| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Wörner, D Schren. 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses apoptosis and leads to hyperphosphorylation of p53 in rat hepatocytes. Environmental toxicology and pharmacology. vol 6. issue 4. 2012-10-02. PMID:21781900. |
this mode of action may result in the observed suppression of the p53 response to apoptogenic uv irradiation, and may contribute to the inhibition of apoptosis. |
2012-10-02 |
2023-08-12 |
rat |
| Raj Kumar, Pankaj Kumar Singh, Rajesh Arora, Ashok Sharma, Jagdish Prasad, Ravinder Sagar, Surendar Singh, Rakesh Kumar Sharm. Radioprotection by Podophyllum hexandrum in the liver of mice: A mechanistic approach. Environmental toxicology and pharmacology. vol 20. issue 2. 2012-10-02. PMID:21783608. |
an increase in bcl-2, proliferating cell nuclear antigen (pcna) along with a decrease in p53, caspase-3, apoptosis inducing factor (aif) expression was observed in the mice treated with p. hexandrum. |
2012-10-02 |
2023-08-12 |
mouse |
| Sncvl Pushpavalli, M Janaki Ramaiah, Ch Srinivas, Debasmita Mukhopadhya, J L Aditya, Ravindra M Kumbhare, Utpal Bhadra, Manika Pal Bhadr. Effect of Benzothiazole based conjugates in causing apoptosis by Regulating p53, PTEN and MAP Kinase proteins affecting miR-195a and miR-101-1. Cancer cell international. vol 11. 2012-10-02. PMID:22035408. |
effect of benzothiazole based conjugates in causing apoptosis by regulating p53, pten and map kinase proteins affecting mir-195a and mir-101-1. |
2012-10-02 |
2023-08-12 |
Not clear |
| Jae Hyang Lim, Chang-Hoon Wo. Laminar flow activation of ERK5 leads to cytoprotective effect via CHIP-mediated p53 ubiquitination in endothelial cells. Anatomy & cell biology. vol 44. issue 4. 2012-10-02. PMID:22254155. |
transcription factor p53 is a major pro-apoptotic factor which contributes to apoptosis in various cell types. |
2012-10-02 |
2023-08-12 |
Not clear |
| Jae Hyang Lim, Chang-Hoon Wo. Laminar flow activation of ERK5 leads to cytoprotective effect via CHIP-mediated p53 ubiquitination in endothelial cells. Anatomy & cell biology. vol 44. issue 4. 2012-10-02. PMID:22254155. |
in this study, we found that 15-deoxy-Δ(12,14)-prostaglandin j(2) induced p53 expression and that endothelial apoptosis was reduced under the l-flow condition. |
2012-10-02 |
2023-08-12 |
Not clear |
| T Littlewood, N McCarthy, M Whyte, S Pelengaris, C James, G Eva. Controllable genetic manipulation of apoptosis of cells in culture. Cytotechnology. vol 22. issue 1-3. 2012-10-02. PMID:22358926. |
we show that inhibition of p53 using dominant negative molecules inhibits apoptosis induced by dna damage but has little effect on myc-induced apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Hitomi Kurose, Masa-Aki Shibata, Munekazu Iinuma, Yoshinori Otsuk. Alterations in cell cycle and induction of apoptotic cell death in breast cancer cells treated with α-mangostin extracted from mangosteen pericarp. Journal of biomedicine & biotechnology. vol 2012. 2012-10-02. PMID:22577295. |
in this study, we investigated the influence of α-mangostin on apoptosis and cell cycle in the human breast cancer cell line mda-mb231 (carrying a p53 mutation, and her2, er, and pgr negative) in order to elucidate its anticancer mechanisms. |
2012-10-02 |
2023-08-12 |
mouse |
| Xiao-Jun Tian, Feng Liu, Xiao-Peng Zhang, Jun Li, Wei Wan. A two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities. PloS one. vol 7. issue 6. 2012-10-02. PMID:22679490. |
at the cell population level, there occur two waves of apoptosis: a fast wave mediated by mitochondrial p53 within three hours postirradiation, and a slow wave mediated by nuclear p53 after eight hours postirradiation. |
2012-10-02 |
2023-08-12 |
Not clear |
| Xiao-Jun Tian, Feng Liu, Xiao-Peng Zhang, Jun Li, Wei Wan. A two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities. PloS one. vol 7. issue 6. 2012-10-02. PMID:22679490. |
the first step is to decide whether dna damage is severe enough to trigger apoptosis directly through the mitochondrial p53 pathway, while the second step is to determine whether the damage is fixed after cell cycle arrest. |
2012-10-02 |
2023-08-12 |
Not clear |
| Xiao-Jun Tian, Feng Liu, Xiao-Peng Zhang, Jun Li, Wei Wan. A two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities. PloS one. vol 7. issue 6. 2012-10-02. PMID:22679490. |
it was also demonstrated that nuclear p53 can inhibit the pro-apoptotic activity of mitochondrial p53 by transactivating p21, and mdm2 can facilitate apoptosis by promoting the mono-ubiquitination of p53. |
2012-10-02 |
2023-08-12 |
Not clear |
| Job de Lange, Amina Fas Teunisse, Matty Verlaan-de Vries, Kirsten Lodder, Suzanne Lam, Gregorius Pm Luyten, Federico Bernal, Martine J Jager, Aart G Jochemse. High levels of Hdmx promote cell growth in a subset of uveal melanomas. American journal of cancer research. vol 2. issue 5. 2012-10-02. PMID:22957303. |
surprisingly, p53 knockdown hardly rescued cell cycle arrest and apoptosis induction upon hdmx knockdown, whereas it effectively prevented growth suppression induced by the potent p53 activator nutlin-3. |
2012-10-02 |
2023-08-12 |
Not clear |
| Dong Wook Kim, Li Zhao, John Hanover, Mark Willingham, Sheue-Yann Chen. Thyroid hormone receptor β suppresses SV40-mediated tumorigenesis via novel nongenomic actions. American journal of cancer research. vol 2. issue 5. 2012-10-02. PMID:22957312. |
trβ- sv40tag interaction also resulted in reactivating p53 to increase the expression of pten, thus attenuating pi3k-akt signaling to decrease cell proliferation and to induce apoptosis. |
2012-10-02 |
2023-08-12 |
mouse |
| Stefano Farioli-Vecchioli, Laura Micheli, Daniele Saraulli, Manuela Ceccarelli, Sara Cannas, Raffaella Scardigli, Luca Leonardi, Irene Cinà, Marco Costanzi, Maria Teresa Ciotti, Pedro Moreira, Jean-Pierre Rouault, Vincenzo Cestari, Felice Tiron. Btg1 is Required to Maintain the Pool of Stem and Progenitor Cells of the Dentate Gyrus and Subventricular Zone. Frontiers in neuroscience. vol 6. 2012-10-02. PMID:22969701. |
remarkably, adult dentate gyrus stem and progenitor cells of btg1-null mice exit the cell cycle after completing the s phase, express p53 and p21 at high levels and undergo apoptosis within 5 days. |
2012-10-02 |
2023-08-12 |
mouse |
| Joydeep Das, Jyotirmoy Ghosh, Prasenjit Manna, Parames C Si. Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis. Amino acids. vol 42. issue 5. 2012-10-01. PMID:21476075. |
taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, fas and caspase 12-mediated apoptosis. |
2012-10-01 |
2023-08-12 |
rat |
| Manju L Prasad, Snehal G Patel, Jatin P Shah, Stacy Hoshaw-Woodard, Klaus J Busa. Prognostic significance of regulators of cell cycle and apoptosis, p16(INK4a), p53, and bcl-2 in primary mucosal melanomas of the head and neck. Head and neck pathology. vol 6. issue 2. 2012-10-01. PMID:22160615. |
prognostic significance of regulators of cell cycle and apoptosis, p16(ink4a), p53, and bcl-2 in primary mucosal melanomas of the head and neck. |
2012-10-01 |
2023-08-12 |
Not clear |
| Amy Jane Turner, Andrew Alexander Knox, Nicholas James Watkin. Nucleolar disruption leads to the spatial separation of key 18S rRNA processing factors. RNA biology. vol 9. issue 2. 2012-10-01. PMID:22418842. |
this stabilizes p53 and leads to either cell cycle arrest or apoptosis. |
2012-10-01 |
2023-08-12 |
human |
| Pani A Apostolidis, Stephan Lindsey, William M Miller, Eleftherios T Papoutsaki. Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation. Physiological genomics. vol 44. issue 12. 2012-10-01. PMID:22548738. |
proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation. |
2012-10-01 |
2023-08-12 |
Not clear |
| Pani A Apostolidis, Stephan Lindsey, William M Miller, Eleftherios T Papoutsaki. Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation. Physiological genomics. vol 44. issue 12. 2012-10-01. PMID:22548738. |
in primary megakaryocytes and in the megakaryocytic cell line chrf, loss or knock-down of p53 enhances cell cycling and inhibits apoptosis, leading to increased polyploidization. |
2012-10-01 |
2023-08-12 |
Not clear |
| Pani A Apostolidis, Stephan Lindsey, William M Miller, Eleftherios T Papoutsaki. Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation. Physiological genomics. vol 44. issue 12. 2012-10-01. PMID:22548738. |
to support the hypothesis that p53 suppresses megakaryocytic polyploidization, we show that stable expression of wild-type p53 in k562 cells (a p53-null cell line) attenuates the cells' ability to undergo polyploidization during megakaryocytic differentiation due to diminished dna synthesis and greater apoptosis. |
2012-10-01 |
2023-08-12 |
Not clear |
| Pani A Apostolidis, Stephan Lindsey, William M Miller, Eleftherios T Papoutsaki. Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation. Physiological genomics. vol 44. issue 12. 2012-10-01. PMID:22548738. |
this suggested that p53's effects during megakaryopoiesis are mediated through cell cycle- and apoptosis-related target genes, possibly by arresting dna synthesis and promoting apoptosis. |
2012-10-01 |
2023-08-12 |
Not clear |