| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Tang, Qinghua Jia, Ping Ma, Fujun Li, Tongde Lv, Xiaoqin H. [The effects of lead exposure on primary cultured hippocampus neurons apoptosis and the expressions of Bcl-2, Bax, p53 and NOS1]. Wei sheng yan jiu = Journal of hygiene research. vol 39. issue 2. 2012-07-06. PMID:20459046. |
[the effects of lead exposure on primary cultured hippocampus neurons apoptosis and the expressions of bcl-2, bax, p53 and nos1]. |
2012-07-06 |
2023-08-12 |
Not clear |
| Yasuhiko Yoshioka, Shigeomi Shimizu, Toshinori Ito, Masahiko Taniguchi, Masaya Nomura, Toshirou Nishida, Yoshiki Saw. p53 inhibits vascular endothelial growth factor expression in solid tumor. The Journal of surgical research. vol 174. issue 2. 2012-07-06. PMID:21324396. |
the p53 tumor-suppressor gene is one of the most frequently mutated genes in cancers, and its mutations affect various biological actions, such as tumor growth, apoptosis, and so on. |
2012-07-06 |
2023-08-12 |
Not clear |
| E McCormack, I Haaland, G Venås, R B Forthun, S Huseby, G Gausdal, S Knappskog, D R Micklem, J B Lorens, O Bruserud, B T Gjertse. Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. Leukemia. vol 26. issue 5. 2012-07-05. PMID:22064349. |
synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. |
2012-07-05 |
2023-08-12 |
Not clear |
| Guoqi Zhu, Xuncui Wang, Shengbing Wu, Qinglin L. Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death. Neurochemistry international. vol 60. issue 4. 2012-07-05. PMID:22265823. |
we further demonstrated that puerarin protected against mpp(+)-induced p53 nuclear accumulation, puma (p53-upregulated mediator of apoptosis) and bax expression and caspase-3-dependent programmed cell death (pcd). |
2012-07-05 |
2023-08-12 |
human |
| S Grabow, P Waring, L Happo, M Cook, K D Mason, P N Kelly, A Strasse. Pharmacological blockade of Bcl-2, Bcl-x(L) and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice. Cell death and differentiation. vol 19. issue 4. 2012-07-03. PMID:21997189. |
as proteins of the bcl-2 family are the critical regulators of apoptosis, we investigated the role of the pro-survival members bcl-2, bcl-x(l) and bcl-w in cancer development in p53(+/-) and p53(-/-) mice by testing whether abt-737, a pharmacological inhibitor of these proteins, could prevent or delay tumourigenesis. |
2012-07-03 |
2023-08-12 |
mouse |
| J J Sandow, A M Jabbour, M R Condina, C P Daunt, F C Stomski, B D Green, C D Riffkin, P Hoffmann, M A Guthridge, J Silke, A F Lopez, P G Eker. Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death. Cell death and differentiation. vol 19. issue 4. 2012-07-03. PMID:21997190. |
p53-upregulated modifier of apoptosis (puma), a pro-apoptotic member of the bcl-2 family, is transcriptionally activated by p53 and is a key effector of p53-dependent apoptosis. |
2012-07-03 |
2023-08-12 |
human |
| S P Garrison, D C Phillips, J R Jeffers, J E Chipuk, M J Parsons, J E Rehg, J T Opferman, D R Green, G P Zambett. Genetically defining the mechanism of Puma- and Bim-induced apoptosis. Cell death and differentiation. vol 19. issue 4. 2012-07-03. PMID:22015606. |
using genetically modified mouse models, we report here that p53 upregulated modulator of apoptosis (puma) and bcl-2 interacting mediator of cell death (bim), two pro-apoptotic members of the b-cell lymphoma protein-2 (bcl-2) family of proteins, cooperate in causing bone marrow and gastrointestinal tract toxicity in response to chemo and radiation therapy. |
2012-07-03 |
2023-08-12 |
mouse |
| C J Watson, H O'Kane, P Maxwell, O Sharaf, I Petak, P L Hyland, D O'Rouke, J McKnight, P Canning, K Williamso. Identification of a methylation hotspot in the death receptor Fas/CD95 in bladder cancer. International journal of oncology. vol 40. issue 3. 2012-07-03. PMID:22076446. |
using rt4 cells as a model, sirna targeting p53 significantly reduced mmc-induced p53 and fas up-regulation and stable dn-fadd transfection decreased mmc-induced apoptosis, suggesting that functional fas enhances chemotherapy responses in a p53-dependent manner. |
2012-07-03 |
2023-08-12 |
Not clear |
| Shao Chin Lee, Jason Cha. Proteomic identification of chaperonin-containing tail-less complex polypeptide-1 gamma subunit as a p53-responsive protein in colon cancer cells. Cancer genomics & proteomics. vol 9. issue 2. 2012-07-03. PMID:22399500. |
we recently reported that functional loss of p53 altered the responses of human hct116 colon cancer cells to apoptosis triggers. |
2012-07-03 |
2023-08-12 |
human |
| Richard Hill, Patricia A Madureira, David M Waisman, Patrick W K Le. DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death. Oncotarget. vol 2. issue 12. 2012-06-29. PMID:22190353. |
these data demonstrate that dna-pkcs negatively regulates p21 expression by directly interacting with the p21 transcription machinery via p53, driving the cell towards apoptosis. |
2012-06-29 |
2023-08-12 |
Not clear |
| Vladislava Juric, Chih-Chiun Chen, Lester F La. TNFα-induced apoptosis enabled by CCN1/CYR61: pathways of reactive oxygen species generation and cytochrome c release. PloS one. vol 7. issue 2. 2012-06-29. PMID:22363611. |
by contrast, lrp1, nsmase1, p53, and p38 mapk are not required when tnfα-dependent apoptosis is facilitated by the presence of cycloheximide, indicating that they function in the ccn1 signaling pathway that converges with tnfα-induced signaling events. |
2012-06-29 |
2023-08-12 |
Not clear |
| Jyotsana Singhal, Lokesh Dalasanur Nagaprashantha, Rit Vatsyayan, Ashutosh, Sanjay Awasthi, Sharad S Singha. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Cancer prevention research (Philadelphia, Pa.). vol 5. issue 3. 2012-06-28. PMID:22174364. |
didymin effectively inhibited proliferation and induced apoptosis irrespective of p53 status in neuroblastomas. |
2012-06-28 |
2023-08-12 |
mouse |
| Javed Ahmad, Maqusood Ahamed, Mohd Javed Akhtar, Salman A Alrokayan, Maqsood A Siddiqui, Javed Musarrat, Abdulaziz A Al-Khedhair. Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2. Toxicology and applied pharmacology. vol 259. issue 2. 2012-06-28. PMID:22245848. |
our data demonstrated that silica nanoparticles induced apoptosis in human liver cells, which is ros mediated and regulated through p53, bax/bcl-2 and caspase pathways. |
2012-06-28 |
2023-08-12 |
human |
| Janaina Fernandes, Patrícia G Guedes, Celso Luiz S Lage, Juliany Cola F Rodrigues, Claudia de Alencar S Lag. Tumor malignancy is engaged to prokaryotic homolog toolbox. Medical hypotheses. vol 78. issue 4. 2012-06-28. PMID:22285198. |
the analysis revealed that selected sequences of proteins involved in apoptosis and tumor suppression (as p53 and prb) scored non-significant (e-value>0.001) with prokaryotic homologs; on the other hand, human proteins involved in cellular chemo- and radio-resistance scored highly significant with prokaryotic and viral homologs (as catalase, e-value=zero). |
2012-06-28 |
2023-08-12 |
human |
| Sheng-jie Guo, Zhi-jian Sun, Wei L. New insights about the early diagnosis of fertility impairment in varicoceles: the DNA repair gene example. Medical hypotheses. vol 78. issue 4. 2012-06-28. PMID:22305334. |
basically, mta1 participates in the maintenance of early apoptotic balance induced by hyperthermal stimulation by elevating the deacetylation level of p53, a master regulator responsible for the initial phase of germ cell apoptosis induced by hyperthermia. |
2012-06-28 |
2023-08-12 |
Not clear |
| Wei Kong, Yi Zh. The pleiotropic effects of statins in the prevention of atherosclerosis : Editorial to: "Simvastatin suppresses apoptosis in vulnerable atherosclerotic plaques through regulating the expression of p53, Bcl-2 en Bcl-xL" by Weiwei Qin et al. Cardiovascular drugs and therapy. vol 26. issue 1. 2012-06-26. PMID:22052376. |
the pleiotropic effects of statins in the prevention of atherosclerosis : editorial to: "simvastatin suppresses apoptosis in vulnerable atherosclerotic plaques through regulating the expression of p53, bcl-2 en bcl-xl" by weiwei qin et al. |
2012-06-26 |
2023-08-12 |
Not clear |
| Qiaoli Ji, Lina Yang, Jun Zhou, Rong Lin, Jiye Zhang, Qinqin Lin, Weirong Wang, Kaifan Zhan. Protective effects of paeoniflorin against cobalt chloride-induced apoptosis of endothelial cells via HIF-1α pathway. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 3. 2012-06-26. PMID:22269387. |
these findings indicate that paeoniflorin had effective protection against hypoxia-induced apoptosis of endothelial cells and that hif-1α, p53 and bnip3 might be involved in this process. |
2012-06-26 |
2023-08-12 |
Not clear |
| S P Kazakov, T N Zabotina, O V Korotkova, A K Dzabarov, I A Kazantsev. Comparative analysis of cells with combined apoptosis and proliferation markers in thyroid tissue specimens from patients with cancer, adenoma, and autoimmune diseases. Bulletin of experimental biology and medicine. vol 150. issue 4. 2012-06-25. PMID:22268042. |
combined phenotypes of cells with membrane and intracellular expression of apoptosis and proliferation regulation markers (p53, bcl-2, cd95, cd95l, ki-67) were studied by flow cytometry of cell suspension from thyroid tissue specimens from patients with autoimmune diseases, adenoma, and thyroid cancer. |
2012-06-25 |
2023-08-12 |
Not clear |
| Jeong Won Hwang, Jung Han Oh, Hwa-Seung Yoo, Yeon-Weol Lee, Chong-Kwan Cho, Ki-Rok Kwon, Jung-Ho Yoon, Junsoo Park, Song Her, Zee-Won Lee, Ik-Soon Jang, Jong-Soon Cho. Mountain ginseng extract exhibits anti-lung cancer activity by inhibiting the nuclear translocation of NF-κB. The American journal of Chinese medicine. vol 40. issue 1. 2012-06-25. PMID:22298458. |
reduced activity of the nf-κb promoter and increased activity of the p53 promoter indicate that bx-mg regulates apoptosis at the level of transcription in lung cancer cells. |
2012-06-25 |
2023-08-12 |
Not clear |
| E M Mil', S M Gurevich, A I Kozachenko, L G Nagler, A A Albantova, L D Fatkullina, E B Burlakov. [Effects of smoking and tumor process on the contents of key proteins of apoptosis and activity of antioxidant enzymes in blood]. Izvestiia Akademii nauk. Seriia biologicheskaia. issue 1. 2012-06-25. PMID:22567868. |
the effects of smoking on the contents of the apoptosis markers bcl-2 and p53 proteins in blood plasma; the activity of the antioxidant (ao) enzymes cu, zn-superoxide dismutase (sod), glutathione peroxidase (gp), glutathione reductase (gr), glutathione s-transferase (gst), and catalase; and the content of malondialdehyde (mda) in erythrocytes from healthy donors and cancer patients were studied. |
2012-06-25 |
2023-08-12 |
Not clear |