| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hung-Yun Lin, Dominique Delmas, Ole Vang, Tze-Chen Hsieh, Sharon Lin, Guei-Yun Cheng, Hsiao-Ling Chiang, Chiao En Chen, Heng-Yuan Tang, Dana R Crawford, Jacqueline Whang-Peng, Jaulang Hwang, Leroy F Liu, Joseph M W. Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol. Journal of cellular biochemistry. vol 114. issue 8. 2013-11-01. PMID:23495037. |
blockade of cyclooxygenase-2 (cox-2) activity by sirna or ns398 correspondingly inhibited ceramide-induced p53 ser-15 phosphorylation and apoptosis; thus cox-2 appears at the apex of the p38 kinase-mediated signaling cascade induced by ceramide. |
2013-11-01 |
2023-08-12 |
human |
| Alexander J Lakhter, Ravi P Sahu, Yang Sun, William K Kaufmann, Elliot J Androphy, Jeffrey B Travers, Samisubbu R Naid. Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation. The Journal of investigative dermatology. vol 133. issue 9. 2013-10-31. PMID:23370537. |
the bcl homology-3 (bh3)-only protein p53 upregulated modulator of apoptosis (puma) counters bcl-2 family anti-apoptotic proteins and promotes apoptosis. |
2013-10-31 |
2023-08-12 |
mouse |
| Aaron E Hoffman, Kathryn Demanelis, Alan Fu, Tongzhang Zheng, Yong Zh. Association of AMP-activated protein kinase with risk and progression of non-Hodgkin lymphoma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 22. issue 4. 2013-10-31. PMID:23396962. |
the heterotrimeric amp-activated protein kinase (ampk) complex is a central regulator of the metabolic system and an important component of the mtor pathway and the p53 axis, making it uniquely positioned to influence carcinogenesis through its canonical functions in the metabolic arena, as well as through more traditional mechanisms such as regulation of apoptosis and angiogenesis. |
2013-10-31 |
2023-08-12 |
Not clear |
| C Z Cotrim, V Fabris, M L Doria, K Lindberg, J-Å Gustafsson, F Amado, C Lanari, L A Helguer. Estrogen receptor beta growth-inhibitory effects are repressed through activation of MAPK and PI3K signalling in mammary epithelial and breast cancer cells. Oncogene. vol 32. issue 19. 2013-10-30. PMID:22751110. |
in vitro, in mc4-l2, eph4 or hc11 cells incubated under basal conditions, erβ agonists induced apoptosis measured as upregulation of p53 and apoptosis-inducible factor protein levels and increased caspase 3 activity, whereas ppt and e2 stimulated proliferation. |
2013-10-30 |
2023-08-12 |
human |
| Feng Zhang, De-Song Kong, Zi-Li Zhang, Na Lei, Xiao-Jing Zhu, Xiao-Ping Zhang, Li Chen, Yin Lu, Shi-Zhong Zhen. Tetramethylpyrazine induces G0/G1 cell cycle arrest and stimulates mitochondrial-mediated and caspase-dependent apoptosis through modulating ERK/p53 signaling in hepatic stellate cells in vitro. Apoptosis : an international journal on programmed cell death. vol 18. issue 2. 2013-10-29. PMID:23247439. |
mechanistic investigations revealed that tmp selectively blocked the extracellular signal-regulated kinase (erk) signaling and activated p53, which was required for tmp induction of caspase-dependent mitochondrial apoptosis in hscs. |
2013-10-29 |
2023-08-12 |
Not clear |
| Anna Rita Bonfigli, Cristina Sirolla, Roberto Testa, Michela Cucchi, Liana Spazzafumo, Stefano Salvioli, Antonio Ceriello, Fabiola Olivieri, Roberto Festa, Antonio Domenico Procopio, Gabriele Brandoni, Massimo Boemi, Maurizio Marra, Claudio Francesch. The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study. Acta diabetologica. vol 50. issue 3. 2013-10-29. PMID:23269546. |
tumor suppressor protein p53 has been demonstrated to regulate genes involved in energy generating metabolic pathways and apoptosis. |
2013-10-29 |
2023-08-12 |
human |
| Hui Jin, Lei Liang, Lifeng Liu, Weiping Deng, Jianwen Li. HDAC inhibitor DWP0016 activates p53 transcription and acetylation to inhibit cell growth in U251 glioblastoma cells. Journal of cellular biochemistry. vol 114. issue 7. 2013-10-29. PMID:23297003. |
besides, sirna assay indicated p53 was the key gene to induce growth inhibition, cell cycle arrest, and apoptosis in dwp0016 treated u251 cells. |
2013-10-29 |
2023-08-12 |
Not clear |
| Xiaogang Peng, Jianghua Shao, Yang Shen, Yunguo Zhou, Qing Cao, Jinzhu Hu, Wenfeng He, Xin Yu, Xiuxia Liu, Ali J Marian, Kui Hon. FAT10 protects cardiac myocytes against apoptosis. Journal of molecular and cellular cardiology. vol 59. 2013-10-29. PMID:23416168. |
the anti-apoptotic effects of fat10 are associated with suppression of p53, probably through fatylation and proteasomal degradation, reduced mir-34a expression, and a shift in the bcl2/bax proteins against apoptosis. |
2013-10-29 |
2023-08-12 |
human |
| Kyongshin Cho, Lawrence Mabasa, Mark W Walters, Chung S Par. Lipotropes enhance the anti-proliferative effect of chemotherapeutic drugs in MCF-7 human breast cancer cells. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23588242. |
lipotropes significantly reduced the growth of mcf-7 cells and increased apoptosis as well as upregulation of caspase-3 and tumor protein 53 (p53) enzyme activities. |
2013-10-29 |
2023-08-12 |
human |
| Jianrong Lu, Feng Zhang, Yong Yuan, Caixia Ding, Liying Zhang, Qing L. All-trans retinoic acid upregulates the expression of p53 via Axin and inhibits the proliferation of glioma cells. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23588680. |
in the present study, we demonstrated that atra activated the expression of p53 via axin and induced cell cycle arrest at the g1/s phase and apoptosis of glioma cells. |
2013-10-29 |
2023-08-12 |
Not clear |
| Jianrong Lu, Feng Zhang, Yong Yuan, Caixia Ding, Liying Zhang, Qing L. All-trans retinoic acid upregulates the expression of p53 via Axin and inhibits the proliferation of glioma cells. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23588680. |
in addition, ectopic expression of axin by transient transfection of c6 cells with raxin revealed that overexpression of axin induced cell cycle arrest and apoptosis with an upregulation of p53. |
2013-10-29 |
2023-08-12 |
Not clear |
| Jianrong Lu, Feng Zhang, Yong Yuan, Caixia Ding, Liying Zhang, Qing L. All-trans retinoic acid upregulates the expression of p53 via Axin and inhibits the proliferation of glioma cells. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23588680. |
furthermore, loss-of-function of axin in glioma cells by rnai blocked atra-induced cell cycle phase arrest and apoptosis via downregulation of p53. |
2013-10-29 |
2023-08-12 |
Not clear |
| Guofu Chen, Haihe Wang, Shuli Xie, Jian Ma, Guangyi Wan. STAT1 negatively regulates hepatocellular carcinoma cell proliferation. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23588992. |
induction of stat1 overexpression significantly inhibited hepg2 cell proliferation and enhanced hcc cell apoptosis, accompanied by upregulation of p53 expression and stat1 phosphorylation, but a reduction in cyclin e expression in hepg2 cells. |
2013-10-29 |
2023-08-12 |
human |
| Guofu Chen, Haihe Wang, Shuli Xie, Jian Ma, Guangyi Wan. STAT1 negatively regulates hepatocellular carcinoma cell proliferation. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23588992. |
in contrast, knockdown of stat1 by introduction of stat1-specific sirna promoted hepg2 cell proliferation, but inhibited hcc cell apoptosis, accompanied by significant downregulation of p53 expression, but enhancement of cyclin e expression in vitro. |
2013-10-29 |
2023-08-12 |
human |
| Kengo Kuroda, Tomokazu Fukuda, Kazuhiko Okumura, Hiroshi Yoneyama, Hiroshi Isogai, Paul B Savage, Emiko Isoga. Ceragenin CSA-13 induces cell cycle arrest and antiproliferative effects in wild-type and p53 null mutant HCT116 colon cancer cells. Anti-cancer drugs. vol 24. issue 8. 2013-10-29. PMID:23817390. |
treatment with csa-13 suppressed hct116 cell proliferation in a dose-dependent manner, increasing the incidence of apoptosis detected by the binding of annexin v. furthermore, cell cycle analysis showed that the cell cycle of csa-13-treated wild-type and p53 null mutant hct116 cells was arrested at the g1/s phase, indicating that csa-13 affects the cell cycle by a p53-independent pathway. |
2013-10-29 |
2023-08-12 |
Not clear |
| Zhidan Xia, Xiangjun Tong, Fang Liang, Yihan Zhang, Chikin Kuok, Yingla Zhang, Xinxing Liu, Zuoyan Zhu, Shuo Lin, Bo Zhan. Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish. Developmental biology. vol 381. issue 1. 2013-10-28. PMID:23791820. |
in addition, p53 was markedly up-regulated in the eif3ba mutant embryos, which correlated with pronounced apoptosis in the cranial area as shown by tunel staining. |
2013-10-28 |
2023-08-12 |
zebrafish |
| Miklos Jaszberenyi, Andrew V Schally, Norman L Block, Mehrdad Nadji, Irving Vidaurre, Luca Szalontay, Ferenc G Ric. Inhibition of U-87 MG glioblastoma by AN-152 (AEZS-108), a targeted cytotoxic analog of luteinizing hormone-releasing hormone. Oncotarget. vol 4. issue 3. 2013-10-25. PMID:23518876. |
genomic (rt-pcr) and proteomic (elisa, western blot) studies revealed that an-152 activated apoptosis, as reflected by the changes in p53 and its regulators and substrates, inhibited cell growth, and elicited changes in intermediary filament pattern. |
2013-10-25 |
2023-08-12 |
mouse |
| Dulce Cunha, Rita Cunha, Manuela Côrte-Real, Susana R Chave. Cisplatin-induced cell death in Saccharomyces cerevisiae is programmed and rescued by proteasome inhibition. DNA repair. vol 12. issue 6. 2013-10-25. PMID:23602516. |
however, cisplatin-induced apoptosis can also occur in p53 deficient cells; thus, elucidation of the molecular mechanism involved will potentially yield new strategies to eliminate tumors that have defects in the p53 pathway. |
2013-10-25 |
2023-08-12 |
Not clear |
| Weiwei Liu, Wuxiyar Otkur, Yuning Zhang, Qiuyuan Li, Yuanchao Ye, Linghe Zang, Hao He, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejim. Silibinin protects murine fibroblast L929 cells from UVB-induced apoptosis through the simultaneous inhibition of ATM-p53 pathway and autophagy. The FEBS journal. vol 280. issue 18. 2013-10-25. PMID:23829351. |
ataxia-telangiectasia-mutated (atm) protein and p53 were activated to cause cell apoptosis, accompanying upregulation of the autophagic flux. |
2013-10-25 |
2023-08-12 |
mouse |
| Weiwei Liu, Wuxiyar Otkur, Yuning Zhang, Qiuyuan Li, Yuanchao Ye, Linghe Zang, Hao He, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejim. Silibinin protects murine fibroblast L929 cells from UVB-induced apoptosis through the simultaneous inhibition of ATM-p53 pathway and autophagy. The FEBS journal. vol 280. issue 18. 2013-10-25. PMID:23829351. |
the pharmacological inhibition of atm, p53 and autophagy or the transfection with autophagy-associated protein-targeted small interfering rnas showed that the uvb-activated atm-p53 axis and autophagy formed a positive feedback loop, which synergistically promoted cell apoptosis. |
2013-10-25 |
2023-08-12 |
mouse |