| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Yonish-Rouach, J Borde, M Gotteland, Z Mishal, A Viron, E Ma. Induction of apoptosis by transiently transfected metabolically stable wt p53 in transformed cell lines. Cell death and differentiation. vol 1. issue 1. 2012-10-02. PMID:17180005. |
induction of apoptosis by transiently transfected metabolically stable wt p53 in transformed cell lines. |
2012-10-02 |
2023-08-12 |
Not clear |
| E Yonish-Rouach, J Borde, M Gotteland, Z Mishal, A Viron, E Ma. Induction of apoptosis by transiently transfected metabolically stable wt p53 in transformed cell lines. Cell death and differentiation. vol 1. issue 1. 2012-10-02. PMID:17180005. |
thus, transient expression of a metabolically stable wt, but not mutant, p53 induces cell death by apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| E Yonish-Rouach, J Borde, M Gotteland, Z Mishal, A Viron, E Ma. Induction of apoptosis by transiently transfected metabolically stable wt p53 in transformed cell lines. Cell death and differentiation. vol 1. issue 1. 2012-10-02. PMID:17180005. |
the present study demonstrates a model system to investigate the functional domains of p53 in the induction of apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| S Dee, D A Haas-Kogan, M A Israe. Inactivation of p53 is associated with decreased levels of radiation-induced apoptosis in medulloblastoma cell lines. Cell death and differentiation. vol 2. issue 4. 2012-10-02. PMID:17180032. |
inactivation of p53 is associated with decreased levels of radiation-induced apoptosis in medulloblastoma cell lines. |
2012-10-02 |
2023-08-12 |
Not clear |
| S Dee, D A Haas-Kogan, M A Israe. Inactivation of p53 is associated with decreased levels of radiation-induced apoptosis in medulloblastoma cell lines. Cell death and differentiation. vol 2. issue 4. 2012-10-02. PMID:17180032. |
p53 mediates radiation-induced apoptosis in many cell types, and p53 mutations have been associated with increased resistance to ionising radiation. |
2012-10-02 |
2023-08-12 |
Not clear |
| S Dee, D A Haas-Kogan, M A Israe. Inactivation of p53 is associated with decreased levels of radiation-induced apoptosis in medulloblastoma cell lines. Cell death and differentiation. vol 2. issue 4. 2012-10-02. PMID:17180032. |
we found that wildtype p53 is required for high levels of apoptosis in medulloblastoma, and cell lines in which p53 had been inactivated by mutation had very low levels of apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| S Dee, D A Haas-Kogan, M A Israe. Inactivation of p53 is associated with decreased levels of radiation-induced apoptosis in medulloblastoma cell lines. Cell death and differentiation. vol 2. issue 4. 2012-10-02. PMID:17180032. |
inactivation of endogenous wildtype p53 in medulloblastoma cells by introduction of a dominant negative mutant of p53 decreased the level of radiation-induced apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| S Dee, D A Haas-Kogan, M A Israe. Inactivation of p53 is associated with decreased levels of radiation-induced apoptosis in medulloblastoma cell lines. Cell death and differentiation. vol 2. issue 4. 2012-10-02. PMID:17180032. |
our results suggest that the sensitivity of medulloblastoma to irradiation involves p53-mediated apoptosis and that p53 gene status may be a predictor of response to radiation therapy. |
2012-10-02 |
2023-08-12 |
Not clear |
| A R Haake, R R Polakowsk. UV-induced apoptosis in skin equivalents: inhibition by phorbol ester and Bcl-2 overexpression. Cell death and differentiation. vol 2. issue 3. 2012-10-02. PMID:17180041. |
dna fragmentation and changes in the patterns of expression of p53 and bcl-2 suggest that the mechanisms operating in uv-induced apoptosis in the skin equivalent are controlled by these factors. |
2012-10-02 |
2023-08-12 |
Not clear |
| C Kitanaka, A Sugiyama, S Kanazu, Y Miyagi, K Mishima, A Asai, Y Kuchin. s-Myc acts as a transcriptional activator and its sequence-specific DNA binding is required for induction of programmed cell death in glioma cells. Cell death and differentiation. vol 2. issue 2. 2012-10-02. PMID:17180074. |
we previously reported that s-myc expression effectively induces programmed cell death (pcd) by apoptosis in glioma cells that express only mutated p53. |
2012-10-02 |
2023-08-12 |
Not clear |
| K K Khanna, T Wie, Q Song, S R Burrows, D J Moss, S Krajewski, J C Reed, M F Lavi. Expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in Burkitt's lymphoma cells. Cell death and differentiation. vol 3. issue 3. 2012-10-02. PMID:17180100. |
expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in burkitt's lymphoma cells. |
2012-10-02 |
2023-08-12 |
human |
| K K Khanna, T Wie, Q Song, S R Burrows, D J Moss, S Krajewski, J C Reed, M F Lavi. Expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in Burkitt's lymphoma cells. Cell death and differentiation. vol 3. issue 3. 2012-10-02. PMID:17180100. |
cell lines with wild type p53 were susceptible to radiation-induced apoptosis but two of five bl lines with only mutant p53 allele also displayed similar susceptibility. |
2012-10-02 |
2023-08-12 |
human |
| K K Khanna, T Wie, Q Song, S R Burrows, D J Moss, S Krajewski, J C Reed, M F Lavi. Expression of p53, bcl-2, bax, bcl-x2 and c-myc in radiation-induced apoptosis in Burkitt's lymphoma cells. Cell death and differentiation. vol 3. issue 3. 2012-10-02. PMID:17180100. |
thus the status of p53, c-myc, bcl-2, bcl-x(l) and bax is not sufficiently informative in bl lines to predict susceptibility to radiation-induced apoptosis. |
2012-10-02 |
2023-08-12 |
human |
| Reza Ghaderi, Fatemeh Haghigh. Immunohistochemistry assessment of p53 protein in Basal cell carcinoma. Iranian journal of allergy, asthma, and immunology. vol 4. issue 4. 2012-10-02. PMID:17301441. |
in a normal situation, p53 is activated upon the induction of dna damage to either arrest the cell cycle or else induce apoptosis. |
2012-10-02 |
2023-08-12 |
human |
| O Csuka, E Remenár, K Koronczay, Z Doleschall, G Német. Predictive value of p53, Bcl2 and bax in the radiotherapy of head and neck cancer. Pathology oncology research : POR. vol 3. issue 3. 2012-10-02. PMID:18470731. |
the apoptosis is modulated by p53, bcl2 and bax proteins. |
2012-10-02 |
2023-08-12 |
Not clear |
| O Csuka, E Remenár, K Koronczay, Z Doleschall, G Német. Predictive value of p53, Bcl2 and bax in the radiotherapy of head and neck cancer. Pathology oncology research : POR. vol 3. issue 3. 2012-10-02. PMID:18470731. |
high level of wild type p53 is required for radiation induced apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Ching-Fong Liao, Shue-Fen Luo, Chin-Shaw Tsai, Tang-Yi Tsao, Shun-Liang Chen, Ming-Chung Jian. CAS Enhances Chemotherapeutic Drug-Induced p53 Accumulation and Apoptosis: Use of CAS for High-Sensitivity Anticancer Drug Screening. Toxicology mechanisms and methods. vol 18. issue 9. 2012-10-02. PMID:20020938. |
cas enhances chemotherapeutic drug-induced p53 accumulation and apoptosis: use of cas for high-sensitivity anticancer drug screening. |
2012-10-02 |
2023-08-12 |
Not clear |
| Ching-Fong Liao, Shue-Fen Luo, Chin-Shaw Tsai, Tang-Yi Tsao, Shun-Liang Chen, Ming-Chung Jian. CAS Enhances Chemotherapeutic Drug-Induced p53 Accumulation and Apoptosis: Use of CAS for High-Sensitivity Anticancer Drug Screening. Toxicology mechanisms and methods. vol 18. issue 9. 2012-10-02. PMID:20020938. |
our studies showed that cas over-expression increased p53 accumulation and apoptosis induced by 5-fluorouracil, doxorubicin, cisplatin, and tamoxifen in ht-29 cancer cells. |
2012-10-02 |
2023-08-12 |
Not clear |
| Ching-Fong Liao, Shue-Fen Luo, Chin-Shaw Tsai, Tang-Yi Tsao, Shun-Liang Chen, Ming-Chung Jian. CAS Enhances Chemotherapeutic Drug-Induced p53 Accumulation and Apoptosis: Use of CAS for High-Sensitivity Anticancer Drug Screening. Toxicology mechanisms and methods. vol 18. issue 9. 2012-10-02. PMID:20020938. |
our study indicates that cas is an important p53 and apoptosis regulator and may be used for high-throughput anticancer drug screening as well as cytotoxic toxin assays. |
2012-10-02 |
2023-08-12 |
Not clear |
| H Hildebrand, G Kempka, A Mahnk. Determination of Apoptosis in Primary Rat Hepatocytes by Real-time Quantitative PCR (TaqMan PCR). Toxicology in vitro : an international journal published in association with BIBRA. vol 13. issue 4-5. 2012-10-02. PMID:20654516. |
for the characterization of apoptosis, the expression of two genes, namely bax and p53 was analysed by quantitative real-time pcr. |
2012-10-02 |
2023-08-12 |
rat |