| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kai-Wei Lin, A-Mei Huang, Tzyh-Chyuan Hour, Shyh-Chyun Yang, Yeong-Shiau Pu, Chun-Nan Li. 18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells. Bioorganic & medicinal chemistry. vol 19. issue 14. 2011-12-20. PMID:21696969. |
18β-glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in ntub1 cells. |
2011-12-20 |
2023-08-12 |
human |
| Kai-Wei Lin, A-Mei Huang, Tzyh-Chyuan Hour, Shyh-Chyun Yang, Yeong-Shiau Pu, Chun-Nan Li. 18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells. Bioorganic & medicinal chemistry. vol 19. issue 14. 2011-12-20. PMID:21696969. |
these results suggested that 25 induced a mitochondrial-mediated apoptosis in ntub1 cells through activation of p53, which are mainly mediated ros generated by 25. |
2011-12-20 |
2023-08-12 |
human |
| Rahul Kumar, Premendra D Dwivedi, Alok Dhawan, Mukul Das, Kausar M Ansar. Citrinin-generated reactive oxygen species cause cell cycle arrest leading to apoptosis via the intrinsic mitochondrial pathway in mouse skin. Toxicological sciences : an official journal of the Society of Toxicology. vol 122. issue 2. 2011-12-19. PMID:21622943. |
single topical application of ctn (50 μg/mouse) for 12-72 h caused significant enhancement in (1) reactive oxygen species (ros); (2) cell cycle arrest at the g0/g1 phase (30-71%) and g2/m phase (56-65%) along with the induction of apoptosis (3.6-27%); (3) expression of p53, p21/waf1; (4) bax/bcl₂ ratio and cytochome c release; and (5) activities of caspase 9 (22-46%) and 3 (42-54%) as well as increased poly(adp-ribose) polymerase cleavage. |
2011-12-19 |
2023-08-12 |
mouse |
| Priyanka Srivastava, Praveen K Jaiswal, Vibha Singh, Rama D Mitta. Role of p53 gene polymorphism and bladder cancer predisposition in northern India. Cancer biomarkers : section A of Disease markers. vol 8. issue 1. 2011-12-16. PMID:21896987. |
p53 is a major orchestrator of cellular response to a broad array of stress types by regulating apoptosis, cell cycle arrest, etc. |
2011-12-16 |
2023-08-12 |
Not clear |
| Carwyn Davies, Linda A Hogarth, Philipp A Dietrich, Petra S Bachmann, Karen L Mackenzie, Andrew G Hall, Richard B Loc. p53-independent epigenetic repression of the p21(WAF1) gene in T-cell acute lymphoblastic leukemia. The Journal of biological chemistry. vol 286. issue 43. 2011-12-15. PMID:21903579. |
the p53 protein is a primary mediator of cellular apoptosis and growth arrest after exposure to dna-damaging agents. |
2011-12-15 |
2023-08-12 |
mouse |
| Wei Liu, Qinsheng Dai, Na Lu, Libin Wei, Jun Ha, Jingjing Rong, Rong Mu, Qidong You, Zhiyu Li, Qinglong Gu. LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 89. issue 3. 2011-12-14. PMID:21491996. |
lyg-202 inhibits the proliferation of human colorectal carcinoma hct-116 cells through induction of g1/s cell cycle arrest and apoptosis via p53 and p21(waf1/cip1) expression. |
2011-12-14 |
2023-08-12 |
human |
| Wei Liu, Qinsheng Dai, Na Lu, Libin Wei, Jun Ha, Jingjing Rong, Rong Mu, Qidong You, Zhiyu Li, Qinglong Gu. LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 89. issue 3. 2011-12-14. PMID:21491996. |
additionally, activation of p53 resulted in the up-regulation of its downstream targets puma and p21(waf1/cip1), as well as the down-regulation of its negative regulator mdm2, suggesting that the p53 pathway may play a crucial role in lyg-202-induced cell cycle arrest and apoptosis. |
2011-12-14 |
2023-08-12 |
human |
| Wei Liu, Qinsheng Dai, Na Lu, Libin Wei, Jun Ha, Jingjing Rong, Rong Mu, Qidong You, Zhiyu Li, Qinglong Gu. LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 89. issue 3. 2011-12-14. PMID:21491996. |
furthermore, sirna knockdown of p53 attenuated the g1 cell cycle arrest and apoptosis induced by lyg-202, as the effects of lyg-202 on up-regulation of p21(waf1/cip1) and down-regulation of bcl-2 and pro-caspase-3 were partly inhibited in p53 sirna transfected cells compared with control sirna transfected cells. |
2011-12-14 |
2023-08-12 |
human |
| Alexander V Sirotkin, Monika Meszarošová, Roland Grossmann, Andrej Benčo, Francisco Valenzuel. Effect of inhibitor and activator of ghrelin receptor (GHS-R1a) on porcine ovarian granulosa cell functions. General and comparative endocrinology. vol 173. issue 1. 2011-12-14. PMID:21600209. |
effects of (d-lys3)-ghrp-6 added at doses of 0, 1, 10 or 100 ng/ml on the expression of markers of proliferation (pcna, cyclin b1, mapk/erk1,2), apoptosis (bax, p53, caspase 3) and release of steroid hormones (progesterone, testosterone, estradiol) were examined. |
2011-12-14 |
2023-08-12 |
Not clear |
| Yuk-Kwan Chen, Shui-Sang Huse, Li-Min Li. Expression of inhibitor of apoptosis family proteins in human oral squamous cell carcinogenesis. Head & neck. vol 33. issue 7. 2011-12-13. PMID:20967871. |
the purpose of this study was to determine inhibitor of apoptosis (iap) expression, its relationship with p53, and epigenetic change in oral carcinogenesis that remain to be elucidated. |
2011-12-13 |
2023-08-12 |
human |
| Johan H Gibcus, Bart-Jan Kroesen, Roelof Koster, Nancy Halsema, Debora de Jong, Steven de Jong, Sibrand Poppema, Joost Kluiver, Arjan Diepstra, Anke van den Ber. MiR-17/106b seed family regulates p21 in Hodgkin's lymphoma. The Journal of pathology. vol 225. issue 4. 2011-12-13. PMID:21953646. |
p21 is regulated by p53 and can function as a cell cycle inhibitor when in the nucleus or as an apoptosis inhibitor when localized in the cytoplasm. |
2011-12-13 |
2023-08-12 |
Not clear |
| Dadi Jiang, Colleen A Brady, Thomas M Johnson, Eunice Y Lee, Eunice J Park, Matthew P Scott, Laura D Attard. Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 41. 2011-12-13. PMID:21969549. |
although p53 limits tumorigenesis through the induction of apoptosis or cell cycle arrest, its molecular mechanism of action in tumor suppression has been elusive. |
2011-12-13 |
2023-08-12 |
mouse |
| Hilla Solomon, Shalom Madar, Varda Rotte. Mutant p53 gain of function is interwoven into the hallmarks of cancer. The Journal of pathology. vol 225. issue 4. 2011-12-13. PMID:22025211. |
this commentary links mutant p53 activities to the hallmarks of cancer, describing its involvement in resistance to apoptosis, genomic instability, aberrant cell cycle, invasion and metastasis, tumour microenvironment, and inflammation. |
2011-12-13 |
2023-08-12 |
human |
| Jewel L Podratz, Andrew M Knight, Lauren E Ta, Nathan P Staff, Jennifer M Gass, Konstantin Genelin, Alexander Schlattau, Liselle Lathroum, Anthony J Windeban. Cisplatin induced mitochondrial DNA damage in dorsal root ganglion neurons. Neurobiology of disease. vol 41. issue 3. 2011-12-12. PMID:21145397. |
we have previously shown that cisplatin induces apoptosis in dorsal root ganglion (drg) sensory neurons by covalently binding to nuclear dna (ndna), resulting in dna damage, subsequent p53 activation and bax-mediated apoptosis via the mitochondria. |
2011-12-12 |
2023-08-12 |
Not clear |
| Lei Jin, Wang Lai Hu, Chen Chen Jiang, Jia Xu Wang, Chuan Chun Han, Ping Chu, Lin Jie Zhang, Rick F Thorne, James Wilmott, Richard A Scolyer, Peter Hersey, Xu Dong Zhang, Mian W. MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 38. 2011-12-12. PMID:21896753. |
the tumor suppressor p53 is activated in response to cellular stress to prevent malignant transformation by activation of the dna repair machinery to preserve the cell, or by induction of apoptosis to eliminate the cell should the damage prove irrevocable. |
2011-12-12 |
2023-08-12 |
mouse |
| Lei Jin, Wang Lai Hu, Chen Chen Jiang, Jia Xu Wang, Chuan Chun Han, Ping Chu, Lin Jie Zhang, Rick F Thorne, James Wilmott, Richard A Scolyer, Peter Hersey, Xu Dong Zhang, Mian W. MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 38. 2011-12-12. PMID:21896753. |
here we show that p53 directly up-regulates microrna-149* (mir-149*) that in turn targets glycogen synthase kinase-3α, resulting in increased expression of mcl-1 and resistance to apoptosis in melanoma cells. |
2011-12-12 |
2023-08-12 |
mouse |
| Anissa Chikh, Rubeta N H Matin, Valentina Senatore, Martin Hufbauer, Danielle Lavery, Claudio Raimondi, Paola Ostano, Maurizia Mello-Grand, Chiara Ghimenti, Adiam Bahta, Sahira Khalaf, Baki Akgül, Kristin M Braun, Giovanna Chiorino, Michael P Philpott, Catherine A Harwood, Daniele Bergamasch. iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia. The EMBO journal. vol 30. issue 20. 2011-12-12. PMID:21897369. |
iaspp, an inhibitory member of the aspp (apoptosis stimulating protein of p53) family, is an evolutionarily conserved inhibitor of p53 which is frequently upregulated in human cancers. |
2011-12-12 |
2023-08-12 |
human |
| Jirouta Kitagaki, Yili Yan. DNA intercalator korkormicin A preferentially kills tumor cells expressing wild type p53. Biochemical and biophysical research communications. vol 414. issue 1. 2011-12-12. PMID:21946062. |
furthermore, korkormicin a preferentially induces apoptosis in transformed cells retaining wild type p53. |
2011-12-12 |
2023-08-12 |
Not clear |
| Jirouta Kitagaki, Yili Yan. DNA intercalator korkormicin A preferentially kills tumor cells expressing wild type p53. Biochemical and biophysical research communications. vol 414. issue 1. 2011-12-12. PMID:21946062. |
as it has been shown that p53 usually induces apoptosis in transformed cells, but only growth arrest in untransformed cells, these results indicate that korkormicin a is a potential antitumor agent for cancers with wild type p53. |
2011-12-12 |
2023-08-12 |
Not clear |
| Yong-Yu Li. Resuscitating wild-type p53 expression by disrupting ceramide glycosylation: a novel approach to target mutant p53 tumors. Cancer research. vol 71. issue 20. 2011-12-12. PMID:21972148. |
recent evidence indicates that disrupting ceramide glycosylation can resuscitate wild-type p53 expression and p53-dependent apoptosis in mutant p53 tumors. |
2011-12-12 |
2023-08-12 |
Not clear |