| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Krishna K Singh, Praphulla C Shukla, Adrian Quan, Fina Lovren, Yi Pan, Jesse I Wolfstadt, Milan Gupta, Mohammed Al-Omran, Howard Leong-Poi, Hwee Teoh, Subodh Verm. Herceptin, a recombinant humanized anti-ERBB2 monoclonal antibody, induces cardiomyocyte death. Biochemical and biophysical research communications. vol 411. issue 2. 2011-10-03. PMID:21749857. |
p53 protein levels are elevated by trastuzumab and the biologically similar rat erbb2/her2/neu antibody; and that this coincides with enhanced apoptosis, increased cleaved caspase-3 levels and diminished cardiac function. |
2011-10-03 |
2023-08-12 |
rat |
| Krishna K Singh, Praphulla C Shukla, Adrian Quan, Fina Lovren, Yi Pan, Jesse I Wolfstadt, Milan Gupta, Mohammed Al-Omran, Howard Leong-Poi, Hwee Teoh, Subodh Verm. Herceptin, a recombinant humanized anti-ERBB2 monoclonal antibody, induces cardiomyocyte death. Biochemical and biophysical research communications. vol 411. issue 2. 2011-10-03. PMID:21749857. |
in conclusion, our findings suggest that the adverse cardiac events observed with trastuzumab may stem from its negative regulation of mdm2 events which impairs p53 degradation resultantly promoting apoptosis leading to cardiac dysfunction. |
2011-10-03 |
2023-08-12 |
rat |
| Jinghua Li, Shutao Yin, Yinhui Dong, Lihong Fan, Hongbo H. p53 activation inhibits ochratoxin A-induced apoptosis in monkey and human kidney epithelial cells via suppression of JNK activation. Biochemical and biophysical research communications. vol 411. issue 2. 2011-10-03. PMID:21763279. |
p53 activation inhibits ochratoxin a-induced apoptosis in monkey and human kidney epithelial cells via suppression of jnk activation. |
2011-10-03 |
2023-08-12 |
human |
| Jinghua Li, Shutao Yin, Yinhui Dong, Lihong Fan, Hongbo H. p53 activation inhibits ochratoxin A-induced apoptosis in monkey and human kidney epithelial cells via suppression of JNK activation. Biochemical and biophysical research communications. vol 411. issue 2. 2011-10-03. PMID:21763279. |
however, the molecular mechanisms involved, especially the role of p53 in ota-induced apoptosis have not been clearly elucidated. |
2011-10-03 |
2023-08-12 |
human |
| Jinghua Li, Shutao Yin, Yinhui Dong, Lihong Fan, Hongbo H. p53 activation inhibits ochratoxin A-induced apoptosis in monkey and human kidney epithelial cells via suppression of JNK activation. Biochemical and biophysical research communications. vol 411. issue 2. 2011-10-03. PMID:21763279. |
in the present study, we find that p53 activation exerts pro-survival function to inhibit apoptosis induction in marc-145, vero monkey kidney cells and hek293 human kidney cells in response to ochratoxin a treatment. |
2011-10-03 |
2023-08-12 |
human |
| Jinghua Li, Shutao Yin, Yinhui Dong, Lihong Fan, Hongbo H. p53 activation inhibits ochratoxin A-induced apoptosis in monkey and human kidney epithelial cells via suppression of JNK activation. Biochemical and biophysical research communications. vol 411. issue 2. 2011-10-03. PMID:21763279. |
to our knowledge, this is first report of pro-survival role of p53 in ota-induced apoptosis in kidney epithelial cells. |
2011-10-03 |
2023-08-12 |
human |
| Zhiping Zhang, Xiaoming Liu, Tao Wu, Junhong Liu, Xu Zhang, Xueyun Yang, Michael J Goodheart, John F Engelhardt, Yujiong Wan. Selective suppression of cervical cancer Hela cells by 2-O-β-D-glucopyranosyl-L-ascorbic acid isolated from the fruit of Lycium barbarum L. Cell biology and toxicology. vol 27. issue 2. 2011-09-30. PMID:20717715. |
similar to vitamin c, the aa-2βg selectively induced cell death repressed the proliferation of hela cells by the mechanism of cell apoptosis and cell cycle arrest induced by aa-2βg through a mechanism of stabilizing p53 protein. |
2011-09-30 |
2023-08-12 |
Not clear |
| Hai-Jia Zhu, Wei Xu, Xin Cao, Cheng Fang, Dan-Xia Zhu, Hua-Jie Dong, Dong-Mei Wang, Chun Qiao, Kou-Rong Miao, Peng Liu, Jian-Yong L. [Detection of puma mRNA levels by real-time quantitative RT-PCR in chronic lymphocytic leukemia and its clinical significance]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 4. 2011-09-30. PMID:20723285. |
this study was aimed to investigate the expression level of puma (p53 up-regulated modulator of apoptosis) mrna in chronic lymphocytic leukemia (cll) and its significance in evaluation of cll prognosis. |
2011-09-30 |
2023-08-12 |
Not clear |
| Sophie Chen, Matt Cooper, Matt Jones, Thumuluru Kavitha Madhuri, Julie Wade, Ashleigh Bachelor, Simon Butler-Manue. Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals. Cell biology and toxicology. vol 27. issue 2. 2011-09-30. PMID:20872277. |
up-regulation of the functional p53 protein in a2780 and down-regulation of akt protein in ptx10 have in part contributed to the apoptosis. |
2011-09-30 |
2023-08-12 |
Not clear |
| Nadine Darwiche, Ansam Sinjab, Ghada Abou-Lteif, Mirella Bou Chedid, Olivier Hermine, Ghassan Dbaibo, Ali Bazarbach. Inhibition of mammalian target of rapamycin signaling by everolimus induces senescence in adult T-cell leukemia/lymphoma and apoptosis in peripheral T-cell lymphomas. International journal of cancer. vol 129. issue 4. 2011-09-30. PMID:21064094. |
everolimus-mediated apoptosis was also associated with an upregulation of p53 upregulated modulator of apoptosis (puma-α) proteins, an increase in bax proteins and downregulation of bcl-x(l) proteins in all tested htlv-i-positive and -negative malignant cell lines. |
2011-09-30 |
2023-08-12 |
human |
| E Rodríguez-Aznar, M A Niet. Repression of Puma by scratch2 is required for neuronal survival during embryonic development. Cell death and differentiation. vol 18. issue 7. 2011-09-30. PMID:21252910. |
although snail factors promote cell survival in development and cancer, the tumor-suppressor p53 promotes apoptosis in response to stress. |
2011-09-30 |
2023-08-12 |
zebrafish |
| E Rodríguez-Aznar, M A Niet. Repression of Puma by scratch2 is required for neuronal survival during embryonic development. Cell death and differentiation. vol 18. issue 7. 2011-09-30. PMID:21252910. |
p53 and snail2 act antagonistically to regulate p53 upregulated modulator of apoptosis (puma) and cell death in hematopoietic progenitors following dna damage. |
2011-09-30 |
2023-08-12 |
zebrafish |
| E Rodríguez-Aznar, M A Niet. Repression of Puma by scratch2 is required for neuronal survival during embryonic development. Cell death and differentiation. vol 18. issue 7. 2011-09-30. PMID:21252910. |
the transcription of scratch2 is induced directly by p53 after dna damage to repress puma, thereby antagonizing p53-mediated apoptosis. |
2011-09-30 |
2023-08-12 |
zebrafish |
| Consuelo Borrás, Mari Carmen Gómez-Cabrera, Jose Viñ. The dual role of p53: DNA protection and antioxidant. Free radical research. vol 45. issue 6. 2011-09-30. PMID:21452930. |
the classical functions of p53 protein are those related to its role on dna damage, cell growth arrest, senescence and apoptosis. |
2011-09-30 |
2023-08-12 |
Not clear |
| In Youb Chang, Jin Nam Kim, Jae Yeoul Jun, Ho Jin You, Young Jin Jeon, Kyeong-Soo Park, Sang Pil Yoo. Repression of apurinic/apyrimidinic endonuclease by p53-dependent apoptosis in hydronephrosis-induced rat kidney. Free radical research. vol 45. issue 6. 2011-09-30. PMID:21473738. |
p53 plays a major role in apoptosis through activation of pro-apoptotic gene bax. |
2011-09-30 |
2023-08-12 |
rat |
| Hideo Kaneko, Toshiyuki Fukao, Kimiko Kasahara, Taketo Yamada, Naomi Kond. Augmented cell death with Bloom syndrome helicase deficiency. Molecular medicine reports. vol 4. issue 4. 2011-09-30. PMID:21567087. |
blm deficiency causes the up-regulation of p53, double-strand break and apoptosis, which are likely observed in irradiated control cells. |
2011-09-30 |
2023-08-12 |
mouse |
| Denis Selimovic, Mutmid Ahmad, Abdelouahid El-Khattouti, Matthias Hannig, Youssef Haïkel, Mohamed Hassa. Apoptosis-related protein-2 triggers melanoma cell death by a mechanism including both endoplasmic reticulum stress and mitochondrial dysregulation. Carcinogenesis. vol 32. issue 8. 2011-09-30. PMID:21693538. |
also, the activation of apoptosis signal-regulating kinase (ask) 1, c-jun-n-terminal kinase (jnk) and the transcription factors ap-1 and p53, and the induction of bax expression were noted in apr-2-expressing cells. |
2011-09-30 |
2023-08-12 |
Not clear |
| Qi Chen, Jie-Fang Shen, Hong-Bing Rui, Jin-Zi Su, Guang-Sheng Zhuo, Ri-Hui Kang, Jun-Fang Li. [Inhibitory effect of p16, p53 transfection on leukemic cell lines K562 and HL-60]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 2. 2011-09-29. PMID:20416157. |
p16 and p53 in the recombinant plasmid pbudce4.1-53-16 synchronously express in leukemic cells after transfection in vitro for 2 days and results in reduced proliferation, g0 arrest and apoptosis increase. |
2011-09-29 |
2023-08-12 |
human |
| James B Johnsto. Mechanism of action of pentostatin and cladribine in hairy cell leukemia. Leukemia & lymphoma. vol 52 Suppl 2. 2011-09-29. PMID:21463108. |
both datp and cdatp cause an initial accumulation of dna strand breaks in lymphocytes and this results in the activation of p53, the release of cytochrome c from mitochondria, and apoptosis. |
2011-09-29 |
2023-08-12 |
Not clear |
| Matthew R Ramsey, Lei He, Nicole Forster, Benjamin Ory, Leif W Ellise. Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. Cancer research. vol 71. issue 13. 2011-09-29. PMID:21527555. |
repression of proapoptotic bcl-2 family member genes including p53 upregulated modulator of apoptosis (puma) by p63/hdac is required for survival of scc cells. |
2011-09-29 |
2023-08-12 |
human |