| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Skírnisdóttir, T Seida. The apoptosis regulators p53, bax and PUMA: Relationship and impact on outcome in early stage (FIGO I-II) ovarian carcinoma after post-surgical taxane-based treatment. Oncology reports. vol 27. issue 3. 2012-08-10. PMID:22159712. |
the objective of this study was to evaluate the prognostic effect of the apoptosis regulators p53, bax and puma for recurrent disease and disease-free survival (dfs) in a series of 105 patients in figo-stages i-ii with epithelial ovarian cancer, all treated with post-surgical platinum-taxane chemotherapy. |
2012-08-10 |
2023-08-12 |
Not clear |
| Lin Yuan, Chunyan Tian, Hongye Wang, Shanshan Song, Deyang Li, Guichun Xing, Yuxin Yin, Fuchu He, Lingqiang Zhan. Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis. EMBO reports. vol 13. issue 4. 2012-08-10. PMID:22334068. |
apak competes with p53 for direct binding to intron 1 of p53aip1 to regulate apoptosis. |
2012-08-10 |
2023-08-12 |
Not clear |
| Dong Chen, Wei Zheng, Aiping Lin, Katherine Uyhazi, Hongyu Zhao, Haifan Li. Pumilio 1 suppresses multiple activators of p53 to safeguard spermatogenesis. Current biology : CB. vol 22. issue 5. 2012-08-10. PMID:22342750. |
deleting pumilio 1 results in strong activation of p53 and apoptosis mostly in spermatocytes, which disrupts sperm production and fertility. |
2012-08-10 |
2023-08-12 |
mouse |
| Dong Chen, Wei Zheng, Aiping Lin, Katherine Uyhazi, Hongyu Zhao, Haifan Li. Pumilio 1 suppresses multiple activators of p53 to safeguard spermatogenesis. Current biology : CB. vol 22. issue 5. 2012-08-10. PMID:22342750. |
removing p53 reduces apoptosis and rescues testicular hypotrophy in pumilio 1 null mice. |
2012-08-10 |
2023-08-12 |
mouse |
| Hossein Sharafi, Rahman Rahim. The effect of resistance exercise on p53, caspase-9, and caspase-3 in trained and untrained men. Journal of strength and conditioning research. vol 26. issue 4. 2012-08-10. PMID:22446679. |
protein p53 plays important roles in regulating apoptosis via mitochondrial pathway. |
2012-08-10 |
2023-08-12 |
human |
| Hossein Sharafi, Rahman Rahim. The effect of resistance exercise on p53, caspase-9, and caspase-3 in trained and untrained men. Journal of strength and conditioning research. vol 26. issue 4. 2012-08-10. PMID:22446679. |
therefore, the aims of this study were to determine the effects of acute resistance exercise (re) on serum p53, caspase-9, and caspase-3, markers of apoptosis, and whether resistance training status influences the magnitude of the re-induced apoptosis. |
2012-08-10 |
2023-08-12 |
human |
| Hossein Sharafi, Rahman Rahim. The effect of resistance exercise on p53, caspase-9, and caspase-3 in trained and untrained men. Journal of strength and conditioning research. vol 26. issue 4. 2012-08-10. PMID:22446679. |
collectively, our data suggest the role of p53 in regulating apoptosis through mitochondrial pathway as measured by caspase-9 and caspase-3 after acute re in ut. |
2012-08-10 |
2023-08-12 |
human |
| Takumi Kudo, Mitsunobu Ikeda, Misa Nishikawa, Zeyu Yang, Kikuo Ohno, Kentaro Nakagawa, Yutaka Hat. The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53. Cancer research. vol 72. issue 11. 2012-08-10. PMID:22593196. |
the rassf3 candidate tumor suppressor induces apoptosis and g1-s cell-cycle arrest via p53. |
2012-08-10 |
2023-08-12 |
Not clear |
| Takumi Kudo, Mitsunobu Ikeda, Misa Nishikawa, Zeyu Yang, Kikuo Ohno, Kentaro Nakagawa, Yutaka Hat. The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53. Cancer research. vol 72. issue 11. 2012-08-10. PMID:22593196. |
we found that rassf3-induced apoptosis depended upon p53 expression. |
2012-08-10 |
2023-08-12 |
Not clear |
| Takumi Kudo, Mitsunobu Ikeda, Misa Nishikawa, Zeyu Yang, Kikuo Ohno, Kentaro Nakagawa, Yutaka Hat. The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53. Cancer research. vol 72. issue 11. 2012-08-10. PMID:22593196. |
together, our findings show the tumor suppressor activity of rassf3, which occurs through p53 stabilization and regulation of apoptosis and the cell cycle. |
2012-08-10 |
2023-08-12 |
Not clear |
| Xudong Li, Shijia Chen, Ren Su. Cdk1 inhibition induces mutually inhibitory apoptosis and reactivation of Kaposi's sarcoma-associated herpesvirus. Journal of virology. vol 86. issue 12. 2012-08-09. PMID:22496227. |
caspases, but not p53, are required for pel cell apoptosis induced by cdk1 inhibition. |
2012-08-09 |
2023-08-12 |
Not clear |
| Zhengli Xu, Changsheng Liu, Jie Wei, Jiao Su. Effects of four types of hydroxyapatite nanoparticles with different nanocrystal morphologies and sizes on apoptosis in rat osteoblasts. Journal of applied toxicology : JAT. vol 32. issue 6. 2012-08-07. PMID:22162110. |
the increased apoptosis rates were accompanied by increased p53 and cytochrome c expression. |
2012-08-07 |
2023-08-12 |
rat |
| M P Gallegos-Arreola, L E Valencia-Rodríguez, A M Puebla-Pérez, L E Figuera, G M Zúñiga-Gonzále. The TP53 16-bp duplication polymorphism is enriched in endometriosis patients. Gynecologic and obstetric investigation. vol 73. issue 2. 2012-08-07. PMID:22353881. |
the tp53 tumor suppressor gene encodes the nuclear phosphoprotein p53, which plays an important role in cell cycle regulation, apoptosis, dna repair and angiogenesis. |
2012-08-07 |
2023-08-12 |
Not clear |
| Qingjuan Shang, Dianliang Zhang, Chunbao Guo, Qiu Lin, Zhenhua Guo, Chun Den. Potential synergism of Bim with p53 in mice with Myc‑induced lymphoma in a mouse lymphoma model. Molecular medicine reports. vol 5. issue 6. 2012-08-07. PMID:22446994. |
we report that bim has an apoptotic function through bax/mitochondrial apoptosis signaling in the p53-independent mode, which is somewhat additive to the effects of p53. |
2012-08-07 |
2023-08-12 |
mouse |
| Qingjuan Shang, Dianliang Zhang, Chunbao Guo, Qiu Lin, Zhenhua Guo, Chun Den. Potential synergism of Bim with p53 in mice with Myc‑induced lymphoma in a mouse lymphoma model. Molecular medicine reports. vol 5. issue 6. 2012-08-07. PMID:22446994. |
thus, myc-induced apoptotic signals through bim and p53 must bifurcate to activate bax, suggesting that the activation of bim and p53 significantly contribute to apoptosis. |
2012-08-07 |
2023-08-12 |
mouse |
| Qingjuan Shang, Dianliang Zhang, Chunbao Guo, Qiu Lin, Zhenhua Guo, Chun Den. Potential synergism of Bim with p53 in mice with Myc‑induced lymphoma in a mouse lymphoma model. Molecular medicine reports. vol 5. issue 6. 2012-08-07. PMID:22446994. |
our results, therefore, establish that p53 and bim are effective key initiators of apoptosis in lymphoma cells, particularly when combined. |
2012-08-07 |
2023-08-12 |
mouse |
| Yongjun Wang, Laura A Solt, Douglas J Kojetin, Thomas P Burri. Regulation of p53 stability and apoptosis by a ROR agonist. PloS one. vol 7. issue 4. 2012-08-07. PMID:22509368. |
regulation of p53 stability and apoptosis by a ror agonist. |
2012-08-07 |
2023-08-12 |
Not clear |
| Yongjun Wang, Laura A Solt, Douglas J Kojetin, Thomas P Burri. Regulation of p53 stability and apoptosis by a ROR agonist. PloS one. vol 7. issue 4. 2012-08-07. PMID:22509368. |
activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. |
2012-08-07 |
2023-08-12 |
Not clear |
| Yongjun Wang, Laura A Solt, Douglas J Kojetin, Thomas P Burri. Regulation of p53 stability and apoptosis by a ROR agonist. PloS one. vol 7. issue 4. 2012-08-07. PMID:22509368. |
we demonstrate that treatment of cancer cells with a newly described synthetic ror agonist, sr1078, leads to p53 stabilization and induction of apoptosis. |
2012-08-07 |
2023-08-12 |
Not clear |
| G V Kochneva, G F Sivolobova, K V Iudina, I V Babkin, P M Chumakov, S V Neteso. [Oncolytic poxviruses]. Molekuliarnaia genetika, mikrobiologiia i virusologiia. issue 1. 2012-08-06. PMID:22702138. |
an attempt to use p53 protein gene expressed by vaccinia virus for addressed apoptosis of tumor cells was reported. |
2012-08-06 |
2023-08-12 |
Not clear |