| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ziyuan Zhou, Erich M Sturgis, Zhensheng Liu, Li-E Wang, Qingyi Wei, Guojun L. Genetic variants of a BH3-only pro-apoptotic gene, PUMA, and risk of HPV16-associated squamous cell carcinoma of the head and neck. Molecular carcinogenesis. vol 51 Suppl 1. 2013-01-22. PMID:22086558. |
p53 up-regulated modulator of apoptosis (puma) is a critical factor in the intrinsic apoptotic pathway. |
2013-01-22 |
2023-08-12 |
human |
| Ziyuan Zhou, Erich M Sturgis, Zhensheng Liu, Li-E Wang, Qingyi Wei, Guojun L. Genetic variants of a BH3-only pro-apoptotic gene, PUMA, and risk of HPV16-associated squamous cell carcinoma of the head and neck. Molecular carcinogenesis. vol 51 Suppl 1. 2013-01-22. PMID:22086558. |
through puma-dependent mechanisms, human papillomavirus 16 (hpv16) oncoprotein may affect apoptosis by e6-mediated p53 degradation. |
2013-01-22 |
2023-08-12 |
human |
| Jayendra B Patel, Kinjal D Patel, Shruti R Patel, Franky D Shah, Shilin N Shukla, Prabhudas S Pate. Recent candidate molecular markers: vitamin D signaling and apoptosis specific regulator of p53 (ASPP) in breast cancer. Asian Pacific journal of cancer prevention : APJCP. vol 13. issue 5. 2013-01-22. PMID:22901112. |
recent candidate molecular markers: vitamin d signaling and apoptosis specific regulator of p53 (aspp) in breast cancer. |
2013-01-22 |
2023-08-12 |
Not clear |
| Ahmed Y Ali, Lee Farrand, Ji Young Kim, Sanguine Byun, Jeong-Yong Suh, Hyong Joo Lee, Benjamin K Tsan. Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum. Annals of the New York Academy of Sciences. vol 1271. 2013-01-22. PMID:23050965. |
p53 is a major tumor suppressor regulating proliferation and apoptosis, and its mutation is a frequent event in human malignancies. |
2013-01-22 |
2023-08-12 |
human |
| Ning Song, Shuken Boku, Shin Nakagawa, Akiko Kato, Hiroyuki Toda, Naoki Takamura, Yuki Omiya, Yuji Kitaichi, Takeshi Inoue, Tsukasa Koyam. Mood stabilizers commonly restore staurosporine-induced increase of p53 expression and following decrease of Bcl-2 expression in SH-SY5Y cells. Progress in neuro-psychopharmacology & biological psychiatry. vol 38. issue 2. 2013-01-21. PMID:22484386. |
in addition, it has been shown that li decreases the expression of p53, which plays a prominent role in apoptosis and regulates the expression of bcl-2. |
2013-01-21 |
2023-08-12 |
rat |
| M Deng, P Chen, F Liu, S Fu, H Tang, Y Fu, Z Xiong, S Hui, W Ji, X Zhang, L Zhang, L Gong, X Hu, W Hu, S Sun, J Liu, L Xiao, W-B Liu, Y-M Xiao, S-J Liu, Y Liu, D W-C L. The p53-Bak apoptotic signaling axis plays an essential role in regulating differentiation of the ocular lens. Current molecular medicine. vol 12. issue 8. 2013-01-21. PMID:22671997. |
the tumor suppressor p53 is a master regulator of apoptosis and also plays a key role in cell cycle checking. |
2013-01-21 |
2023-08-12 |
mouse |
| F-Y Liu, X-C Tang, M Deng, P Chen, W Ji, X Zhang, L Gong, Z Woodward, J Liu, L Zhang, S Sun, J-P Liu, K Wu, M-X Wu, X-L Liu, M-B Yu, Y Liu, D W-C L. The tumor suppressor p53 regulates c-Maf and Prox-1 to control lens differentiation. Current molecular medicine. vol 12. issue 8. 2013-01-21. PMID:22827438. |
the tumor suppressor p53 plays a key role in regulating apoptosis and cell cycle progression. |
2013-01-21 |
2023-08-12 |
mouse |
| J Slovackova, J Smarda, J Smardov. Roscovitine-induced apoptosis of H1299 cells depends on functional status of p53. Neoplasma. vol 59. issue 6. 2013-01-18. PMID:22862161. |
roscovitine-induced apoptosis of h1299 cells depends on functional status of p53. |
2013-01-18 |
2023-08-12 |
Not clear |
| J Slovackova, J Smarda, J Smardov. Roscovitine-induced apoptosis of H1299 cells depends on functional status of p53. Neoplasma. vol 59. issue 6. 2013-01-18. PMID:22862161. |
the cells expressing p98a, s215g and y220c p53 mutants exhibited only weak sensitivity to roscovitine and underwent apoptosis in low frequency. |
2013-01-18 |
2023-08-12 |
Not clear |
| Rakesh K Rai, Naveen K Vishvakarma, Tribhuban M Mohapatra, Sukh Mahendra Sing. Augmented macrophage differentiation and polarization of tumor-associated macrophages towards M1 subtype in listeria-administered tumor-bearing host. Journal of immunotherapy (Hagerstown, Md. : 1997). vol 35. issue 7. 2013-01-18. PMID:22892451. |
bone marrow cell of listeria-administered tumor-bearing mice showed augmented survival, declined expression of p53 upregulated modulator of apoptosis with an upregulated differentiation into activation responsive bone marrow-derived macrophages along with altered expression of macrophage-colony stimulating factor, macrophage-colony stimulating factor receptor, and granulocyte macrophage-colony stimulating factor receptor. |
2013-01-18 |
2023-08-12 |
mouse |
| Shanmiao Gou, Tao Liu, Xiangsheng Li, Jing Cui, Chidan Wan, Chunyou Wan. Pancreatic ductal cells acquire mesenchymal characteristics through cell fusion with bone marrow-derived mesenchymal stem cells and SIRT1 attenuates the apoptosis of hybrid cells. Cells, tissues, organs. vol 196. issue 2. 2013-01-17. PMID:22269821. |
expression of the tumor suppressor protein p53, which initiates apoptosis, was detected in hybrid cells but not in pdcs or bmscs. |
2013-01-17 |
2023-08-12 |
mouse |
| Shanmiao Gou, Tao Liu, Xiangsheng Li, Jing Cui, Chidan Wan, Chunyou Wan. Pancreatic ductal cells acquire mesenchymal characteristics through cell fusion with bone marrow-derived mesenchymal stem cells and SIRT1 attenuates the apoptosis of hybrid cells. Cells, tissues, organs. vol 196. issue 2. 2013-01-17. PMID:22269821. |
the addition of nicotinamide (nam) inhibited the deacetylation activity of sirt1 on p53 and induced cell apoptosis in hybrid cells. |
2013-01-17 |
2023-08-12 |
mouse |
| Ziyuan Zhou, Erich M Sturgis, Zhensheng Liu, Li-E Wang, Qingyi Wei, Guojun L. Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck. BMC cancer. vol 12. 2013-01-17. PMID:22548841. |
human papillomavirus 16 (hpv16), by inducing p53 and prb-e2f degradation, may play an essential role in development of squamous cell carcinoma of the head and neck (scchn) through noxa-mcl1 axis-mediated apoptosis. |
2013-01-17 |
2023-08-12 |
human |
| Peter E Clayton, Dan Hanson, Lucia Magee, Philip G Murray, Emma Saunders, Sayeda N Abu-Amero, Gudrun E Moore, Graeme C M Blac. Exploring the spectrum of 3-M syndrome, a primordial short stature disorder of disrupted ubiquitination. Clinical endocrinology. vol 77. issue 3. 2013-01-17. PMID:22624670. |
ccdc8 is the newest member of the pathway and interacts with obsl1 and, like cul7, associates with p53, acting as a co-factor in p53-medicated apoptosis. |
2013-01-17 |
2023-08-12 |
Not clear |
| I Zajc, M Filipič, T T La. Xanthohumol induces different cytotoxicity and apoptotic pathways in malignant and normal astrocytes. Phytotherapy research : PTR. vol 26. issue 11. 2013-01-16. PMID:22407755. |
xn induced a higher rate of apoptosis in glioblastoma cells than in normal astrocytes, which was associated with activation of p53 and an elevated bax/bcl-2 ratio in glioblastoma cells, indicating an intrinsic caspase-dependent apoptotic pathway. |
2013-01-16 |
2023-08-12 |
human |
| Jong-Lyel Roh, Jung Ho Ko, Soo Jin Moon, Chang Hwan Ryu, Jun Young Choi, Wayne M Koc. The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer. Cancer letters. vol 325. issue 1. 2013-01-16. PMID:22634494. |
we evaluated whether the restoration of p53 function by the p53-reactivating small molecule rita (reactivation of p53 and induction of tumor cell apoptosis enhances cisplatin-induced cytotoxicity and apoptosis in head-and-neck cancer (hnc). |
2013-01-16 |
2023-08-12 |
Not clear |
| Jong-Lyel Roh, Jung Ho Ko, Soo Jin Moon, Chang Hwan Ryu, Jun Young Choi, Wayne M Koc. The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer. Cancer letters. vol 325. issue 1. 2013-01-16. PMID:22634494. |
rita promoted apoptosis in association with upregulation of p21, bax, and cleaved caspase-3; notably, the apoptotic response was blocked by pifithrin-α, demonstrating its p53 dependence. |
2013-01-16 |
2023-08-12 |
Not clear |
| Jong-Lyel Roh, Jung Ho Ko, Soo Jin Moon, Chang Hwan Ryu, Jun Young Choi, Wayne M Koc. The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer. Cancer letters. vol 325. issue 1. 2013-01-16. PMID:22634494. |
our data suggest that the restoration of p53 tumor-suppressive function by rita enhances the cytotoxicity and apoptosis of cisplatin, an action that may offer an attractive strategy for treating hnc. |
2013-01-16 |
2023-08-12 |
Not clear |
| Tai-Ho Hung, Szu-Fu Chen, Liang-Ming Lo, Meng-Jen Li, Yi-Lin Yeh, T'sang-T'ang Hsie. Increased autophagy in placentas of intrauterine growth-restricted pregnancies. PloS one. vol 7. issue 7. 2013-01-16. PMID:22815878. |
the aims of this work were (1) to compare the differences in autophagy, p53 expression, and apoptosis between placentas of women with normal or iugr pregnancies; (2) to study the effects of hypoxia and the role of p53 in regulating trophoblast autophagy; and (3) to investigate the relationship between autophagy and apoptosis in hypoxic trophoblasts. |
2013-01-16 |
2023-08-12 |
Not clear |
| Twee Tsao, Yuexi Shi, Steven Kornblau, Hongbo Lu, Sergej Konoplev, Ansu Antony, Vivian Ruvolo, Yi Hua Qiu, Ninaxiang Zhang, Kevin R Coombes, Michael Andreeff, Kensuke Kojima, Marina Konoplev. Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells. Annals of hematology. vol 91. issue 12. 2013-01-16. PMID:22893484. |
although absence of p53 limited apoptotic activities of 5-aza and abt-737 as single agents, the combination synergistically induced apoptosis independent of p53 expression. |
2013-01-16 |
2023-08-12 |
Not clear |