| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takuya Kumazawa, Kazuho Nishimura, Takao Kuroda, Wakana Ono, Chie Yamaguchi, Naohiro Katagiri, Mai Tsuchiya, Hiroshi Masumoto, Yuka Nakajima, Akiko Murayama, Keiji Kimura, Junn Yanagisaw. Novel nucleolar pathway connecting intracellular energy status with p53 activation. The Journal of biological chemistry. vol 286. issue 23. 2011-08-05. PMID:21471221. |
the translocated mybbp1a induces acetylation and accumulation of p53 by enhancing the interaction between p300 and p53, which eventually leads to the cell cycle arrest (or apoptosis). |
2011-08-05 |
2023-08-12 |
Not clear |
| Rida Fares, Samer Bazzi, Serine E Baydoun, Roula M Abdel-Massi. The antioxidant and anti-proliferative activity of the Lebanese Olea europaea extract. Plant foods for human nutrition (Dordrecht, Netherlands). vol 66. issue 1. 2011-08-04. PMID:21318304. |
to study whether cell death was due to apoptosis, cells were stained with annexin v-fitc and pi and the expression of important regulatory proteins (bcl-2, bax, and p53) involved in apoptosis were examined by western blot. |
2011-08-04 |
2023-08-12 |
human |
| Jan Magdalan, Aleksandra Piotrowska, Agnieszka Gomułkiewicz, Tomasz Sozański, Marzena Podhorska-Okołów, Adam Szeląg, Piotr Dzięgie. Benzylpenicyllin and acetylcysteine protection from α-amanitin-induced apoptosis in human hepatocyte cultures. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 63. issue 4. 2011-08-03. PMID:20207116. |
viability of cultured hepatocytes was assessed using the mtt assay, whereas apoptosis processes were evaluated by the electron microscopy, detection of dna laddering, determination of caspase-3 activity, and measuring annexin v, p53 and bcl-2 protein concentration. |
2011-08-03 |
2023-08-12 |
human |
| Sherry X Yang, Seth M Steinberg, Dat Nguyen, Sandra M Swai. p53, HER2 and tumor cell apoptosis correlate with clinical outcome after neoadjuvant bevacizumab plus chemotherapy in breast cancer. International journal of oncology. vol 38. issue 5. 2011-08-03. PMID:21399868. |
p53, her2 and tumor cell apoptosis correlate with clinical outcome after neoadjuvant bevacizumab plus chemotherapy in breast cancer. |
2011-08-03 |
2023-08-12 |
Not clear |
| Sherry X Yang, Seth M Steinberg, Dat Nguyen, Sandra M Swai. p53, HER2 and tumor cell apoptosis correlate with clinical outcome after neoadjuvant bevacizumab plus chemotherapy in breast cancer. International journal of oncology. vol 38. issue 5. 2011-08-03. PMID:21399868. |
baseline p53, her2, tumor apoptosis, ki67, estrogen receptor (er), vegf-a, serum vegf (svegf), vegfr2-y951 and microvessel density (mvd) were prospectively designed and determined by immunohistochemistry and enzyme-linked immunosorbent assay. |
2011-08-03 |
2023-08-12 |
Not clear |
| Sherry X Yang, Seth M Steinberg, Dat Nguyen, Sandra M Swai. p53, HER2 and tumor cell apoptosis correlate with clinical outcome after neoadjuvant bevacizumab plus chemotherapy in breast cancer. International journal of oncology. vol 38. issue 5. 2011-08-03. PMID:21399868. |
with a median follow-up of 65.9 months, patients with low apoptosis or p53-negative tumors had significantly longer survival than those with high apoptosis or p53-positive tumors (median 61.5 vs. 20.2 months; hr 0.22; p=0.011 for apoptosis and median 59.6 vs. 24.2 months; hr 0.27; p=0.016 for p53). |
2011-08-03 |
2023-08-12 |
Not clear |
| Sherry X Yang, Seth M Steinberg, Dat Nguyen, Sandra M Swai. p53, HER2 and tumor cell apoptosis correlate with clinical outcome after neoadjuvant bevacizumab plus chemotherapy in breast cancer. International journal of oncology. vol 38. issue 5. 2011-08-03. PMID:21399868. |
our data suggest that baseline p53, apoptosis and her2 are each significantly associated with outcome in patients who received bevacizumab plus chemotherapy. |
2011-08-03 |
2023-08-12 |
Not clear |
| Maciej Pietrzak, Scott C Smith, Justin T Geralds, Theo Hagg, Cynthia Gomes, Michal Hetma. Nucleolar disruption and apoptosis are distinct neuronal responses to etoposide-induced DNA damage. Journal of neurochemistry. vol 117. issue 6. 2011-08-03. PMID:21517844. |
in that system, activation of the dna double strand break signaling kinase ataxia telangiectasia-mutated protein kinase, p53 and p53-dependent apoptosis required lower etoposide concentrations than did the p53-independent induction of nucleolar stress. |
2011-08-03 |
2023-08-12 |
rat |
| Saeid Ghavami, Mark M Mutawe, Pawan Sharma, Behzad Yeganeh, Karol D McNeill, Thomas Klonisch, Helmut Unruh, Hessam H Kashani, Dedmer Schaafsma, Marek Los, Andrew J Halayk. Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. PloS one. vol 6. issue 1. 2011-08-02. PMID:21304979. |
mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. |
2011-08-02 |
2023-08-12 |
human |
| Saeid Ghavami, Mark M Mutawe, Pawan Sharma, Behzad Yeganeh, Karol D McNeill, Thomas Klonisch, Helmut Unruh, Hessam H Kashani, Dedmer Schaafsma, Marek Los, Andrew J Halayk. Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. PloS one. vol 6. issue 1. 2011-08-02. PMID:21304979. |
simvastatin concomitantly increased p53-dependent expression of p53 up-regulated modulator of apoptosis (puma), noxa, and damage-regulated autophagy modulator (dram). |
2011-08-02 |
2023-08-12 |
human |
| Saeid Ghavami, Mark M Mutawe, Pawan Sharma, Behzad Yeganeh, Karol D McNeill, Thomas Klonisch, Helmut Unruh, Hessam H Kashani, Dedmer Schaafsma, Marek Los, Andrew J Halayk. Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. PloS one. vol 6. issue 1. 2011-08-02. PMID:21304979. |
notably both mevalonate cascade inhibition-induced autophagy and apoptosis were p53 dependent: simvastatin increased nuclear p53 accumulation, and both cyclic pifithrin-α and p53 shrnai partially inhibited noxa, puma expression and caspase-3/7 cleavage (apoptosis) and dram expression, atg5-12 complex formation, lc3 lipidation, and autophagosome formation (autophagy). |
2011-08-02 |
2023-08-12 |
human |
| Saeid Ghavami, Mark M Mutawe, Pawan Sharma, Behzad Yeganeh, Karol D McNeill, Thomas Klonisch, Helmut Unruh, Hessam H Kashani, Dedmer Schaafsma, Marek Los, Andrew J Halayk. Mevalonate cascade regulation of airway mesenchymal cell autophagy and apoptosis: a dual role for p53. PloS one. vol 6. issue 1. 2011-08-02. PMID:21304979. |
furthermore, the autophagy response is induced rapidly, significantly delaying apoptosis, suggesting the existence of a temporally coordinated p53 regulation network. |
2011-08-02 |
2023-08-12 |
human |
| Soo Kyung Bae, Jungsug Gwak, Im-Sook Song, Hyung-Soon Park, Sangtaek O. Induction of apoptosis in colon cancer cells by a novel topoisomerase I inhibitor TopIn. Biochemical and biophysical research communications. vol 409. issue 1. 2011-08-02. PMID:21549095. |
the tumor suppressor p53 plays an important role in cellular emergency mechanisms through regulating the genes involved in cell cycle arrest and apoptosis. |
2011-08-02 |
2023-08-12 |
Not clear |
| Soo Kyung Bae, Jungsug Gwak, Im-Sook Song, Hyung-Soon Park, Sangtaek O. Induction of apoptosis in colon cancer cells by a novel topoisomerase I inhibitor TopIn. Biochemical and biophysical research communications. vol 409. issue 1. 2011-08-02. PMID:21549095. |
additionally, topin induced dna fragmentation, caspase-3/7 activation and poly adp ribose polymerase cleavage, typical biochemical markers of apoptosis, in p53 wild-type and mutated colon cancer cells. |
2011-08-02 |
2023-08-12 |
Not clear |
| Magdalena Lukamowicz, Katherine Woodward, Micheline Kirsch-Volders, Willi Suter, Azeddine Elhajouj. A flow cytometry based in vitro micronucleus assay in TK6 cells--validation using early stage pharmaceutical development compounds. Environmental and molecular mutagenesis. vol 52. issue 5. 2011-08-01. PMID:20963789. |
this fact may be related to the underestimation of apoptosis or necrosis, the p53 status of the cell system or the cytotoxicity assay, and the top dose selection. |
2011-08-01 |
2023-08-12 |
Not clear |
| Fei Wang, Jianfeng Liu, Delira Robbins, Kerri Morris, Amos Sit, Yong-Yu Liu, Yunfeng Zha. Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 3. 2011-08-01. PMID:21107702. |
ellipticine enhanced p53 mitochondrial translocation, decreased complex i activity, and sensitized p53 mutant cells to doxorubicin-induced apoptosis. |
2011-08-01 |
2023-08-12 |
human |
| Zhengtang Qi, Jie He, Yuan Zhang, Yue Shao, Shuzhe Din. Exercise training attenuates oxidative stress and decreases p53 protein content in skeletal muscle of type 2 diabetic Goto-Kakizaki rats. Free radical biology & medicine. vol 50. issue 7. 2011-08-01. PMID:21185935. |
in vitro data indicate that cellular levels of reactive oxygen species depend on the expression and activity of p53, which plays a key role in energy metabolism and as a crucial transcription factor for sco cytochrome oxidase deficient homolog 2 (sco2) and tumor p53-induced glycolysis and apoptosis regulator (tigar), which regulate mitochondrial respiration and glycolysis in cells. |
2011-08-01 |
2023-08-12 |
rat |
| C Becker, I Riedmaier, M Reiter, A Tichopad, M J Groot, A A M Stolker, M W Pfaffl, M F W Nielen, H H D Meye. Influence of anabolic combinations of an androgen plus an estrogen on biochemical pathways in bovine uterine endometrium and ovary. The Journal of steroid biochemistry and molecular biology. vol 125. issue 3-5. 2011-08-01. PMID:21272641. |
both studies identified significant regulations in steroid and growth factor receptors (ar, erβ, lhr, fshr, flt-1, pr, igf-1r, alk-6), angiogenic and tissue remodeling factors (vegfs, fgfs, bmps, angpt-2, mmps, timp-2, ctsb), steroid synthesis (s5a1, hsd17, cyp19a1), proliferation (tnfα, igf-1, igfbps, p53, c-fos; cebpd, c-kit), apoptosis (casp3, fasl, p53) and others (c7, inha, star). |
2011-08-01 |
2023-08-12 |
cattle |
| Meng-Liang Lin, Yao-Cheng Lu, Hong-Lin Su, Hsin-Ting Lin, Chuan-Chun Lee, Shang-En Kang, Tan-Chen Lai, Jing-Gung Chung, Shih-Shun Che. Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells. Journal of cellular biochemistry. vol 112. issue 4. 2011-08-01. PMID:21308745. |
using short hairpin rna against p53, transient ectopic expression of wild-type p53 or mutant p53 (r248w or r175h), and a p53- and p21-dependent luciferase reporter assay, we demonstrated that growth arrest and apoptosis of fadu (human pharyngeal squamous cell carcinoma), hep3b (hepatoma), and mg-63 (osteosarcoma) cells induced by aloe-emodin (ae) are p53-independent. |
2011-08-01 |
2023-08-12 |
human |
| Tingting Wu, Zhe Dong, Jing Geng, Yingying Sun, Guanghui Liu, Weiqiang Kang, Yun Zhang, Zhiming G. Valsartan protects against ER stress-induced myocardial apoptosis via CHOP/Puma signaling pathway in streptozotocin-induced diabetic rats. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 42. issue 5. 2011-08-01. PMID:21345370. |
by using of immunofluorescence and rt-pcr, valsartan has been found to play a protective role via down-regulating the expression of transcriptional induction of c/ebp homologous protein (chop) and p53 upregulated modulator of apoptosis (puma), two crucial factors known to be implicated in the er stress-induced myocardial apoptosis. |
2011-08-01 |
2023-08-12 |
rat |