| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tai Li, Lin Wang, Xiao-Xue Ke, Xue-Yang Gong, Jian-Hua Wan, Xiang-Wei Hao, Man Xu, Zonghuai Xiang, Zhao-Bo Cui, Hongjuan Cu. DNA-damaging drug-induced apoptosis sensitized by N-myc in neuroblastoma cells. Cell biology international. vol 36. issue 4. 2012-09-17. PMID:21929510. |
for example, activated p53 then targets both intrinsic and extrinsic pathways to promote apoptosis through transcription-dependent and -independent mechanisms. |
2012-09-17 |
2023-08-12 |
Not clear |
| Tai Li, Lin Wang, Xiao-Xue Ke, Xue-Yang Gong, Jian-Hua Wan, Xiang-Wei Hao, Man Xu, Zonghuai Xiang, Zhao-Bo Cui, Hongjuan Cu. DNA-damaging drug-induced apoptosis sensitized by N-myc in neuroblastoma cells. Cell biology international. vol 36. issue 4. 2012-09-17. PMID:21929510. |
inactivation of p53 protects cells from drug-triggered apoptosis sensitized by n-myc. |
2012-09-17 |
2023-08-12 |
Not clear |
| Tai Li, Lin Wang, Xiao-Xue Ke, Xue-Yang Gong, Jian-Hua Wan, Xiang-Wei Hao, Man Xu, Zonghuai Xiang, Zhao-Bo Cui, Hongjuan Cu. DNA-damaging drug-induced apoptosis sensitized by N-myc in neuroblastoma cells. Cell biology international. vol 36. issue 4. 2012-09-17. PMID:21929510. |
these findings thus define a molecular pathway for mediating dna-damaging drug-induced apoptosis sensitized by oncogene, and suggest that inactivation of p53 or other components of this apoptotic pathway may confer drug resistance in neuroblastoma cells. |
2012-09-17 |
2023-08-12 |
Not clear |
| Braj R Singh, Brahma N Singh, W Khan, H B Singh, A H Naqv. ROS-mediated apoptotic cell death in prostate cancer LNCaP cells induced by biosurfactant stabilized CdS quantum dots. Biomaterials. vol 33. issue 23. 2012-09-17. PMID:22594971. |
results also showed involvement of caspases, bcl-2 family proteins, heat shock protein 70, and a cell-cycle checkpoint protein p53 in apoptosis induction by bscds qds in lncap cells. |
2012-09-17 |
2023-08-12 |
human |
| Xiaorong Li, Jing Chen, Yong Yi, Chenghua Li, Yujun Zhan. DNA damage down-regulates ΔNp63α and induces apoptosis independent of wild type p53. Biochemical and biophysical research communications. vol 423. issue 2. 2012-09-17. PMID:22659744. |
dna damage down-regulates Δnp63α and induces apoptosis independent of wild type p53. |
2012-09-17 |
2023-08-12 |
Not clear |
| Xiaorong Li, Jing Chen, Yong Yi, Chenghua Li, Yujun Zhan. DNA damage down-regulates ΔNp63α and induces apoptosis independent of wild type p53. Biochemical and biophysical research communications. vol 423. issue 2. 2012-09-17. PMID:22659744. |
the tumor suppressor p53 is pivotal in cell growth arrest and apoptosis upon cellular stresses including dna damage. |
2012-09-17 |
2023-08-12 |
Not clear |
| Xiaorong Li, Jing Chen, Yong Yi, Chenghua Li, Yujun Zhan. DNA damage down-regulates ΔNp63α and induces apoptosis independent of wild type p53. Biochemical and biophysical research communications. vol 423. issue 2. 2012-09-17. PMID:22659744. |
mounting evidence indicates that p63 proteins, which are homologs of p53, are also involved in apoptosis under certain circumstances. |
2012-09-17 |
2023-08-12 |
Not clear |
| Xiaorong Li, Jing Chen, Yong Yi, Chenghua Li, Yujun Zhan. DNA damage down-regulates ΔNp63α and induces apoptosis independent of wild type p53. Biochemical and biophysical research communications. vol 423. issue 2. 2012-09-17. PMID:22659744. |
in this study, we found that treatment with dna damage agents leads to down-regulation of Δnp63α and induces apoptosis in fadu and hacat cells carrying mutant p53. |
2012-09-17 |
2023-08-12 |
Not clear |
| Jayasree S Nair, Alan L Ho, Gary K Schwart. The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent. Cell cycle (Georgetown, Tex.). vol 11. issue 4. 2012-09-14. PMID:22293494. |
cells expressing wild-type p53 showed a short delay in mitosis followed by cytokinesis, resulting in 2n cells along with apoptosis. |
2012-09-14 |
2023-08-12 |
Not clear |
| Jayasree S Nair, Alan L Ho, Gary K Schwart. The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent. Cell cycle (Georgetown, Tex.). vol 11. issue 4. 2012-09-14. PMID:22293494. |
p53-dependent apoptosis by mk8745 was further confirmed in hct 116 p53(-/-) cells transfected with wild-type p53. |
2012-09-14 |
2023-08-12 |
Not clear |
| Jayasree S Nair, Alan L Ho, Gary K Schwart. The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent. Cell cycle (Georgetown, Tex.). vol 11. issue 4. 2012-09-14. PMID:22293494. |
transient knockdown of aurora a by specific sirna recapitulated these p53- dependent effects, with greater percent induction of apoptosis in p53 wild-type cells. |
2012-09-14 |
2023-08-12 |
Not clear |
| Jayasree S Nair, Alan L Ho, Gary K Schwart. The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent. Cell cycle (Georgetown, Tex.). vol 11. issue 4. 2012-09-14. PMID:22293494. |
in conclusion, our studies show p53 as a determining factor for induction of apoptosis vs. polyploidy upon inhibition of aurora a. |
2012-09-14 |
2023-08-12 |
Not clear |
| Mariano Francesco Caratozzolo, Lucia Micale, Maria Giuseppina Turturo, Silvia Cornacchia, Carmela Fusco, Flaviana Marzano, Bartolomeo Augello, Anna Maria D'Erchia, Luisa Guerrini, Graziano Pesole, Elisabetta Sbisà, Giuseppe Merla, Apollonia Tull. TRIM8 modulates p53 activity to dictate cell cycle arrest. Cell cycle (Georgetown, Tex.). vol 11. issue 3. 2012-09-13. PMID:22262183. |
to maintain genome integrity in response to cellular stress, p53 directly regulates the transcription of genes involved in cell cycle arrest, dna repair, apoptosis and/or senescence. |
2012-09-13 |
2023-08-12 |
human |
| Shun-Chang Wang, Zhi-Zhong Geng, Yun Wang, Zhong-Hua Tong, Han-Qing Y. Essential roles of p53 and MAPK cascades in microcystin-LR-induced germline apoptosis in Caenorhabditis elegans. Environmental science & technology. vol 46. issue 6. 2012-09-13. PMID:22353034. |
essential roles of p53 and mapk cascades in microcystin-lr-induced germline apoptosis in caenorhabditis elegans. |
2012-09-13 |
2023-08-12 |
caenorhabditis_elegans |
| Shing-Chuan Shen, Woan-Rouh Lee, Liang-Yo Yang, Hsiou-Hsin Tsai, Ling-Ling Yang, Yen-Chou Che. Quercetin enhancement of arsenic-induced apoptosis via stimulating ROS-dependent p53 protein ubiquitination in human HaCaT keratinocytes. Experimental dermatology. vol 21. issue 5. 2012-09-13. PMID:22509835. |
quercetin enhancement of arsenic-induced apoptosis via stimulating ros-dependent p53 protein ubiquitination in human hacat keratinocytes. |
2012-09-13 |
2023-08-12 |
human |
| Shing-Chuan Shen, Woan-Rouh Lee, Liang-Yo Yang, Hsiou-Hsin Tsai, Ling-Ling Yang, Yen-Chou Che. Quercetin enhancement of arsenic-induced apoptosis via stimulating ROS-dependent p53 protein ubiquitination in human HaCaT keratinocytes. Experimental dermatology. vol 21. issue 5. 2012-09-13. PMID:22509835. |
que plus as(+3) stimulation of apoptosis in human hacat keratinocytes via activating ros-dependent p53 protein ubiquitination may offer a rationale for the use of que to improve the clinical efficacy of arsenics in treating psoriasis. |
2012-09-13 |
2023-08-12 |
human |
| Carmen Rivas, Stuart A Aaronson, Cesar Munoz-Fontel. Dual Role of p53 in Innate Antiviral Immunity. Viruses. vol 2. issue 1. 2012-09-10. PMID:21994612. |
tumor suppressor p53 is widely known as 'the guardian of the genome' due to its ability to prevent the emergence of transformed cells by the induction of cell cycle arrest and apoptosis. |
2012-09-10 |
2023-08-12 |
Not clear |
| Carmen Rivas, Stuart A Aaronson, Cesar Munoz-Fontel. Dual Role of p53 in Innate Antiviral Immunity. Viruses. vol 2. issue 1. 2012-09-10. PMID:21994612. |
p53 has been shown to contribute to virus-induced apoptosis, therefore dampening the ability of a wide range of viruses to replicate and spread. |
2012-09-10 |
2023-08-12 |
Not clear |
| Carmen Rivas, Stuart A Aaronson, Cesar Munoz-Fontel. Dual Role of p53 in Innate Antiviral Immunity. Viruses. vol 2. issue 1. 2012-09-10. PMID:21994612. |
these findings indicate that p53 may play a key role in antiviral innate immunity by both inducing apoptosis in response to viral infection, and enforcing the type i ifn response, and provide a new insight into the evolutionary reasons why many viruses encode p53 antagonistic proteins. |
2012-09-10 |
2023-08-12 |
Not clear |
| J de Lange, M Verlaan-de Vries, A F A S Teunisse, A G Jochemse. Chk2 mediates RITA-induced apoptosis. Cell death and differentiation. vol 19. issue 6. 2012-09-10. PMID:22158418. |
reactivation of the p53 tumor-suppressor protein by small molecules like nutlin-3 and rita (reactivation of p53 and induction of tumor cell apoptosis) is a promising strategy for cancer therapy. |
2012-09-10 |
2023-08-12 |
Not clear |