| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingzhen Yang, Fang Yuan, Peng Li, Zhongjiao Chen, An Chen, Shuhui Li, Chuanmin H. Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells. Molecular cancer. vol 11. 2012-12-13. PMID:22888789. |
interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells. |
2012-12-13 |
2023-08-12 |
human |
| Corrie L Gallant-Behm, Matthew R Ramsey, Claire L Bensard, Ignacio Nojek, Jack Tran, Minghua Liu, Leif W Ellisen, Joaquín M Espinos. ΔNp63α represses anti-proliferative genes via H2A.Z deposition. Genes & development. vol 26. issue 20. 2012-12-13. PMID:23019126. |
because Δnp63α and p53 bind virtually identical dna sequence motifs, it has been proposed that Δnp63α functions as a dominant-negative inhibitor of p53 to promote proliferation and block apoptosis. |
2012-12-13 |
2023-08-12 |
Not clear |
| Fatma Ser. MicroRNA changes in advanced radiotherapy techniques and its effect to secondary cancers. Medical hypotheses. vol 79. issue 3. 2012-12-12. PMID:22658362. |
mirnas can activate the initiation of apoptosis, cessation of the cell cycle and aging in case of dna damage by stimulating the tumor suppressor target gene p53 directly and indirectly. |
2012-12-12 |
2023-08-12 |
human |
| Purusottam Mohapatra, Ranjan Preet, Dipon Das, Shakti Ranjan Satapathy, Tathagata Choudhuri, Michael D Wyatt, Chanakya Nath Kund. Quinacrine-mediated autophagy and apoptosis in colon cancer cells is through a p53- and p21-dependent mechanism. Oncology research. vol 20. issue 2-3. 2012-12-11. PMID:23193914. |
collectively, the results suggest that qc-mediated autophagy and apoptosis dependent on p53 and p21. |
2012-12-11 |
2023-08-12 |
Not clear |
| Kazuho Suzuki, Nurmaa Dashzeveg, Zheng-Guang Lu, Naoe Taira, Yoshio Miki, Kiyotsugu Yoshid. Programmed cell death 6, a novel p53-responsive gene, targets to the nucleus in the apoptotic response to DNA damage. Cancer science. vol 103. issue 10. 2012-12-10. PMID:22712728. |
following dna damage, the tumor suppressor gene p53 activates and plays critical roles in cell cycle arrest, activation of dna repair and in the event of irreparable damage, induction of apoptosis. |
2012-12-10 |
2023-08-12 |
Not clear |
| Jinxiong Wei, Jennifer Noto, Elena Zaika, Judith Romero-Gallo, Pelayo Correa, Wael El-Rifai, Richard M Peek, Alexander Zaik. Pathogenic bacterium Helicobacter pylori alters the expression profile of p53 protein isoforms and p53 response to cellular stresses. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 38. 2012-12-10. PMID:22927405. |
if cellular damage is beyond the capability of the repair mechanisms, p53 induces apoptosis or cell cycle arrest, preventing damaged cells from becoming cancerous. |
2012-12-10 |
2023-08-12 |
human |
| Shwetha K Shetty, Yashodhar P Bhandary, Amarnath S Marudamuthu, Daniel Abernathy, Thirunavukkarasu Velusamy, Barry Starcher, Sreerama Shett. Regulation of airway and alveolar epithelial cell apoptosis by p53-Induced plasminogen activator inhibitor-1 during cigarette smoke exposure injury. American journal of respiratory cell and molecular biology. vol 47. issue 4. 2012-12-07. PMID:22592924. |
here, we show that cs induces p53 and pai-1 expression and apoptosis in cultured beas2b and primary alveolar type (at)ii cells. |
2012-12-07 |
2023-08-12 |
mouse |
| Shwetha K Shetty, Yashodhar P Bhandary, Amarnath S Marudamuthu, Daniel Abernathy, Thirunavukkarasu Velusamy, Barry Starcher, Sreerama Shett. Regulation of airway and alveolar epithelial cell apoptosis by p53-Induced plasminogen activator inhibitor-1 during cigarette smoke exposure injury. American journal of respiratory cell and molecular biology. vol 47. issue 4. 2012-12-07. PMID:22592924. |
wild-type mice exposed to passive cs likewise show augmented p53 and pai-1 with parallel induction of atii cell apoptosis, whereas mice deficient for p53 or pai-1 expression resisted apoptosis of atii cells. |
2012-12-07 |
2023-08-12 |
mouse |
| Shwetha K Shetty, Yashodhar P Bhandary, Amarnath S Marudamuthu, Daniel Abernathy, Thirunavukkarasu Velusamy, Barry Starcher, Sreerama Shett. Regulation of airway and alveolar epithelial cell apoptosis by p53-Induced plasminogen activator inhibitor-1 during cigarette smoke exposure injury. American journal of respiratory cell and molecular biology. vol 47. issue 4. 2012-12-07. PMID:22592924. |
csp suppressed cs-induced atii cell apoptosis in wild-type mice and abrogated p53-pai-1 mrna interaction with parallel inhibition of p53 and pai-1 expression. |
2012-12-07 |
2023-08-12 |
mouse |
| Shwetha K Shetty, Yashodhar P Bhandary, Amarnath S Marudamuthu, Daniel Abernathy, Thirunavukkarasu Velusamy, Barry Starcher, Sreerama Shett. Regulation of airway and alveolar epithelial cell apoptosis by p53-Induced plasminogen activator inhibitor-1 during cigarette smoke exposure injury. American journal of respiratory cell and molecular biology. vol 47. issue 4. 2012-12-07. PMID:22592924. |
these observations demonstrate that inhibition of p53 binding to pai-1 mrna 3'utr attenuates cs-induced atii cell apoptosis. |
2012-12-07 |
2023-08-12 |
mouse |
| Victoria L Haley, David J Barnes, Ionel Sandovici, Miguel Constancia, Christopher F Graham, Francesco Pezzella, Claudia Bühnemann, Emma J Carter, A Bassim Hassa. Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes. EMBO molecular medicine. vol 4. issue 8. 2012-12-07. PMID:22674894. |
accelerated carcinoma and sarcoma tumour formation in p53(+/-) females with bi-allelic igf2 expression was associated with reductions in p53 loss of heterozygosity and apoptosis. |
2012-12-07 |
2023-08-12 |
mouse |
| Camila Zogbi, Renato B Tesser, Giselly Encinas, Sandra M Miraglia, Taiza Stump. Gonocyte development in rats: proliferation, distribution and death revisited. Histochemistry and cell biology. vol 138. issue 2. 2012-12-06. PMID:22527699. |
rat testes were collected at 19 dpc and at 1, 3, 5, 8, 11 and 15 dpp and submitted to apoptosis investigation through morphological analysis and tunel, p53 and cleaved caspase 3 labeling. |
2012-12-06 |
2023-08-12 |
rat |
| Eiko Ozono, Hideyuki Komori, Ritsuko Iwanaga, Tatsuya Tanaka, Takahiro Sakae, Hodaka Kitamura, Shoji Yamaoka, Kiyoshi Ohtan. Tumor suppressor TAp73 gene specifically responds to deregulated E2F activity in human normal fibroblasts. Genes to cells : devoted to molecular & cellular mechanisms. vol 17. issue 8. 2012-12-06. PMID:22702391. |
we show here that the tumor suppressor tap73 gene, which can induce apoptosis independently of p53, responds to deregulated e2f activity, but not to physiological e2f activity induced by growth stimulation in human normal fibroblasts. |
2012-12-06 |
2023-08-12 |
human |
| Josiana A Vaz, Isabel C F R Ferreira, Catarina Tavares, Gabriela M Almeida, Anabela Martins, M Helena Vasconcelo. Suillus collinitus methanolic extract increases p53 expression and causes cell cycle arrest and apoptosis in a breast cancer cell line. Food chemistry. vol 135. issue 2. 2012-12-06. PMID:22868134. |
suillus collinitus methanolic extract increases p53 expression and causes cell cycle arrest and apoptosis in a breast cancer cell line. |
2012-12-06 |
2023-08-12 |
human |
| Guang-Hui Dong, Jing Wang, Ying-Hua Zhang, Miao-Miao Liu, Da Wang, Li Zheng, Yi-He Ji. Induction of p53-mediated apoptosis in splenocytes and thymocytes of C57BL/6 mice exposed to perfluorooctane sulfonate (PFOS). Toxicology and applied pharmacology. vol 264. issue 2. 2012-12-04. PMID:22959464. |
we analyzed the cell death via apoptosis with an annexin-v/propidium iodide assay by flow cytometry, and observed that both the percentage of apoptosis and the expression of the pro-apoptotic proteins p53 in splenocytes and thymocytes increased in a dose-related manner after pfos treatment. |
2012-12-04 |
2023-08-12 |
mouse |
| B Wu, W Li, C Qian, Z Zhou, W Xu, J W. Down-regulated P53 by siRNA increases Smad4's activity in promoting cell apoptosis in MCF-7 cells. European review for medical and pharmacological sciences. vol 16. issue 9. 2012-12-04. PMID:23047509. |
down-regulated p53 by sirna increases smad4's activity in promoting cell apoptosis in mcf-7 cells. |
2012-12-04 |
2023-08-12 |
Not clear |
| Taeyoung Koo, Il-Kyu Choi, Minjung Kim, Jung-Sun Lee, Eonju Oh, Jungho Kim, Chae-Ok Yu. Negative regulation-resistant p53 variant enhances oncolytic adenoviral gene therapy. Human gene therapy. vol 23. issue 6. 2012-12-03. PMID:22248367. |
we found that ad-mΔ19/p53vpΔ30 induced apoptosis through accumulation of p53vpΔ30, regardless of endogenous p53 and mdm2 status. |
2012-12-03 |
2023-08-12 |
mouse |
| Ahmed Kamal, Jaki R Tamboli, M Janaki Ramaiah, S F Adil, G Koteswara Rao, A Viswanath, Adla Mallareddy, S N C V L Pushpavalli, Manika Pal-Bhadr. Anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates as p53 activators in cervical cancer cells. ChemMedChem. vol 7. issue 8. 2012-12-03. PMID:22700474. |
immunoblot and rt-pcr analyses proved the presence of mitochondria-mediated apoptosis with involvement p53 target genes such as bax, bcl2, and p21 (cdki). |
2012-12-03 |
2023-08-12 |
Not clear |
| Ahmed Kamal, Jaki R Tamboli, M Janaki Ramaiah, S F Adil, G Koteswara Rao, A Viswanath, Adla Mallareddy, S N C V L Pushpavalli, Manika Pal-Bhadr. Anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates as p53 activators in cervical cancer cells. ChemMedChem. vol 7. issue 8. 2012-12-03. PMID:22700474. |
moreover, these compounds increased the phosphorylated forms of p53 and provide signals for apoptosis induction. |
2012-12-03 |
2023-08-12 |
Not clear |
| E Halasova, M Adamkov, T Matakova, D Vybohova, M Antosova, M Janickova, A Singliar, D Dobrota, V Jakusov. Expression of Ki-67, Bcl-2, Survivin and p53 Proteins in Patients with Pulmonary Carcinoma. Advances in experimental medicine and biology. vol 756. 2012-12-03. PMID:22836614. |
p53 is one of the tumor suppressor proteins, prevents tumor formation through cell cycle blocking and eliminates damaged cells via the activation of apoptosis. |
2012-12-03 |
2023-08-12 |
Not clear |