| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Krishna K Singh, Praphulla C Shukla, Adrian Quan, Jean-François Desjardins, Fina Lovren, Yi Pan, Vinay Garg, Sumandeep Gosal, Ankit Garg, Paul E Szmitko, Michael D Schneider, Thomas G Parker, William L Stanford, Howard Leong-Poi, Hwee Teoh, Mohammed Al-Omran, Subodh Verm. BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22157755. |
the levels of p53 and the p53-related proapoptotic proteins p53-up-regulated modulator of apoptosis (puma) and bax were significantly increased in samples from cm-brca2(-/-) mice. |
2012-04-25 |
2023-08-12 |
mouse |
| J de Lange, L V Ly, K Lodder, M Verlaan-de Vries, A F A S Teunisse, M J Jager, A G Jochemse. Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma. Oncogene. vol 31. issue 9. 2012-04-24. PMID:21765463. |
we investigated the use of combination therapies for intraocular melanoma, based on the p53 activators nutlin-3 and reactivation of p53 and induction of tumor cell apoptosis (rita) and the topoisomerase i inhibitor topotecan. |
2012-04-24 |
2023-08-12 |
human |
| Atsushi Hoshino, Satoaki Matoba, Eri Iwai-Kanai, Hideo Nakamura, Masaki Kimata, Mikihiko Nakaoka, Maki Katamura, Yoshifumi Okawa, Makoto Ariyoshi, Yuichiro Mita, Koji Ikeda, Tomomi Ueyama, Mitsuhiko Okigaki, Hiroaki Matsubar. p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia. Journal of molecular and cellular cardiology. vol 52. issue 1. 2012-04-24. PMID:22044588. |
analysis of autophagic mediators acting downstream of p53 revealed that tigar (tp53-induced glycolysis and apoptosis regulator) was exclusively up-regulated in ischemic myocardium. |
2012-04-24 |
2023-08-12 |
mouse |
| Jade Yee, Robert E White, Emma Anderton, Martin J Allda. Latent Epstein-Barr virus can inhibit apoptosis in B cells by blocking the induction of NOXA expression. PloS one. vol 6. issue 12. 2012-04-23. PMID:22174825. |
latent epstein-barr virus (ebv) has been shown to protect burkitt's lymphoma-derived b cells from apoptosis induced by agents that cause damage to dna, in the context of mutant p53. |
2012-04-23 |
2023-08-12 |
Not clear |
| Jing-Ru Weng, Li-Yuan Bai, Chang-Fang Chiu, Ying-Chu Wang, Ming-Hsui Tsa. The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-κB, MAPK, and p53 signaling. Chemico-biological interactions. vol 195. issue 3. 2012-04-23. PMID:22290291. |
the dietary phytochemical 3,3'-diindolylmethane induces g2/m arrest and apoptosis in oral squamous cell carcinoma by modulating akt-nf-κb, mapk, and p53 signaling. |
2012-04-23 |
2023-08-12 |
Not clear |
| C-L Lin, H-C Tseng, R-F Chen, W-P Chen, M-J Su, K-M Fang, M-L W. Intracellular zinc release-activated ERK-dependent GSK-3β-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury. Cell death and differentiation. vol 18. issue 10. 2012-04-20. PMID:21660051. |
flavonoids and u0126 (a mek1/2 inhibitor) largely inhibited the myocyte apoptosis and the tpen-sensitive i/r- or zn(2+)(i) supplement-induced persistent extracellular signal-regulated kinase 1 and 2 (erk1/2) phosphorylation, dephosphorylation of p-ser9 on glycogen synthase kinase 3β (gsk-3β), and the translocation into and accumulation of p-tyr216 gsk-3β and p53 in, the nucleus. |
2012-04-20 |
2023-08-12 |
Not clear |
| Yan-Tao Han, Xue-Hong Chen, Jing Xie, Song-Mei Zhan, Chun-Bo Wang, Le-Xin Wan. Purple sweet potato pigments scavenge ROS, reduce p53 and modulate Bcl-2/Bax to inhibit irradiation-induced apoptosis in murine thymocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 28. issue 5. 2012-04-20. PMID:22178939. |
purple sweet potato pigments scavenge ros, reduce p53 and modulate bcl-2/bax to inhibit irradiation-induced apoptosis in murine thymocytes. |
2012-04-20 |
2023-08-12 |
Not clear |
| Yan-Tao Han, Xue-Hong Chen, Jing Xie, Song-Mei Zhan, Chun-Bo Wang, Le-Xin Wan. Purple sweet potato pigments scavenge ROS, reduce p53 and modulate Bcl-2/Bax to inhibit irradiation-induced apoptosis in murine thymocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 28. issue 5. 2012-04-20. PMID:22178939. |
in this study, we further investigated the effect of psp pigments on apoptosis related ros, p53 and bcl-2 family. |
2012-04-20 |
2023-08-12 |
Not clear |
| Gong-Ping Liu, Wei Wei, Xin Zhou, Yao Zhang, Hai-Hong Shi, Jun Yin, Xiu-Qing Yao, Cai-Xia Peng, Juan Hu, Qun Wang, Hong-Lian Li, Jian-Zhi Wan. I(2)(PP2A) regulates p53 and Akt correlatively and leads the neurons to abort apoptosis. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20138402. |
i(2)(pp2a) regulates p53 and akt correlatively and leads the neurons to abort apoptosis. |
2012-04-19 |
2023-08-12 |
mouse |
| Gong-Ping Liu, Wei Wei, Xin Zhou, Yao Zhang, Hai-Hong Shi, Jun Yin, Xiu-Qing Yao, Cai-Xia Peng, Juan Hu, Qun Wang, Hong-Lian Li, Jian-Zhi Wan. I(2)(PP2A) regulates p53 and Akt correlatively and leads the neurons to abort apoptosis. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20138402. |
our results suggest that the increased i(2)(pp2a) may trigger apoptosis by p53 upregulation, but due to simultaneous activation of akt, the neurons are aborted from the apoptotic pathway. |
2012-04-19 |
2023-08-12 |
mouse |
| Fábio T Watanabe, Daher C Chade, Sabrina T Reis, Camila Piantino, Marcos Francisco Dall' Oglio, Miguel Srougi, Katia R M Leit. Curcumin, but not Prima-1, decreased tumor cell proliferation in the syngeneic murine orthotopic bladder tumor model. Clinics (Sao Paulo, Brazil). vol 66. issue 12. 2012-04-19. PMID:22189739. |
among the mediators of this effect of smoking is nuclear factor-kappa b. curcumin suppresses cellular transformation by downregulating the activity of nuclear factor-kappa b. prima-1 is a compound that induces apoptosis in human tumor cells, restoring the function of mutant p53. |
2012-04-19 |
2023-08-12 |
human |
| Chizu Tanikawa, Hidewaki Nakagawa, Yoichi Furukawa, Yusuke Nakamura, Koichi Matsud. CLCA2 as a p53-inducible senescence mediator. Neoplasia (New York, N.Y.). vol 14. issue 2. 2012-04-19. PMID:22431922. |
activated p53 protein regulates its downstream genes and subsequently inhibits malignant transformation by inducing cell cycle arrest, apoptosis, dna repair, and senescence. |
2012-04-19 |
2023-08-12 |
Not clear |
| Dong Chen, Xuefeng Zheng, Dalu Kang, Bomin Yan, Xiaoyi Liu, Yuan Gao, Kejun Zhan. Apoptosis and expression of the Bcl-2 family of proteins and P53 in human pancreatic ductal adenocarcinoma. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. vol 21. issue 1. 2012-04-17. PMID:22024503. |
apoptosis and expression of the bcl-2 family of proteins and p53 in human pancreatic ductal adenocarcinoma. |
2012-04-17 |
2023-08-12 |
human |
| Dong Chen, Xuefeng Zheng, Dalu Kang, Bomin Yan, Xiaoyi Liu, Yuan Gao, Kejun Zhan. Apoptosis and expression of the Bcl-2 family of proteins and P53 in human pancreatic ductal adenocarcinoma. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. vol 21. issue 1. 2012-04-17. PMID:22024503. |
the purpose of this study was to clarify the association between p53 and the bcl-2 family (bcl-2, bax, bcl-xl, bcl-xs) expression and apoptosis in pancreatic ductal adenocarcinoma (pdac). |
2012-04-17 |
2023-08-12 |
human |
| Ubaldo E Martinez-Outschoorn, Allison Goldberg, Zhao Lin, Ying-Hui Ko, Neal Flomenberg, Chenguang Wang, Stephanos Pavlides, Richard G Pestell, Anthony Howell, Federica Sotgia, Michael P Lisant. Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells. Cancer biology & therapy. vol 12. issue 10. 2012-04-17. PMID:22041887. |
in coculture, tamoxifen induces the upregulation of tigar (tp53-induced glycolysis and apoptosis regulator), a p53 regulated gene that simultaneously inhibits glycolysis, autophagy and apoptosis and reduces ros generation, thereby promoting oxidative mitochondrial metabolism. |
2012-04-17 |
2023-08-12 |
Not clear |
| Fang-hua Qi, An-yuan Li, Lin Zhao, Li Zhang, Guan-hua Du, Wei Tan. [Apoptosis-inducing effect of cinobufacini on human hepatoma cell line HepG2 and its mechanism of action]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 45. issue 3. 2012-04-16. PMID:21351507. |
quantitative real-time rt-pcr and western blotting analysis were used to detect the mrna and protein expressions of apoptosis related factors bcl-2, bax and p53. |
2012-04-16 |
2023-08-12 |
human |
| Ying-Cheng Chung, Feng-Yao Tang, Jiunn-Wang Liao, Chia-Hua Chung, Ting-Ting Jong, Shih-Shiung Chen, Ching-Hsiu Tsai, En-Pei Chian. Isatis indigotica induces hepatocellular cancer cell death via caspase-independent apoptosis-inducing factor translocation apoptotic pathway in vitro and in vivo. Integrative cancer therapies. vol 10. issue 2. 2012-04-16. PMID:21382959. |
furthermore, cedli activates p53 and bax, reduces bcl-2 expression, and causes mitochondrial stress and the release of apoptosis-inducing factor into the cytosol followed by its translocation into the nucleus, resulting in hepatoma cell apoptosis. |
2012-04-16 |
2023-08-12 |
mouse |
| Yashodhar P Bhandary, Shwetha K Shetty, Amarnath S Marudamuthu, Margaret R Gyetko, Steven Idell, Mehrnaz Gharaee-Kermani, Rashmi S Shetty, Barry C Starcher, Sreerama Shett. Regulation of alveolar epithelial cell apoptosis and pulmonary fibrosis by coordinate expression of components of the fibrinolytic system. American journal of physiology. Lung cellular and molecular physiology. vol 302. issue 5. 2012-04-16. PMID:22140072. |
tissues as well as isolated atii cells from the lungs of wild-type (wt) mice with blm injury show increased apoptosis, p53, and pai-1, and reciprocal suppression of upa and upa receptor (upar) protein expression. |
2012-04-16 |
2023-08-12 |
mouse |
| Yashodhar P Bhandary, Shwetha K Shetty, Amarnath S Marudamuthu, Margaret R Gyetko, Steven Idell, Mehrnaz Gharaee-Kermani, Rashmi S Shetty, Barry C Starcher, Sreerama Shett. Regulation of alveolar epithelial cell apoptosis and pulmonary fibrosis by coordinate expression of components of the fibrinolytic system. American journal of physiology. Lung cellular and molecular physiology. vol 302. issue 5. 2012-04-16. PMID:22140072. |
treatment of wt mice with csp reverses these effects and protects atii cells against bleomycin (blm)-induced apoptosis whereas csp fails to attenuate atii cell apoptosis or decrease p53 or pai-1 in upa-deficient mice. |
2012-04-16 |
2023-08-12 |
mouse |
| Yashodhar P Bhandary, Shwetha K Shetty, Amarnath S Marudamuthu, Margaret R Gyetko, Steven Idell, Mehrnaz Gharaee-Kermani, Rashmi S Shetty, Barry C Starcher, Sreerama Shett. Regulation of alveolar epithelial cell apoptosis and pulmonary fibrosis by coordinate expression of components of the fibrinolytic system. American journal of physiology. Lung cellular and molecular physiology. vol 302. issue 5. 2012-04-16. PMID:22140072. |
thus p53 is increased and inhibits expression of upa and upar while increasing pai-1, changes that promote atii cell apoptosis in mice with blm-induced ali. |
2012-04-16 |
2023-08-12 |
mouse |