| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claudia Fiorini, Marta Menegazzi, Chiara Padroni, Ilaria Dando, Elisa Dalla Pozza, Alex Gregorelli, Chiara Costanzo, Marta Palmieri, Massimo Donadell. Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis. Apoptosis : an international journal on programmed cell death. vol 18. issue 3. 2013-11-06. PMID:23238993. |
here, we show that two of these compounds, cp-31398 and rita, induce cell growth inhibition, apoptosis, and autophagy by activating p53/dna binding and p53 phosphorylation (ser15), without affecting the total p53 amount. |
2013-11-06 |
2023-08-12 |
human |
| Yazhen Huo, Lihong Fan, Shutao Yin, Yinhui Dong, Xiao Guo, Hanchun Yang, Hongbo H. Involvement of unfolded protein response, p53 and Akt in modulation of porcine reproductive and respiratory syndrome virus-mediated JNK activation. Virology. vol 444. issue 1-2. 2013-11-06. PMID:23850458. |
we also found that p53 and akt were activated at the early stage of infection and functioned as negative regulator of jnk activation to counteract the prrsv-mediated apoptosis. |
2013-11-06 |
2023-08-12 |
Not clear |
| Yazhen Huo, Lihong Fan, Shutao Yin, Yinhui Dong, Xiao Guo, Hanchun Yang, Hongbo H. Involvement of unfolded protein response, p53 and Akt in modulation of porcine reproductive and respiratory syndrome virus-mediated JNK activation. Virology. vol 444. issue 1-2. 2013-11-06. PMID:23850458. |
furthermore, induction of upr, p53 and akt was not only involved in modulation of prrsv-mediated apoptosis, but also contributed to the virus replication. |
2013-11-06 |
2023-08-12 |
Not clear |
| Pierre-Jacques Hamard, Nicolas Barthelery, Brandon Hogstad, Sathish Kumar Mungamuri, Crystal A Tonnessen, Luis A Carvajal, Emir Senturk, Virginia Gillespie, Stuart A Aaronson, Miriam Merad, James J Manfred. The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo. Genes & development. vol 27. issue 17. 2013-11-06. PMID:24013501. |
here, the hyperactive p53(Δctd) induces apoptosis via enhanced expression of the proapoptotic bbc3 (puma) and pmaip1 (noxa). |
2013-11-06 |
2023-08-12 |
mouse |
| Vaiyapuri S Periasamy, Ali A Alshatw. Tea polyphenols modulate antioxidant redox system on cisplatin-induced reactive oxygen species generation in a human breast cancer cell. Basic & clinical pharmacology & toxicology. vol 112. issue 6. 2013-11-05. PMID:23145928. |
the effect of tpp on cell growth, intracellular reactive oxygen species (ros) level, apoptosis and gene expression of caspase-3, caspase-8 and caspase-9 and p53 was investigated. |
2013-11-05 |
2023-08-12 |
human |
| Vaiyapuri S Periasamy, Ali A Alshatw. Tea polyphenols modulate antioxidant redox system on cisplatin-induced reactive oxygen species generation in a human breast cancer cell. Basic & clinical pharmacology & toxicology. vol 112. issue 6. 2013-11-05. PMID:23145928. |
the combined tpp and cp treatment synergistically induced apoptosis through both caspase-8 and caspase-9 activation and p53 over-expression. |
2013-11-05 |
2023-08-12 |
human |
| D Li, Y Zhang, Y Xie, J Xiang, Y Zhu, J Yan. Enhanced tumor suppression by adenoviral PTEN gene therapy combined with cisplatin chemotherapy in small-cell lung cancer. Cancer gene therapy. vol 20. issue 4. 2013-11-05. PMID:23470565. |
the enhanced therapeutic efficacy elicited by advpten plus ddp was closely associated with additive induction of g1 phase arrest and apoptosis via substantially modulating cell-cycle regulation molecules and activating intrinsic apoptotic pathway through p53 restoration, and overlapping inhibition of tumor angiogenesis. |
2013-11-05 |
2023-08-12 |
mouse |
| Catherine A Taylor, Qifa Zheng, Zhongda Liu, John E Thompso. Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cells. Molecular cancer. vol 12. 2013-11-05. PMID:23638878. |
role of p38 and jnk mapk signaling pathways and tumor suppressor p53 on induction of apoptosis in response to ad-eif5a1 in a549 lung cancer cells. |
2013-11-05 |
2023-08-12 |
Not clear |
| Tobias Hohenauer, Carola Berking, Andreas Schmidt, Sebastian Haferkamp, Daniela Senft, Claudia Kammerbauer, Sabine Fraschka, Saskia Anna Graf, Martin Irmler, Johannes Beckers, Michael Flaig, Achim Aigner, Sabrina Höbel, Franziska Hoffmann, Heiko Hermeking, Simon Rothenfusser, Stefan Endres, Thomas Ruzicka, Robert Besc. The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival. EMBO molecular medicine. vol 5. issue 6. 2013-11-05. PMID:23666755. |
activated dna damage signalling caused stabilization of the tumour suppressor p53, which resulted in cell cycle arrest and apoptosis. |
2013-11-05 |
2023-08-12 |
Not clear |
| Juqiang Han, Xiaojie Xu, Hongzhen Qin, Anheng Liu, Zhongyi Fan, Lei Kang, Jing Fu, Jiahong Liu, Qinong Y. The molecular mechanism and potential role of heat shock-induced p53 protein accumulation. Molecular and cellular biochemistry. vol 378. issue 1-2. 2013-11-04. PMID:23456460. |
although heat stress has been shown to induce the accumulation of p53 protein, a key regulator of cell cycle, apoptosis, dna repair, and autophagy, how it regulates p53 protein accumulation and what the p53 targets are remain unclear. |
2013-11-04 |
2023-08-12 |
Not clear |
| Swetha Inturi, Neera Tewari-Singh, Anil K Jain, Srirupa Roy, Carl W White, Rajesh Agarwa. Absence of a p53 allele delays nitrogen mustard-induced early apoptosis and inflammation of murine skin. Toxicology. vol 311. issue 3. 2013-11-04. PMID:23845566. |
absence of a p53 allele delays nitrogen mustard-induced early apoptosis and inflammation of murine skin. |
2013-11-04 |
2023-08-12 |
mouse |
| Swetha Inturi, Neera Tewari-Singh, Anil K Jain, Srirupa Roy, Carl W White, Rajesh Agarwa. Absence of a p53 allele delays nitrogen mustard-induced early apoptosis and inflammation of murine skin. Toxicology. vol 311. issue 3. 2013-11-04. PMID:23845566. |
transcription factor p53 plays a critical role in dna damage by regulating cell cycle progression and apoptosis. |
2013-11-04 |
2023-08-12 |
mouse |
| Bo S Kim, Leonid Serebreni, Omar Hamdan, Lan Wang, Ahmad Parniani, Thomas Sussan, R Scott Stephens, Laurent Boyer, Mahendra Damarla, Paul M Hassoun, Rachel Damic. Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis. Free radical biology & medicine. vol 60. 2013-11-01. PMID:23380026. |
in addition, we demonstrate that primary pulmonary human lung microvascular endothelial cells exposed to cigarette smoke extract undergo increased rates of caspase-dependent apoptosis that are reliant on xor activity, ros production, and p53 function/expression. |
2013-11-01 |
2023-08-12 |
mouse |
| Bo S Kim, Leonid Serebreni, Omar Hamdan, Lan Wang, Ahmad Parniani, Thomas Sussan, R Scott Stephens, Laurent Boyer, Mahendra Damarla, Paul M Hassoun, Rachel Damic. Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis. Free radical biology & medicine. vol 60. 2013-11-01. PMID:23380026. |
we also demonstrate that exogenous xor is sufficient to increase p53 expression and induce apoptosis, suggesting that xor is an upstream mediator of p53 in cs-induced ec apoptosis. |
2013-11-01 |
2023-08-12 |
mouse |
| Bo S Kim, Leonid Serebreni, Omar Hamdan, Lan Wang, Ahmad Parniani, Thomas Sussan, R Scott Stephens, Laurent Boyer, Mahendra Damarla, Paul M Hassoun, Rachel Damic. Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis. Free radical biology & medicine. vol 60. 2013-11-01. PMID:23380026. |
in conclusion, cs increases xor expression, and the enzyme is both sufficient and necessary for p53 induction and cs-induced ec apoptosis. |
2013-11-01 |
2023-08-12 |
mouse |
| Martine Müller Kloster, Elin Hallan Naderi, Ingvild Haaland, Bjørn Tore Gjertsen, Heidi Kiil Blomhoff, Soheil Nader. cAMP signalling inhibits p53 acetylation and apoptosis via HDAC and SIRT deacetylases. International journal of oncology. vol 42. issue 5. 2013-11-01. PMID:23483263. |
camp signalling inhibits p53 acetylation and apoptosis via hdac and sirt deacetylases. |
2013-11-01 |
2023-08-12 |
Not clear |
| Martine Müller Kloster, Elin Hallan Naderi, Ingvild Haaland, Bjørn Tore Gjertsen, Heidi Kiil Blomhoff, Soheil Nader. cAMP signalling inhibits p53 acetylation and apoptosis via HDAC and SIRT deacetylases. International journal of oncology. vol 42. issue 5. 2013-11-01. PMID:23483263. |
activation of camp signalling potently inhibits dna damage-induced apoptosis in acute lymphoblastic leukemia cells by promoting the turnover of p53 protein. |
2013-11-01 |
2023-08-12 |
Not clear |
| Martine Müller Kloster, Elin Hallan Naderi, Ingvild Haaland, Bjørn Tore Gjertsen, Heidi Kiil Blomhoff, Soheil Nader. cAMP signalling inhibits p53 acetylation and apoptosis via HDAC and SIRT deacetylases. International journal of oncology. vol 42. issue 5. 2013-11-01. PMID:23483263. |
importantly, diminishing the activity of hdacs and sirt1 was also found to reverse the inhibitory effect of camp on the dna damage-induced p53 stabilization and apoptosis, suggesting the involvement of the p53 acetylation pathway in the anti-apoptotic effect of camp signalling. |
2013-11-01 |
2023-08-12 |
Not clear |
| Ruizan Shi, Hongwei Peng, Xiangfei Yuan, Xiuli Zhang, Yanjun Zhang, Dongmei Fan, Xuyi Liu, Dongsheng Xion. Down-regulation of c-fos by shRNA sensitizes adriamycin-resistant MCF-7/ADR cells to chemotherapeutic agents via P-glycoprotein inhibition and apoptosis augmentation. Journal of cellular biochemistry. vol 114. issue 8. 2013-11-01. PMID:23494858. |
further results proved that c-fos down-regulation in mcf-7/adr cells resulted in decreased p-gp expression and activity, enhanced apoptosis, and altered expression of apoptosis-associated proteins (i.e., bax, bcl-2, p53, and puma). |
2013-11-01 |
2023-08-12 |
human |
| Hung-Yun Lin, Dominique Delmas, Ole Vang, Tze-Chen Hsieh, Sharon Lin, Guei-Yun Cheng, Hsiao-Ling Chiang, Chiao En Chen, Heng-Yuan Tang, Dana R Crawford, Jacqueline Whang-Peng, Jaulang Hwang, Leroy F Liu, Joseph M W. Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol. Journal of cellular biochemistry. vol 114. issue 8. 2013-11-01. PMID:23495037. |
exposure to ceramide activates extracellular-signal-regulated kinases (erk)1/2- and p38 kinase-dependent apoptosis in human ovarian cancer ovcar-3 cells, concomitant with an increase in the expression of cox-2 and p53 phosphorylation. |
2013-11-01 |
2023-08-12 |
human |