| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julia Donauer, Ilona Schreck, Urban Liebel, Carsten Weis. Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells. Archives of toxicology. vol 86. issue 2. 2012-07-16. PMID:21983885. |
as reported previously, we could reconfirm a critical role of p53 in bpde-induced apoptosis. |
2012-07-16 |
2023-08-12 |
human |
| Julia Donauer, Ilona Schreck, Urban Liebel, Carsten Weis. Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells. Archives of toxicology. vol 86. issue 2. 2012-07-16. PMID:21983885. |
furthermore, induced levels of total p53 and its transcriptional target p21 declined at higher bpde concentrations correlating with reduced rates of apoptosis. |
2012-07-16 |
2023-08-12 |
human |
| Julia Donauer, Ilona Schreck, Urban Liebel, Carsten Weis. Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells. Archives of toxicology. vol 86. issue 2. 2012-07-16. PMID:21983885. |
interestingly, increased phosphorylation of p53 at serine 15 remained elevated at higher bpde concentrations thus disconnecting p53 phosphorylation from downstream apoptosis. |
2012-07-16 |
2023-08-12 |
human |
| Julia Donauer, Ilona Schreck, Urban Liebel, Carsten Weis. Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells. Archives of toxicology. vol 86. issue 2. 2012-07-16. PMID:21983885. |
hence, phosphorylation of p53 seems not only to be a more sensitive biomarker of bpde exposure but might serve other functions unrelated to apoptosis. |
2012-07-16 |
2023-08-12 |
human |
| Julia Donauer, Ilona Schreck, Urban Liebel, Carsten Weis. Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells. Archives of toxicology. vol 86. issue 2. 2012-07-16. PMID:21983885. |
although several routes of mutual regulation of p53 and sapk have been described, we present evidence that the sapk pathway in response to genotoxic stress can unexpectedly operate independently of p53 and controls apoptosis by a novel mechanism possibly downstream of caspases. |
2012-07-16 |
2023-08-12 |
human |
| S Tan, E G E de Vries, A G J van der Zee, S de Jon. Anticancer drugs aimed at E6 and E7 activity in HPV-positive cervical cancer. Current cancer drug targets. vol 12. issue 2. 2012-07-16. PMID:22165971. |
hr hpv e6-induced proteasomal degradation of p53 hampers p53 functionality in cell cycle arrest and apoptosis. |
2012-07-16 |
2023-08-12 |
human |
| Annina Steinbach, Andrea Tautzenberger, Anita Ignatius, Manuela Pluntke, Othmar Marti, Dirk Volkme. Coatings from micropatterned sulfobetaine polymer brushes as substrates for MC3T3-E1 cells. Journal of materials science. Materials in medicine. vol 23. issue 2. 2012-07-16. PMID:22193781. |
the osteoblastic cells display a more elongated morphology than cells on the control substrates, but show no sign of elevated levels of the apoptosis marker p53 or diminished levels of ki-67 or h4, which serve as indicators of proliferation. |
2012-07-16 |
2023-08-12 |
Not clear |
| Yoshito Kinoshita, H Jürgen Wenzel, Chizuru Kinoshita, Philip A Schwartzkroin, Richard S Morriso. Acute, but reversible, kainic acid-induced DNA damage in hippocampal CA1 pyramidal cells of p53-deficient mice. Epilepsia. vol 53 Suppl 1. 2012-07-16. PMID:22612817. |
these results suggest that seizure-induced dna strand breaks are accumulated to a greater extent but do not lead to apoptosis in the absence of p53. |
2012-07-16 |
2023-08-12 |
mouse |
| Yoshito Kinoshita, H Jürgen Wenzel, Chizuru Kinoshita, Philip A Schwartzkroin, Richard S Morriso. Acute, but reversible, kainic acid-induced DNA damage in hippocampal CA1 pyramidal cells of p53-deficient mice. Epilepsia. vol 53 Suppl 1. 2012-07-16. PMID:22612817. |
in wild-type animals, therefore, p53 appears to stimulate dna repair and also mediate apoptosis in ca1 neurons in this excitotoxicity model. |
2012-07-16 |
2023-08-12 |
mouse |
| Nian-Kang Sun, Shang-Lang Huang, Kun-Yi Chien, Chuck C-K Cha. Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming GS28-MDM2-p53 complexes and by preventing the ubiquitination and degradation of p53. The Biochemical journal. vol 444. issue 2. 2012-07-13. PMID:22397410. |
golgi-snare gs28 potentiates cisplatin-induced apoptosis by forming gs28-mdm2-p53 complexes and by preventing the ubiquitination and degradation of p53. |
2012-07-13 |
2023-08-12 |
human |
| Nian-Kang Sun, Shang-Lang Huang, Kun-Yi Chien, Chuck C-K Cha. Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming GS28-MDM2-p53 complexes and by preventing the ubiquitination and degradation of p53. The Biochemical journal. vol 444. issue 2. 2012-07-13. PMID:22397410. |
taken together, these results suggest that gs28 may potentiate cells to dna-damage-induced apoptosis by inhibiting the ubiquitination and degradation of p53. |
2012-07-13 |
2023-08-12 |
human |
| Zhao-Xia Wang, Dong Xue, Zhi-Li Liu, Bin-Bin Lu, Hai-Bo Bian, Xuan Pan, Yong-Mei Yi. Overexpression of polo-like kinase 1 and its clinical significance in human non-small cell lung cancer. The international journal of biochemistry & cell biology. vol 44. issue 1. 2012-07-12. PMID:22064247. |
polo-like kinase 1 inhibition could significantly inhibit in vitro and in vivo proliferation, induce cell arrest of g(2)/m phase and apoptosis enhancement in non-small cell lung cancer cells, which might be activation of the p53 pathway and the cdc25c/cdc2/cyclin b1 feedback loop. |
2012-07-12 |
2023-08-12 |
human |
| Nomesh K Gopalani, Ram Niwas Meena, Dipti N Prasad, Govindaswamy Ilavazhagan, Manish Sharm. Cooperativity between inhibition of cytosolic K+ efflux and AMPK activation during suppression of hypoxia-induced cellular apoptosis. The international journal of biochemistry & cell biology. vol 44. issue 1. 2012-07-12. PMID:22064248. |
additionally, we present experimental evidence for the functional role of ampk and p53 activation during suppression of hypoxia-induced apoptosis. |
2012-07-12 |
2023-08-12 |
Not clear |
| Surajit Sinha, Sunil Kumar Malonia, Smriti P K Mittal, Jinumary Mathai, Jayanta K Pal, Samit Chattopadhya. Chromatin remodelling protein SMAR1 inhibits p53 dependent transactivation by regulating acetyl transferase p300. The international journal of biochemistry & cell biology. vol 44. issue 1. 2012-07-12. PMID:22074660. |
acetylation of p53 is indispensable for its transcriptional activities and induction of apoptosis upon dna damage. |
2012-07-12 |
2023-08-12 |
Not clear |
| Surajit Sinha, Sunil Kumar Malonia, Smriti P K Mittal, Jinumary Mathai, Jayanta K Pal, Samit Chattopadhya. Chromatin remodelling protein SMAR1 inhibits p53 dependent transactivation by regulating acetyl transferase p300. The international journal of biochemistry & cell biology. vol 44. issue 1. 2012-07-12. PMID:22074660. |
here, we show that chromatin remodelling protein smar1 inhibits p53 acetylation and p53 dependent apoptosis by repressing p300 expression in response to dna damage. |
2012-07-12 |
2023-08-12 |
Not clear |
| Mattia Frontini, Luca Proietti-De-Santi. Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. Aging. vol 4. issue 2. 2012-07-11. PMID:22383384. |
the tumor suppressor p53 plays a pivotal role in triggering senescence and apoptosis and suppressing tumorigenesis. |
2012-07-11 |
2023-08-12 |
Not clear |
| A Kunwar, S Jayakumar, A K Srivastava, K I Priyadarsin. Dimethoxycurcumin-induced cell death in human breast carcinoma MCF7 cells: evidence for pro-oxidant activity, mitochondrial dysfunction, and apoptosis. Archives of toxicology. vol 86. issue 4. 2012-07-10. PMID:22119759. |
the s-phase arrest and apoptosis could also be correlated with the changes in the expressions of cell cycle proteins like p53, p21, cdk4, and cyclin-d1 and apoptotic markers like bax and bcl-2. |
2012-07-10 |
2023-08-12 |
human |
| Jum-Ji Kim, Mi-Young Le. p53 is not necessary for nuclear translocation of GAPDH during NO-induced apoptosis. BMB reports. vol 44. issue 12. 2012-07-09. PMID:22189680. |
p53 is not necessary for nuclear translocation of gapdh during no-induced apoptosis. |
2012-07-09 |
2023-08-12 |
Not clear |
| Tingxiu Xiang, Lili Li, Xuedong Yin, Chenfu Yuan, Cui Tan, Xianwei Su, Lei Xiong, Thomas C Putti, Michael Oberst, Kathleen Kelly, Guosheng Ren, Qian Ta. The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer. PloS one. vol 7. issue 1. 2012-07-09. PMID:22279545. |
the ubiquitin peptidase uchl1 induces g0/g1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer. |
2012-07-09 |
2023-08-12 |
Not clear |
| Nitika Paudel, Sathish Sadagopan, Sayan Chakraborty, Grzegorz Sarek, Päivi M Ojala, Bala Chandra. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with multifunctional angiogenin to utilize its antiapoptotic functions. Journal of virology. vol 86. issue 11. 2012-07-09. PMID:22438557. |
silencing ang or inhibiting its nuclear translocation resulted in decreased nuclear lana-1 and ang levels, decreased interactions between ang-lana-1, ang-p53, and lana-1-p53, the induction of p53, p21, and bax proteins, the increased cytoplasmic localization of p53, the downregulation of bcl-2, the increased cleavage of caspase-3, and the apoptosis of cells. |
2012-07-09 |
2023-08-12 |
Not clear |