| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Auw-Hädrich, N Göbel, G Illerhau. [Infectious agents in ocular adnexal tumours]. Klinische Monatsblatter fur Augenheilkunde. vol 227. issue 7. 2010-11-30. PMID:20535664. |
based on the localisation of cin, ultraviolet b radiation seems to play a primary role, leading to p53 inactivation and subsequent inhibition of apoptosis. |
2010-11-30 |
2023-08-12 |
Not clear |
| A R M Ruhul Amin, Dongsheng Wang, Hongzheng Zhang, Shifang Peng, Hyung Ju C Shin, Johann C Brandes, Mourad Tighiouart, Fadlo R Khuri, Zhuo Georgia Chen, Dong M Shi. Enhanced anti-tumor activity by the combination of the natural compounds (-)-epigallocatechin-3-gallate and luteolin: potential role of p53. The Journal of biological chemistry. vol 285. issue 45. 2010-11-30. PMID:20826787. |
moreover, we found more efficient stabilization and atm-dependent ser(15) phosphorylation of p53 due to dna damage by the combination, and ablation of p53 using shrna strongly inhibited apoptosis as evidenced by decreased poly(adp-ribose) polymerase and caspase-3 cleavage. |
2010-11-30 |
2023-08-12 |
mouse |
| Antonio F Santidrián, Diana M González-Gironès, Daniel Iglesias-Serret, Llorenç Coll-Mulet, Ana M Cosialls, Mercè de Frias, Clara Campàs, Eva González-Barca, Esther Alonso, Verena Labi, Benoit Viollet, Adalberto Benito, Gabriel Pons, Andreas Villunger, Joan Gi. AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells. Blood. vol 116. issue 16. 2010-11-29. PMID:20664053. |
aicar induces apoptosis independently of ampk and p53 through up-regulation of the bh3-only proteins bim and noxa in chronic lymphocytic leukemia cells. |
2010-11-29 |
2023-08-12 |
mouse |
| Xing-Ding Zhang, Ye Wang, Yan Wang, Xuan Zhang, Rong Han, Jun-Chao Wu, Zhong-Qin Liang, Zhen-Lun Gu, Feng Han, Kohji Fukunaga, Zheng-Hong Qi. p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum. Autophagy. vol 5. issue 3. 2010-11-26. PMID:19305162. |
3-np upregulated the expression of tumor suppressor protein 53 (p53) and its target genes including bax, p53-upregulated modulator of apoptosis (puma) and damage-regulated autophagy modulator (dram). |
2010-11-26 |
2023-08-12 |
rat |
| Xing-Ding Zhang, Ye Wang, Yan Wang, Xuan Zhang, Rong Han, Jun-Chao Wu, Zhong-Qin Liang, Zhen-Lun Gu, Feng Han, Kohji Fukunaga, Zheng-Hong Qi. p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum. Autophagy. vol 5. issue 3. 2010-11-26. PMID:19305162. |
these results suggest that p53 plays roles in signaling both autophagy and apoptosis. |
2010-11-26 |
2023-08-12 |
rat |
| Juni Chakraborty, Shuvomoy Banerjee, Pallab Ray, Dewan Md Sakib Hossain, Sankar Bhattacharyya, Arghya Adhikary, Sreya Chattopadhyay, Tanya Das, Gaurisankar S. Gain of cellular adaptation due to prolonged p53 impairment leads to functional switchover from p53 to p73 during DNA damage in acute myeloid leukemia cells. The Journal of biological chemistry. vol 285. issue 43. 2010-11-24. PMID:20675383. |
tumor suppressor p53 plays the central role in regulating apoptosis in response to genotoxic stress. |
2010-11-24 |
2023-08-12 |
Not clear |
| Juni Chakraborty, Shuvomoy Banerjee, Pallab Ray, Dewan Md Sakib Hossain, Sankar Bhattacharyya, Arghya Adhikary, Sreya Chattopadhyay, Tanya Das, Gaurisankar S. Gain of cellular adaptation due to prolonged p53 impairment leads to functional switchover from p53 to p73 during DNA damage in acute myeloid leukemia cells. The Journal of biological chemistry. vol 285. issue 43. 2010-11-24. PMID:20675383. |
from an evolutionary perspective, the activity of p53 has to be backed up by other protein(s) in case of any functional impairment of this protein, to trigger dna damage-induced apoptosis in cancer cells. |
2010-11-24 |
2023-08-12 |
Not clear |
| Juni Chakraborty, Shuvomoy Banerjee, Pallab Ray, Dewan Md Sakib Hossain, Sankar Bhattacharyya, Arghya Adhikary, Sreya Chattopadhyay, Tanya Das, Gaurisankar S. Gain of cellular adaptation due to prolonged p53 impairment leads to functional switchover from p53 to p73 during DNA damage in acute myeloid leukemia cells. The Journal of biological chemistry. vol 285. issue 43. 2010-11-24. PMID:20675383. |
we adopted multiple experimental approaches to demonstrate that in p53-impaired cancer cells, dna damage caused accumulation of p53 paralogue p73 via chk-1 that strongly impacted bax expression and p53-independent apoptosis. |
2010-11-24 |
2023-08-12 |
Not clear |
| Lauy Al-Anati, Johan Högberg, Ulla Steniu. Non-dioxin-like PCBs interact with benzo[a]pyrene-induced p53-responses and inhibit apoptosis. Toxicology and applied pharmacology. vol 249. issue 2. 2010-11-24. PMID:20840854. |
we have evaluated the effects of some highly purified ndl-pcbs and benzo[a]pyrene (bp) on bp-induced raf, erk, mdm2, p53 signaling and on bp-induced apoptosis and cell cycle arrest. |
2010-11-24 |
2023-08-12 |
Not clear |
| Lauy Al-Anati, Johan Högberg, Ulla Steniu. Non-dioxin-like PCBs interact with benzo[a]pyrene-induced p53-responses and inhibit apoptosis. Toxicology and applied pharmacology. vol 249. issue 2. 2010-11-24. PMID:20840854. |
it attenuated bp-induced p53 response and apoptosis. |
2010-11-24 |
2023-08-12 |
Not clear |
| Lauy Al-Anati, Johan Högberg, Ulla Steniu. Non-dioxin-like PCBs interact with benzo[a]pyrene-induced p53-responses and inhibit apoptosis. Toxicology and applied pharmacology. vol 249. issue 2. 2010-11-24. PMID:20840854. |
this phosphorylation promotes a cytoplasmic translocation of foxo3a and p53 and our data suggest that ndl-pcbs may inhibit bp-induced apoptosis by preventing a foxo3a-dependent translocation of p53 to the cytoplasm. |
2010-11-24 |
2023-08-12 |
Not clear |
| Meirong Zhao, Ying Zhang, Cui Wang, Zhengwei Fu, Weiping Liu, Jay Ga. Induction of macrophage apoptosis by an organochlorine insecticide acetofenate. Chemical research in toxicology. vol 22. issue 3. 2010-11-23. PMID:19166338. |
these results, for the first time, revealed that the increase of endogenous ros and dna damage comediating ocp-induced apoptosis in macrophages may be by the mitochondria and p53 signal pathway. |
2010-11-23 |
2023-08-12 |
mouse |
| Zhichao Zhang, Yuanyuan Wang, Ting Song, Jin Gao, Guiye Wu, Jing Zhang, Xuhong Qia. DNA double helix unwinding triggers transcription block-dependent apoptosis: a semiquantitative probe of the response of ATM, RNAPII, and p53 to two DNA intercalators. Chemical research in toxicology. vol 22. issue 3. 2010-11-23. PMID:19182866. |
dna double helix unwinding triggers transcription block-dependent apoptosis: a semiquantitative probe of the response of atm, rnapii, and p53 to two dna intercalators. |
2010-11-23 |
2023-08-12 |
Not clear |
| Zhichao Zhang, Yuanyuan Wang, Ting Song, Jin Gao, Guiye Wu, Jing Zhang, Xuhong Qia. DNA double helix unwinding triggers transcription block-dependent apoptosis: a semiquantitative probe of the response of ATM, RNAPII, and p53 to two DNA intercalators. Chemical research in toxicology. vol 22. issue 3. 2010-11-23. PMID:19182866. |
subsequently, p53 accumulation and phosphorylation events occur that lead to apoptosis in the case of (1)a exposure. |
2010-11-23 |
2023-08-12 |
Not clear |
| Hui Wang, Yan Ye, Jian-Hong Chui, Guo-Yuan Zhu, Ying-Wei Li, David W F Fong, Zhi-Ling Y. Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells. Oncology reports. vol 24. issue 3. 2010-11-23. PMID:20664969. |
oridonin induces g2/m cell cycle arrest and apoptosis through mapk and p53 signaling pathways in hepg2 cells. |
2010-11-23 |
2023-08-12 |
Not clear |
| Hui Wang, Yan Ye, Jian-Hong Chui, Guo-Yuan Zhu, Ying-Wei Li, David W F Fong, Zhi-Ling Y. Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells. Oncology reports. vol 24. issue 3. 2010-11-23. PMID:20664969. |
in conclusion, oridonin induced g2/m cell cycle arrest and apoptosis in hepg2 cells through mapk and p53 pathways, which advances our understanding on the molecular mechanisms of oridonin in hepatocarcinoma management. |
2010-11-23 |
2023-08-12 |
Not clear |
| Jessica E Teague, Heui-Young Ryu, Michael Kirber, David H Sherr, Jennifer J Schlezinge. Proximal events in 7,12-dimethylbenz[a]anthracene-induced, stromal cell-dependent bone marrow B cell apoptosis: stromal cell-B cell communication and apoptosis signaling. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 6. 2010-11-23. PMID:20720205. |
furthermore, dmba-3,4-dihydrodiol-1,2-epoxide, a dna-reactive metabolite of dmba, was sufficient to upregulate p53, induce caspase-9 cleavage, and initiate b cell apoptosis in the absence of stromal cells, suggesting that production of this metabolite by the stromal cells and transfer to the b cells are proximal events in triggering apoptosis. |
2010-11-23 |
2023-08-12 |
Not clear |
| Weilin Wang, Xiaofei Cheng, Jianju Lu, Jianfeng Wei, Guanghou Fu, Feng Zhu, Changku Jia, Lin Zhou, Haiyang Xie, Shusen Zhen. Mitofusin-2 is a novel direct target of p53. Biochemical and biophysical research communications. vol 400. issue 4. 2010-11-23. PMID:20804729. |
the tumor suppressor p53 modulates transcription of a number of target genes involved in cell cycle arrest, apoptosis, dna repair, and other important cellular responses. |
2010-11-23 |
2023-08-12 |
Not clear |
| Joana D Amaral, Rui E Castro, Susana Solá, Clifford J Steer, Cecília M P Rodrigue. Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53. Biochemical and biophysical research communications. vol 400. issue 4. 2010-11-23. PMID:20807506. |
finally, the protective effect of udca against p53-induced apoptosis was abolished after inhibition of proteasome activity and prevention of p53 ubiquitination by mdm-2. |
2010-11-23 |
2023-08-12 |
rat |
| Emily F Mason, Yuxing Zhao, Pankuri Goraksha-Hicks, Jonathan L Coloff, Hugh Gannon, Stephen N Jones, Jeffrey C Rathmel. Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. Cancer research. vol 70. issue 20. 2010-11-23. PMID:20876800. |
aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of bcr-abl. |
2010-11-23 |
2023-08-12 |
Not clear |