| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefano Campaner, Fabio Spreafico, Thomas Burgold, Mirko Doni, Umberto Rosato, Bruno Amati, Giuseppe Test. The methyltransferase Set7/9 (Setd7) is dispensable for the p53-mediated DNA damage response in vivo. Molecular cell. vol 43. issue 4. 2011-10-31. PMID:21855806. |
c-myc oncogene-induced apoptosis was also independent of set7/9, and analysis of p53 target genes showed that set7/9 is not required for the p53-dependent gene expression program. |
2011-10-31 |
2023-08-12 |
mouse |
| Steve A Maxwell, Evan M Cherry, Kayla J Bayles. Akt, 14-3-3ζ, and vimentin mediate a drug-resistant invasive phenotype in diffuse large B-cell lymphoma. Leukemia & lymphoma. vol 52. issue 5. 2011-10-27. PMID:21323512. |
two-dimensional differential in-gel (dige) analysis identified 10 differentially expressed proteins between chop-sensitive and -resistant dlbcl cells that play roles in glycolysis (triosephosphate isomerase-1, enolase-1), cytoskeletal structure (ezrin, vimentin, tubulin-specific chaperone b), purine biosynthesis (serine hydroxymethyltransferase), calcium binding (sorcin), and apoptosis (p53, 14-3-3ζ, akt). |
2011-10-27 |
2023-08-12 |
Not clear |
| Xin Liang, Ke Xu, Yufang Xu, Jianwen Liu, Xuhong Qia. B1-induced caspase-independent apoptosis in MCF-7 cells is mediated by down-regulation of Bcl-2 via p53 binding to P2 promoter TATA box. Toxicology and applied pharmacology. vol 256. issue 1. 2011-10-27. PMID:21821060. |
b1-induced caspase-independent apoptosis in mcf-7 cells is mediated by down-regulation of bcl-2 via p53 binding to p2 promoter tata box. |
2011-10-27 |
2023-08-12 |
Not clear |
| Xin Liang, Ke Xu, Yufang Xu, Jianwen Liu, Xuhong Qia. B1-induced caspase-independent apoptosis in MCF-7 cells is mediated by down-regulation of Bcl-2 via p53 binding to P2 promoter TATA box. Toxicology and applied pharmacology. vol 256. issue 1. 2011-10-27. PMID:21821060. |
these data suggest that b1-induced caspase-independent apoptosis in mcf-7 cells is associated with the activation of p53 and the down-regulation of bcl-2. |
2011-10-27 |
2023-08-12 |
Not clear |
| Cheng Wang, Jing Wang, Han Jiang, Min Zhu, Baoguo Chen, Weiguang Ba. In vitro study on apoptosis induced by strontium-89 in human breast carcinoma cell line. Journal of biomedicine & biotechnology. vol 2011. 2011-10-25. PMID:21716903. |
and the mitochondrion transmembrane potential decrease would induce the apoptosis of mcf-7 cell notably, which were controlled by p53 and bcl-2 genes, involved with the fas acceptor. |
2011-10-25 |
2023-08-12 |
human |
| María Elena Maldonado, Souad Bousserouel, Francine Gossé, Annelise Lobstein, Francis Rau. Implication of NF-κB and p53 in the expression of TRAIL-death receptors and apoptosis by apple procyanidins in human metastatic SW620 cells. Biomedica : revista del Instituto Nacional de Salud. vol 30. issue 4. 2011-10-24. PMID:21713362. |
implication of nf-κb and p53 in the expression of trail-death receptors and apoptosis by apple procyanidins in human metastatic sw620 cells. |
2011-10-24 |
2023-08-12 |
human |
| Maria Luisa Manca Bitti, Patrizia Saccucci, Francesca Capasso, Simona Piccinini, Federica Angelini, Novella Rapini, Marta Porcari, Susanna Arcano, Arianna Petrelli, Elisabetta Del Duca, Egidio Bottini, Fulvia Gloria-Bottin. Genotypes of p53 codon 72 correlate with age at onset of type 1 diabetes in a sex-specific manner. Journal of pediatric endocrinology & metabolism : JPEM. vol 24. issue 7-8. 2011-10-24. PMID:21932578. |
in type 1 diabetes mellitus (t1d) p53 pathways are up-regulated and there is an increased susceptibility to apoptosis. |
2011-10-24 |
2023-08-12 |
human |
| V G Artiukhov, M S Trubitsyna, M A Nakvasina, E V Solov'eva, O V Lidokhov. [Ways of realizing apoptosis of human lymphocytes induced by UV-light and reactive oxygen species]. Radiatsionnaia biologiia, radioecologiia. vol 51. issue 4. 2011-10-24. PMID:21950100. |
changes of dna structural condition, the level of membrane fas-receptor expression, caspase-3 functional activity, concentrations of ca2+, p53 and cytochrome c proteins of human lymphocytes in dynamics of apoptosis development induced by uv-light (240-390 nm) at doses 151, 1510, 3020 j/m2 and reactive oxygen species (superoxide anion-radical, hydroxyl radicals, hydrogen peroxide, singlet oxygen) have been studied. |
2011-10-24 |
2023-08-12 |
human |
| Zdeněk Andrysík, Jan Vondráček, Soňa Marvanová, Miroslav Ciganek, Jiří Neča, Kateřina Pěnčíková, Brinda Mahadevan, Jan Topinka, William M Baird, Alois Kozubík, Miroslav Machal. Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of polycyclic aromatic hydrocarbons. Mutation research. vol 714. issue 1-2. 2011-10-20. PMID:21762708. |
both the organic extract and its neutral aromatic fraction formed a low number of dna adducts per nucleotide in the liver epithelial wb-f344 cells model, without inducing dna damage response, such as tumor suppressor p53 activation and apoptosis. |
2011-10-20 |
2023-08-12 |
Not clear |
| Leszek Błaszczyk, Jerzy Ciesiołk. Secondary structure and the role in translation initiation of the 5'-terminal region of p53 mRNA. Biochemistry. vol 50. issue 33. 2011-10-20. PMID:21770379. |
the p53 protein is one of the major factors involved in cell cycle control, dna repair, and induction of apoptosis. |
2011-10-20 |
2023-08-12 |
Not clear |
| J Bellmunt, M Gui. New agents for bladder cancer. Annals of oncology : official journal of the European Society for Medical Oncology. vol 21 Suppl 7. 2011-10-17. PMID:20943643. |
these include agents that target several pathways involved in the pathogenesis of the disease--such as growth factor receptors, angiogenic pathways, p53, cell cycle checkpoints and apoptosis--as well as novel chemotherapeutic agents. |
2011-10-17 |
2023-08-12 |
Not clear |
| Daniel R Croft, Diane Crighton, Michael S Samuel, Filipe C Lourenco, June Munro, Jenifer Wood, Karim Bensaad, Karen H Vousden, Owen J Sansom, Kevin M Ryan, Michael F Olso. p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell research. vol 21. issue 4. 2011-10-17. PMID:21079653. |
the central arbiter of cell fate in response to dna damage is p53, which regulates the expression of genes involved in cell cycle arrest, survival and apoptosis. |
2011-10-17 |
2023-08-12 |
Not clear |
| F Cheng, J Liu, C Teh, S-W Chong, V Korzh, Y-J Jiang, L-W Den. Camptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53. Oncogene. vol 30. issue 33. 2011-10-17. PMID:21423215. |
the role of mll5 in cpt-induced p53 activation was conserved in developing zebrafish, where cpt downregulated zebrafish mll5 protein, and the microinjection of zebrafish mll5 mrna substantially blocked the cpt-induced apoptosis. |
2011-10-17 |
2023-08-12 |
zebrafish |
| Bu-Shan Xie, Hong-Chuan Zhao, Shu-Kun Yao, De-Xiang Zhuo, Bo Jin, Dui-Cai Lv, Cheng-Lin Wu, Dai-Long Ma, Chun Gao, Xiao-Ming Shu, Zheng-Lin A. Autophagy inhibition enhances etoposide-induced cell death in human hepatoma G2 cells. International journal of molecular medicine. vol 27. issue 4. 2011-10-14. PMID:21274505. |
furthermore, activation of p53 and ampk was detected in etoposide-treated cells and inhibition of ampk triggered apoptosis through suppression of autophagy. |
2011-10-14 |
2023-08-12 |
human |
| Lenka Trilecová, Simona Krčková, Soňa Marvanová, Kateřina Pĕnčíková, Pavel Krčmář, Jiří Neča, Petra Hulinková, Lenka Pálková, Miroslav Ciganek, Alena Milcová, Jan Topinka, Jan Vondráček, Miroslav Machal. Toxic effects of methylated benzo[a]pyrenes in rat liver stem-like cells. Chemical research in toxicology. vol 24. issue 6. 2011-10-14. PMID:21604763. |
we identified 1-mebap as the most potent inducer of ahr activation, stable dna adduct formation, checkpoint kinase 1 and p53 phosphorylation, and apoptosis. |
2011-10-14 |
2023-08-12 |
rat |
| Joo-Hee An, Jung-Woong Kim, Sang-Min Jang, Chul-Hong Kim, Eun-Jin Kang, Kyung-Hee Cho. Gelsolin negatively regulates the activity of tumor suppressor p53 through their physical interaction in hepatocarcinoma HepG2 cells. Biochemical and biophysical research communications. vol 412. issue 1. 2011-10-14. PMID:21801713. |
as a transcription factor, p53 modulates several cellular responses including cell-cycle control, apoptosis, and differentiation. |
2011-10-14 |
2023-08-12 |
Not clear |
| Joo-Hee An, Jung-Woong Kim, Sang-Min Jang, Chul-Hong Kim, Eun-Jin Kang, Kyung-Hee Cho. Gelsolin negatively regulates the activity of tumor suppressor p53 through their physical interaction in hepatocarcinoma HepG2 cells. Biochemical and biophysical research communications. vol 412. issue 1. 2011-10-14. PMID:21801713. |
taken together, these results suggest that gsn binds to p53 and this interaction leads to the inhibition of p53-induced apoptosis by anchoring of p53 in the cytoplasm in hepg2 cells. |
2011-10-14 |
2023-08-12 |
Not clear |
| Jiejie Hao, Weili Shen, Lijuan Sun, Jiangang Long, Edward Sharman, Xianglin Shi, Jiankang Li. Mitochondrial dysfunction in the liver of type 2 diabetic Goto-Kakizaki rats: improvement by a combination of nutrients. The British journal of nutrition. vol 106. issue 5. 2011-10-13. PMID:21418712. |
livers of untreated gk rats showed (1) abnormal changes in the activities of mitochondrial complexes (decreases in i, iii and iv and increases in ii and v), (2) increases in protein oxidation, (3) decreases in antioxidant enzymes (superoxide dismutase, glutathione s-transferase, nadh-quinone oxidoreductase-1), (4) a decrease in total antioxidant capacity but increases in reduced glutathione level and glyceraldehyde 3-phosphate dehydrogenase expression and (5) significant increases in apoptosis biomarkers, including expression of p21 and p53. |
2011-10-13 |
2023-08-12 |
rat |
| Stefano Fumagalli, George Thoma. The role of p53 in ribosomopathies. Seminars in hematology. vol 48. issue 2. 2011-10-13. PMID:21435506. |
in recent years it has become clear that perturbation of this process triggers a cell-cycle checkpoint that, through activation of the tumor-suppressor p53, leads to cell-cycle arrest and apoptosis. |
2011-10-13 |
2023-08-12 |
Not clear |
| Navjotsingh Pabla, Guie Dong, Man Jiang, Shuang Huang, M Vijay Kumar, Robert O Messing, Zheng Don. Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer. The Journal of clinical investigation. vol 121. issue 7. 2011-10-13. PMID:21633170. |
after activation, pkcδ regulated mapks, but not p53, to induce renal cell apoptosis. |
2011-10-13 |
2023-08-12 |
mouse |