| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Zhang, Yanyan Gao, Guoping Zhang, Shuyan Huang, Zhixiong Dong, Chenfei Kong, Dongmei Su, Juan Du, Shan Zhu, Qian Liang, Jianchao Zhang, Jun Lu, Baiqu Huan. DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells. International journal of cancer. vol 128. issue 3. 2011-01-14. PMID:20473858. |
at high concentrations, dox activates p53 leading to apoptosis without enhancing p21 expression. |
2011-01-14 |
2023-08-12 |
Not clear |
| Yu Zhang, Yanyan Gao, Guoping Zhang, Shuyan Huang, Zhixiong Dong, Chenfei Kong, Dongmei Su, Juan Du, Shan Zhu, Qian Liang, Jianchao Zhang, Jun Lu, Baiqu Huan. DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells. International journal of cancer. vol 128. issue 3. 2011-01-14. PMID:20473858. |
here, we report that the dna methyltransferase (dnmt) dnmt3a was upregulated by dox especially at concentrations that induced apoptosis in hct116 colorectal cancer cells, and this process was regulated by p53. |
2011-01-14 |
2023-08-12 |
Not clear |
| Guy C Brow. Nitric oxide and neuronal death. Nitric oxide : biology and chemistry. vol 23. issue 3. 2011-01-14. PMID:20547235. |
alternatively, if energy levels are maintained, no can induce apoptosis, via oxidant activation of: p53, p38 mapk pathway or endoplasmic reticulum stress. |
2011-01-14 |
2023-08-12 |
Not clear |
| Cho-Rok Jung, Jung Hwa Lim, Yoonjung Choi, Dae-Ghon Kim, Koo Jeong Kang, Seung-Moo Noh, Dong-Soo I. Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice. The Journal of clinical investigation. vol 120. issue 12. 2011-01-14. PMID:21060154. |
as the balance between mdm2 and p53 levels plays a crucial role in regulating cell proliferation and apoptosis, we sought to identify factors selectively inhibiting mdm2 self-ubiquitination. |
2011-01-14 |
2023-08-12 |
mouse |
| C F Cheok, N Kua, P Kaldis, D P Lan. Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53. Cell death and differentiation. vol 17. issue 9. 2011-01-13. PMID:20203688. |
nongenotoxic activation of p53 using nutlin led to a reversible activation of g1 and g2 arrest in normal cells, which prevents them from entering mitosis, thus protecting them from the side effects of aurora kinase inhibition (vx-680), namely endoreduplication and apoptosis. |
2011-01-13 |
2023-08-12 |
Not clear |
| Masaki Kimata, Satoaki Matoba, Eri Iwai-Kanai, Hideo Nakamura, Atsushi Hoshino, Mikihiko Nakaoka, Maki Katamura, Yoshifumi Okawa, Yuichiro Mita, Mitsuhiko Okigaki, Koji Ikeda, Tetsuya Tatsumi, Hiroaki Matsubar. p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress. American journal of physiology. Heart and circulatory physiology. vol 299. issue 6. 2011-01-13. PMID:20935145. |
we investigated the role of p53 and its transcriptional target gene tp53-induced glycolysis and apoptosis regulator (tigar) in myocardial energy metabolism under conditions simulating ischemia that can lead to heart failure. |
2011-01-13 |
2023-08-12 |
mouse |
| Masaki Kimata, Satoaki Matoba, Eri Iwai-Kanai, Hideo Nakamura, Atsushi Hoshino, Mikihiko Nakaoka, Maki Katamura, Yoshifumi Okawa, Yuichiro Mita, Mitsuhiko Okigaki, Koji Ikeda, Tetsuya Tatsumi, Hiroaki Matsubar. p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress. American journal of physiology. Heart and circulatory physiology. vol 299. issue 6. 2011-01-13. PMID:20935145. |
knockdown of p53 or tigar increased glycolysis with elevated fructose-2,6-bisphosphate levels and reduced myocyte apoptosis. |
2011-01-13 |
2023-08-12 |
mouse |
| Masaki Kimata, Satoaki Matoba, Eri Iwai-Kanai, Hideo Nakamura, Atsushi Hoshino, Mikihiko Nakaoka, Maki Katamura, Yoshifumi Okawa, Yuichiro Mita, Mitsuhiko Okigaki, Koji Ikeda, Tetsuya Tatsumi, Hiroaki Matsubar. p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress. American journal of physiology. Heart and circulatory physiology. vol 299. issue 6. 2011-01-13. PMID:20935145. |
our data demonstrate that p53 and tigar inhibit glycolysis in hypoxic myocytes and that inhibition of glycolysis is closely involved in apoptosis, suggesting that p53 and tigar are significant mediators of cellular energy homeostasis and cell death under ischemic stress. |
2011-01-13 |
2023-08-12 |
mouse |
| Huiping Yuan, Yonggang Lu, Xiuqing Huang, Qinghua He, Yong Man, Yingsheng Zhou, Shu Wang, Jian L. Suppression of NADPH oxidase 2 substantially restores glucose-induced dysfunction of pancreatic NIT-1 cells. The FEBS journal. vol 277. issue 24. 2011-01-13. PMID:21073655. |
furthermore, high glucose concentrations led to apoptosis of β-cells by activation of p38mapk and p53, and dysfunction of β-cells through phosphatase and tensih homolog (pten)-dependent jun n-terminal kinase (jnk) activation and protein kinase b (akt/pkb) inhibition, which induced the translocation of forkhead box o1 and pancreatic duodenal homeobox-1, followed by reduced insulin expression and secretion. |
2011-01-13 |
2023-08-12 |
rat |
| Honghong Chen, Rongfei Jia, Meijun Zhou, Aihong Xu, Yuxing Hu, Wenying Cheng, Chunlin Sha. The role of nucleophosmin/B23 in radiation-induced chromosomal instability in human lymphoblastoid cells of different p53 genotypes. International journal of radiation biology. vol 86. issue 12. 2011-01-12. PMID:20807181. |
to investigate the role of nucleophosmin (npm/b23) in radiation-induced chromosomal instability and apoptosis in human lymphoblastoid cells with different protein 53 (p53) status. |
2011-01-12 |
2023-08-12 |
human |
| L Tian, G Peng, J M Parant, V Leventaki, E Drakos, Q Zhang, J Parker-Thornburg, T J Shackleford, H Dai, S-Y Lin, G Lozano, G Z Rassidakis, F X Clare. Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair. Oncogene. vol 29. issue 46. 2011-01-11. PMID:20802511. |
loss of jab1 expression sensitized both mouse primary embryonic fibroblasts and osteosarcoma cells to γ-radiation-induced apoptosis, with an increase in spontaneous dna damage and homologous recombination (hr) defects, both of which correlated with reduced levels of the dna repair protein rad51 and elevated levels of p53. |
2011-01-11 |
2023-08-12 |
mouse |
| Rhone A Mendoza, Emily E Moody, Marlene I Enriquez, Sylvia M Mejia, Gudmundur Thordarso. Tumorigenicity of MCF-7 human breast cancer cells lacking the p38α mitogen-activated protein kinase. The Journal of endocrinology. vol 208. issue 1. 2011-01-11. PMID:20974639. |
however, the min-p38 mapk cells did show a significant decreased rate of apoptosis after e₂ treatment and a reduction in the basal phosphorylation of p53 tumor suppressor protein compared to controls. |
2011-01-11 |
2023-08-12 |
mouse |
| Rhone A Mendoza, Emily E Moody, Marlene I Enriquez, Sylvia M Mejia, Gudmundur Thordarso. Tumorigenicity of MCF-7 human breast cancer cells lacking the p38α mitogen-activated protein kinase. The Journal of endocrinology. vol 208. issue 1. 2011-01-11. PMID:20974639. |
increased tumorigenicity of min-p38 mapk cells was caused mainly by a decrease in the apoptosis rate indicating that the lack of the p38 mapk caused an imbalance to increase the erα:erβ ratio and a reduction in the activity of the p53 tumor suppressor protein. |
2011-01-11 |
2023-08-12 |
mouse |
| Rhone A Mendoza, Marlene I Enriquez, Sylvia M Mejia, Emily E Moody, Gudmundur Thordarso. Interactions between IGF-I, estrogen receptor-α (ERα), and ERβ in regulating growth/apoptosis of MCF-7 human breast cancer cells. The Journal of endocrinology. vol 208. issue 1. 2011-01-11. PMID:20974640. |
we hypothesize that a decreased erα:erβ ratio triggered a rapid phosphorylation of p38 mapk, which in turn phosphorylated the p53 tumor suppressor and accelerated apoptosis rate. |
2011-01-11 |
2023-08-12 |
human |
| Molly S Stitt-Fischer, Rachel K Ungerman, Daniel S Wilen, Karla Wasserloos, Lara M Renz, Shannon E Raub, Jim Peterson, Linda L Pearc. Manganese superoxide dismutase is not protective in bovine pulmonary artery endothelial cells at systemic oxygen levels. Radiation research. vol 174. issue 6. 2011-01-11. PMID:21128791. |
radiation does not increase apoptosis in bpaec but inhibits cell growth and up-regulates p53 and p21 at either 3% or 20% oxygen. |
2011-01-11 |
2023-08-12 |
cattle |
| L M Tian, J Liu, X L Sun, C X Gao, Y Fan, Q Gu. A protective effect of endomorphins on the oxidative injury of islet. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 118. issue 8. 2011-01-10. PMID:20429050. |
our data also showed both that ems inhibited cell apoptosis and cell cycle g1 arrest induced by stz and alx through down-regulaing p53 and p21 expression. |
2011-01-10 |
2023-08-12 |
rat |
| N Rökaeus, J Shen, I Eckhardt, V J N Bykov, K G Wiman, M T Wilhel. PRIMA-1(MET)/APR-246 targets mutant forms of p53 family members p63 and p73. Oncogene. vol 29. issue 49. 2011-01-10. PMID:20818419. |
the low molecular weight compound prima-1 and the structural analog prima-1(met), also named apr-246, reactivate mutant p53 through covalent binding to the core domain and induce apoptosis in tumor cells. |
2011-01-10 |
2023-08-12 |
human |
| Ping Chen, Liya Huang, Yongping Zhang, Minmin Qiao, Yaozong Yua. SiRNA-mediated PIAS1 silencing promotes inflammatory response and leads to injury of cerulein-stimulated pancreatic acinar cells via regulation of the P38MAPK signaling pathway. International journal of molecular medicine. vol 26. issue 4. 2011-01-10. PMID:20818504. |
thus, the cerulein-stimulated piasi gene-silenced cells obviously increased cell arrest in the g1/m phase by increasing p21 and p27 expression, and also induced apoptosis by regulating the p53 signaling pathway. |
2011-01-10 |
2023-08-12 |
rat |
| Natalia Tapia, Hans R Schöle. p53 connects tumorigenesis and reprogramming to pluripotency. The Journal of experimental medicine. vol 207. issue 10. 2011-01-10. PMID:20876313. |
the tumor suppressor gene p53 prevents the initiation of tumor formation by inducing cell cycle arrest, senescence, dna repair, and apoptosis. |
2011-01-10 |
2023-08-12 |
Not clear |
| Kyoichi Kaira, Toshiaki Takahashi, Masato Abe, Hiroaki Akamatsu, Kazuo Nakagawa, Yasuhisa Ohde, Takehiro Okumura, Haruyasu Murakami, Asuka Tsuya, Yukiko Nakamura, Tateaki Naito, Haruhiko Kondo, Takashi Nakajima, Masahiro Endo, Nobuyuki Yamamot. CD98 expression is associated with the grade of malignancy in thymic epithelial tumors. Oncology reports. vol 24. issue 4. 2011-01-06. PMID:20811665. |
tumor sections were stained by immunohistochemistry for cd98; vascular endothelial growth factor (vegf); micro-vessels (cd31 and cd34); cell cycle control marker (p53); and apoptosis marker (bcl-2). |
2011-01-06 |
2023-08-12 |
human |