| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Li, Li-Jun Zhang, Zhou-Liang Zhang, Min Long, Ji-Hong Ren, Fang Lin, Xi Wang, Jun-Xia Wei, Ke Dong, Hui-Zhong Zhan. Synergistic tumor growth-inhibitory effect of the prostate-specific antigen-activated fusion peptide BSD352 for prostate cancer therapy. Anti-cancer drugs. vol 22. issue 3. 2011-08-23. PMID:21150773. |
in this study, we designed a novel fusion peptide, bsd352, containing three functional domains: a protein transduction domain from hiv transactivating regulatory protein (tat) followed by the bh3 domain of the p53 upregulated modulator of apoptosis (tat-bh3), an anti-vascular endothelial growth factor peptide (sp5.2), and an anti-basic fibroblast growth factor peptide (dg2). |
2011-08-23 |
2023-08-12 |
mouse |
| Eui-Man Jung, Kyung-Chul Choi, Eui-Bae Jeun. Expression of calbindin-D28k is inversely correlated with proapototic gene expression in hydrogen peroxide-induced cell death in endometrial cancer cells. International journal of oncology. vol 38. issue 4. 2011-08-23. PMID:21258766. |
interestingly, overexpression of cabp-28k inhibited cell death and caused a decrease in bax, p53 and caspase 3 expression during h2o2-induced apoptosis, suggesting that cabp-28k blocks the up-regulation of apoptosis-related gene expression. |
2011-08-23 |
2023-08-12 |
human |
| Reshu Gupta, Venkateswara Rao Gogineni, Arun Kumar Nalla, Chandramu Chetty, Jeffrey D Klopfenstein, Andrew J Tsung, Sanjeeva Mohanam, Jasti S Ra. Oncogenic role of p53 is suppressed by si-RNA bicistronic construct of uPA, uPAR and cathepsin-B in meningiomas both in vitro and in vivo. International journal of oncology. vol 38. issue 4. 2011-08-23. PMID:21290090. |
we showed that apoptosis caused by these bicistronic constructs involves bcl-2, bcl-xl, p53 inactivation, cytochrome c release from mitochondria and caspase-9 activation, followed by the activation of caspase-3. |
2011-08-23 |
2023-08-12 |
human |
| Reshu Gupta, Venkateswara Rao Gogineni, Arun Kumar Nalla, Chandramu Chetty, Jeffrey D Klopfenstein, Andrew J Tsung, Sanjeeva Mohanam, Jasti S Ra. Oncogenic role of p53 is suppressed by si-RNA bicistronic construct of uPA, uPAR and cathepsin-B in meningiomas both in vitro and in vivo. International journal of oncology. vol 38. issue 4. 2011-08-23. PMID:21290090. |
we also determined that apoptosis caused by puc and pu2 involves a mechanism which includes inactivation of p53 by its translocation from nucleus to cytoplasm as confirmed by immunofluorescence, which shows the oncogenic potential of p53 in meningiomas. |
2011-08-23 |
2023-08-12 |
human |
| Xiao-Peng Zhang, Feng Liu, Wei Wan. Two-phase dynamics of p53 in the DNA damage response. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 22. 2011-08-23. PMID:21576488. |
the tumor suppressor p53 mainly induces cell cycle arrest/dna repair or apoptosis in the dna damage response. |
2011-08-23 |
2023-08-12 |
Not clear |
| Xiao-Peng Zhang, Feng Liu, Wei Wan. Two-phase dynamics of p53 in the DNA damage response. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 22. 2011-08-23. PMID:21576488. |
if the damage cannot be fixed after a critical number of p53 pulses, then p53 is fully activated by further modifications such as phosphorylation at ser-46 to trigger apoptosis, with its concentration switching to rather high levels. |
2011-08-23 |
2023-08-12 |
Not clear |
| Xiao-Peng Zhang, Feng Liu, Wei Wan. Two-phase dynamics of p53 in the DNA damage response. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 22. 2011-08-23. PMID:21576488. |
such combinations of pulsatile and switch-like behaviors of p53 may represent a flexible and efficient control mode, avoiding the premature apoptosis and promoting the execution of apoptosis. |
2011-08-23 |
2023-08-12 |
Not clear |
| Céline Charvet, Manuela Wissler, Prisca Brauns-Schubert, Shang-Jui Wang, Yi Tang, Florian C Sigloch, Hestia Mellert, Martin Brandenburg, Silke E Lindner, Bernhard Breit, Douglas R Green, Steven B McMahon, Christoph Borner, Wei Gu, Ulrich Maure. Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Molecular cell. vol 42. issue 5. 2011-08-23. PMID:21658600. |
phosphorylation of tip60 by gsk-3 determines the induction of puma and apoptosis by p53. |
2011-08-23 |
2023-08-12 |
Not clear |
| Céline Charvet, Manuela Wissler, Prisca Brauns-Schubert, Shang-Jui Wang, Yi Tang, Florian C Sigloch, Hestia Mellert, Martin Brandenburg, Silke E Lindner, Bernhard Breit, Douglas R Green, Steven B McMahon, Christoph Borner, Wei Gu, Ulrich Maure. Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Molecular cell. vol 42. issue 5. 2011-08-23. PMID:21658600. |
activation of p53 by dna damage results in either cell-cycle arrest, allowing dna repair and cell survival, or induction of apoptosis. |
2011-08-23 |
2023-08-12 |
Not clear |
| Céline Charvet, Manuela Wissler, Prisca Brauns-Schubert, Shang-Jui Wang, Yi Tang, Florian C Sigloch, Hestia Mellert, Martin Brandenburg, Silke E Lindner, Bernhard Breit, Douglas R Green, Steven B McMahon, Christoph Borner, Wei Gu, Ulrich Maure. Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Molecular cell. vol 42. issue 5. 2011-08-23. PMID:21658600. |
our data suggest that gsk-3 mediated tip60s86 phosphorylation provides a link between pi3k signaling and the choice for or against apoptosis induction by p53. |
2011-08-23 |
2023-08-12 |
Not clear |
| Paweł Golusinski, Katarzyna Lamperska, Jakub Pazdrowski, Wojciech Golusinsk. [Analysis of mutations within the TP53 gene in patients with squamous cell carcinoma of the head and neck]. Otolaryngologia polska = The Polish otolaryngology. vol 65. issue 2. 2011-08-23. PMID:21735667. |
mutations in the tp53 gene frequently occur in many cancers and are present in 50-60% of head and neck cancers, p53 plays a sentinel role in the pathways that prevent development of cancer by inducing apoptosis, dna repair and cell cycle arrest in response to different types of cellular stress the aim of the study, was the assessment of the tp53 mutations prevalence in the head and neck cancer patients and it's relation with the clinical data and course of the disease. |
2011-08-23 |
2023-08-12 |
Not clear |
| B Testoni, V Schinzari, F Guerrieri, S Gerbal-Chaloin, G Blandino, M Levrer. p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor. Oncogene. vol 30. issue 23. 2011-08-19. PMID:21399658. |
increased levels of dnp73 proteins confer to hcc cells resistance to apoptosis and, irrespective to p53 status, a chemoresistant phenotype. |
2011-08-19 |
2023-08-12 |
human |
| Sara Calhoun, Valerie Dagget. Structural effects of the L145Q, V157F, and R282W cancer-associated mutations in the p53 DNA-binding core domain. Biochemistry. vol 50. issue 23. 2011-08-19. PMID:21561095. |
the p53 tumor suppressor is a transcription factor involved in many important signaling pathways, such as apoptosis and cell-cycle arrest. |
2011-08-19 |
2023-08-12 |
human |
| Ling Zhang, Yuan-yuan Li, Huai-cai Zeng, Miao Li, Yan-Jian Wan, Hermann J Schluesener, Zhi-yuan Zhang, Shun-qing X. Perfluorooctane sulfonate induces apoptosis in N9 microglial cell line. International journal of toxicology. vol 30. issue 2. 2011-08-18. PMID:21115943. |
the results showed that pfos could reduce the cell viability significantly, and the cellular apoptosis induced by pfos was closely accompanied with dissipation of mitochondria membrane potential, upregulation messenger rnas (mrnas) of p53, bax, caspase 9, and caspase 3, and decreased expression of bcl-2 mrna. |
2011-08-18 |
2023-08-12 |
human |
| Pragathi Pallepati, Diana A Averill-Bate. Mild thermotolerance induced at 40°C protects HeLa cells against activation of death receptor-mediated apoptosis by hydrogen peroxide. Free radical biology & medicine. vol 50. issue 6. 2011-08-18. PMID:21130866. |
fasl up-regulation; activation of caspases-8, -2, -9, and -3; and chromatin condensation were decreased by the p53 inhibitor pifithrin-α, implicating p53 as an upstream factor in the activation of death receptor-mediated apoptosis by h(2)o(2). |
2011-08-18 |
2023-08-12 |
Not clear |
| Deepika Jain, Neelam Pathak, Saba Khan, Gorantla Venkata Raghuram, Arpit Bhargava, Ravindra Samarth, Pradyumna Kumar Mishr. Evaluation of cytotoxicity and anticarcinogenic potential of Mentha leaf extracts. International journal of toxicology. vol 30. issue 2. 2011-08-18. PMID:21300767. |
of all the extracts tested, chloroform and ethyl acetate extracts of m piperita showed significant dose- and time-dependent anticarcinogenic activity leading to g1 cell cycle arrest and mitochondrial-mediated apoptosis, perturbation of oxidative balance, upregulation of bax gene, elevated expression of p53 and p21 in the treated cells, acquisition of senescence phenotype, while inducing pro-inflammatory cytokines response. |
2011-08-18 |
2023-08-12 |
human |
| Wynand P Roos, Eva Jöst, Christina Belohlavek, Georg Nagel, Gerhard Fritz, Bernd Kain. Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-β and valproic acid. Cancer research. vol 71. issue 12. 2011-08-18. PMID:21493591. |
we show that in malignant melanoma cells with wild-type p53, the temozolomide-induced dna damage o(6)meg triggers upregulation of the fas/cd95/apo-1 receptor without activating the apoptosis cascade. |
2011-08-18 |
2023-08-12 |
mouse |
| Vipra Kundoor, Xiaoying Zhang, Ajay Bommareddy, Sherief Khalifa, Hesham Fahmy, Chandradhar Dwived. Chemopreventive effects of sarcotriol on ultraviolet B-induced skin tumor development in SKH-1 hairless mice. Marine drugs. vol 5. issue 4. 2011-08-17. PMID:18463728. |
together, this study for the first time identifies the chemopreventive effects of st in uvb-induced carcinogenesis possibly by inducing apoptosis and upregulating p53. |
2011-08-17 |
2023-08-12 |
mouse |
| Zchong-Zcho Wu, Nian-Kang Sun, Chuck C-K Cha. Knockdown of CITED2 using short-hairpin RNA sensitizes cancer cells to cisplatin through stabilization of p53 and enhancement of p53-dependent apoptosis. Journal of cellular physiology. vol 226. issue 9. 2011-08-17. PMID:21660965. |
knockdown of cited2 using short-hairpin rna sensitizes cancer cells to cisplatin through stabilization of p53 and enhancement of p53-dependent apoptosis. |
2011-08-17 |
2023-08-12 |
human |
| Jiajie Zou, Qian Chen, Xi Jin, Shusheng Tang, Kaipao Chen, Ting Zhang, Xilong Xia. Olaquindox induces apoptosis through the mitochondrial pathway in HepG2 cells. Toxicology. vol 285. issue 3. 2011-08-16. PMID:21549799. |
in conclusion, olaquindox induced apoptosis of hepg2 cells through a caspase-9 and -3 dependent mitochondrial pathway, involving p53, bcl-2 family protein expression, Δψ(m) disruption and mptp opening. |
2011-08-16 |
2023-08-12 |
Not clear |