| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Cai, Shi Qiu, Xing Gao, Shou-Zhi Gu, Ze-Jun Li. iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes. Apoptosis : an international journal on programmed cell death. vol 17. issue 8. 2012-10-17. PMID:22538442. |
the ability to induce apoptosis is the most important tumor-suppression function of p53. |
2012-10-17 |
2023-08-12 |
human |
| Yun Cai, Shi Qiu, Xing Gao, Shou-Zhi Gu, Ze-Jun Li. iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes. Apoptosis : an international journal on programmed cell death. vol 17. issue 8. 2012-10-17. PMID:22538442. |
iaspp suppresses apoptosis by inhibiting the transactivation function of p53 on the promoters of proapoptotic genes; however, the mechanism whereby iaspp influences apoptosis in tumor cells with mutant or deficient p53 has not been completely defined. |
2012-10-17 |
2023-08-12 |
human |
| Yun Cai, Shi Qiu, Xing Gao, Shou-Zhi Gu, Ze-Jun Li. iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes. Apoptosis : an international journal on programmed cell death. vol 17. issue 8. 2012-10-17. PMID:22538442. |
iaspp inhibited apoptosis independently of p53 in tumor cells, mainly by inhibiting the transcriptional activity of p63/p73 on the promoters of proapoptotic genes. |
2012-10-17 |
2023-08-12 |
human |
| Ramovatar Meena, Madhu Rani, Ruchita Pal, Paulraj Rajaman. Nano-TiO2-induced apoptosis by oxidative stress-mediated DNA damage and activation of p53 in human embryonic kidney cells. Applied biochemistry and biotechnology. vol 167. issue 4. 2012-10-17. PMID:22614867. |
nano-tio2-induced apoptosis by oxidative stress-mediated dna damage and activation of p53 in human embryonic kidney cells. |
2012-10-17 |
2023-08-12 |
human |
| Ramovatar Meena, Madhu Rani, Ruchita Pal, Paulraj Rajaman. Nano-TiO2-induced apoptosis by oxidative stress-mediated DNA damage and activation of p53 in human embryonic kidney cells. Applied biochemistry and biotechnology. vol 167. issue 4. 2012-10-17. PMID:22614867. |
in conclusion, ros-mediated oxidative stress, the activation of p53, bax, caspase-3 and oxidative dna damage are involved in the mechanistic pathways of nano-tio(2)-induced apoptosis in hek-293 cells. |
2012-10-17 |
2023-08-12 |
human |
| Jihane Basbous, Dora Knani, Nathalie Bonneaud, Dominique Giorgi, Jean-Marc Brondello, Sylvie Rouquie. Induction of ASAP (MAP9) contributes to p53 stabilization in response to DNA damage. Cell cycle (Georgetown, Tex.). vol 11. issue 12. 2012-10-17. PMID:22672907. |
in response to genotoxic stress, p53 is stabilized and activated, resulting in controlled activation of genes involved in cell cycle arrest, dna repair and/or apoptosis. |
2012-10-17 |
2023-08-12 |
Not clear |
| Lili Li, Wei Li, Lanbo Xiao, Juan Xu, Xue Chen, Min Tang, Zigang Dong, Qian Tao, Ya Ca. Viral oncoprotein LMP1 disrupts p53-induced cell cycle arrest and apoptosis through modulating K63-linked ubiquitination of p53. Cell cycle (Georgetown, Tex.). vol 11. issue 12. 2012-10-17. PMID:22684299. |
viral oncoprotein lmp1 disrupts p53-induced cell cycle arrest and apoptosis through modulating k63-linked ubiquitination of p53. |
2012-10-17 |
2023-08-12 |
Not clear |
| Lili Li, Wei Li, Lanbo Xiao, Juan Xu, Xue Chen, Min Tang, Zigang Dong, Qian Tao, Ya Ca. Viral oncoprotein LMP1 disrupts p53-induced cell cycle arrest and apoptosis through modulating K63-linked ubiquitination of p53. Cell cycle (Georgetown, Tex.). vol 11. issue 12. 2012-10-17. PMID:22684299. |
furthermore, lmp1 rescued tumor cell apoptosis and cell cycle arrest mediated by k63-linked ubiquitination of p53. |
2012-10-17 |
2023-08-12 |
Not clear |
| Liqing Zhou, Qipeng Yuan, Ming Yan. A functional germline variant in the P53 polyadenylation signal and risk of esophageal squamous cell carcinoma. Gene. vol 506. issue 2. 2012-10-17. PMID:22800615. |
p53 plays a critical role in the maintenance of genomic stability as well as the control of cell growth and apoptosis. |
2012-10-17 |
2023-08-12 |
Not clear |
| Xiantao Wang, Anthony J Di Pasqua, Sudha Govind, Erin McCracken, Charles Hong, Lixin Mi, Yuehua Mao, Jessie Yu-Chieh Wu, York Tomita, Jordan C Woodrick, Robert L Fine, Fung-Lung Chun. Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships. Journal of medicinal chemistry. vol 54. issue 3. 2012-10-16. PMID:21241062. |
2,2-diphenylethyl itc, a synthetic itc, is one of the most potent depletors of mutant p53 studies and induces apoptosis to the greatest extent in mutant p53 breast cancer cells. |
2012-10-16 |
2023-08-12 |
Not clear |
| Roberto Jose Diaz, Brian Golbourn, Maryam Shekarforoush, Christian A Smith, James T Rutk. Aurora kinase B/C inhibition impairs malignant glioma growth in vivo. Journal of neuro-oncology. vol 108. issue 3. 2012-10-16. PMID:22382783. |
reduction in cell viability of u251 (p53(r273h)) cells was secondary to cytokinesis blockade and apoptosis induction following endoreplication. |
2012-10-16 |
2023-08-12 |
mouse |
| Dan-Xia Zhu, Wei Zhu, Cheng Fang, Lei Fan, Zhi-Jian Zou, Yin-Hua Wang, Ping Liu, Min Hong, Kou-Rong Miao, Peng Liu, Wei Xu, Jian-Yong L. miR-181a/b significantly enhances drug sensitivity in chronic lymphocytic leukemia cells via targeting multiple anti-apoptosis genes. Carcinogenesis. vol 33. issue 7. 2012-10-16. PMID:22610076. |
transfection of mir-34a, mir-181a and mir-181b mimics into cll cells from p53 wild-type patients led to significant increase in apoptosis compared with mirna control. |
2012-10-16 |
2023-08-12 |
human |
| Hanna Piotrowska, Krzysztof Myszkowski, Alicja Ziółkowska, Katarzyna Kulcenty, Marcin Wierzchowski, Mariusz Kaczmarek, Marek Murias, Eliza Kwiatkowska-Borowczyk, Jadwiga Jodynis-Lieber. Resveratrol analogue 3,4,4',5-tetramethoxystilbene inhibits growth, arrests cell cycle and induces apoptosis in ovarian SKOV-3 and A-2780 cancer cells. Toxicology and applied pharmacology. vol 263. issue 1. 2012-10-16. PMID:22687606. |
in skov-3 cells dmu-212 caused up-regulation of pro-apoptotic bax, apaf-1 and p53 genes, specific to intrinsic pathway of apoptosis, and a decrease in bcl-2 and bcl 2110 mrna expressions. |
2012-10-16 |
2023-08-12 |
human |
| Naveen Kumar Vishvakarma, Anjani Kumar, Ajay Kumar, Shiva Kant, Alok Chandra Bharti, Sukh Mahendra Sing. Myelopotentiating effect of curcumin in tumor-bearing host: role of bone marrow resident macrophages. Toxicology and applied pharmacology. vol 263. issue 1. 2012-10-16. PMID:22714040. |
curcumin administration modulated expression of cell survival regulatory molecules: bcl2, p53, caspase-activated dnase (cad) and p53-upregulated modulator of apoptosis (puma) along with enhanced expression of genes of receptors for m-csf and gm-csf in bmc. |
2012-10-16 |
2023-08-12 |
Not clear |
| Q Zhang, Z Qian, L Pan, H Li, H Zh. Hypoxia-inducible factor 1 mediates the anti-apoptosis of berberine in neurons during hypoxia/ischemia. Acta physiologica Hungarica. vol 99. issue 3. 2012-10-16. PMID:22982719. |
tunel and immunohistochemistry were used to demonstrate apoptosis, hif-1α and p53 levels in cerebral tissue of middle cerebral artery occlusion (mcao) rats. |
2012-10-16 |
2023-08-12 |
rat |
| Q Zhang, Z Qian, L Pan, H Li, H Zh. Hypoxia-inducible factor 1 mediates the anti-apoptosis of berberine in neurons during hypoxia/ischemia. Acta physiologica Hungarica. vol 99. issue 3. 2012-10-16. PMID:22982719. |
significant reduction of apoptosis, hif-1α and p53 were found in cerebral tissue of mcao rats treated with berberine. |
2012-10-16 |
2023-08-12 |
rat |
| K K Gireesh, Aijaz Rashid, Soumyananda Chakraborti, Dulal Panda, Tapas Mann. CIL-102 binds to tubulin at colchicine binding site and triggers apoptosis in MCF-7 cells by inducing monopolar and multinucleated cells. Biochemical pharmacology. vol 84. issue 5. 2012-10-15. PMID:22705644. |
cil-102-treatment induced apoptosis in mcf-7 cells in association with increased nuclear accumulation of p53 and p21 suggesting that apoptosis is triggered through a p53-p21 dependent pathway. |
2012-10-15 |
2023-08-12 |
Not clear |
| Guangtao Yang, Xue Zhou, Jing Wang, Wenjuan Zhang, Hongyan Zheng, Wenhong Lu, Jing Yua. MEHP-induced oxidative DNA damage and apoptosis in HepG2 cells correlates with p53-mediated mitochondria-dependent signaling pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 7. 2012-10-12. PMID:22542555. |
these findings indicated that mehp induced oxidative dna damage and apoptosis in hepg2 cells, and p53 and its downstream proteins were involved in mitochondria- and caspase-mediated apoptosis induced by mehp. |
2012-10-12 |
2023-08-12 |
human |
| Hao Sang, Lijuan Zhang, Jue L. Anti-benzopyrene-7,8-diol-9,10-epoxide induces apoptosis via mitochondrial pathway in human bronchiolar epithelium cells independent of the mitochondria permeability transition pore. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 7. 2012-10-12. PMID:22565279. |
in conclusion, these results suggest that bpde-mediated apoptosis occurs via caspase-9 dependent mitochondria pathway associated with ros formation, loss of ΔΨ(m), up-regulation of p53 and down-regulation of c-myc, but independent of the opening of mptp in 16hbe cells. |
2012-10-12 |
2023-08-12 |
human |
| Wen-Jun Yan, Kai-Bao Wu, Zhi-Yong M. [Function of tumor suppressor p53 and its role in antiviral immunity]. Bing du xue bao = Chinese journal of virology. vol 28. issue 4. 2012-10-12. PMID:22978174. |
tumor suppressor p53, known as 'the guardian of the genome', has the ability to prevent the emergence of transformed cells by the induction of cell cycle arrest and apoptosis. |
2012-10-12 |
2023-08-12 |
Not clear |