cells. Journal of pharmaceutical and biomedical analysis. vol 71. 2013-03-14. PMID:22944355. |
the suppression of p53 protein results in interruption of dna repair mechanisms in dividing malignant cells thereby increasing the dna damage and activating p53-independent mechanisms of apoptosis. |
2013-03-14 |
2023-08-12 |
mouse |
| Yan Wen, Prachi Wani, Lu Zhou, Tom Baer, Smruti Madan Phadnis, Renee A Reijo Pera, Bertha Che. Reprogramming of fibroblasts from older women with pelvic floor disorders alters cellular behavior associated with donor age. Stem cells translational medicine. vol 2. issue 2. 2013-03-14. PMID:23341439. |
there was no significant difference in expression of senescence and apoptosis markers (p21, p53, and bax) in ipscs derived from the younger subject compared with the older subject. |
2013-03-14 |
2023-08-12 |
human |
| Weimin Chen, Tao Jiang, Huihui Wang, Shasha Tao, Alexandria Lau, Deyu Fang, Donna D Zhan. Does Nrf2 contribute to p53-mediated control of cell survival and death? Antioxidants & redox signaling. vol 17. issue 12. 2013-03-12. PMID:22559194. |
however, at high levels or extended exposure of ros, p53 expression is enhanced, activating pro-oxidant genes and resulting in p53-dependent apoptosis. |
2013-03-12 |
2023-08-12 |
Not clear |
| Xin Li, Hong-mei Zhang, Qiao Niu, Fu-sheng Yua. [Changes of cdk5, p35 and p53 gene expression levels in arsenic-induced neural cell apoptosis]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 30. issue 2. 2013-03-12. PMID:22801079. |
[changes of cdk5, p35 and p53 gene expression levels in arsenic-induced neural cell apoptosis]. |
2013-03-12 |
2023-08-12 |
Not clear |
| Xin Li, Hong-mei Zhang, Qiao Niu, Fu-sheng Yua. [Changes of cdk5, p35 and p53 gene expression levels in arsenic-induced neural cell apoptosis]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 30. issue 2. 2013-03-12. PMID:22801079. |
to study the expression levels of cdk5, p35 and p53 genes in arsenic trioxide (as2o3o)-induced neuron apoptosis and to explore the potential mechanism. |
2013-03-12 |
2023-08-12 |
Not clear |
| Xiu Dong, Jian-Chun Li, Yuan-Yuan Jiang, Ming-Yu Xia, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejim. p38-NF-κB-promoted mitochondria-associated apoptosis and G2/M cell cycle arrest in norcantharidin-treated HeLa cells. Journal of Asian natural products research. vol 14. issue 11. 2013-03-12. PMID:23281704. |
moreover, nctd-induced apoptosis and cell cycle arrest were significantly blocked by sb203580 and pdtc but not by pifithrin-α (p53 inhibitor). |
2013-03-12 |
2023-08-12 |
human |
| S Catuogno, L Cerchia, G Romano, P Pognonec, G Condorelli, V de Francisci. miR-34c may protect lung cancer cells from paclitaxel-induced apoptosis. Oncogene. vol 32. issue 3. 2013-03-11. PMID:22370637. |
we demonstrate that bmf (bcl-2-modifying factor) is a target of mir-34c-5p, and that its silencing, together with that of c-myc, a known target of mir-34c-5p, contributes to resistance to apoptosis induced by paclitaxel through p53 downregulation. |
2013-03-11 |
2023-08-12 |
Not clear |
| Xiangming Ji, Zhiwei Wang, Andreea Geamanu, Arvind Goja, Fazlul H Sarkar, Smiti V Gupt. Delta-tocotrienol suppresses Notch-1 pathway by upregulating miR-34a in nonsmall cell lung cancer cells. International journal of cancer. vol 131. issue 11. 2013-03-08. PMID:22438124. |
moreover, re-expression of mir-34a by transfection in nsclc cells resulted in inhibition of cell growth and invasiveness, induction of apoptosis and enhanced p53 activity. |
2013-03-08 |
2023-08-12 |
Not clear |
| Wei-jun Mai, Peng Liu, Weina Wan. Characterization of the tilapia p53 gene and its role in chemical-induced apoptosis. Biotechnology letters. vol 34. issue 10. 2013-03-08. PMID:22714278. |
characterization of the tilapia p53 gene and its role in chemical-induced apoptosis. |
2013-03-08 |
2023-08-12 |
rabbit |
| Wei-jun Mai, Peng Liu, Weina Wan. Characterization of the tilapia p53 gene and its role in chemical-induced apoptosis. Biotechnology letters. vol 34. issue 10. 2013-03-08. PMID:22714278. |
in addition, atm, p53 and bax proteins, associated with dna damage responses and apoptosis, were all upregulated in tilapia liver after treatment with the stress inducers etoposide and cdcl(2). |
2013-03-08 |
2023-08-12 |
rabbit |
| Emiko Sano, Shinnya Tashiro, Hisashi Tadakuma, Toshiaki Takei, Takuya Ueda, Kouhei Tsumot. Type 1 IFN inhibits the growth factor deprived apoptosis of cultured human aortic endothelial cells and protects the cells from chemically induced oxidative cytotoxicity. Journal of cellular biochemistry. vol 113. issue 12. 2013-03-08. PMID:22821369. |
it was considered that ifn-β inhibits the executive late stage apoptosis from the results of annexin-v-fitc/pi double staining and the inhibition of caspase-3 activity, and that the anti-apoptotic effect might be owing to the direct inhibition of the apoptotic pathway mediated by p53 from the transient down-regulation of bax mrna expression. |
2013-03-08 |
2023-08-12 |
human |
| Matthew Jones, Ashish La. MicroRNAs, wild-type and mutant p53: more questions than answers. RNA biology. vol 9. issue 6. 2013-03-06. PMID:22664917. |
the tumor suppressor p53 is a sequence-specific transcription factor that activates the expression of genes involved in apoptosis, cell cycle arrest and senescence. |
2013-03-06 |
2023-08-12 |
Not clear |
| Reema Roshan, Tanay Ghosh, Mugdha Gadgil, Beena Pilla. Regulation of BACE1 by miR-29a/b in a cellular model of Spinocerebellar Ataxia 17. RNA biology. vol 9. issue 6. 2013-03-06. PMID:22664922. |
with mir-29a/b down regulation, we found an increased expression of targets of mir-29a/b -beta-site amyloid precursor protein cleaving enzyme 1 (bace1), p53 upregulated modulator of apoptosis (puma) and bak, increased cytochrome c release and apoptosis. |
2013-03-06 |
2023-08-12 |
Not clear |