| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Agliano, G Naso, I Silvestri, A Gradilone, R Vercillo, M Napolitano, P Gazzaniga, O Gandini, M Realacci, C Santangelo, G Saccani, V Manzari, L Frat. Involvement of bcl-2 and bax gene expression in apoptosis and differentiation of the non-tumorigenic murine hematopoietic cell line, 32DC13(G). International journal of oncology. vol 11. issue 6. 2012-10-02. PMID:21528334. |
furthermore, results from experiments on p53 transfected cells demonstrate that excess wild-type p53 activity, on its own, fails to elicit apoptosis as long as il-3 is present and does not induce differentiation if g-csf is not added to the culture medium. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Agliano, G Naso, I Silvestri, A Gradilone, R Vercillo, M Napolitano, P Gazzaniga, O Gandini, M Realacci, C Santangelo, G Saccani, V Manzari, L Frat. Involvement of bcl-2 and bax gene expression in apoptosis and differentiation of the non-tumorigenic murine hematopoietic cell line, 32DC13(G). International journal of oncology. vol 11. issue 6. 2012-10-02. PMID:21528334. |
we conclude that in apoptosis and differentiation of 32dcl3(g) the alterate ratio of bcl-2 and box gene expression, modulated by p53, is an early event dependent on il-3 withdrawal and that the appearance of bax and the decrease of bcl-2 expression are necessary, but not sufficient for the acquisition of a completely mature granulocytic phenotype. |
2012-10-02 |
2023-08-12 |
Not clear |
| H Kim, G Li, S Han, K Rahman, H Liu, D Waid, Y Le. Levels of p21(WAF1/CIP1) do not affect radiation-induced cell death in human breast epithelial cells. International journal of oncology. vol 11. issue 6. 2012-10-02. PMID:21528344. |
we previously showed that overexpression of bcl-2 downregulates expression of p21(waf1/cip1) (a cyclin dependent kinase inhibitor which mediates p53 dependent g(1) arrest) and suppresses dna damage-induced apoptosis in mcf10a cells. |
2012-10-02 |
2023-08-12 |
human |
| J Baek, C Bertolami, B Bonavida, N Par. Normal human oral keratinocytes are more sensitive to N-methyl-N'-nitro-N-nitrosoguanidine-induced cytotoxicity and apoptosis than HPV-immortalized oral keratinocytes. International journal of oncology. vol 10. issue 1. 2012-10-02. PMID:21533342. |
mnng-induced apoptosis was not attributable to down regulation of the anti-apoptotic product bcl-2 in normal cells; however, exposure of normal keratinocytes to mnng did result in induction of the apoptotic gene p53. |
2012-10-02 |
2023-08-12 |
human |
| J Baek, C Bertolami, B Bonavida, N Par. Normal human oral keratinocytes are more sensitive to N-methyl-N'-nitro-N-nitrosoguanidine-induced cytotoxicity and apoptosis than HPV-immortalized oral keratinocytes. International journal of oncology. vol 10. issue 1. 2012-10-02. PMID:21533342. |
these findings suggest that the selective sensitivity of normal keratinocytes to mnng-induced apoptosis is in part due to the induction of p53. |
2012-10-02 |
2023-08-12 |
human |
| T Hsieh, J W. Differential expression and regulation of p53 in human prostatic cells. International journal of oncology. vol 10. issue 6. 2012-10-02. PMID:21533491. |
induction of apoptosis in jca-1 cells by treatment with the retinoid 4-hpr caused the virtual disappearance of p53, which coincided with specific processing of p53 into lower molecular weight 28 kd fragments. |
2012-10-02 |
2023-08-12 |
human |
| T Hsieh, J W. Differential expression and regulation of p53 in human prostatic cells. International journal of oncology. vol 10. issue 6. 2012-10-02. PMID:21533491. |
we propose that rapid and dynamic posttranslational changes in p53 may actively participate in determining mutually exclusive functional cellular events such as proliferation, differentiation, and apoptosis. |
2012-10-02 |
2023-08-12 |
human |
| M Kato, H Sato, K Ishizaki, H Anzai, M Nagayoshi, Y Ikaw. No significant changes in the expression of the fas,fasl,bcl-2 and bax genes in apoptosis of an erythroleukemic cell line by p53. International journal of oncology. vol 9. issue 2. 2012-10-02. PMID:21541511. |
no significant changes in the expression of the fas,fasl,bcl-2 and bax genes in apoptosis of an erythroleukemic cell line by p53. |
2012-10-02 |
2023-08-12 |
Not clear |
| M Kato, H Sato, K Ishizaki, H Anzai, M Nagayoshi, Y Ikaw. No significant changes in the expression of the fas,fasl,bcl-2 and bax genes in apoptosis of an erythroleukemic cell line by p53. International journal of oncology. vol 9. issue 2. 2012-10-02. PMID:21541511. |
transcripts of the bcl-2 and fas1 gene were not detected in the cells either at 37 degrees c or 32 degrees c. these results suggest that other gene(s) than bax, fas, fas1 and bcl-2 may be important for induction of apoptosis of this erythroleukemic cell line by p53. |
2012-10-02 |
2023-08-12 |
Not clear |
| W Hu, Y Gazit. bcl-2 plays a major role in resistance to dexamethasone induced apoptosis in multiple myeloma cell lines. International journal of oncology. vol 9. issue 2. 2012-10-02. PMID:21541525. |
we have recently studied the steady-state levels of mrna transcripts for bcl-2, bar and p53 in 8 mm cell lines and found inverse correlation between the levels of bcl-2 mrna transcripts and sensitivity to dexamethasone (dex) induced apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| W Hu, Y Gazit. bcl-2 plays a major role in resistance to dexamethasone induced apoptosis in multiple myeloma cell lines. International journal of oncology. vol 9. issue 2. 2012-10-02. PMID:21541525. |
in this study, we determined the steady-state levels of bcl-2, p53 and bar proteins in 4 myeloma cell lines, and the levels were correlated with sensitivity to dex induced apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| W Hu, Y Gazit. bcl-2 plays a major role in resistance to dexamethasone induced apoptosis in multiple myeloma cell lines. International journal of oncology. vol 9. issue 2. 2012-10-02. PMID:21541525. |
induction of apoptosis in the dex sensitive cells resulted in an early down-regulation of bcl-2 and p53 protein, whereas the levels of bar protein were only slightly decreased. |
2012-10-02 |
2023-08-12 |
Not clear |
| K Scheidtmann, G Landsber. UV irradiation leads to transient changes in phosphorylation and stability of tumor suppressor protein p53. International journal of oncology. vol 9. issue 6. 2012-10-02. PMID:21541638. |
dna damage caused by genotoxic drugs, uv or gamma-irradiation leads to accumulation of p53 and activation of its dna binding and transcriptional activities and subsequently to cell cycle arrest or apoptosis. |
2012-10-02 |
2023-08-12 |
rat |
| K Scheidtmann, G Landsber. UV irradiation leads to transient changes in phosphorylation and stability of tumor suppressor protein p53. International journal of oncology. vol 9. issue 6. 2012-10-02. PMID:21541638. |
our results suggest i) that both cell types share a common pathway which upon uv irradiation results in enhanced stability and phosphorylation of p53 and ii) that the decision whether a cell undergoes a growth arrest or apoptosis may be determined independent of p53 by the cellular environment i.e. |
2012-10-02 |
2023-08-12 |
rat |
| E Tian, Y Gazit. The role of p53, bcl-2 and bax network in dexamethasone induced apoptosis in multiple myeloma cell lines. International journal of oncology. vol 8. issue 4. 2012-10-02. PMID:21544419. |
the role of p53, bcl-2 and bax network in dexamethasone induced apoptosis in multiple myeloma cell lines. |
2012-10-02 |
2023-08-12 |
Not clear |
| E Tian, Y Gazit. The role of p53, bcl-2 and bax network in dexamethasone induced apoptosis in multiple myeloma cell lines. International journal of oncology. vol 8. issue 4. 2012-10-02. PMID:21544419. |
eight myeloma cell lines were screened for their expression of mrna transcripts for p53, bcl-2 and bax, and the levels were correlated for sensitivity to dex induced apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| E Tian, Y Gazit. The role of p53, bcl-2 and bax network in dexamethasone induced apoptosis in multiple myeloma cell lines. International journal of oncology. vol 8. issue 4. 2012-10-02. PMID:21544419. |
induction of apoptosis in 8226 and arp-1 cells (dex sensitive) resulted, within 24 h, in a transient but marked down-regulation of mrna transcripts for bcl-2 and p53, whereas the level of expression of bax mrna transcripts were unchanged, except for arp-1 cells (lacking p53), where slight down-regulation of mrna transcripts for bax, was observed. |
2012-10-02 |
2023-08-12 |
Not clear |
| S Mundle, V Kotelnikov, N Wood, J Coon, E Horvath, S Taylor, S Lafollette, D Caldarelli, J Hutchinson, W Panje, H Preisler, A Raz. Assessment of apoptosis in relation to proliferation and mutational status of p53 gene in head and neck cancers. International journal of oncology. vol 8. issue 6. 2012-10-02. PMID:21544492. |
assessment of apoptosis in relation to proliferation and mutational status of p53 gene in head and neck cancers. |
2012-10-02 |
2023-08-12 |
Not clear |
| S Mundle, V Kotelnikov, N Wood, J Coon, E Horvath, S Taylor, S Lafollette, D Caldarelli, J Hutchinson, W Panje, H Preisler, A Raz. Assessment of apoptosis in relation to proliferation and mutational status of p53 gene in head and neck cancers. International journal of oncology. vol 8. issue 6. 2012-10-02. PMID:21544492. |
the extent of spontaneous apoptosis in untreated tumors was correlated with histological grade, percent s-phase cells (labeling index, li) and with the mutational status of p53 gene in these tumors. |
2012-10-02 |
2023-08-12 |
Not clear |
| S Mundle, V Kotelnikov, N Wood, J Coon, E Horvath, S Taylor, S Lafollette, D Caldarelli, J Hutchinson, W Panje, H Preisler, A Raz. Assessment of apoptosis in relation to proliferation and mutational status of p53 gene in head and neck cancers. International journal of oncology. vol 8. issue 6. 2012-10-02. PMID:21544492. |
interestingly, tumors with a mutated p53 gene (n=6) showed intermediate to high degree of pretherapy, baseline apoptosis in contrast to low or undetectable levels of apoptosis in tumors bearing wild-type p53 (n=13, p=0.034). |
2012-10-02 |
2023-08-12 |
Not clear |