| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrei V Gudkov, Elena A Komarov. Pathologies associated with the p53 response. Cold Spring Harbor perspectives in biology. vol 2. issue 7. 2010-10-21. PMID:20595398. |
p53-mediated damage is strictly tissue specific and occurs in tissues prone to p53-dependent apoptosis (e.g., hematopoietic system and hair follicles); on the contrary, p53 can serve as a survival factor in tissues that respond to p53 activation by cell cycle arrest (e.g., endothelium of small intestine). |
2010-10-21 |
2023-08-12 |
Not clear |
| Shan Wang, Chunyan Tian, Guichun Xing, Mei Gao, Wenjuan Jiao, Tingting Xiao, Yuxin Yin, Fuchu He, Lingqiang Zhan. ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress. FEBS letters. vol 584. issue 18. 2010-10-21. PMID:20713054. |
the krab-type zinc-finger protein apak (atm and p53 associated kznf protein) specifically suppresses p53-mediated apoptosis. |
2010-10-21 |
2023-08-12 |
Not clear |
| Wael M Elsham. Induction of breast cancer in wild type p53 cells by BRCA1-IRIS overexpression. Hawaii medical journal. vol 69. issue 8. 2010-10-21. PMID:20845286. |
activation of p38mapk and p53 following these stresses help protect cells against cancer development by initiating apoptosis. |
2010-10-21 |
2023-08-12 |
Not clear |
| Ming-Jyh Sheu, Pei-Yu Chou, Chin-Shiu Huang, I-Chun Tsai, Yi-Chung Chien, Sung-Yuan Lin, Huei-Yann Tsai, Hsu-Chen Cheng, Chieh-Hsi W. Pipoxolan inhibits proliferation of HL-60 human leukaemia cancer cells by arresting the cell cycle at the G0/G1 phase. Clinical and experimental pharmacology & physiology. vol 37. issue 5-6. 2010-10-20. PMID:20082627. |
the expression of factors affecting the cell cycle and apoptosis, including p53, p21, bax, bcl2, cytochrome c, caspase 3 and caspase 9, was examined by western blotting. |
2010-10-20 |
2023-08-12 |
human |
| Hua-Pei Song, Lei Zhang, Yong-Ming Dang, Hong Yan, Zhi-Gang Chu, Yue-Sheng Huan. The phosphatidylinositol 3-kinase-Akt pathway protects cardiomyocytes from ischaemic and hypoxic apoptosis via mitochondrial function. Clinical and experimental pharmacology & physiology. vol 37. issue 5-6. 2010-10-20. PMID:20082630. |
cardiomyocytes cultured under hypoxic conditions exhibited increased apoptosis, decreased cell viability, enhanced caspase 3 activity, a decreased mitochondrial membrane potential, increased cytoplasmic calcium transients and increased p53 and bax mrna expression. |
2010-10-20 |
2023-08-12 |
rat |
| Tomoko Yamaguchi, Yoshio Miki, Kiyotsugu Yoshid. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage. Apoptosis : an international journal on programmed cell death. vol 15. issue 8. 2010-10-20. PMID:20563669. |
we also show that, upon exposure to genotoxic stress, overexpression of pitx1 is associated with marked induction of apoptosis that is independent of p53 status. |
2010-10-20 |
2023-08-12 |
human |
| Paola Belloni, Paolo Latini, Fabrizio Palitt. Relationship between spontaneous or radiation-induced apoptosis and telomere shortening in G(0) human lymphocytes. Mutation research. vol 701. issue 2. 2010-10-20. PMID:20580855. |
spontaneous and radiation-induced apoptosis are dependent on expression of p53. |
2010-10-20 |
2023-08-12 |
human |
| Paola Belloni, Paolo Latini, Fabrizio Palitt. Relationship between spontaneous or radiation-induced apoptosis and telomere shortening in G(0) human lymphocytes. Mutation research. vol 701. issue 2. 2010-10-20. PMID:20580855. |
in contrast, p53 may not play an effective role in telomere shortening, because spontaneous apoptosis did not correlate with telomere shortening. |
2010-10-20 |
2023-08-12 |
human |
| F-W Chang, G-H Sun, Y-Y Cheng, I-C Chen, H-H Chien, G-J W. Effects of varicocele upon the expression of apoptosis-related proteins. Andrologia. vol 42. issue 4. 2010-10-18. PMID:20629644. |
an increased expression of parp, bak and p53 for varicocele-afflicted individuals indicated an increased participation by these agents in the regulating of apoptosis in the ejaculated semen from patients with varicocele, suggesting that certain protein-development apoptotic mechanisms might originate in the cytoplasmic droplet or within mitochondria of spermatocytes and then might function within the nucleus of the cell. |
2010-10-18 |
2023-08-12 |
Not clear |
| Clay C C Wang, Yi-Ming Chiang, Mike B Praseuth, Po-Lin Kuo, Hsin-Lin Liang, Ya-Ling Hs. Asperfuranone from Aspergillus nidulans inhibits proliferation of human non-small cell lung cancer A549 cells via blocking cell cycle progression and inducing apoptosis. Basic & clinical pharmacology & toxicology. vol 107. issue 1. 2010-10-12. PMID:20148857. |
to identity the anti-cancer mechanism of asperfuranone, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21 waf1/cip1, fas/apo-1 receptor and fas ligand. |
2010-10-12 |
2023-08-12 |
human |
| P Smile. [Molecular predictors in head and neck tumours]. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti. vol 23. issue 4. 2010-10-12. PMID:20806819. |
these markers could be evaluated in every step that is believed to be necessary for the development of a cancer: acquisition of autonomous proliferative signalling (egfr), proliferative activity of tumour cells (dna content, ki-67, mitotic index), inhibition of growth inhibitory signals (bcl-2), apoptosis (p53), immortalization (telomerase), angiogenesis (cd34, vegf) and metastasis (mmp-9, e-cadherin, i-cam aj.). |
2010-10-12 |
2023-08-12 |
Not clear |
| Roberta Meschini, Andrea Berni, Vincenza Ortenzi, Pierluigi Mancinelli, Fabrizio Palitt. Relation between DNA repair, apoptosis and chromosomal aberrations in presence of pifithrin-alpha, an inhibitor of p53. Mutation research. vol 701. issue 1. 2010-10-08. PMID:20348016. |
relation between dna repair, apoptosis and chromosomal aberrations in presence of pifithrin-alpha, an inhibitor of p53. |
2010-10-08 |
2023-08-12 |
human |
| Roberta Meschini, Andrea Berni, Vincenza Ortenzi, Pierluigi Mancinelli, Fabrizio Palitt. Relation between DNA repair, apoptosis and chromosomal aberrations in presence of pifithrin-alpha, an inhibitor of p53. Mutation research. vol 701. issue 1. 2010-10-08. PMID:20348016. |
the aim of this study was to investigate the impact of inhibition of p53 in x-irradiated human peripheral blood lymphocytes (hpbl) in the g0 phase of the cell cycle in the presence or absence of pifithrin-alpha (pft-alpha), a specific inhibitor of p53, on repair of dna damage or induced apoptosis. |
2010-10-08 |
2023-08-12 |
human |
| Sean M Post, Alfonso Quintás-Cardama, Vinod Pant, Tomoo Iwakuma, Amir Hamir, James G Jackson, Daniela R Maccio, Gareth L Bond, David G Johnson, Arnold J Levine, Guillermina Lozan. A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development. Cancer cell. vol 18. issue 3. 2010-10-08. PMID:20832750. |
mdm2(snp309g/g) cells exhibit elevated mdm2 levels, reduced p53 levels, and decreased apoptosis. |
2010-10-08 |
2023-08-12 |
mouse |
| Alexander H Stegh, Cameron Brennan, John A Mahoney, Kristin L Forloney, Harry T Jenq, Janina P Luciano, Alexei Protopopov, Lynda Chin, Ronald A Depinh. Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes & development. vol 24. issue 19. 2010-10-08. PMID:20837658. |
here, we show that nuclear bcl2l12 physically and functionally interacts with the p53 tumor suppressor, as evidenced by the capacity of bcl2l12 to (1) enable bypass of replicative senescence without concomitant loss of p53 or p19 (arf), (2) inhibit p53-dependent dna damage-induced apoptosis, (3) impede the capacity of p53 to bind some of its target gene promoters, and (4) attenuate endogenous p53-directed transcriptomic changes following genotoxic stress. |
2010-10-08 |
2023-08-12 |
human |
| Amrita Cheema, Chad D Knights, Mahadev Rao, Jason Catania, Ricardo Perez, Brigitte Simons, Sivanesan Dakshanamurthy, Vamsi K Kolukula, Maddalena Tilli, Priscilla A Furth, Christopher Albanese, Maria Laura Avantaggiat. Functional mimicry of the acetylated C-terminal tail of p53 by a SUMO-1 acetylated domain, SAD. Journal of cellular physiology. vol 225. issue 2. 2010-10-07. PMID:20458745. |
in the acetylable form sumo-1 tunes the p53 response by modifying p53 transcriptional program, by promoting binding onto selected promoters and by favoring apoptosis. |
2010-10-07 |
2023-08-12 |
Not clear |
| Jürgen den Hollander, Sara Rimpi, Joanne R Doherty, Martina Rudelius, Andreas Buck, Alexander Hoellein, Marcus Kremer, Nikolas Graf, Markus Scheerer, Mark A Hall, Andrei Goga, Nikolas von Bubnoff, Justus Duyster, Christian Peschel, John L Cleveland, Jonas A Nilsson, Ulrich Kelle. Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state. Blood. vol 116. issue 9. 2010-10-07. PMID:20519624. |
importantly, apoptosis provoked by aurk inhibition was p53 independent, suggesting that aurka/aurkb inhibitors will show efficacy in treating primary or relapsed malignancies having myc involvement and/or loss of p53 function. |
2010-10-07 |
2023-08-12 |
mouse |
| Svitlana Kurinna, Sabrina A Stratton, Wen-Wei Tsai, Kadir C Akdemir, Weisong Gu, Pallavi Singh, Triona Goode, Gretchen J Darlington, Michelle Craig Barto. Direct activation of forkhead box O3 by tumor suppressors p53 and p73 is disrupted during liver regeneration in mice. Hepatology (Baltimore, Md.). vol 52. issue 3. 2010-10-07. PMID:20564353. |
the p53 family of proteins regulates the expression of target genes that promote cell cycle arrest and apoptosis, which may be linked to cellular growth control as well as tumor suppression. |
2010-10-07 |
2023-08-12 |
mouse |
| Peter Muench, Sonja Probst, Johanna Schuetz, Natalie Leiprecht, Martin Busch, Sebastian Wesselborg, Frank Stubenrauch, Thomas Iftne. Cutaneous papillomavirus E6 proteins must interact with p300 and block p53-mediated apoptosis for cellular immortalization and tumorigenesis. Cancer research. vol 70. issue 17. 2010-10-07. PMID:20663910. |
in this study, we show that the interaction of crpve6, or hpv38e6, with the histone acetyltransferase p300 is crucial to inhibit the ability of p53 to induce apoptosis. |
2010-10-07 |
2023-08-12 |
human |
| Peter Muench, Sonja Probst, Johanna Schuetz, Natalie Leiprecht, Martin Busch, Sebastian Wesselborg, Frank Stubenrauch, Thomas Iftne. Cutaneous papillomavirus E6 proteins must interact with p300 and block p53-mediated apoptosis for cellular immortalization and tumorigenesis. Cancer research. vol 70. issue 17. 2010-10-07. PMID:20663910. |
strikingly, e6 mutants deficient for p300 binding are incapable of preventing p53 acetylation, p53-dependent transcription, and apoptosis induction. |
2010-10-07 |
2023-08-12 |
human |