| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antony Gomes, Biplab Giri, Aftab Alam, Sanghamitra Mukherjee, Pushpak Bhattacharjee, Aparna Gome. Anticancer activity of a low immunogenic protein toxin (BMP1) from Indian toad (Bufo melanostictus, Schneider) skin extract. Toxicon : official journal of the International Society on Toxinology. vol 58. issue 1. 2011-12-09. PMID:21635912. |
the parallel induction of bax and p53 expression in hepg2 cells and the up-regulation of caspase 3 and caspase 9 due to bmp1 treatment indicated the involvement of p53-dependent intrinsic pathway of apoptosis. |
2011-12-09 |
2023-08-12 |
mouse |
| Ingeborg Zehbe, Hava Lichtig, Ashley Westerback, Paul F Lambert, Massimo Tommasino, Levana Sherma. Rare human papillomavirus 16 E6 variants reveal significant oncogenic potential. Molecular cancer. vol 10. 2011-12-09. PMID:21702904. |
low and high prevalence e6 variants displayed similar abilities in abrogation of growth arrest and inhibition of p53 elevation induced by actinomycin d. differences were detected in the abilities to dysregulate stratification and differentiation of niks in organotypic raft cultures, modulate detachment induced apoptosis (anoikis) and hyperactivate wnt signaling. |
2011-12-09 |
2023-08-12 |
human |
| Mateusz Dezor, Jolanta Dorszewska, Jolanta Florczak, Bartosz Kempisty, Joanna Jaroszewska-Kolecka, Agata Rozycka, Anna Polrolniczak, Robert Bugaj, Paweł P Jagodzinski, Wojciech Kozubsk. Expression of 8-oxoguanine DNA glycosylase 1 (OGG1) and the level of p53 and TNF-αlpha proteins in peripheral lymphocytes of patients with Alzheimer's disease. Folia neuropathologica. vol 49. issue 2. 2011-12-07. PMID:21845541. |
it is possible that ogg1 and p53 and tnf-α proteins together or separately may be involved in pathogenesis of ad by repair of oxidative dna damage and/or apoptosis. |
2011-12-07 |
2023-08-12 |
Not clear |
| Jason A Lehman, David L Waning, Christopher N Batuello, Rocky Cipriano, Madhavi P Kadakia, Lindsey D May. Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress. The Journal of biological chemistry. vol 286. issue 42. 2011-12-07. PMID:21873427. |
pten can directly or indirectly activate p53 to promote apoptosis. |
2011-12-07 |
2023-08-12 |
Not clear |
| Jason A Lehman, David L Waning, Christopher N Batuello, Rocky Cipriano, Madhavi P Kadakia, Lindsey D May. Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress. The Journal of biological chemistry. vol 286. issue 42. 2011-12-07. PMID:21873427. |
thus, a p73-pten protein complex is engaged to induce apoptosis independent of p53 in response to dna damage. |
2011-12-07 |
2023-08-12 |
Not clear |
| Jia Hu, Yingqiang Guo, Eryong Zhang, Weilin Xu, Yingkang Sh. [Pressure mediated effects on proliferation, apoptosis and apoptosis-associated protein of endothelial cells in the flow field in vitro]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 26. issue 4. 2011-12-06. PMID:19813622. |
the expressions of p53, bcl-2 and fas proteins are essential for regulating the genesis and process of ecs apoptosis induced by -40 cmh2o pressure. |
2011-12-06 |
2023-08-12 |
Not clear |
| Takuya Umemoto, Tomohiro Asai, Koji Hirashima, Kosuke Shimizu, Motohiro Mihara, Koji Yamamoto, Koji Kubota, Shin-ichi Miyagawa, Naoto Ok. Proapoptotic action of p53-Tom5 in p53-resistant A549 human non-small cell lung cancer cells through direct mitochondrial dysfunction. Biological & pharmaceutical bulletin. vol 34. issue 4. 2011-12-06. PMID:21467644. |
transcription-dependent apoptosis triggered by p53 hardly occurs in alternative reading frame (arf)-null cancer cells. |
2011-12-06 |
2023-08-12 |
human |
| Yanyan Cao, Susan C Evans, Eroica Soans, Ahmed Malki, Yi Liu, Yan Liu, Xiaozhuo Che. Insulin receptor signaling activated by penta-O-galloyl-α-D: -glucopyranose induces p53 and apoptosis in cancer cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 9. 2011-12-06. PMID:21671008. |
insulin receptor signaling activated by penta-o-galloyl-α-d: -glucopyranose induces p53 and apoptosis in cancer cells. |
2011-12-06 |
2023-08-12 |
Not clear |
| Yanyan Cao, Susan C Evans, Eroica Soans, Ahmed Malki, Yi Liu, Yan Liu, Xiaozhuo Che. Insulin receptor signaling activated by penta-O-galloyl-α-D: -glucopyranose induces p53 and apoptosis in cancer cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 9. 2011-12-06. PMID:21671008. |
p53 is essential for cell cycle arrest and apoptosis induction while insulin receptor (ir) signaling is important for cell metabolism and proliferation and found upregulated in cancers. |
2011-12-06 |
2023-08-12 |
Not clear |
| Yanyan Cao, Susan C Evans, Eroica Soans, Ahmed Malki, Yi Liu, Yan Liu, Xiaozhuo Che. Insulin receptor signaling activated by penta-O-galloyl-α-D: -glucopyranose induces p53 and apoptosis in cancer cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 9. 2011-12-06. PMID:21671008. |
while ir has recently been found to be involved in apoptosis, p53 induction or apoptosis mediated through ir signaling activation has never been documented. |
2011-12-06 |
2023-08-12 |
Not clear |
| Yanyan Cao, Susan C Evans, Eroica Soans, Ahmed Malki, Yi Liu, Yan Liu, Xiaozhuo Che. Insulin receptor signaling activated by penta-O-galloyl-α-D: -glucopyranose induces p53 and apoptosis in cancer cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 9. 2011-12-06. PMID:21671008. |
here, we report that the ir signaling pathway, particularly the ir-mek pathway, mediates biological and biochemical changes in p53 and apoptosis in tumor cells. |
2011-12-06 |
2023-08-12 |
Not clear |
| Yanyan Cao, Susan C Evans, Eroica Soans, Ahmed Malki, Yi Liu, Yan Liu, Xiaozhuo Che. Insulin receptor signaling activated by penta-O-galloyl-α-D: -glucopyranose induces p53 and apoptosis in cancer cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 9. 2011-12-06. PMID:21671008. |
α-pgg induced apoptosis in rko cells through p53, bax and caspase 3. |
2011-12-06 |
2023-08-12 |
Not clear |
| Yanyan Cao, Susan C Evans, Eroica Soans, Ahmed Malki, Yi Liu, Yan Liu, Xiaozhuo Che. Insulin receptor signaling activated by penta-O-galloyl-α-D: -glucopyranose induces p53 and apoptosis in cancer cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 9. 2011-12-06. PMID:21671008. |
all these results suggested that α-pgg induced p53, bax, and apoptosis through the ir-mek signaling pathway. |
2011-12-06 |
2023-08-12 |
Not clear |
| Paula Takahashi, Amanda Polson, David Reisma. Elevated transcription of the p53 gene in early S-phase leads to a rapid DNA-damage response during S-phase of the cell cycle. Apoptosis : an international journal on programmed cell death. vol 16. issue 9. 2011-12-06. PMID:21710255. |
since this is not what would be predicted from a gene involved in growth arrest and apoptosis, in this study, we provide evidence that this induction occurs to provide sufficient p53 mrna to ensure a rapid response to dna damage before exiting s-phase. |
2011-12-06 |
2023-08-12 |
Not clear |
| Paula Takahashi, Amanda Polson, David Reisma. Elevated transcription of the p53 gene in early S-phase leads to a rapid DNA-damage response during S-phase of the cell cycle. Apoptosis : an international journal on programmed cell death. vol 16. issue 9. 2011-12-06. PMID:21710255. |
when comparing exponentially growing swiss3t3 cells to those synchronized to enter s-phase simultaneously and treated with the dna damaging agent camptothecin, we found that with cells in s-phase, p53 protein levels increased earlier, bax and p21 transcription was activated earlier and to a greater extent and apoptosis occurred earlier and to a greater extent. |
2011-12-06 |
2023-08-12 |
Not clear |
| Sunny O Abarikwu, Ebenezer O Farombi, Mahendra P Kashyap, Aditya B Pan. Kolaviron protects apoptotic cell death in PC12 cells exposed to atrazine. Free radical research. vol 45. issue 9. 2011-12-06. PMID:21726175. |
kv treatment also demonstrates significant restoration in atz-induced alterations in the expression of apoptosis markers viz., p53, bax, bcl2, caspase-3, caspase-9, cyclooxygenase-2 (cox-2), c-jun and c-fos. |
2011-12-06 |
2023-08-12 |
rat |
| Tiam Feridooni, Adam Hotchkiss, Sarah Remley-Carr, Yumiko Saga, Kishore B S Pasumarth. Cardiomyocyte specific ablation of p53 is not sufficient to block doxorubicin induced cardiac fibrosis and associated cytoskeletal changes. PloS one. vol 6. issue 7. 2011-12-06. PMID:21829519. |
the pathophysiological mechanism of dox induced cardiotoxicity appears to involve increased expression of the tumor suppressor protein p53 in cardiomyocytes, followed by cellular apoptosis. |
2011-12-06 |
2023-08-12 |
mouse |
| Tiam Feridooni, Adam Hotchkiss, Sarah Remley-Carr, Yumiko Saga, Kishore B S Pasumarth. Cardiomyocyte specific ablation of p53 is not sufficient to block doxorubicin induced cardiac fibrosis and associated cytoskeletal changes. PloS one. vol 6. issue 7. 2011-12-06. PMID:21829519. |
in this study we measured the effects of acute dox treatment on myocardial and perivascular apoptosis and fibrosis in a conditional knockout (cko) mouse model system which harbours inactive p53 alleles specifically in cardiomyocytes. |
2011-12-06 |
2023-08-12 |
mouse |
| Tiam Feridooni, Adam Hotchkiss, Sarah Remley-Carr, Yumiko Saga, Kishore B S Pasumarth. Cardiomyocyte specific ablation of p53 is not sufficient to block doxorubicin induced cardiac fibrosis and associated cytoskeletal changes. PloS one. vol 6. issue 7. 2011-12-06. PMID:21829519. |
cko mice treated with a single dose of dox (20 mg/kg), did not display lower levels of myocardial apoptosis or reactive oxygen and nitrogen species (ros/rns) compared to control mice with intact p53 alleles. |
2011-12-06 |
2023-08-12 |
mouse |
| Tiam Feridooni, Adam Hotchkiss, Sarah Remley-Carr, Yumiko Saga, Kishore B S Pasumarth. Cardiomyocyte specific ablation of p53 is not sufficient to block doxorubicin induced cardiac fibrosis and associated cytoskeletal changes. PloS one. vol 6. issue 7. 2011-12-06. PMID:21829519. |
overall, these results indicate that selective loss of p53 in cardiomyocytes is not sufficient to prevent dox induced myocardial ros/rns generation, apoptosis, interstitial fibrosis and perivascular fibrosis. |
2011-12-06 |
2023-08-12 |
mouse |