| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emily F Mason, Yuxing Zhao, Pankuri Goraksha-Hicks, Jonathan L Coloff, Hugh Gannon, Stephen N Jones, Jeffrey C Rathmel. Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. Cancer research. vol 70. issue 20. 2010-11-23. PMID:20876800. |
cell metabolism may be central to this cell death pathway, as we have shown that growth factor deprivation leads to decreased glycolysis that promotes apoptosis via p53 activation and induction of the proapoptotic protein puma. |
2010-11-23 |
2023-08-12 |
Not clear |
| Yuji Miyamoto, Manabu Futamura, Noriaki Kitamura, Yasuyuki Nakamura, Hideo Baba, Hiroufmi Arakaw. Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis. International journal of oncology. vol 36. issue 5. 2010-11-22. PMID:20372800. |
identification of unc5a as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis. |
2010-11-22 |
2023-08-12 |
mouse |
| Yuji Miyamoto, Manabu Futamura, Noriaki Kitamura, Yasuyuki Nakamura, Hideo Baba, Hiroufmi Arakaw. Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis. International journal of oncology. vol 36. issue 5. 2010-11-22. PMID:20372800. |
here, we report that unc5a regulates apoptosis as a downstream target of p53. |
2010-11-22 |
2023-08-12 |
mouse |
| Yuji Miyamoto, Manabu Futamura, Noriaki Kitamura, Yasuyuki Nakamura, Hideo Baba, Hiroufmi Arakaw. Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis. International journal of oncology. vol 36. issue 5. 2010-11-22. PMID:20372800. |
these results suggest that unc5a is a novel transcriptional target of p53 and plays a role in p53-dependent apoptosis. |
2010-11-22 |
2023-08-12 |
mouse |
| Adriana Rodríguez-Marí, Cristian Cañestro, Ruth A Bremiller, Alexandria Nguyen-Johnson, Kazuhide Asakawa, Koichi Kawakami, John H Postlethwai. Sex reversal in zebrafish fancl mutants is caused by Tp53-mediated germ cell apoptosis. PLoS genetics. vol 6. issue 7. 2010-11-22. PMID:20661450. |
remarkably, results showed that the introduction of a tp53 (p53) mutation into fancl mutants rescued the sex-reversal phenotype by reducing germ cell apoptosis and, thus, allowed fancl mutants to become fertile females. |
2010-11-22 |
2023-08-12 |
zebrafish |
| Sergey V Tokalov, Andrij M Abramyuk, Nasreddin D Abolmaal. Protection of p53 wild type cells from taxol by genistein in the combined treatment of lung cancer. Nutrition and cancer. vol 62. issue 6. 2010-11-22. PMID:20661829. |
the proposed therapeutic strategy allows protection of p53 wild type cells from taxol and selectively increases apoptosis in p53-deficient cells. |
2010-11-22 |
2023-08-12 |
Not clear |
| Baosheng Chen, Mark S Longtine, Yoel Sadovsky, D Michael Nelso. Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. American journal of physiology. Cell physiology. vol 299. issue 5. 2010-11-22. PMID:20810912. |
hypoxia downregulates p53 but induces apoptosis and enhances expression of bad in cultures of human syncytiotrophoblasts. |
2010-11-22 |
2023-08-12 |
human |
| Baosheng Chen, Mark S Longtine, Yoel Sadovsky, D Michael Nelso. Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. American journal of physiology. Cell physiology. vol 299. issue 5. 2010-11-22. PMID:20810912. |
we previously showed that hypoxia upregulates p53 and enhances apoptosis in primary cultures of human cytotrophoblasts. |
2010-11-22 |
2023-08-12 |
human |
| Baosheng Chen, Mark S Longtine, Yoel Sadovsky, D Michael Nelso. Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. American journal of physiology. Cell physiology. vol 299. issue 5. 2010-11-22. PMID:20810912. |
here we tested the hypothesis that hypoxia also induces apoptosis in syncytiotrophoblasts by upregulation of p53. |
2010-11-22 |
2023-08-12 |
human |
| Baosheng Chen, Mark S Longtine, Yoel Sadovsky, D Michael Nelso. Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. American journal of physiology. Cell physiology. vol 299. issue 5. 2010-11-22. PMID:20810912. |
conversely, staurosporine, a kinase inhibitor, and nutlin-3, a drug that enhances p53 expression, both raised p53 levels and increased the rate of apoptosis in syncytiotrophoblasts compared with vehicle controls. |
2010-11-22 |
2023-08-12 |
human |
| Baosheng Chen, Mark S Longtine, Yoel Sadovsky, D Michael Nelso. Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. American journal of physiology. Cell physiology. vol 299. issue 5. 2010-11-22. PMID:20810912. |
we speculate that downregulation of p53 activity in response to hypoxia reduces or eliminates the apoptosis transduced by the p53 pathway in syncytiotrophoblasts, thereby limiting cell death and maintaining the integrity of this critical villous component. |
2010-11-22 |
2023-08-12 |
human |
| Ruth Scherz-Shouval, Hilla Weidberg, Chagay Gonen, Sylvia Wilder, Zvulun Elazar, Moshe Ore. p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 43. 2010-11-22. PMID:20937856. |
loss of p53 impairs autophagic flux and causes excessive lc3 accumulation upon starvation, culminating in apoptosis. |
2010-11-22 |
2023-08-12 |
human |
| Nikolas Desilet, Tessa N Campbell, Francis Y M Cho. p53-based anti-cancer therapies: An empty promise? Current issues in molecular biology. vol 12. issue 3. 2010-11-16. PMID:19918091. |
the p53 protein mediates critical cellular functions including the response to genotoxic stress, differentiation, senescence, and apoptosis, and has been shown to be mutated in a large proportion of human cancers. |
2010-11-16 |
2023-08-12 |
human |
| A Ghosh, N E Joo, T C Chen, Y L Kapil. Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells. Journal of periodontal research. vol 45. issue 4. 2010-11-16. PMID:20337881. |
previously, we found that a disease-associated fibronectin fragment triggers apoptosis of primary human periodontal ligament cells via a novel apoptotic pathway in which the tumor suppressor, p53, is transcriptionally downregulated. |
2010-11-16 |
2023-08-12 |
human |
| Amanda Polson, Paula Takahashi, David Reisma. ChIP (chromatin immunoprecipitation) analysis demonstrates co-ordinated binding of two transcription factors to the promoter of the p53 tumour-suppressor gene. Cell biology international. vol 34. issue 9. 2010-11-16. PMID:20446924. |
p53 is a tumour-suppressor protein that plays a role in many cellular processes, including regulation of the cell cycle, dna repair, transcriptional regulation of genes, chromosomal segregation, cell senescence and apoptosis. |
2010-11-16 |
2023-08-12 |
human |
| L Ricks-Santi, T Mason, V Apprey, C Ahaghotu, A McLauchlin, D Josey, G Bonney, G M Dunsto. p53 Pro72Arg polymorphism and prostate cancer in men of African descent. The Prostate. vol 70. issue 16. 2010-11-16. PMID:20593380. |
p53 is a transcription factor that regulates the cell cycle, dna repair, and apoptosis. |
2010-11-16 |
2023-08-12 |
Not clear |
| Xiaoyun Cheng, Weiya Xia, Jer-Yen Yang, Jennifer L Hsu, Jing-Yu Lang, Chao-Kai Chou, Yi Du, Hui-Lung Sun, Shannon L Wyszomierski, Gordon B Mills, William J Muller, Dihua Yu, Mien-Chie Hun. Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. Cancer research. vol 70. issue 19. 2010-11-15. PMID:20841468. |
activation of mdm2 delayed mammary gland involution and accelerated tumor progression in mouse mammary tumor virus/neu transgenic mice by inhibiting apoptosis in a manner associated with decreased p53 expression. |
2010-11-15 |
2023-08-12 |
mouse |
| Guillaume A Odri, Sophie Dumoucel, Gaëlle Picarda, Séverine Battaglia, François Lamoureux, Nadège Corradini, Julie Rousseau, Franck Tirode, Karine Laud, Olivier Delattre, François Gouin, Dominique Heymann, Françoise Redin. Zoledronic acid as a new adjuvant therapeutic strategy for Ewing's sarcoma patients. Cancer research. vol 70. issue 19. 2010-11-15. PMID:20841471. |
the combined effects of zoledronic acid and mafosfamide were investigated on cell proliferation, viability, apoptosis, and cell cycle distribution of human es cell lines differing in their p53 and p16/ink4 status. |
2010-11-15 |
2023-08-12 |
mouse |
| Michael Milyavsky, Olga I Gan, Magan Trottier, Martin Komosa, Ofer Tabach, Faiyaz Notta, Eric Lechman, Karin G Hermans, Kolja Eppert, Zhanna Konovalova, Olga Ornatsky, Eytan Domany, M Stephen Meyn, John E Dic. A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell stem cell. vol 7. issue 2. 2010-11-12. PMID:20619763. |
p53 inactivation or bcl-2 overexpression reduced radiation-induced apoptosis and preserved in vivo repopulating hsc function. |
2010-11-12 |
2023-08-12 |
human |
| Michael Milyavsky, Olga I Gan, Magan Trottier, Martin Komosa, Ofer Tabach, Faiyaz Notta, Eric Lechman, Karin G Hermans, Kolja Eppert, Zhanna Konovalova, Olga Ornatsky, Eytan Domany, M Stephen Meyn, John E Dic. A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell stem cell. vol 7. issue 2. 2010-11-12. PMID:20619763. |
despite similar protection from irradiation-induced apoptosis, only bcl-2-overexpressing hscs showed higher self-renewal capacity, establishing that intact p53 positively regulates self-renewal independently from apoptosis. |
2010-11-12 |
2023-08-12 |
human |