| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Zhou, Ying Wei, Jing Zhu, Qingyuan Wang, Liang Bao, Yang Ma, Yu Chen, Dingqing Feng, Aijin Zhang, Jie Sun, Shreeram C Nallar, Keng Shen, Dhananjaya V Kalvakolanu, Weihua Xiao, Bin Lin. GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers. PloS one. vol 6. issue 7. 2011-11-09. PMID:21765936. |
the aims of this study were to determine the potential role of grim-19 in rescuing p53 protein and inducing cervical cancer cell apoptosis. |
2011-11-09 |
2023-08-12 |
human |
| M-C Lacroix, A Rodriguez-Enfedaque, D Grébert, I Laziz, N Meunier, R Monnerie, M-A Persuy, S Riviere, M Caillol, F Renau. Insulin but not leptin protects olfactory mucosa from apoptosis. Journal of neuroendocrinology. vol 23. issue 7. 2011-11-07. PMID:21554433. |
both odora cells (an olfactive cell line) and om cells treated with etoposide, a p53 activity inducer, exhibited mitochondrial-dependent apoptosis that was inhibited by the pan-caspase inhibitor zvad-fmk. |
2011-11-07 |
2023-08-12 |
Not clear |
| R G Wickremasinghe, A G Prentice, A J Steel. p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies. Leukemia. vol 25. issue 9. 2011-11-07. PMID:21566651. |
the p53 tumor suppressor protein has a key role in the induction of apoptosis of chronic lymphocytic leukemia (cll) cells. |
2011-11-07 |
2023-08-12 |
Not clear |
| R G Wickremasinghe, A G Prentice, A J Steel. p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies. Leukemia. vol 25. issue 9. 2011-11-07. PMID:21566651. |
this review describes recent advances in understanding the mechanisms that regulate p53 levels and the role of p53 in the control of the cell cycle and of apoptosis. |
2011-11-07 |
2023-08-12 |
Not clear |
| R G Wickremasinghe, A G Prentice, A J Steel. p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies. Leukemia. vol 25. issue 9. 2011-11-07. PMID:21566651. |
in contrast, a novel model emphasizes p53's non-transcriptional actions as the major route of apoptosis induction, whereas its transcriptional arm predominantly upregulates antiapoptotic genes, thus providing a negative feedback mechanism that limits apoptosis. |
2011-11-07 |
2023-08-12 |
Not clear |
| R G Wickremasinghe, A G Prentice, A J Steel. p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies. Leukemia. vol 25. issue 9. 2011-11-07. PMID:21566651. |
in contrast to the classical model, the novel model predicts that pharmacological inhibition of p53's transcriptional function or of the notch signaling pathway will augment apoptosis induction by cytotoxic agents. |
2011-11-07 |
2023-08-12 |
Not clear |
| Yi-de Zhou, Da-Lian Ding, Hong-Liang Zheng, Gui-Liang Zheng, Xiao-Hua Shen, Qing Zhang, Richad J Salv. [Hair cells apoptosis and the activation of P53 protein in intensive impulse noise induced cochlear lesion]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery. vol 46. issue 1. 2011-11-03. PMID:21429338. |
[hair cells apoptosis and the activation of p53 protein in intensive impulse noise induced cochlear lesion]. |
2011-11-03 |
2023-08-12 |
Not clear |
| Yi-de Zhou, Da-Lian Ding, Hong-Liang Zheng, Gui-Liang Zheng, Xiao-Hua Shen, Qing Zhang, Richad J Salv. [Hair cells apoptosis and the activation of P53 protein in intensive impulse noise induced cochlear lesion]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery. vol 46. issue 1. 2011-11-03. PMID:21429338. |
to explore the pattern of hair cell injury and expression of p53 apoptosis protein in intensive impulse noise injured cochlear hair cells in guinea pigs. |
2011-11-03 |
2023-08-12 |
Not clear |
| Xiao Sun, Gui-Bo Sun, Min Wang, Jing Xiao, Xiao-Bo Su. Protective effects of cynaroside against H₂O₂-induced apoptosis in H9c2 cardiomyoblasts. Journal of cellular biochemistry. vol 112. issue 8. 2011-11-02. PMID:21445859. |
these results suggest that cynaroside prevents h(2) o(2) -induced apoptosis in h9c2 cell by reducing the endogenous production of ros, maintaining mitochondrial function, and modulating the jnk and p53 pathways. |
2011-11-02 |
2023-08-12 |
Not clear |
| Hong Wu, Roger P Len. UBE4B, a ubiquitin chain assembly factor, is required for MDM2-mediated p53 polyubiquitination and degradation. Cell cycle (Georgetown, Tex.). vol 10. issue 12. 2011-11-02. PMID:21558803. |
our findings revealed that ube4b negatively regulates the level of p53 and inhibits p53-dependent transactivation and apoptosis. |
2011-11-02 |
2023-08-12 |
Not clear |
| Subhash Thalappilly, Xiaolan Feng, Svitlana Pastyryeva, Keiko Suzuki, Daniel Muruve, Daniel Larocque, Stephane Richard, Matthias Truss, Andreas von Deimling, Karl Riabowol, Gesche Talle. The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitination. PloS one. vol 6. issue 6. 2011-11-02. PMID:21731648. |
ing1 induces apoptosis independently of p53 but other studies suggest proapoptotic interdependence of ing1 and p53 leaving their functional relationship unclear. |
2011-11-02 |
2023-08-12 |
Not clear |
| A T Abdrashitova, T N Panova, I A Belolapenk. [Changes in ageing pace and major immune parameters among individuals with long exposure to hydrogen sulfide]. Meditsina truda i promyshlennaia ekologiia. issue 7. 2011-11-02. PMID:21938919. |
the authors revealed increase in ageing pace, higher level of pro-inflammatory cytokine interleukin-8 and apoptosis marker (p53 protein) in individuals with chronic exposure to gas containing hydrogen sulfide. |
2011-11-02 |
2023-08-12 |
Not clear |
| Paola Secchiero, Raffaella Bosco, Claudio Celeghini, Giorgio Zaul. Recent advances in the therapeutic perspectives of Nutlin-3. Current pharmaceutical design. vol 17. issue 6. 2011-11-01. PMID:21391907. |
nutlin-3 is a small molecule inhibitor of the mdm2/p53 interaction, which leads to the non-genotoxic p53 stabilization, activation of cell cycle arrest and apoptosis pathways. |
2011-11-01 |
2023-08-12 |
Not clear |
| Sun-Hye Lee, Bum-Joon Par. p53 activation by blocking Snail: a novel pharmacological strategy for cancer. Current pharmaceutical design. vol 17. issue 6. 2011-11-01. PMID:21391911. |
since p53 is the strongest tumor suppressor gene, which can regulate apoptosis, cell cycle arrest and senescence, re-activation of p53 and its pathway seem to be very plausible target for cancer therapy. |
2011-11-01 |
2023-08-12 |
human |
| R Koster, H Timmer-Bosscha, R Bischoff, J A Gietema, S de Jon. Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway. Cell death & disease. vol 2. 2011-11-01. PMID:21509038. |
wild-type p53 has a major role in the response and execution of apoptosis after chemotherapy in many cancers. |
2011-11-01 |
2023-08-12 |
human |
| R Koster, H Timmer-Bosscha, R Bischoff, J A Gietema, S de Jon. Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway. Cell death & disease. vol 2. 2011-11-01. PMID:21509038. |
inhibition of the mdm2-p53 interaction using either nutlin-3 or mdm2 rna interference resulted in hyperactivation of the p53 pathway and a strong induction of apoptosis in cisplatin-sensitive and -resistant tc cells. |
2011-11-01 |
2023-08-12 |
human |
| R Koster, H Timmer-Bosscha, R Bischoff, J A Gietema, S de Jon. Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway. Cell death & disease. vol 2. 2011-11-01. PMID:21509038. |
importantly, an analogous fas-dependent mechanism of apoptosis upon nutlin-3 treatment is executed in wild-type p53 expressing hodgkin lymphoma and acute myeloid leukaemia cell lines. |
2011-11-01 |
2023-08-12 |
human |
| A V Vaseva, A R Yallowitz, N D Marchenko, S Xu, U M Mol. Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors. Cell death & disease. vol 2. 2011-11-01. PMID:21562588. |
p53 inhibition by unopposed mdmx is one major cause for apoptosis resistance to nutlin. |
2011-11-01 |
2023-08-12 |
Not clear |
| Juan Duan, Qian Ba, Ziliang Wang, Miao Hao, Xiaoguang Li, Pingting Hu, Deyi Zhang, Ruiwen Zhang, Hui Wan. Knockdown of ribosomal protein S7 causes developmental abnormalities via p53 dependent and independent pathways in zebrafish. The international journal of biochemistry & cell biology. vol 43. issue 8. 2011-10-31. PMID:21550419. |
in rps7-deficient embryos, p53 was activated, and its downstream target genes and biological events were induced, including apoptosis and cell cycle arrest. |
2011-10-31 |
2023-08-12 |
human |
| Omar M Rahal, Rosalia C M Simme. Paracrine-acting adiponectin promotes mammary epithelial differentiation and synergizes with genistein to enhance transcriptional response to estrogen receptor β signaling. Endocrinology. vol 152. issue 9. 2011-10-31. PMID:21712365. |
the enhancement of erβ signaling with apn + genistein cotreatments was associated with induction of apoptosis, increased expression of proapoptotic/prodifferentiation genes (bad, p53, and pten), and decreased antiapoptotic (bcl2 and survivin) transcript levels. |
2011-10-31 |
2023-08-12 |
Not clear |