| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danupon Nantajit, Ming Fan, Nadire Duru, Yunfei Wen, John C Reed, Jian Jian L. Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. PloS one. vol 5. issue 8. 2010-11-04. PMID:20808790. |
enforced translocation of cyclin b1 and cdk1 into mitochondria with a mitochondrial-targeting-peptide increased levels of ser-315 phosphorylation on mitochondrial p53, improved atp production and decreased apoptosis by sequestering p53 from binding to bcl-2 and bcl-xl. |
2010-11-04 |
2023-08-12 |
mouse |
| Danupon Nantajit, Ming Fan, Nadire Duru, Yunfei Wen, John C Reed, Jian Jian L. Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. PloS one. vol 5. issue 8. 2010-11-04. PMID:20808790. |
furthermore, reconstitution of wild-type p53 in p53-deficient hct116 p53(-/-) cells resulted in an increased mitochondrial atp production and suppression of apoptosis. |
2010-11-04 |
2023-08-12 |
mouse |
| Bunliang Suphim, Auemduan Prawan, Upa Kukongviriyapan, Sarinya Kongpetch, Benjaporn Buranrat, Veerapol Kukongviriyapa. Redox modulation and human bile duct cancer inhibition by curcumin. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 48. issue 8-9. 2010-11-03. PMID:20510329. |
up-regulation of p53 and bax was associated with marked oxidative stress and apoptosis. |
2010-11-03 |
2023-08-12 |
human |
| J Hurst-Kennedy, M Zhong, V Gupta, B D Boyan, Z Schwart. 24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: a signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis. The Journal of steroid biochemistry and molecular biology. vol 122. issue 4. 2010-11-03. PMID:20594980. |
24r,25-dihydroxyvitamin d3, lysophosphatidic acid, and p53: a signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis. |
2010-11-03 |
2023-08-12 |
Not clear |
| J Hurst-Kennedy, M Zhong, V Gupta, B D Boyan, Z Schwart. 24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: a signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis. The Journal of steroid biochemistry and molecular biology. vol 122. issue 4. 2010-11-03. PMID:20594980. |
the effects of 24r,25(oh)(2)d(3) are mediated by activation of phospholipase d (pld), resulting in increased production of lysophosphatidic acid (lpa) and lpa-mediated proliferation, maturation, inhibition of pi-induced apoptosis, and reduction of p53. |
2010-11-03 |
2023-08-12 |
Not clear |
| J Hurst-Kennedy, M Zhong, V Gupta, B D Boyan, Z Schwart. 24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: a signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis. The Journal of steroid biochemistry and molecular biology. vol 122. issue 4. 2010-11-03. PMID:20594980. |
taken together, these data show that 24r,25(oh)(2)d(3) inhibits pi-induced apoptosis through ca(2+), pld, and plc signaling and through lpa-lpa1/3-g(αi)-pi(3)k-mdm2-mediated p53 degradation, resulting in decreased cytochrome c translocation and caspase-3 activity. |
2010-11-03 |
2023-08-12 |
Not clear |
| Tatsuto Ishimaru, Jasmine Lau, Amy L Jackson, Jaime F Modiano, Robert H Weis. Pharmacological inhibition of cyclin dependent kinases causes p53 dependent apoptosis in renal cell carcinoma. The Journal of urology. vol 184. issue 5. 2010-11-02. PMID:20850841. |
pharmacological inhibition of cyclin dependent kinases causes p53 dependent apoptosis in renal cell carcinoma. |
2010-11-02 |
2023-08-12 |
Not clear |
| F Hu, R B Gartenhaus, D Eichberg, Z Liu, H-B Fang, A P Rapopor. PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21. Oncogene. vol 29. issue 40. 2010-11-01. PMID:20622899. |
gene microarray studies identified additional p53 target genes involved in apoptosis or cell cycling, which were differentially regulated by pbk knockdown. |
2010-11-01 |
2023-08-12 |
Not clear |
| Yong Hwan Han, Woo Hyun Par. Pyrogallol-induced As4.1 juxtaglomerular cell death is attenuated by MAPK inhibitors via preventing GSH depletion. Archives of toxicology. vol 84. issue 8. 2010-10-29. PMID:20191265. |
it also induced apoptosis and the loss of mitochondrial membrane potential (mmp; deltapsi(m)) and increased the level of p53 protein. |
2010-10-29 |
2023-08-12 |
Not clear |
| Joana D Amaral, Joana M Xavier, Clifford J Steer, Cecília M P Rodrigue. Targeting the p53 pathway of apoptosis. Current pharmaceutical design. vol 16. issue 22. 2010-10-29. PMID:20500145. |
targeting the p53 pathway of apoptosis. |
2010-10-29 |
2023-08-12 |
human |
| Joana D Amaral, Joana M Xavier, Clifford J Steer, Cecília M P Rodrigue. Targeting the p53 pathway of apoptosis. Current pharmaceutical design. vol 16. issue 22. 2010-10-29. PMID:20500145. |
the tumor suppressor protein, p53 is regarded as a key player in tumor suppression, as it promotes growth arrest, apoptosis and cellular senescence, while also blocking angiogenesis. |
2010-10-29 |
2023-08-12 |
human |
| Joana D Amaral, Joana M Xavier, Clifford J Steer, Cecília M P Rodrigue. Targeting the p53 pathway of apoptosis. Current pharmaceutical design. vol 16. issue 22. 2010-10-29. PMID:20500145. |
pathological conditions such as cancer, neurodegeneration, ischemia, cholestasis or atherosclerosis are all strongly associated with deregulated levels of apoptosis in which p53 dysfunction has a prominent role. |
2010-10-29 |
2023-08-12 |
human |
| Rieko Arakaki, Naozumi Ishimaru, Yoshio Hayash. Immunotherapeutic targets in estrogen deficiency-dependent Sjögren's syndrome-related manifestations. Immunotherapy. vol 2. issue 3. 2010-10-29. PMID:20635899. |
rbap48-inducible transfectants result in rapid apoptosis with p53 phosphorylation (ser9), and alpha-fodrin cleavage. |
2010-10-29 |
2023-08-12 |
mouse |
| Sabine Karl, Yvonne Pritschow, Meta Volcic, Sabine Häcker, Bernd Baumann, Lisa Wiesmüller, Klaus-Michael Debatin, Simone Fuld. Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response. Journal of cellular and molecular medicine. vol 13. issue 10. 2010-10-28. PMID:19725919. |
genetic silencing of p53 by rna interference reveals that nf-kappab promotes drug-induced apoptosis in a p53-independent manner. |
2010-10-28 |
2023-08-12 |
Not clear |
| Kok Meng Chan, Nor Fadilah Rajab, David Siegel, Laily Bin Din, David Ross, Salmaan Hussain Inayat-Hussai. Goniothalamin induces coronary artery smooth muscle cells apoptosis: the p53-dependent caspase-2 activation pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 116. issue 2. 2010-10-28. PMID:20498002. |
the gn-induced dna damage occurred with concomitant elevation of p53 as early as 2 h, demonstrating an upstream signal for apoptosis. |
2010-10-28 |
2023-08-12 |
Not clear |
| Hsien-Ming Wu, Andrew V Schally, Jung-Chien Cheng, Marta Zarandi, Jozsef Varga, Peter C K Leun. Growth hormone-releasing hormone antagonist induces apoptosis of human endometrial cancer cells through PKCδ-mediated activation of p53/p21. Cancer letters. vol 298. issue 1. 2010-10-28. PMID:20630651. |
knockdown of endogenous p53 and p21 by sirnas abolished the jmr-132-induced cell growth inhibition and apoptosis. |
2010-10-28 |
2023-08-12 |
human |
| Delira Robbins, Xin Gu, Runhua Shi, Jianfeng Liu, Fei Wang, Jacqulyne Ponville, Joe M McCord, Yunfeng Zha. The chemopreventive effects of Protandim: modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis. PloS one. vol 5. issue 7. 2010-10-28. PMID:20689586. |
the chemopreventive effects of protandim: modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis. |
2010-10-28 |
2023-08-12 |
mouse |
| Delira Robbins, Xin Gu, Runhua Shi, Jianfeng Liu, Fei Wang, Jacqulyne Ponville, Joe M McCord, Yunfeng Zha. The chemopreventive effects of Protandim: modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis. PloS one. vol 5. issue 7. 2010-10-28. PMID:20689586. |
recently, more attention has been focused on transcription-independent mechanisms of the tumor suppressor, p53, that mediate apoptosis. |
2010-10-28 |
2023-08-12 |
mouse |
| P Pratheeshkumar, P Thejass, Girija Kuta. Diallyl disulfide induces caspase-dependent apoptosis via mitochondria-mediated intrinsic pathway in B16F-10 melanoma cells by up-regulating p53, caspase-3 and down-regulating pro-inflammatory cytokines and nuclear factor-κβ-mediated Bcl-2 activation. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 29. issue 2. 2010-10-28. PMID:20932246. |
diallyl disulfide induces caspase-dependent apoptosis via mitochondria-mediated intrinsic pathway in b16f-10 melanoma cells by up-regulating p53, caspase-3 and down-regulating pro-inflammatory cytokines and nuclear factor-κβ-mediated bcl-2 activation. |
2010-10-28 |
2023-08-12 |
Not clear |
| P Pratheeshkumar, P Thejass, Girija Kuta. Diallyl disulfide induces caspase-dependent apoptosis via mitochondria-mediated intrinsic pathway in B16F-10 melanoma cells by up-regulating p53, caspase-3 and down-regulating pro-inflammatory cytokines and nuclear factor-κβ-mediated Bcl-2 activation. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 29. issue 2. 2010-10-28. PMID:20932246. |
dads induces caspase-dependent apoptosis through a mitochondria-mediated intrinsic pathway in b16f-10 melanoma cells by activating p53 and caspase-3 gene expression and suppressing pro-inflammatory cytokines and nf-b-mediated bcl-2 activation. |
2010-10-28 |
2023-08-12 |
Not clear |