| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J de Lange, M Verlaan-de Vries, A F A S Teunisse, A G Jochemse. Chk2 mediates RITA-induced apoptosis. Cell death and differentiation. vol 19. issue 6. 2012-09-10. PMID:22158418. |
a partial rescue of apoptosis observed in noxa knockdown cells emphasized the relevance of p53 transcriptional activity for rita-induced apoptosis. |
2012-09-10 |
2023-08-12 |
Not clear |
| J de Lange, M Verlaan-de Vries, A F A S Teunisse, A G Jochemse. Chk2 mediates RITA-induced apoptosis. Cell death and differentiation. vol 19. issue 6. 2012-09-10. PMID:22158418. |
furthermore, the rita-induced dna damage response, which was not a secondary effect of apoptosis induction, was strongly attenuated in cells lacking p53 or chk2. |
2012-09-10 |
2023-08-12 |
Not clear |
| Zhifu Li, Jun Shen, Yuxian Chen, Janying Pan, Hua Zeng, Hang Fang, Zhiqiang Ye, Chun Zeng, Rongkai Zhang, Daozhang Ca. Mitochondrial genome sequencing of chondrocytes in osteoarthritis by human mitochondria RT2 Profiler™ PCR array. Molecular medicine reports. vol 6. issue 1. 2012-09-10. PMID:22504941. |
western blot analysis confirmed that the p53 upregulated modulator of apoptosis (puma; encoded by the bb3 gene) was significantly upregulated in oa cartilage. |
2012-09-10 |
2023-08-12 |
human |
| Dana Austin, Alan Baer, Lindsay Lundberg, Nazly Shafagati, Annalise Schoonmaker, Aarthi Narayanan, Taissia Popova, Jean Jacques Panthier, Fatah Kashanchi, Charles Bailey, Kylene Kehn-Hal. p53 Activation following Rift Valley fever virus infection contributes to cell death and viral production. PloS one. vol 7. issue 5. 2012-09-10. PMID:22574148. |
activation of p53 is important for the dna damage signaling cascade, initiation of apoptosis, cell cycle arrest and transcriptional regulation of multiple genes. |
2012-09-10 |
2023-08-12 |
Not clear |
| Dana Austin, Alan Baer, Lindsay Lundberg, Nazly Shafagati, Annalise Schoonmaker, Aarthi Narayanan, Taissia Popova, Jean Jacques Panthier, Fatah Kashanchi, Charles Bailey, Kylene Kehn-Hal. p53 Activation following Rift Valley fever virus infection contributes to cell death and viral production. PloS one. vol 7. issue 5. 2012-09-10. PMID:22574148. |
qrt-pcr data showed a transcriptional up-regulation of several p53 targeted genes involved in cell cycle and apoptosis regulation following rvfv infection. |
2012-09-10 |
2023-08-12 |
Not clear |
| Steven S Foster, Saurav De, Linda K Johnson, John H J Petrini, Travis H Stracke. Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 25. 2012-09-10. PMID:22670056. |
we show that loss of chk2 or a mutation in p53 (r172p), which selectively impairs its function in apoptosis, rescued the lethality of mice lacking lig4, a ligase required for nonhomologous end-joining (nhej) repair of dna double-strand breaks in g0/g1. |
2012-09-10 |
2023-08-12 |
mouse |
| Rajan Gogna, Esha Madan, Bernhard Keppler, Uttam Pat. Gallium compound GaQ(3) -induced Ca(2+) signalling triggers p53-dependent and -independent apoptosis in cancer cells. British journal of pharmacology. vol 166. issue 2. 2012-09-07. PMID:22074401. |
here, we have explored the mechanism(s) of gaq(3) -induced apoptosis in cancer cells, focusing on p53 and intracellular ca(2+) signalling. |
2012-09-07 |
2023-08-12 |
Not clear |
| Rajan Gogna, Esha Madan, Bernhard Keppler, Uttam Pat. Gallium compound GaQ(3) -induced Ca(2+) signalling triggers p53-dependent and -independent apoptosis in cancer cells. British journal of pharmacology. vol 166. issue 2. 2012-09-07. PMID:22074401. |
experimental approach gaq(3) -induced cytotoxicity and apoptosis were determined in cancer cell lines, with different p53 status (p53(+/+) , p53(-/-) and p53 mutant). |
2012-09-07 |
2023-08-12 |
Not clear |
| Rajan Gogna, Esha Madan, Bernhard Keppler, Uttam Pat. Gallium compound GaQ(3) -induced Ca(2+) signalling triggers p53-dependent and -independent apoptosis in cancer cells. British journal of pharmacology. vol 166. issue 2. 2012-09-07. PMID:22074401. |
ca(2+) signalling, p53, p300 and ros were serially knocked down to study ca(2+) -p53-ros ineractions in gaq(3) -induced apoptosis. |
2012-09-07 |
2023-08-12 |
Not clear |
| K F Huang, G D Zhang, Y Q Huang, Y Dia. Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. International immunopharmacology. vol 12. issue 2. 2012-09-07. PMID:22182776. |
wogonin-induced apoptosis was accompanied by a significant decrease of the bcl-2 and survivin and increase of bax and p53. |
2012-09-07 |
2023-08-12 |
human |
| I-Neng Lee, Martin Hsiu-Chu Lin, Chiu-Yen Chung, Ming-Hsueh Lee, Hsu-Huei Weng, Jen-Tsung Yan. Chronic cigarette smoke exposure enhances brain-derived neurotrophic factor expression in rats with traumatic brain injury. Metabolic brain disease. vol 27. issue 2. 2012-09-07. PMID:22476923. |
compared to the tbi group without smoke exposure, chronic cigarette smoke exposure in rats inhibited the decrease of the bcl-2/bax ratio and reduced p53 expression and apoptosis 24 h after tbi. |
2012-09-07 |
2023-08-12 |
rat |
| Lin Gao, Yanhui Gao, Xiaobo Li, Paul Howell, Rajeev Kumar, Xiulan Su, Alexander V Vlassov, Gary A Piazza, Adam I Riker, Dianjun Sun, Yaguang X. Aquaporins mediate the chemoresistance of human melanoma cells to arsenite. Molecular oncology. vol 6. issue 1. 2012-09-06. PMID:22130551. |
functional studies showed that aqp3 and aqp9 can inhibit cell apoptosis induced by arsenite through down-regulating p53 and up-regulating bcl-2 and xiap. |
2012-09-06 |
2023-08-12 |
human |
| Brahmasani Sambasiva Rao, Yelisetti Uma Mahesh, Katari Venu Charan, Komjeti Suman, Nithya Sekhar, Sisinthy Shivaj. Effect of vitrification on meiotic maturation and expression of genes in immature goat cumulus oocyte complexes. Cryobiology. vol 64. issue 3. 2012-09-06. PMID:22280956. |
the aim of the study was to evaluate meiotic maturation, and expression of genes coding for oocyte secreted factors (gdf9, bmp15, tgfbr1, and bpr2) and apoptosis (bcl2, bax and p53) after vitrification of immature goat cumulus oocyte complexes (cocs) and in vitro maturation. |
2012-09-06 |
2023-08-12 |
Not clear |
| Maha Elnaggar, Elisa Giovannetti, Godefridus J Peter. Molecular targets of gemcitabine action: rationale for development of novel drugs and drug combinations. Current pharmaceutical design. vol 18. issue 19. 2012-09-06. PMID:22390765. |
however, cytidine deaminase polymorphisms and activity were correlated with clinical outcome and severe toxicities, whereas further studies should evaluate both p53 dependent and independent pathways involved in gemcitabine induced apoptosis. |
2012-09-06 |
2023-08-12 |
Not clear |
| Kelly D Sullivan, Nuria Padilla-Just, Ryan E Henry, Christopher C Porter, Jihye Kim, John J Tentler, S Gail Eckhardt, Aik Choon Tan, James DeGregori, Joaquín M Espinos. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nature chemical biology. vol 8. issue 7. 2012-09-06. PMID:22660439. |
the p53 tumor suppressor orchestrates alternative stress responses including cell cycle arrest and apoptosis, but the mechanisms defining cell fate upon p53 activation are poorly understood. |
2012-09-06 |
2023-08-12 |
Not clear |
| Kelly D Sullivan, Nuria Padilla-Just, Ryan E Henry, Christopher C Porter, Jihye Kim, John J Tentler, S Gail Eckhardt, Aik Choon Tan, James DeGregori, Joaquín M Espinos. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nature chemical biology. vol 8. issue 7. 2012-09-06. PMID:22660439. |
genetic or pharmacological interference with atm or met activity converts the cellular response from cell cycle arrest into apoptosis in diverse cancer cell types without affecting expression of key p53 target genes. |
2012-09-06 |
2023-08-12 |
Not clear |
| Dongsheng Pei, Yanping Zhang, Junnian Zhen. Regulation of p53: a collaboration between Mdm2 and Mdmx. Oncotarget. vol 3. issue 3. 2012-09-05. PMID:22410433. |
p53 plays an important role in the regulation of the cell cycle, dna repair, and apoptosis and is an attractive cancer therapeutic target. |
2012-09-05 |
2023-08-12 |
Not clear |
| Martin H Ellis, Lior Baraf, Aviv Shaish, Adi Har-Zahav, Dror Harats, Osnat Ashur-Fabia. Alteration of lipids and the transcription of lipid-related genes in myelodysplastic syndromes via a TP53-related pathway. Experimental hematology. vol 40. issue 7. 2012-09-04. PMID:22381680. |
mds patients frequently have lower lipids and high rates of apoptosis and p53 (tp53) expression. |
2012-09-04 |
2023-08-12 |
mouse |
| Dong Joon Kim, Yan Li, Kanamata Reddy, Mee-Hyun Lee, Myoung Ok Kim, Yong-Yeon Cho, Sung-Young Lee, Jong-Eun Kim, Ann M Bode, Zigang Don. Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. Cancer research. vol 72. issue 12. 2012-09-04. PMID:22523035. |
hi-topk-032 also inhibited anchorage-dependent and -independent colon cancer cell growth by reducing erk-rsk phosphorylation as well as increasing colon cancer cell apoptosis through regulation of the abundance of p53, cleaved caspase-7, and cleaved parp. |
2012-09-04 |
2023-08-12 |
Not clear |
| Lin Wang, Juxiang Huang, Minghu Jiang, Hong Li. Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputation. Immunologic research. vol 52. issue 3. 2012-09-04. PMID:22528125. |
tsta3-activated network enhanced the regulation of apoptosis, cyclin-dependent protein kinase activity, cell migration, insulin secretion, transcription, cell division, cell proliferation, dna replication, postreplication repair, cell differentiation, t-cell homeostasis, neutrophil-mediated immunity, neutrophil chemotaxis, interleukin-8 production, inflammatory response, immune response, b-cell activation, humoral immune response, actin filament organization, xenobiotic metabolism, lipid metabolism, phospholipid metabolism, leukotriene biosynthesis, organismal lipid catabolism, phosphatidylcholine metabolism, arachidonic acid secretion, activation of phospholipase a2, deoxyribonucleotide biosynthesis, heterophilic cell adhesion, activation of mapk activity, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, g-protein-coupled receptor protein signaling pathway, response to toxin, acute-phase response, dna damage response, intercellular junction assembly, cell communication, and cell recognition, as a result of inducing immune response-mediated metabolism coupling cell cycle to postreplication repair in no-tumor hepatitis/cirrhotic tissues. |
2012-09-04 |
2023-08-12 |
human |