| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiangdong Lu, Chunyu Yang, Chaoying Yin, Terry Van Dyke, Karl Simi. Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression. Molecular cancer research : MCR. vol 9. issue 4. 2011-08-09. PMID:21385880. |
this finding is consistent with previous reports that apoptosis is the primary p53 function selected against during eμ-myc-induced mouse lymphoma progression. |
2011-08-09 |
2023-08-12 |
mouse |
| Xiangdong Lu, Chunyu Yang, Chaoying Yin, Terry Van Dyke, Karl Simi. Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression. Molecular cancer research : MCR. vol 9. issue 4. 2011-08-09. PMID:21385880. |
however, unlike observed in the eμ-myc-induced lymphoma model, attenuation of apoptosis is not sufficient to phenocopy the aggressive tumor progression associated with complete loss of p53 activity. |
2011-08-09 |
2023-08-12 |
mouse |
| Xiangdong Lu, Chunyu Yang, Chaoying Yin, Terry Van Dyke, Karl Simi. Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression. Molecular cancer research : MCR. vol 9. issue 4. 2011-08-09. PMID:21385880. |
we conclude that apoptosis is the primary tumor suppressive p53 function and the ablation of additional p53 pleiotropic effects further exacerbates tumor progression. |
2011-08-09 |
2023-08-12 |
mouse |
| E Drakos, R R Singh, G Z Rassidakis, E Schlette, J Li, F X Claret, R J Ford, F Vega, L J Medeiro. Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21). Leukemia. vol 25. issue 5. 2011-08-09. PMID:21394100. |
we show that nutlin-3a activates p53 in dlbcl cells associated with t(14;18)(q32;q21), bcl2 overexpression and wt p53, resulting in cell cycle arrest and apoptosis. |
2011-08-09 |
2023-08-12 |
Not clear |
| E Drakos, R R Singh, G Z Rassidakis, E Schlette, J Li, F X Claret, R J Ford, F Vega, L J Medeiro. Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21). Leukemia. vol 25. issue 5. 2011-08-09. PMID:21394100. |
nutlin-3a-induced apoptosis was accompanied by bax and puma upregulation, bcl-xl downregulation, serine-70 dephosphorylation of bcl2, direct binding of bcl2 by p53, caspase-9 upregulation and caspase-3 cleavage. |
2011-08-09 |
2023-08-12 |
Not clear |
| Ping-Ping Wu, Hui-Wen Chung, Kuo-Ching Liu, Rick Sai-Chuen Wu, Jai-Sing Yang, Nou-Ying Tang, Chyi Lo, Te-Chun Hsia, Chien-Chih Yu, Fu-Shin Chueh, Song-Shei Lin, Jing-Gung Chun. Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways. International journal of oncology. vol 38. issue 6. 2011-08-09. PMID:21424116. |
diallyl sulfide induces cell cycle arrest and apoptosis in hela human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways. |
2011-08-09 |
2023-08-12 |
human |
| Ping-Ping Wu, Hui-Wen Chung, Kuo-Ching Liu, Rick Sai-Chuen Wu, Jai-Sing Yang, Nou-Ying Tang, Chyi Lo, Te-Chun Hsia, Chien-Chih Yu, Fu-Shin Chueh, Song-Shei Lin, Jing-Gung Chun. Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways. International journal of oncology. vol 38. issue 6. 2011-08-09. PMID:21424116. |
in conclusion, das induced g0/g1 cell cycle arrest and apoptosis in hela cells through caspase- and mitochondria and p53 pathways providing further understanding of the molecular mechanisms of das action in cervical cancer. |
2011-08-09 |
2023-08-12 |
human |
| Jieqiong Ma, Chanmin Liu, Yongqiang Chen, Jihong Jiang, Zhihong Qi. Cellular and molecular mechanisms of the Ganoderma applanatum extracts induces apoptosis on SGC-7901 gastric cancer cells. Cell biochemistry and function. vol 29. issue 3. 2011-08-09. PMID:21465494. |
to investigate the inhibition effect of ganoderma applanatum extract (gaeae) on human gastric cancer cell lines and apoptosis mechanism, alamar blue assay was used to assess the inhibition and apoptosis-inducing effect of the gaeae on proliferation of sgc-7901 cells, the dna ladders of the apoptosis cells was done, the mrna expression of p53, bax, bcl-2 and jnk were analysed by reverse transcription-polymerase chain reaction. |
2011-08-09 |
2023-08-12 |
human |
| Jieqiong Ma, Chanmin Liu, Yongqiang Chen, Jihong Jiang, Zhihong Qi. Cellular and molecular mechanisms of the Ganoderma applanatum extracts induces apoptosis on SGC-7901 gastric cancer cells. Cell biochemistry and function. vol 29. issue 3. 2011-08-09. PMID:21465494. |
in conclusion, our results indicated that the gaeae could enhance the sensitivity of sgc-7901 cells to the c-jun, p53, bax and bcl-2 induced apoptosis and provided a promising approach to anti-human gastric cancer therapy with ganoderma applanatum. |
2011-08-09 |
2023-08-12 |
human |
| Susan Z Y Lo, James H Steer, David A Joyc. TNF-α renders macrophages resistant to a range of cancer chemotherapeutic agents through NF-κB-mediated antagonism of apoptosis signalling. Cancer letters. vol 307. issue 1. 2011-08-09. PMID:21482450. |
in addition to nf-κb-dependent factors previously identified as anti-apoptotic, we found an absolute requirement for very early antagonism of mitochondrial cytochrome c release, which sufficed to prevent apoptosis in the face of activation of a range of upstream apoptosis pathways, including p53, disc-linked, mitochondrial depolarisation and calcium-sensitive pathways. |
2011-08-09 |
2023-08-12 |
Not clear |
| Yuanxiang Jin, Shanshan Zheng, Zhengwei F. Embryonic exposure to cypermethrin induces apoptosis and immunotoxicity in zebrafish (Danio rerio). Fish & shellfish immunology. vol 30. issue 4-5. 2011-08-08. PMID:21316461. |
the mrna levels of some key genes including p53, puma, bax, apaf1, cas9 and cas3 on the mitochondrial pathway of cell apoptosis were significantly up-regulated at the concentration of 3 and 10 μg/l cyp. |
2011-08-08 |
2023-08-12 |
zebrafish |
| Yujie Shi, Shihe Yang, Sandi Troup, Xin Lu, Steve Callaghan, David S Park, Ying Xing, Xiaohe Yan. Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1. Oncology reports. vol 25. issue 6. 2011-08-08. PMID:21479363. |
here, we used mcf-7 and mda-mb231 breast cancer cells as a model to demonstrate that resveratrol induced the expression of aspp1, a new member of the aspp (apoptosis stimulation protein of p53) family, which plays an important role in the regulation of apoptosis. |
2011-08-08 |
2023-08-12 |
human |
| Mst Thangima Zannat, Rumpa B Bhattacharjee, Jnanankur Ba. In the absence of cellular poly (A) binding protein, the glycolytic enzyme GAPDH translocated to the cell nucleus and activated the GAPDH mediated apoptotic pathway by enhancing acetylation and serine 46 phosphorylation of p53. Biochemical and biophysical research communications. vol 409. issue 2. 2011-08-08. PMID:21539808. |
as a result, p53 translocated to the mitochondria to initiate bax mediated apoptosis. |
2011-08-08 |
2023-08-12 |
Not clear |
| Linda A Heffernan-Stroud, Lina M Obei. p53 and regulation of bioactive sphingolipids. Advances in enzyme regulation. vol 51. issue 1. 2011-08-05. PMID:21035490. |
whereas some investigations have suggested that ceramide and more complex sphingolipids function upstream of p53 or in a p53-independent manner, other studies propose that p53-dependent alterations in these sphingolipids can also contribute to apoptosis. |
2011-08-05 |
2023-08-12 |
Not clear |
| Linda A Heffernan-Stroud, Lina M Obei. p53 and regulation of bioactive sphingolipids. Advances in enzyme regulation. vol 51. issue 1. 2011-08-05. PMID:21035490. |
however, whereas various components of the sphingolipid and p53 pathways may simultaneously function to elicit apoptosis and/or growth inhibition, smase and sk1 may undergo explicit regulation by p53 that could contribute to ceramide-induced senescence in cells. |
2011-08-05 |
2023-08-12 |
Not clear |
| Amanda K Frank, E Christine Pietsch, Patrick Dumont, Joy Tao, Maureen E Murph. Wild-type and mutant p53 proteins interact with mitochondrial caspase-3. Cancer biology & therapy. vol 11. issue 8. 2011-08-05. PMID:21307660. |
p53 interacts with various members of the bcl2 family at the mitochondria, and this interaction is key to its ability to induce apoptosis. |
2011-08-05 |
2023-08-12 |
Not clear |
| E Y So, M Ausman, T Saeki, T Ouch. Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis. Cell death & disease. vol 2. 2011-08-05. PMID:21390062. |
dfo-induced apoptosis is decreased in atr-mutant hct116 cells, although p53 is normally activated in those cells. |
2011-08-05 |
2023-08-12 |
human |
| L Davies, D Spiller, M R H White, I Grierson, L Paraoa. PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells. Cell death & disease. vol 2. 2011-08-05. PMID:21451571. |
the activation and regulation of target genes by the tumour-suppressor p53 dictates the fate of a cell, with cell cycle arrest or apoptosis being two distinct outcomes. |
2011-08-05 |
2023-08-12 |
Not clear |
| L Davies, D Spiller, M R H White, I Grierson, L Paraoa. PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells. Cell death & disease. vol 2. 2011-08-05. PMID:21451571. |
perp (p53 apoptosis effector related to pmp-22), a p53 transcriptional target, is induced specifically during apoptosis but not cell cycle arrest. |
2011-08-05 |
2023-08-12 |
Not clear |
| L Davies, D Spiller, M R H White, I Grierson, L Paraoa. PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells. Cell death & disease. vol 2. 2011-08-05. PMID:21451571. |
these results implicate a role for perp in amplifying functional p53 levels that promote p53-dependent apoptosis, and reveal a potential target for exploitation in enhancing p53 activity. |
2011-08-05 |
2023-08-12 |
Not clear |