| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Jeong Kim, Eun Byul Jung, Seong Jun Seo, Kwan Hee Park, Min Won Lee, Chung Soo Le. Quercetin-3-O-(2"-galloyl)-α-l-rhamnopyranoside prevents TRAIL-induced apoptosis in human keratinocytes by suppressing the caspase-8- and Bid-pathways and the mitochondrial pathway. Chemico-biological interactions. vol 204. issue 3. 2013-10-17. PMID:23711929. |
trail triggers apoptosis by inducing a decrease in bid, bcl-2, bcl-xl and survivin protein levels, increase in bax and vdac1 levels, loss of the mitochondrial transmembrane potential, release of cytochrome c, activation of caspases (-8, -9 and -3), cleavage of parp-1, and an increase in the tumor suppressor p53 levels. |
2013-10-17 |
2023-08-12 |
human |
| Robert Domitrović, Olga Cvijanović, Ester Pernjak Pugel, Gordana Blagojević Zagorac, Hana Mahmutefendić, Marko Škod. Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney. Toxicology. vol 310. 2013-10-17. PMID:23770416. |
simultaneously, the increase in renal p53 and caspase-3 expression indicated apoptosis of tubular cells. |
2013-10-17 |
2023-08-12 |
mouse |
| Shang-ze Li, Hui-hui Zhang, Jia-nong Zhang, Ze-yan Zhang, Xiao-fei Zhang, Xiao-dong Zhang, Run-lei D. ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. Biochemical and biophysical research communications. vol 437. issue 2. 2013-10-17. PMID:23831472. |
to explore the role of alln against colon cancer and in promoting apoptosis, we used colon cancer hct116 cell lines, p53 or bax-deficient hct116 cell lines. |
2013-10-17 |
2023-08-12 |
mouse |
| Gonzalo I Cancino, Adelaide P Yiu, Michael P Fatt, Chandrasagar B Dugani, Elsa R Flores, Paul W Frankland, Sheena A Josselyn, Freda D Miller, David R Kapla. p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 31. 2013-10-17. PMID:23904595. |
these reductions were attributable to enhanced apoptosis of npcs and newborn neurons and were rescued by inhibition of caspase activity, p53, or the p53 apoptotic effector puma (p53-upregulated modulator of apoptosis). |
2013-10-17 |
2023-08-12 |
mouse |
| Xiao-Hong Zhang, Nan Zhang, Jian-Mei Lu, Qing-Zhong Kong, Yun-Feng Zha. Tetrazolium violet induced apoptosis and cell cycle arrest in human lung cancer a549 cells. Biomolecules & therapeutics. vol 20. issue 2. 2013-10-11. PMID:24116292. |
the conclusion of this study is that tetrazolium violet induced p53 expression which caused cell cycle arrest and apoptosis. |
2013-10-11 |
2023-08-12 |
human |
| Sylvie Bourthoumieu, Amandine Magnaudeix, Faraj Terro, Philippe Leveque, Alice Collin, Catherine Yardi. Study of p53 expression and post-transcriptional modifications after GSM-900 radiofrequency exposure of human amniotic cells. Bioelectromagnetics. vol 34. issue 1. 2013-10-01. PMID:22767080. |
in response to genetic damage, the p53 protein is activated and can induce cell cycle arrest allowing more time for dna repair or elimination of damaged cells through apoptosis. |
2013-10-01 |
2023-08-12 |
human |
| Haifeng Wang, Wujiang Liu, Jie Jin, Liqun Zhou, Lili Liang, Yinglu Gu. M-ds-P21 induces cell apoptosis in bladder cancer T24 cells through P53 independent pathway. Journal of cancer research and therapeutics. vol 9. issue 1. 2013-10-01. PMID:23575075. |
m-ds-p21 induces cell apoptosis in bladder cancer t24 cells through p53 independent pathway. |
2013-10-01 |
2023-08-12 |
Not clear |
| Q H Du, K J Zhang, X L Jiao, J Zhao, M Zhang, B M Yan, Y B X. Prognostic significance of PUMA in pancreatic ductal adenocarcinoma. The Journal of international medical research. vol 40. issue 6. 2013-09-30. PMID:23321162. |
to investigate retrospectively whether alterations of p53 upregulated mediator of apoptosis (puma) protein levels and somatic mutations of the puma gene are characteristic of pancreatic ductal adenocarcinoma (pdac). |
2013-09-30 |
2023-08-12 |
Not clear |
| Y-C Chen, J Y-H Chan, Y-L Chiu, S-T Liu, G Lozano, S-L Wang, C-L Ho, S-M Huan. Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis. Cell death and differentiation. vol 20. issue 5. 2013-09-30. PMID:23370271. |
the transcription factor p53 is a multifunctional tumor suppressor that arrests the cell cycle in response to stress and modulates the dna repair process or induces apoptosis. |
2013-09-30 |
2023-08-12 |
Not clear |
| Y-C Chen, J Y-H Chan, Y-L Chiu, S-T Liu, G Lozano, S-L Wang, C-L Ho, S-M Huan. Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis. Cell death and differentiation. vol 20. issue 5. 2013-09-30. PMID:23370271. |
grail also senses and regulates cellular p53 levels, modulates a panel of p53-targeted promoters, and has a role in p53-induced apoptosis in cultured cells. |
2013-09-30 |
2023-08-12 |
Not clear |
| Y-C Chen, J Y-H Chan, Y-L Chiu, S-T Liu, G Lozano, S-L Wang, C-L Ho, S-M Huan. Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis. Cell death and differentiation. vol 20. issue 5. 2013-09-30. PMID:23370271. |
overexpression of grail inhibited p53-induced apoptosis by increasing p53 degradation. |
2013-09-30 |
2023-08-12 |
Not clear |
| Jee-Eun Kim, Dong-Hoon Jin, Wang Jae Lee, Daeyoung Hur, T-C Wu, Daejin Ki. Bortezomib enhances antigen-specific cytotoxic T cell responses against immune-resistant cancer cells generated by STAT3-ablated dendritic cells. Pharmacological research. vol 71. 2013-09-30. PMID:23428347. |
we found that apoptosis via down-regulation of stat3 and nf-κb and up-regulation of fas and death receptor 5 (dr5) expression in tc-1(p3) induced by bortezomib was independent of p53 status. |
2013-09-30 |
2023-08-12 |
mouse |
| Bairbre A McNicholas, Matthew D Griffi. Double-edged sword: a p53 regulator mediates both harmful and beneficial effects in experimental acute kidney injury. Kidney international. vol 81. issue 12. 2013-09-27. PMID:22648356. |
their results indicate that mdm2 promotes renal regeneration by limiting p53-mediated apoptosis but also enhances early inflammation by facilitating dna binding of nuclear factor-κb independently of p53. |
2013-09-27 |
2023-08-12 |
mouse |
| Justin A Freeman, Joaquin M Espinos. The impact of post-transcriptional regulation in the p53 network. Briefings in functional genomics. vol 12. issue 1. 2013-09-26. PMID:23242178. |
the p53 transcription factor regulates the synthesis of mrnas encoding proteins involved in diverse cellular stress responses such as cell-cycle arrest, apoptosis, autophagy and senescence. |
2013-09-26 |
2023-08-12 |
Not clear |
| X Yulin, L Lizhen, Z Lifei, F Shan, L Ru, H Kaimin, H Huan. Efficient generation of induced pluripotent stem cells from human bone marrow mesenchymal stem cells. Folia biologica. vol 58. issue 6. 2013-09-26. PMID:23438847. |
p53 sirna, vpa and vc had a synergetic effect on cell reprogramming and the combinatorial use of these substances greatly improved the efficiency of ipsc generation by suppressing the expression of p53, decreasing cell apoptosis, up-regulating the expression of the pluripotent gene oct4 and modifying the cell cycle. |
2013-09-26 |
2023-08-12 |
human |
| Bryant England, Tiangui Huang, Michael Kars. Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 4. 2013-09-26. PMID:23737287. |
various roles of p53 that protect against neoplastic transformation include modulation of cell cycle, dna repair, apoptosis, senescence, angiogenesis, and metabolism, resulting in an extremely complex signaling network. |
2013-09-26 |
2023-08-12 |
mouse |
| Krishnaveni Mohareer, Sudhir Sahdev, Seyed E Hasnai. Spodoptera frugiperda FKBP-46 is a consensus p53 motif binding protein. Journal of cellular biochemistry. vol 114. issue 4. 2013-09-25. PMID:23097306. |
p53 protein, the central molecule of the apoptosis pathway, is mutated in 50% of the human cancers. |
2013-09-25 |
2023-08-12 |
human |
| Krishnaveni Mohareer, Sudhir Sahdev, Seyed E Hasnai. Spodoptera frugiperda FKBP-46 is a consensus p53 motif binding protein. Journal of cellular biochemistry. vol 114. issue 4. 2013-09-25. PMID:23097306. |
identification of fkbp-46 as a novel p53 motif-binding protein in insect cells adds a new facet to our understanding of the mechanisms of apoptosis under oxidative stress in the absence of a typical p53 homologue. |
2013-09-25 |
2023-08-12 |
human |
| Yong Huang, Li Ding, Zhaocai Li, Meiling Dai, Xiaomin Zhao, Wei Li, Qian Du, Xingang Xu, Dewen Ton. Transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signalling. The Journal of general virology. vol 94. issue Pt 8. 2013-09-24. PMID:23677787. |
transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signalling. |
2013-09-24 |
2023-08-12 |
Not clear |
| Yong Huang, Li Ding, Zhaocai Li, Meiling Dai, Xiaomin Zhao, Wei Li, Qian Du, Xingang Xu, Dewen Ton. Transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signalling. The Journal of general virology. vol 94. issue Pt 8. 2013-09-24. PMID:23677787. |
blocking of p53 activation significantly inhibited the occurrence of apoptosis through suppressing the tgev-induced fasl expression, bcl-2 reduction, bax and cytochrome c redistribution, while inhibition of p38 activity moderately blocked apoptosis induction and partly attenuated the accumulation and activation of p53. |
2013-09-24 |
2023-08-12 |
Not clear |