| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Li, S Liu, W Li, S Hu, J Xiong, X Shu, Q Hu, Q Zheng, Z Son. Vascular smooth muscle cell apoptosis promotes transplant arteriosclerosis through inducing the production of SDF-1α. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 12. issue 8. 2012-12-26. PMID:22845908. |
we transferred wild-type p53 to induce apoptosis of cultured smcs. |
2012-12-26 |
2023-08-12 |
rat |
| b' Alena Rajnochov\\xc3\\xa1 Svobodov\\xc3\\xa1, Ad\\xc3\\xa9la Galand\\xc3\\xa1kov\\xc3\\xa1, Jarmila Siansk\\xc3\\xa1, Dalibor Dole\\xc5\\xbeal, Radka Lichnovsk\\xc3\\xa1, Jitka Ulrichov\\xc3\\xa1, Jitka Vost\\xc3\\xa1lov\\xc3\\xa. DNA damage after acute exposure of mice skin to physiological doses of UVB and UVA light. Archives of dermatological research. vol 304. issue 5. 2012-12-21. PMID:22271212.' |
the number of dna single-strand breaks (ssb) in lymphocytes, amount of phosphorylated histone h2ax (gamma-h2ax) and apoptosis or dna fragmentation (tunel-positive cells) in skin sections and level of gamma-h2ax, activated caspase-3 and phosphorylated p53 in skin were evaluated after 4 and 24 h. ssb analyzed by alkaline comet assay were found to be 4 and 24 h following uvb and uva treatment, respectively. |
2012-12-21 |
2023-08-12 |
mouse |
| Song-qiang Xie, Ya-hong Zhang, Qian Li, Feng-hua Xu, Jiu-wang Miao, Jin Zhao, Chao-jie Wan. 3-Nitro-naphthalimide and nitrogen mustard conjugate NNM-25 induces hepatocellular carcinoma apoptosis via PARP-1/p53 pathway. Apoptosis : an international journal on programmed cell death. vol 17. issue 7. 2012-12-21. PMID:22395446. |
inhibition of p53 by sirna resulted in a significant decrease of nnm-25-induced apoptosis, which corroborated that p53 played a vital role in the cell apoptosis triggered by nnm-25. |
2012-12-21 |
2023-08-12 |
mouse |
| M P Puissegur, R Eichner, C Quelen, E Coyaud, B Mari, K Lebrigand, C Broccardo, F Nguyen-Khac, M Bousquet, P Brousse. B-cell regulator of immunoglobulin heavy-chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells. Leukemia. vol 26. issue 10. 2012-12-21. PMID:22469780. |
in addition, overexpression of mir-125b protected pre-bi and leukemic b-cell lines from apoptosis by blockade of caspase activation by a mechanism that was independent of p53 and bak1. |
2012-12-21 |
2023-08-12 |
human |
| Muhammad Khan, Fei Yi, Azhar Rasul, Ting Li, Nan Wang, Hongwen Gao, Rong Gao, Tonghui M. Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB life. vol 64. issue 9. 2012-12-21. PMID:22837216. |
the alantolactone-induced apoptosis was found to be associated with glutathione (gsh) depletion, reactive oxygen species (ros) generation, mitochondrial transmembrane potential dissipation, cardiolipin oxidation, upregulation of p53 and bax, downregulation of bcl-2, cytochrome c release, activation of caspases (caspase 9 and 3), and cleavage of poly (adp-ribose) polymerase. |
2012-12-21 |
2023-08-12 |
mouse |
| Wei-Ting Hsiao, Ming-Dar Tsai, Guey-Mei Jow, Lu-Tai Tien, Yih-Jing Le. Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. Molecular vision. vol 18. 2012-12-21. PMID:22876131. |
involvement of smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. |
2012-12-21 |
2023-08-12 |
human |
| E Marchetti, J Romero, R Sanchez, J Vargas, C Dominguez, J Lacal, S Ramon y Caja. Oncogenes and cellular-sensitivity to radiotherapy - a study on murine keratinocytes transformed by v-h-ras, v-myc, v-Neu, adenovirus e1a and mutant p53. International journal of oncology. vol 5. issue 3. 2012-12-20. PMID:21559621. |
p53 protein was studied by western-blot and apoptosis in dna agarose gels. |
2012-12-20 |
2023-08-12 |
mouse |
| E Marchetti, J Romero, R Sanchez, J Vargas, C Dominguez, J Lacal, S Ramon y Caja. Oncogenes and cellular-sensitivity to radiotherapy - a study on murine keratinocytes transformed by v-h-ras, v-myc, v-Neu, adenovirus e1a and mutant p53. International journal of oncology. vol 5. issue 3. 2012-12-20. PMID:21559621. |
mechanisms involved in radiosensitivity mediated by the ela oncogene seem to be related to p53 protein level, induction of apoptosis and to an irreversible premitotic arrest in g2/m phase, ineffective for repair of dna damage. |
2012-12-20 |
2023-08-12 |
mouse |
| Athanassios Kotsinas, Vimla Aggarwal, E-Jean Tan, Brynn Levy, Vassilis G Gorgouli. PIG3: a novel link between oxidative stress and DNA damage response in cancer. Cancer letters. vol 327. issue 1-2. 2012-12-20. PMID:22178897. |
p53 inducible gene 3 (pig3 or tp53i3) was identified in an analysis of genes induced by p53 before the onset of apoptosis. |
2012-12-20 |
2023-08-12 |
Not clear |
| Athanassios Kotsinas, Vimla Aggarwal, E-Jean Tan, Brynn Levy, Vassilis G Gorgouli. PIG3: a novel link between oxidative stress and DNA damage response in cancer. Cancer letters. vol 327. issue 1-2. 2012-12-20. PMID:22178897. |
the first is that of ros producer linked to p53 induced apoptosis. |
2012-12-20 |
2023-08-12 |
Not clear |
| Mohanad Mossalam, Karina J Matissek, Abood Okal, Jonathan E Constance, Carol S Li. Direct induction of apoptosis using an optimal mitochondrially targeted p53. Molecular pharmaceutics. vol 9. issue 5. 2012-12-20. PMID:22380534. |
direct induction of apoptosis using an optimal mitochondrially targeted p53. |
2012-12-20 |
2023-08-12 |
Not clear |
| Mohanad Mossalam, Karina J Matissek, Abood Okal, Jonathan E Constance, Carol S Li. Direct induction of apoptosis using an optimal mitochondrially targeted p53. Molecular pharmaceutics. vol 9. issue 5. 2012-12-20. PMID:22380534. |
(1, 2) p53 forms a complex with the antiapoptotic bcl-xl, which leads to bak and bax oligomerization resulting in apoptosis via mitochondrial outer membrane permeabilization. |
2012-12-20 |
2023-08-12 |
Not clear |
| Radim Havelek, Pavel Siman, Jana Cmielova, Alena Stoklasova, Jirina Vavrova, Jaromir Vinklarek, Jiri Knizek, Martina Rezacov. Differences in vanadocene dichloride and cisplatin effect on MOLT-4 leukemia and human peripheral blood mononuclear cells. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 8. issue 4. 2012-12-18. PMID:22530915. |
vdc induces apoptosis in leukemia cells; the induction is, however, lower than that of cisplatin, and in contrary to cisplatin, vdc does not induce p53 up-regulation. |
2012-12-18 |
2023-08-12 |
human |
| Mikhail V Blagosklonn. Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression? Aging. vol 4. issue 7. 2012-12-18. PMID:22869016. |
tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression? |
2012-12-18 |
2023-08-12 |
Not clear |
| Marie Morfouace, Lisenn Lalier, Muriel Bahut, Virginie Bonnamain, Philippe Naveilhan, Catherine Guette, Lisa Oliver, Naig Gueguen, Pascal Reynier, Francois M Vallett. Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications. The Journal of biological chemistry. vol 287. issue 40. 2012-12-14. PMID:22782899. |
the former phenomenon is related to dca-induced foxo3 and p53 expression, resulting in the overexpression of bh3-only proteins (bad, noxa, and puma), which in turn facilitates bax-dependent apoptosis. |
2012-12-14 |
2023-08-12 |
rat |
| Joern Henze, Thomas Mühlenberg, Susanne Simon, Florian Grabellus, Brian Rubin, Georg Taeger, Martin Schuler, Juergen Treckmann, Maria Debiec-Rychter, Takahiro Taguchi, Jonathan A Fletcher, Sebastian Baue. p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors. PloS one. vol 7. issue 5. 2012-12-13. PMID:22662219. |
upregulation of p53 by mdm2 inhibitors has been shown to induce apoptosis in p53 wildtype tumors. |
2012-12-13 |
2023-08-12 |
Not clear |
| Joern Henze, Thomas Mühlenberg, Susanne Simon, Florian Grabellus, Brian Rubin, Georg Taeger, Martin Schuler, Juergen Treckmann, Maria Debiec-Rychter, Takahiro Taguchi, Jonathan A Fletcher, Sebastian Baue. p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors. PloS one. vol 7. issue 5. 2012-12-13. PMID:22662219. |
rita induced p53 in gist48b, followed by antiproliferative effects and a strong induction of apoptosis. |
2012-12-13 |
2023-08-12 |
Not clear |
| Hui Li, Wenwei Qian, Xisheng Weng, Zhihong Wu, Huihua Li, Qianyu Zhuang, Bin Feng, Yanyan Bia. Glucocorticoid receptor and sequential P53 activation by dexamethasone mediates apoptosis and cell cycle arrest of osteoblastic MC3T3-E1 cells. PloS one. vol 7. issue 6. 2012-12-13. PMID:22719835. |
glucocorticoid receptor and sequential p53 activation by dexamethasone mediates apoptosis and cell cycle arrest of osteoblastic mc3t3-e1 cells. |
2012-12-13 |
2023-08-12 |
Not clear |
| Hui Li, Wenwei Qian, Xisheng Weng, Zhihong Wu, Huihua Li, Qianyu Zhuang, Bin Feng, Yanyan Bia. Glucocorticoid receptor and sequential P53 activation by dexamethasone mediates apoptosis and cell cycle arrest of osteoblastic MC3T3-E1 cells. PloS one. vol 7. issue 6. 2012-12-13. PMID:22719835. |
we also proved that dexamethasone can't induce apoptosis and cell cycle arrest when p53 was inhibited by p53 rna interference. |
2012-12-13 |
2023-08-12 |
Not clear |
| Gry Irene Magnussen, Ruth Holm, Elisabeth Emilsen, Anne Katrine Ree Rosnes, Ana Slipicevic, Vivi Ann Flørene. High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapy. PloS one. vol 7. issue 6. 2012-12-13. PMID:22719872. |
both latter cell lines displayed dna damage and induction of apoptosis, in the absence of wee1, indicating that the effect of silencing wee1 may not be solely dependent of the p53 status of the cells. |
2012-12-13 |
2023-08-12 |
Not clear |