| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prem Khanal, Won-Keun Oh, Phuong Thien Thuong, Sung Dae Cho, Hong Seok Cho. 24-hydroxyursolic acid from the leaves of the Diospyros kaki (Persimmon) induces apoptosis by activation of AMP-activated protein kinase. Planta medica. vol 76. issue 7. 2010-10-26. PMID:19960411. |
in addition, 24-hydroxyursolic acid induced cellular apoptosis by activation of poly(adp-ribose) polymerase (parp), caspase-3, and phosphorylation of p53 at ser15. |
2010-10-26 |
2023-08-12 |
human |
| F Zhu, P Wang, A Kontrogianni-Konstantopoulos, K Konstantopoulo. Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases. Cell death and differentiation. vol 17. issue 8. 2010-10-26. PMID:20150912. |
plks target p53, which controls the transcription of p53 effectors (tp53inps, fas and bax) involved in chondrocyte apoptosis. |
2010-10-26 |
2023-08-12 |
human |
| Cong-Jun Wang, Hui Zhang, Kun Chen, Jian-Wei Zheng, Chao-Wen Xiao, Wen-Wei Ji, Yuan Yu, Hui-Yi Hu, Yan Li, Xin-Bo Xu. Ad.mda-7 (IL-24) selectively induces apoptosis in hepatocellular carcinoma cell lines, suppresses metastasis, and enhances the effect of doxorubicin on xenograft tumors. Oncology research. vol 18. issue 11-12. 2010-10-26. PMID:20939432. |
adenovirus-mediated overexpression of mda-7 facilitated the mda-7/il-24-induced apoptosis and g2/m arrest in hcc cells, but not in the normal liver cell line l02, and the effect was independent of the p53 status. |
2010-10-26 |
2023-08-12 |
human |
| Cong-Jun Wang, Hui Zhang, Kun Chen, Jian-Wei Zheng, Chao-Wen Xiao, Wen-Wei Ji, Yuan Yu, Hui-Yi Hu, Yan Li, Xin-Bo Xu. Ad.mda-7 (IL-24) selectively induces apoptosis in hepatocellular carcinoma cell lines, suppresses metastasis, and enhances the effect of doxorubicin on xenograft tumors. Oncology research. vol 18. issue 11-12. 2010-10-26. PMID:20939432. |
these data suggested that mda-7/il-24 induces its selective antitumor properties in hcc cells by promoting apoptosis independent of p53 status, inhibiting subcutaneous tumor growth and metastasis, and increasing the effect of chemotherapeutic agents. |
2010-10-26 |
2023-08-12 |
human |
| Darren C Phillips, H K Irundika Dias, George D Kitas, Helen R Griffith. Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival, and therapeutic intervention. Antioxidants & redox signaling. vol 12. issue 6. 2010-10-25. PMID:19686039. |
as the hypercellularity of the rheumatoid joint and the associated persistence of hematopoietic cells within the rheumatoid joint are symptomatic of unresponsiveness to apoptotic stimuli, the role of apoptotic signaling proteins (specifically bcl-2 family members and the tumor suppressor p53) as regulators of ros generation and apoptosis are considered, evaluating evidence for their aberrant expression and function in ra. |
2010-10-25 |
2023-08-12 |
Not clear |
| Wafica S Itani, Sarah H El-Banna, Saadia B Hassan, Rolf L Larsson, Ali Bazarbachi, Hala U Gali-Muhtasi. Anti colon cancer components from Lebanese sage (Salvia libanotica) essential oil: Mechanistic basis. Cancer biology & therapy. vol 7. issue 11. 2010-10-22. PMID:18787402. |
in response to the three components, 58% apoptosis occurred in p53(+/+) cells and 38% in p53(-/-) cells. |
2010-10-22 |
2023-08-12 |
human |
| Wafica S Itani, Sarah H El-Banna, Saadia B Hassan, Rolf L Larsson, Ali Bazarbachi, Hala U Gali-Muhtasi. Anti colon cancer components from Lebanese sage (Salvia libanotica) essential oil: Mechanistic basis. Cancer biology & therapy. vol 7. issue 11. 2010-10-22. PMID:18787402. |
in p53(-/-) cells, the disruption of mitochondrial membrane potential was observed but to a lesser extent than in p53(+/+) cells and caspase activation or cleavage did not appear to be involved in drug-induced apoptosis. |
2010-10-22 |
2023-08-12 |
human |
| Wafica S Itani, Sarah H El-Banna, Saadia B Hassan, Rolf L Larsson, Ali Bazarbachi, Hala U Gali-Muhtasi. Anti colon cancer components from Lebanese sage (Salvia libanotica) essential oil: Mechanistic basis. Cancer biology & therapy. vol 7. issue 11. 2010-10-22. PMID:18787402. |
pretreatment with the caspase-3 inhibitor and pan caspase inhibitor abrogated drug-mediated apoptosis and blocked procaspase-3 activation and partially blocked parp cleavage in p53(+/+) cells. |
2010-10-22 |
2023-08-12 |
human |
| Wafica S Itani, Sarah H El-Banna, Saadia B Hassan, Rolf L Larsson, Ali Bazarbachi, Hala U Gali-Muhtasi. Anti colon cancer components from Lebanese sage (Salvia libanotica) essential oil: Mechanistic basis. Cancer biology & therapy. vol 7. issue 11. 2010-10-22. PMID:18787402. |
it appears that apoptosis in p53(+/+) cells is through the mitochondrial-mediated, caspase-dependent pathway, while in p53(-/-) cells apoptosis is mostly caspase independent despite the presence and features indicating caspase-dependent cell death, such as cytochrome c release and parp cleavage. |
2010-10-22 |
2023-08-12 |
human |
| Corinna Busch, Claus Jacob, Awais Anwar, Torsten Burkholz, Lalla Aicha Ba, Claudia Cerella, Marc Diederich, Wolfgang Brandt, Ludger Wessjohann, Mathias Montenar. Diallylpolysulfides induce growth arrest and apoptosis. International journal of oncology. vol 36. issue 3. 2010-10-22. PMID:20126995. |
furthermore, using hct116 cells which were either positive or negative for p53 revealed that p53 is clearly dispensable for induction of apoptosis. |
2010-10-22 |
2023-08-12 |
human |
| Zhixiong Chen, Jiong Yang, Qiong Huan. Correlation and expression of COX-2 and P53 protein in basal cell carcinoma of eyelid. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 3. 2010-10-21. PMID:19513627. |
the correlation between the expression of cox-2 and p53 protein in basal cell carcinoma (bcc) of eyelid and apoptosis was investigated. |
2010-10-21 |
2023-08-12 |
Not clear |
| Zhixiong Chen, Jiong Yang, Qiong Huan. Correlation and expression of COX-2 and P53 protein in basal cell carcinoma of eyelid. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 3. 2010-10-21. PMID:19513627. |
it was concluded that cox-2 can increase the expression of p53 protein, therefore suppressing apoptosis. |
2010-10-21 |
2023-08-12 |
Not clear |
| Saravana Kumar Jaganathan, Mahitosh Manda. Involvement of non-protein thiols, mitochondrial dysfunction, reactive oxygen species and p53 in honey-induced apoptosis. Investigational new drugs. vol 28. issue 5. 2010-10-21. PMID:19705065. |
involvement of non-protein thiols, mitochondrial dysfunction, reactive oxygen species and p53 in honey-induced apoptosis. |
2010-10-21 |
2023-08-12 |
Not clear |
| Saravana Kumar Jaganathan, Mahitosh Manda. Involvement of non-protein thiols, mitochondrial dysfunction, reactive oxygen species and p53 in honey-induced apoptosis. Investigational new drugs. vol 28. issue 5. 2010-10-21. PMID:19705065. |
honey induced apoptosis was accompanied by up-regulating the p53 and modulating the expression of pro and anti-apoptotic proteins. |
2010-10-21 |
2023-08-12 |
Not clear |
| Hironobu Ikehata, Ryuhei Okuyama, Eisaku Ogawa, Shingo Nakamura, Atsuko Usami, Toshio Mori, Kiyoji Tanaka, Setsuya Aiba, Tetsuya On. Influences of p53 deficiency on the apoptotic response, DNA damage removal and mutagenesis in UVB-exposed mouse skin. Mutagenesis. vol 25. issue 4. 2010-10-21. PMID:20462948. |
to address the p53 contribution to these skin responses in vivo, we analyzed the time course of dna damage removal, apoptosis induction and hyperplasia in the skin after uvb irradiation in p53-knockout mice. |
2010-10-21 |
2023-08-12 |
mouse |
| Hironobu Ikehata, Ryuhei Okuyama, Eisaku Ogawa, Shingo Nakamura, Atsuko Usami, Toshio Mori, Kiyoji Tanaka, Setsuya Aiba, Tetsuya On. Influences of p53 deficiency on the apoptotic response, DNA damage removal and mutagenesis in UVB-exposed mouse skin. Mutagenesis. vol 25. issue 4. 2010-10-21. PMID:20462948. |
we found that p53 deficiency does not abolish the uvb-induced apoptotic response in the epidermis but delays the process and the following hyperplasia 12-24 h. regardless of the p53 genotype, 1 kj/m(2) uvb induced a total replacement of the epidermal layer by destroying the damaged epidermis by apoptosis and rebuilding a new one through hyperplasia. |
2010-10-21 |
2023-08-12 |
mouse |
| Hironobu Ikehata, Ryuhei Okuyama, Eisaku Ogawa, Shingo Nakamura, Atsuko Usami, Toshio Mori, Kiyoji Tanaka, Setsuya Aiba, Tetsuya On. Influences of p53 deficiency on the apoptotic response, DNA damage removal and mutagenesis in UVB-exposed mouse skin. Mutagenesis. vol 25. issue 4. 2010-10-21. PMID:20462948. |
these results indicate that p53 protects the skin genome from the uvb genotoxicity by facilitating ner, whereas its contribution to the uvb-induced apoptosis is limited. |
2010-10-21 |
2023-08-12 |
mouse |
| Rachael Rutkowski, Kay Hofmann, Anton Gartne. Phylogeny and function of the invertebrate p53 superfamily. Cold Spring Harbor perspectives in biology. vol 2. issue 7. 2010-10-21. PMID:20595397. |
in invertebrate models amenable to genetic analysis p53 superfamily members mainly act in apoptosis regulation in response to genotoxic agents and do not have overt developmental functions. |
2010-10-21 |
2023-08-12 |
caenorhabditis_elegans |
| Rachael Rutkowski, Kay Hofmann, Anton Gartne. Phylogeny and function of the invertebrate p53 superfamily. Cold Spring Harbor perspectives in biology. vol 2. issue 7. 2010-10-21. PMID:20595397. |
we summarize the literature on cnidarian and mollusc p53 superfamily members and focus on the function and regulation of drosophila melanogaster and caenorhabditis elegans p53 superfamily members in triggering apoptosis. |
2010-10-21 |
2023-08-12 |
caenorhabditis_elegans |
| Rachael Rutkowski, Kay Hofmann, Anton Gartne. Phylogeny and function of the invertebrate p53 superfamily. Cold Spring Harbor perspectives in biology. vol 2. issue 7. 2010-10-21. PMID:20595397. |
furthermore, we examine the emerging evidence showing that invertebrate p53 superfamily proteins also have functions unrelated to apoptosis, such as dna repair, cell cycle checkpoint responses, compensatory proliferation, aging, autophagy, and innate immunity. |
2010-10-21 |
2023-08-12 |
caenorhabditis_elegans |