| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jae Hyeong Kim, Eun-Kyung Yoon, Hye-Jin Chung, Seong-Yeol Park, Kyeong-Man Hong, Chang-Hun Lee, Yeon-Su Lee, Kyungho Choi, Young Yang, Kyungtae Kim, In-Hoo Ki. p53 acetylation enhances Taxol-induced apoptosis in human cancer cells. Apoptosis : an international journal on programmed cell death. vol 18. issue 1. 2013-10-21. PMID:23161364. |
p53 acetylation enhances taxol-induced apoptosis in human cancer cells. |
2013-10-21 |
2023-08-12 |
human |
| Jae Hyeong Kim, Eun-Kyung Yoon, Hye-Jin Chung, Seong-Yeol Park, Kyeong-Man Hong, Chang-Hun Lee, Yeon-Su Lee, Kyungho Choi, Young Yang, Kyungtae Kim, In-Hoo Ki. p53 acetylation enhances Taxol-induced apoptosis in human cancer cells. Apoptosis : an international journal on programmed cell death. vol 18. issue 1. 2013-10-21. PMID:23161364. |
here we investigated the function of p53 in taxol-induced apoptosis using p53 wild type and p53 null cancer cell lines. |
2013-10-21 |
2023-08-12 |
human |
| Jae Hyeong Kim, Eun-Kyung Yoon, Hye-Jin Chung, Seong-Yeol Park, Kyeong-Man Hong, Chang-Hun Lee, Yeon-Su Lee, Kyungho Choi, Young Yang, Kyungtae Kim, In-Hoo Ki. p53 acetylation enhances Taxol-induced apoptosis in human cancer cells. Apoptosis : an international journal on programmed cell death. vol 18. issue 1. 2013-10-21. PMID:23161364. |
p53 was upregulated upon taxol treatment in p53 wild type cells and deletion of p53 diminished taxol-induced apoptosis. |
2013-10-21 |
2023-08-12 |
human |
| Jae Hyeong Kim, Eun-Kyung Yoon, Hye-Jin Chung, Seong-Yeol Park, Kyeong-Man Hong, Chang-Hun Lee, Yeon-Su Lee, Kyungho Choi, Young Yang, Kyungtae Kim, In-Hoo Ki. p53 acetylation enhances Taxol-induced apoptosis in human cancer cells. Apoptosis : an international journal on programmed cell death. vol 18. issue 1. 2013-10-21. PMID:23161364. |
conversely, when the wild type p53 was re-introduced into two different p53 null cancer cell lines, taxol-induced apoptosis was enhanced. |
2013-10-21 |
2023-08-12 |
human |
| Jae Hyeong Kim, Eun-Kyung Yoon, Hye-Jin Chung, Seong-Yeol Park, Kyeong-Man Hong, Chang-Hun Lee, Yeon-Su Lee, Kyungho Choi, Young Yang, Kyungtae Kim, In-Hoo Ki. p53 acetylation enhances Taxol-induced apoptosis in human cancer cells. Apoptosis : an international journal on programmed cell death. vol 18. issue 1. 2013-10-21. PMID:23161364. |
when acetylation was enhanced by anti-sirt1 sirna or an hdac inhibitor, taxol-induced apoptosis was enhanced, which was not observed in p53 null cells. |
2013-10-21 |
2023-08-12 |
human |
| Jae Hyeong Kim, Eun-Kyung Yoon, Hye-Jin Chung, Seong-Yeol Park, Kyeong-Man Hong, Chang-Hun Lee, Yeon-Su Lee, Kyungho Choi, Young Yang, Kyungtae Kim, In-Hoo Ki. p53 acetylation enhances Taxol-induced apoptosis in human cancer cells. Apoptosis : an international journal on programmed cell death. vol 18. issue 1. 2013-10-21. PMID:23161364. |
when an acetylation-defective mutant of p53 was re-introduced to p53 null cells, apoptosis was partially reduced compared to the re-introduction of the wild type p53. |
2013-10-21 |
2023-08-12 |
human |
| Jae Hyeong Kim, Eun-Kyung Yoon, Hye-Jin Chung, Seong-Yeol Park, Kyeong-Man Hong, Chang-Hun Lee, Yeon-Su Lee, Kyungho Choi, Young Yang, Kyungtae Kim, In-Hoo Ki. p53 acetylation enhances Taxol-induced apoptosis in human cancer cells. Apoptosis : an international journal on programmed cell death. vol 18. issue 1. 2013-10-21. PMID:23161364. |
thus, p53 plays a pro-apoptotic role in taxol-induced apoptosis and acetylation of p53 contributes to this pro-apoptotic function in response to taxol in several human cancer cell lines, suggesting that enhancing acetylation of p53 could have potential implication for increasing the sensitivity of cancer cells to taxol. |
2013-10-21 |
2023-08-12 |
human |
| Muneeb U Rehman, Mir Tahir, Abdul Quaiyoom Khan, Rehan Khan, Abdul Lateef, Oday O Hamiza, Farrah Ali, Sarwat Sultan. Diosmin protects against trichloroethylene-induced renal injury in Wistar rats: plausible role of p53, Bax and caspases. The British journal of nutrition. vol 110. issue 4. 2013-10-21. PMID:23402272. |
the animals in groups ii and iii received an oral treatment of dm at doses of 20 and 40 mg/kg body weight, respectively, for twenty consecutive days, while groups i and v were given maize oil (5 ml/kg body weight and dm 40 mg/kg body weight, respectively) for 20 d. the protective effects of dm on tce-induced oxidative stress and caspase-dependent apoptosis were investigated by assaying oxidative stress biomarkers, lipid peroxidation (lpo), serum toxicity markers, alkaline unwinding assay, caspase-3, -7 and -9, bax and p53 expression. |
2013-10-21 |
2023-08-12 |
rat |
| Eun Young Won, Yong Xie, Chie Takemoto, Lirong Chen, Zhi Jie Liu, Bi Cheng Wang, Daeyoup Lee, Eui Jeon Woo, Sung Goo Park, Mikako Shirouzu, Shigeyuki Yokoyama, Seung Jun Kim, Seung Wook Ch. High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26. Acta crystallographica. Section D, Biological crystallography. vol 69. issue Pt 6. 2013-10-21. PMID:23695260. |
human dusp26 inhibits the apoptosis of cancer cells by dephosphorylating substrates such as p38 and p53. |
2013-10-21 |
2023-08-12 |
human |
| Hee-Jin Ahn, Gwangil Kim, Kyung-Soon Par. Ell3 stimulates proliferation, drug resistance, and cancer stem cell properties of breast cancer cells via a MEK/ERK-dependent signaling pathway. Biochemical and biophysical research communications. vol 437. issue 4. 2013-10-21. PMID:23850691. |
recent studies in our laboratory showed that ell3 induces the differentiation of mouse embryonic stem cells by protecting differentiating cells from apoptosis via the promotion of p53 degradation. |
2013-10-21 |
2023-08-12 |
mouse |
| Young Cha, Dae-Kwan Kim, Jashil Hyun, Seong-Jin Kim, Kyung-Soon Par. TCEA3 binds to TGF-beta receptor I and induces Smad-independent, JNK-dependent apoptosis in ovarian cancer cells. Cellular signalling. vol 25. issue 5. 2013-10-18. PMID:23357533. |
recently, knockdown of tcea1, the most well-characterized isoform of tfiis, by rna silencing was reported to inhibit cancer cell proliferation and induce apoptosis in breast, lung and pancreatic cancer cell lines through activation of p53 (hubbard et al., 2008 [1]). |
2013-10-18 |
2023-08-12 |
mouse |
| Yimiao Xu, Ying Diao, Shimei Qi, Xiaolong Pan, Qi Wang, Yinqiang Xin, Xiang Cao, Jie Ruan, Zhihui Zhao, Lan Luo, Chang Liu, Zhimin Yi. Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis. Cellular signalling. vol 25. issue 5. 2013-10-18. PMID:23357534. |
phosphorylated hsp27 activates atm-dependent p53 signaling and mediates the resistance of mcf-7 cells to doxorubicin-induced apoptosis. |
2013-10-18 |
2023-08-12 |
human |
| Yimiao Xu, Ying Diao, Shimei Qi, Xiaolong Pan, Qi Wang, Yinqiang Xin, Xiang Cao, Jie Ruan, Zhihui Zhao, Lan Luo, Chang Liu, Zhimin Yi. Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis. Cellular signalling. vol 25. issue 5. 2013-10-18. PMID:23357534. |
dna damage activates p53 and its downstream target genes, which further leads to apoptosis or survival either by the cell cycle arrest or by dna repair. |
2013-10-18 |
2023-08-12 |
human |
| Yimiao Xu, Ying Diao, Shimei Qi, Xiaolong Pan, Qi Wang, Yinqiang Xin, Xiang Cao, Jie Ruan, Zhihui Zhao, Lan Luo, Chang Liu, Zhimin Yi. Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis. Cellular signalling. vol 25. issue 5. 2013-10-18. PMID:23357534. |
in contrast, inhibition of hsp27 phosphorylation retarded both p53 induction and p21 accumulation, and led to cell apoptosis. |
2013-10-18 |
2023-08-12 |
human |
| Sandy Wan-Heng Hoi, Hoi Ming Wong, Judy Yuet-Wa Chan, Grace Gar Lee Yue, Gary Man-Kit Tse, Bonita Ka-Bo Law, Wing Ping Fong, Kwok Pui Fun. Photodynamic therapy of Pheophorbide a inhibits the proliferation of human breast tumour via both caspase-dependent and -independent apoptotic pathways in in vitro and in vivo models. Phytotherapy research : PTR. vol 26. issue 5. 2013-10-17. PMID:22072524. |
up-regulation of tumour suppressor protein p53, cleavage of caspase-9 and poly (adp-ribose) polymerase suggested that the caspase-dependent pathway was induced, while the release of apoptosis-inducing factors demonstrated that the apoptosis was also mediated by the caspase-independent mechanism. |
2013-10-17 |
2023-08-12 |
mouse |
| Joe Hasei, Tsuyoshi Sasaki, Hiroshi Tazawa, Shuhei Osaki, Yasuaki Yamakawa, Toshiyuki Kunisada, Aki Yoshida, Yuuri Hashimoto, Teppei Onishi, Futoshi Uno, Shunsuke Kagawa, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwar. Dual programmed cell death pathways induced by p53 transactivation overcome resistance to oncolytic adenovirus in human osteosarcoma cells. Molecular cancer therapeutics. vol 12. issue 3. 2013-10-17. PMID:23315976. |
tumor suppressor p53 is a multifunctional transcription factor that regulates diverse cell fates, including apoptosis and autophagy in tumor biology. |
2013-10-17 |
2023-08-12 |
human |
| Hu Peng, Huanhai Liu, Shuwei Zhao, Jian Wu, Jingping Fan, Jianchun Lia. Silencing of RASSF3 by DNA hypermethylation is associated with tumorigenesis in somatotroph adenomas. PloS one. vol 8. issue 3. 2013-10-17. PMID:23555615. |
rassf3 overexpression in gh3 and gt1.1 cells inhibited proliferation, induced apoptosis accompanied by increased bax, p53, and caspase-3 protein and decreased bcl-2 protein expression. |
2013-10-17 |
2023-08-12 |
mouse |
| Hu Peng, Huanhai Liu, Shuwei Zhao, Jian Wu, Jingping Fan, Jianchun Lia. Silencing of RASSF3 by DNA hypermethylation is associated with tumorigenesis in somatotroph adenomas. PloS one. vol 8. issue 3. 2013-10-17. PMID:23555615. |
we also found that the antitumor effect of rassf3 was p53 dependent, and p53 knockdown blocked rassf3-induced apoptosis and growth inhibition. |
2013-10-17 |
2023-08-12 |
mouse |
| Partab Rai, Andrei Plagov, Xiqian Lan, Nirupama Chandel, Tejinder Singh, Rivka Lederman, Kamesh R Ayasolla, Peter W Mathieson, Moin A Saleem, Mohammad Husain, Ashwani Malhotra, Praveen N Chander, Pravin C Singha. mTOR plays a critical role in p53-induced oxidative kidney cell injury in HIVAN. American journal of physiology. Renal physiology. vol 305. issue 3. 2013-10-17. PMID:23678040. |
since hp/hiv silenced for mtor displayed a lack of expression of p53 as well as attenuated podocyte apoptosis, this suggests that mtor is critical for kidney cell p53 activation and associated oxidative kidney cell injury in the hiv milieu. |
2013-10-17 |
2023-08-12 |
mouse |
| Jiang Cao, Li Li, Chong Chen, Chao Lv, Fanjing Meng, Lingyu Zeng, Zhenyu Li, Qingyun Wu, Kai Zhao, Bin Pan, Hai Cheng, Wei Chen, Kailin X. RNA interference-mediated silencing of NANOG leads to reduced proliferation and self-renewal, cell cycle arrest and apoptosis in T-cell acute lymphoblastic leukemia cells via the p53 signaling pathway. Leukemia research. vol 37. issue 9. 2013-10-17. PMID:23683786. |
rna interference-mediated silencing of nanog leads to reduced proliferation and self-renewal, cell cycle arrest and apoptosis in t-cell acute lymphoblastic leukemia cells via the p53 signaling pathway. |
2013-10-17 |
2023-08-12 |
human |