| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kiyoe Shimazaki, Takafumi Uchida, Akihiko Komine, Katsuhiko Takahash. p53 Retards cell-growth and suppresses etoposide-induced apoptosis in Pin1-deficient mouse embryonic fibroblasts. Biochemical and biophysical research communications. vol 422. issue 1. 2012-08-16. PMID:22564744. |
we studied the effects of pin1, a regulatory molecule of the oncosuppressor p53, on both cell cycle arrest and apoptosis by treating primary mouse embryonic fibroblasts (mefs) with etoposide. |
2012-08-16 |
2023-08-12 |
mouse |
| Kiyoe Shimazaki, Takafumi Uchida, Akihiko Komine, Katsuhiko Takahash. p53 Retards cell-growth and suppresses etoposide-induced apoptosis in Pin1-deficient mouse embryonic fibroblasts. Biochemical and biophysical research communications. vol 422. issue 1. 2012-08-16. PMID:22564744. |
both pin1(-/-) and pin1(-/-)p53(-/-) mefs were enhanced the release of cytochrome c from the mitochondria, which might induce apoptosis. |
2012-08-16 |
2023-08-12 |
mouse |
| Kiyoe Shimazaki, Takafumi Uchida, Akihiko Komine, Katsuhiko Takahash. p53 Retards cell-growth and suppresses etoposide-induced apoptosis in Pin1-deficient mouse embryonic fibroblasts. Biochemical and biophysical research communications. vol 422. issue 1. 2012-08-16. PMID:22564744. |
these results suggest that p53 retards growth and suppresses etoposide-induced apoptosis in pin1(-/-) mefs. |
2012-08-16 |
2023-08-12 |
mouse |
| Yi-Fang Tu, Pei-Jung Lu, Chao-Ching Huang, Chien-Jung Ho, Ya-Ping Cho. Moderate dietary restriction reduces p53-mediated neurovascular damage and microglia activation after hypoxic ischemia in neonatal brain. Stroke. vol 43. issue 2. 2012-08-15. PMID:22076005. |
the p53 upregulation is involved in apoptosis, endothelial cell damage, and microglia activation. |
2012-08-15 |
2023-08-12 |
rat |
| Kaisar A Talukder, Ishrat J Azmi, K Ahtesham Ahmed, M Sabir Hossain, Yearul Kabir, Alejandro Cravioto, David A Sack, Alam Nur-E-Kama. Activation of p53/ATM-dependent DNA damage signaling pathway by shiga toxin in mammalian cells. Microbial pathogenesis. vol 52. issue 6. 2012-08-15. PMID:22406215. |
stx-1-induced nuclear condensation significantly reduced in p53-, and atm-knockout cells suggesting an involvement of p53 and atm in transducing signals produced by stx in inducing apoptosis in mammalian cells. |
2012-08-15 |
2023-08-12 |
mouse |
| Xiaodu Wang, Xufang Deng, Wenjun Yan, Zixiang Zhu, Yang Shen, Yafeng Qiu, Zixue Shi, Donghua Shao, Jianchao Wei, Xianzhu Xia, Zhiyong M. Stabilization of p53 in influenza A virus-infected cells is associated with compromised MDM2-mediated ubiquitination of p53. The Journal of biological chemistry. vol 287. issue 22. 2012-08-15. PMID:22474335. |
in response to iav infection, p53, a tumor suppressor involved in regulating apoptosis and host antiviral defense, accumulates and becomes activated. |
2012-08-15 |
2023-08-12 |
Not clear |
| Tongyuan Li, Ning Kon, Le Jiang, Minjia Tan, Thomas Ludwig, Yingming Zhao, Richard Baer, Wei G. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell. vol 149. issue 6. 2012-08-15. PMID:22682249. |
cell-cycle arrest, apoptosis, and senescence are widely accepted as the major mechanisms by which p53 inhibits tumor formation. |
2012-08-15 |
2023-08-12 |
mouse |
| Tongyuan Li, Ning Kon, Le Jiang, Minjia Tan, Thomas Ludwig, Yingming Zhao, Richard Baer, Wei G. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell. vol 149. issue 6. 2012-08-15. PMID:22682249. |
although p53(k117r/k117r) cells are competent for p53-mediated cell-cycle arrest and senescence, but not apoptosis, all three of these processes are ablated in p53(3kr/3kr) cells. |
2012-08-15 |
2023-08-12 |
mouse |
| Ying Jiang, Kaimin Rao, Guangtao Yang, Xi Chen, Qian Wang, Ailin Liu, Hongyan Zheng, Jing Yua. Benzo(a)pyrene induces p73 mRNA expression and necrosis in human lung adenocarcinoma H1299 cells. Environmental toxicology. vol 27. issue 4. 2012-08-14. PMID:20862736. |
p53 can mediate dna damage-induced apoptosis in various cell lines treated with benzo(a)pyrene (bap). |
2012-08-14 |
2023-08-12 |
human |
| Ying Jiang, Kaimin Rao, Guangtao Yang, Xi Chen, Qian Wang, Ailin Liu, Hongyan Zheng, Jing Yua. Benzo(a)pyrene induces p73 mRNA expression and necrosis in human lung adenocarcinoma H1299 cells. Environmental toxicology. vol 27. issue 4. 2012-08-14. PMID:20862736. |
in this study, normal fetal lung fibroblasts (mrc-5) and human lung adenocarcinoma cells (h1299, p53-null) were treated with bap at concentrations of 8, 16, 32, 64, and 128 μm for 4 and 12 h. the oxidative stress status, extent of dna damage, expression of p53, p73, mdm2, bcl-2, and bax at the mrna and protein levels, and the percentages of apoptosis and/or necrosis were assessed. |
2012-08-14 |
2023-08-12 |
human |
| Vanessa R Sohn, Anna Giros, Rosa M Xicola, Lourdes Fluvià, Mike Grzybowski, Anna Anguera, Xavier Llo. Stool-fermented Plantago ovata husk induces apoptosis in colorectal cancer cells independently of molecular phenotype. The British journal of nutrition. vol 107. issue 11. 2012-08-14. PMID:22018732. |
the fermentation products of po induced apoptosis in all primary tumour and metastatic cell lines, independent of p53, adenomatous polyposis coli, β-catenin or cyclo-oxygenase-2 status. |
2012-08-14 |
2023-08-12 |
human |
| Nageswara Rao Dunna, Sugunakar Vure, K Sailaja, D Surekha, D Raghunadharao, Senthil Rajappa, S Vishnupriy. TP53 codon 72 polymorphism and risk of acute leukemia. Asian Pacific journal of cancer prevention : APJCP. vol 13. issue 1. 2012-08-14. PMID:22502699. |
tp53 is the mostly commonly mutated gene in many cancers and the p53 tumor suppressor protein is involved in multiple cellular processes, including transcription, dna repair, genomic stability, senescence, cell cycle control and apoptosis. |
2012-08-14 |
2023-08-12 |
Not clear |
| Yi Lin, Zuxin Cheng, Zhijian Yang, Jingui Zheng, Tongxiang Li. DNp73 improves generation efficiency of human induced pluripotent stem cells. BMC cell biology. vol 13. 2012-08-13. PMID:22449255. |
however, dnp73, on the other hand acts as an oncogene to suppress p53 and p73 induced apoptosis. |
2012-08-13 |
2023-08-12 |
human |
| Lingchao Chen, Junxia Zhang, Lei Han, Anling Zhang, Chunzhi Zhang, Yongri Zheng, Tao Jiang, Peiyu Pu, Chuanlu Jiang, Chunsheng Kan. Downregulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status. Oncology reports. vol 27. issue 3. 2012-08-10. PMID:22075712. |
downregulation of mir-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status. |
2012-08-10 |
2023-08-12 |
human |
| Lingchao Chen, Junxia Zhang, Lei Han, Anling Zhang, Chunzhi Zhang, Yongri Zheng, Tao Jiang, Peiyu Pu, Chuanlu Jiang, Chunsheng Kan. Downregulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status. Oncology reports. vol 27. issue 3. 2012-08-10. PMID:22075712. |
here, we demostrate that knockdown of mir-221/222 increases apoptosis in human gliomas of different p53 types (u251 cells, p53 mutant-type; ln308 cells, p53 null-type; and u87 cells, p53 wild-type). |
2012-08-10 |
2023-08-12 |
human |
| Lingchao Chen, Junxia Zhang, Lei Han, Anling Zhang, Chunzhi Zhang, Yongri Zheng, Tao Jiang, Peiyu Pu, Chuanlu Jiang, Chunsheng Kan. Downregulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status. Oncology reports. vol 27. issue 3. 2012-08-10. PMID:22075712. |
in addition, when a specific sirna against p53 was employed in u87 cells, no attenuation of apoptosis was found after knockdown of mir-221/222. |
2012-08-10 |
2023-08-12 |
human |
| Lingchao Chen, Junxia Zhang, Lei Han, Anling Zhang, Chunzhi Zhang, Yongri Zheng, Tao Jiang, Peiyu Pu, Chuanlu Jiang, Chunsheng Kan. Downregulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status. Oncology reports. vol 27. issue 3. 2012-08-10. PMID:22075712. |
taken together, our study indicates that downregulated mir-221/222 can sensitize glioma cells to tmz by regulating apoptosis independently of p53 status. |
2012-08-10 |
2023-08-12 |
human |
| Andrew Kekapa'a Knutson, Jennifer Welsh, Travis Taylor, Somdutta Roy, Wei-Lin Winnie Wang, Martin Tenniswoo. Comparative effects of histone deacetylase inhibitors on p53 target gene expression, cell cycle and apoptosis in MCF-7 breast cancer cells. Oncology reports. vol 27. issue 3. 2012-08-10. PMID:22159450. |
comparative effects of histone deacetylase inhibitors on p53 target gene expression, cell cycle and apoptosis in mcf-7 breast cancer cells. |
2012-08-10 |
2023-08-12 |
human |
| Andrew Kekapa'a Knutson, Jennifer Welsh, Travis Taylor, Somdutta Roy, Wei-Lin Winnie Wang, Martin Tenniswoo. Comparative effects of histone deacetylase inhibitors on p53 target gene expression, cell cycle and apoptosis in MCF-7 breast cancer cells. Oncology reports. vol 27. issue 3. 2012-08-10. PMID:22159450. |
in contrast, cg-1521 significantly induces the expression of several p53 target genes associated with apoptosis including bnip3/bnip3l, p21/p21b and gdf15. |
2012-08-10 |
2023-08-12 |
human |
| I Skírnisdóttir, T Seida. The apoptosis regulators p53, bax and PUMA: Relationship and impact on outcome in early stage (FIGO I-II) ovarian carcinoma after post-surgical taxane-based treatment. Oncology reports. vol 27. issue 3. 2012-08-10. PMID:22159712. |
the apoptosis regulators p53, bax and puma: relationship and impact on outcome in early stage (figo i-ii) ovarian carcinoma after post-surgical taxane-based treatment. |
2012-08-10 |
2023-08-12 |
Not clear |