| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Basant Kumar Thakur, Tino Dittrich, Prakash Chandra, Annette Becker, Yannick Lippka, Divakarvel Selvakumar, Jan-Henning Klusmann, Dirk Reinhardt, Karl Welt. Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells. Biochemical and biophysical research communications. vol 424. issue 3. 2012-11-19. PMID:22728882. |
additionally, knockdown of p53 attenuated the effect of fk866 on cell proliferation, apoptosis, and cell cycle arrest. |
2012-11-19 |
2023-08-12 |
human |
| Basant Kumar Thakur, Tino Dittrich, Prakash Chandra, Annette Becker, Yannick Lippka, Divakarvel Selvakumar, Jan-Henning Klusmann, Dirk Reinhardt, Karl Welt. Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells. Biochemical and biophysical research communications. vol 424. issue 3. 2012-11-19. PMID:22728882. |
the data presented here shed light on two important facts: (1) that p53 in 293t cells is active in the presence of fk866, an inhibitor of nampt pathway; (2) the apoptosis induced by fk866 in 293t cells is associated with increased acetylation of p53 at lys382, which is required for the functional activity of p53. |
2012-11-19 |
2023-08-12 |
human |
| Nilambra Dogra, Tapas Mukhopadhya. Impairment of the ubiquitin-proteasome pathway by methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate leads to a potent cytotoxic effect in tumor cells: a novel antiproliferative agent with a potential therapeutic implication. The Journal of biological chemistry. vol 287. issue 36. 2012-11-19. PMID:22745125. |
a number of apoptosis regulatory proteins that are normally degraded by the ubiquitin-proteasome pathway like cyclins, p53, and iκbα were found to be accumulated in fz-treated cells. |
2012-11-19 |
2023-08-12 |
human |
| Shuo Tu, Zhuo-Qi Liu, Jing-Jing Fu, Wei-Feng Zhu, Da-Ya Luo, Fu-Sheng Wa. Inhibitory effect of p53 upregulated modulator of apoptosis targeting siRNA on hypoxia/reoxygenation-induced cardiomyocyte apoptosis in rats. Cardiology. vol 122. issue 2. 2012-11-19. PMID:22760064. |
inhibitory effect of p53 upregulated modulator of apoptosis targeting sirna on hypoxia/reoxygenation-induced cardiomyocyte apoptosis in rats. |
2012-11-19 |
2023-08-12 |
rat |
| Shuo Tu, Zhuo-Qi Liu, Jing-Jing Fu, Wei-Feng Zhu, Da-Ya Luo, Fu-Sheng Wa. Inhibitory effect of p53 upregulated modulator of apoptosis targeting siRNA on hypoxia/reoxygenation-induced cardiomyocyte apoptosis in rats. Cardiology. vol 122. issue 2. 2012-11-19. PMID:22760064. |
the effect of p53 upregulated modulator of apoptosis (puma) in hypoxia/reoxygenation-induced cardiomyocyte injuries in rats was investigated. |
2012-11-19 |
2023-08-12 |
rat |
| Tae-Rin Kwon, Soo-Jin Jeong, Hyo-Jeong Lee, Hyo-Jung Lee, Eun Jung Sohn, Ji Hoon Jung, Ji-Hyun Kim, Deok-Beom Jung, Junxaun Lu, Sung-Hoon Ki. Reactive oxygen species-mediated activation of JNK and down-regulation of DAXX are critically involved in penta-O-galloyl-beta-d-glucose-induced apoptosis in chronic myeloid leukemia K562 cells. Biochemical and biophysical research communications. vol 424. issue 3. 2012-11-19. PMID:22771329. |
although 1,2,3,4,6-penta-o-galloyl-beta-d-glucose (pgg) was well known to have antitumor activities in breast, prostate, kidney, liver cancers and hl-60 leukemia via regulation of caspase 3, p53, s-phase kinase-associated protein 2 (skp2) and insulin receptor signaling, the underlying mechanism of pgg-induced apoptosis linked with reactive oxygen species (ros) mediated c-jun n-terminal kinase (jnk) and daxx was never elucidated in chronic myeloid leukemia (cml) k562 cells until now. |
2012-11-19 |
2023-08-12 |
Not clear |
| Crystal E Berger, Yingjuan Qian, Gang Liu, Hongwu Chen, Xinbin Che. p53, a target of estrogen receptor (ER) α, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells. The Journal of biological chemistry. vol 287. issue 36. 2012-11-19. PMID:22787161. |
in response to genotoxic stress, the p53 tumor suppressor induces target genes for cell cycle arrest, apoptosis, and dna repair. |
2012-11-19 |
2023-08-12 |
human |
| Hugh S Gannon, Stephen N Jone. Using Mouse Models to Explore MDM-p53 Signaling in Development, Cell Growth, and Tumorigenesis. Genes & cancer. vol 3. issue 3-4. 2012-11-19. PMID:23150754. |
the p53 transcription factor regulates the expression of numerous genes whose products affect cell proliferation, senescence, cellular metabolism, apoptosis, and dna repair. |
2012-11-19 |
2023-08-12 |
mouse |
| Laura A Tollini, Yanping Zhan. p53 Regulation Goes Live-Mdm2 and MdmX Co-Star: Lessons Learned from Mouse Modeling. Genes & cancer. vol 3. issue 3-4. 2012-11-19. PMID:23150755. |
classically, p53 is considered to be an overarching tumor suppressor gene, important in its role as a transcription factor for a number of genes critical for cell cycle arrest, apoptosis, and senescence. |
2012-11-19 |
2023-08-12 |
mouse |
| Ian M Love, Steven R Grossma. It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53. Genes & cancer. vol 3. issue 3-4. 2012-11-19. PMID:23150758. |
cell-cycle inhibition, apoptosis, and autophagy are all regulated by p53 in a cell- and context-specific manner, underscoring the need for p53 activity to be kept low in most circumstances. |
2012-11-19 |
2023-08-12 |
Not clear |
| N I Grineva, E A Duchovenskay, A M Timofeev, T V Akhlynina, L P Gerasimova, T V Borovkova, D A Schmarov, N G Sarycheva, N M Naydenova, A R Gavrichkova, L Y Kolosova, T I Kolosheynova, L G Kovalev. Gene Expression upon Proliferation and Differentiation of Hematopoietic Cells with Ph Chromosome ex vivo. Acta naturae. vol 4. issue 3. 2012-11-19. PMID:23150808. |
the blocking of ph(+)cell apoptosis, neutrophil accumulation, and decrease in the expression of the p53, mdm2 and p21, c-myc,bcr/abl genes occur at the maturation stage. |
2012-11-19 |
2023-08-12 |
Not clear |
| Rumpa Biswas Bhattacharjee, Thangima Zannat, Jnanankur Ba. Expression of the polyalanine expansion mutant of nuclear poly(A)-binding protein induces apoptosis via the p53 pathway. Cell biology international. vol 36. issue 8. 2012-11-16. PMID:22519734. |
expression of the polyalanine expansion mutant of nuclear poly(a)-binding protein induces apoptosis via the p53 pathway. |
2012-11-16 |
2023-08-12 |
human |
| Rumpa Biswas Bhattacharjee, Thangima Zannat, Jnanankur Ba. Expression of the polyalanine expansion mutant of nuclear poly(A)-binding protein induces apoptosis via the p53 pathway. Cell biology international. vol 36. issue 8. 2012-11-16. PMID:22519734. |
in cells expressing pabpn1-a17, the abundance of pro-apoptotic proteins, p53, puma (p53 up-regulated modulator of apoptosis) and noxa, are up-regulated. |
2012-11-16 |
2023-08-12 |
human |
| Victor Chun-Lam Wong, Haley L Cash, Jessica L Morse, Shan Lu, Anatoly Zhitkovic. S-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde. Cell cycle (Georgetown, Tex.). vol 11. issue 13. 2012-11-16. PMID:22722496. |
unlike other s-phase stressors, fa-activated p53 was functional transcriptionally, promoted apoptosis in lung epithelial cells and caused senescence in normal lung fibroblasts. |
2012-11-16 |
2023-08-12 |
human |
| Nirmalya Sen, Yatendra Kumar Satija, Sanjeev Da. p53 and metabolism: old player in a new game. Transcription. vol 3. issue 3. 2012-11-16. PMID:22771946. |
tumor suppressor p53 is a well studied transcription factor intimately linked with the control of cell cycle progression and apoptosis. |
2012-11-16 |
2023-08-12 |
Not clear |
| Caroline H Topham, Nicholas Billinton, Richard M Walmsle. Nongenotoxic apoptosis inducers do not produce misleading positive results in the TK6 cell-based GADD45a-GFP genotoxicity assay. Toxicological sciences : an official journal of the Society of Toxicology. vol 128. issue 1. 2012-11-13. PMID:22491427. |
compounds hypothesized to stimulate apoptosis in the gadd45a-gfp assay or to induce gadd45a in the absence of genotoxic stress, such as p53 activators, nf-κb and bcl-2 inhibitors were selected. |
2012-11-13 |
2023-08-12 |
Not clear |
| Naomi Miyake, Hiroki Chikumi, Miyako Takata, Masaki Nakamoto, Tadashi Igishi, Eiji Shimiz. Rapamycin induces p53-independent apoptosis through the mitochondrial pathway in non-small cell lung cancer cells. Oncology reports. vol 28. issue 3. 2012-11-08. PMID:22710790. |
we found that rapamycin induced apoptosis in nsclc cell lines with p53 mutations. |
2012-11-08 |
2023-08-12 |
Not clear |
| Janine Kah, Andrea Wüstenberg, Amelie Dorothea Keller, Hüseyin Sirma, Roberta Montalbano, Matthias Ocker, Tassilo Volz, Maura Dandri, Gisa Tiegs, Gabriele Sas. Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression. Oncology reports. vol 28. issue 3. 2012-11-08. PMID:22710979. |
selective induction of apoptosis by hmg-coa reductase inhibitors in hepatoma cells and dependence on p53 expression. |
2012-11-08 |
2023-08-12 |
mouse |
| H Moniz, M Gastou, T Leblanc, C Hurtaud, A Crétien, Y Lécluse, H Raslova, J Larghero, L Croisille, M Faubladier, O Bluteau, L Lordier, G Tchernia, W Vainchenker, N Mohandas, L Da Cost. Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro. Cell death & disease. vol 3. 2012-11-08. PMID:22833095. |
in marked contrast, rpl11 mutations led to a dramatic decrease in progenitor cell proliferation and a delayed erythroid differentiation with a marked increase in apoptosis and g₀/g₁ cell cycle arrest with activation of p53. |
2012-11-08 |
2023-08-12 |
Not clear |
| A Minutolo, S Grelli, F Marino-Merlo, F M Cordero, A Brandi, B Macchi, A Mastin. D(-)lentiginosine-induced apoptosis involves the intrinsic pathway and is p53-independent. Cell death & disease. vol 3. 2012-11-08. PMID:22833097. |
u937bcl-2 transfectants, highly expressing bcl-2, were reluctant to undergo apoptosis even following treatment with 500 μm d(-)lentiginosine, whereas apoptosis by d(-)lentiginosine was induced also in u937 cells, naturally deficient in p53. |
2012-11-08 |
2023-08-12 |
Not clear |