| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anat Achiron, Roi Mashiach, Rina Zilkha-Falb, Michael M Meijler, Michael Gurevic. Polymerase I pathway inhibitor ameliorates experimental autoimmune encephalomyelitis. Journal of neuroimmunology. vol 263. issue 1-2. 2013-11-25. PMID:23998422. |
the effect of pol1-i treatment was modulated through decreased expression of pol1 pathway key-related genes lrpprc, pre-rna, polr1d and rrn3 together with activation of p53 dependent apoptosis of cd4+ splenocytes. |
2013-11-25 |
2023-08-12 |
mouse |
| Wen-Jun Gu, Hai-Lin Li. Induction of pancreatic cancer cell apoptosis, invasion, migration, and enhancement of chemotherapy sensitivity of gemcitabine, 5-FU, and oxaliplatin by hnRNP A2/B1 siRNA. Anti-cancer drugs. vol 24. issue 6. 2013-11-19. PMID:23525071. |
hnrnp a2/b1 sirna combined with gemcitabine, 5-fu and oxaliplatin significantly increased (p<0.01) apoptosis of pancreatic cancer cell lines sw1990 and bxpc-3, increased the expression level of bax mrna, decreased bcl-2 mrna and mdr1 mrna expression (p<0.01), and induced no change in p53, trail, and survivin mrna expression in sw1990. |
2013-11-19 |
2023-08-12 |
human |
| Jianying Bai, Peiyu Lei, Jidong Zhang, Chunyan Zhao, Ruifeng Lian. Sulfite exposure-induced hepatocyte death is not associated with alterations in p53 protein expression. Toxicology. vol 312. 2013-11-19. PMID:23973939. |
in general, apoptosis that is induced by oxidative stress is triggered by increases in p53 and alterations in mdm2 and bcl-2. |
2013-11-19 |
2023-08-12 |
Not clear |
| Thomas G Hofmann, Carolina Glas, Nadja Bitomsk. HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 35. issue 1. 2013-11-18. PMID:23169233. |
hipk2 is activated by the checkpoint kinase atm, and triggers apoptosis through regulatory phosphorylation of a set of cellular key molecules including the tumour suppressor p53 and the anti-apoptotic corepressor ctbp. |
2013-11-18 |
2023-08-12 |
Not clear |
| Ophélie Meynet, Barbara Zunino, Lina Happo, Ludivine A Pradelli, Johanna Chiche, Marie A Jacquin, Laura Mondragón, Jean-François Tanti, Bruno Taillan, Georges Garnier, Julie Reverso-Meinietti, Nicolas Mounier, Jean-François Michiels, Ewa M Michalak, Michel Carles, Clare L Scott, Jean-Ehrland Ricc. Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice. Blood. vol 122. issue 14. 2013-11-18. PMID:23966420. |
thus, cr can influence mcl-1 expression and sensitize cells to bh3 mimetic-induced apoptosis, independently of the main bh3-only proteins and of p53. |
2013-11-18 |
2023-08-12 |
mouse |
| Hong Shik Yun, Eun-Hee Hong, Su-Jae Lee, Jeong-Hwa Baek, Chang-Woo Lee, Ji-Hye Yim, Hong-Duck Um, Sang-Gu Hwan. Depletion of hepatoma-derived growth factor-related protein-3 induces apoptotic sensitization of radioresistant A549 cells via reactive oxygen species-dependent p53 activation. Biochemical and biophysical research communications. vol 439. issue 3. 2013-11-18. PMID:24012673. |
this increase in apoptosis was associated with a substantial generation of reactive oxygen species (ros) that was attributable to inhibition of the nrf2/ho-1 antioxidant pathway and resulted in enhanced ros-dependent p53 activation and p53-dependent expression of puma (p53 upregulated modulator of apoptosis). |
2013-11-18 |
2023-08-12 |
Not clear |
| Johanna Selvaratnam, Haiyan Guan, James Koropatnick, Kaiping Yan. Metallothionein-I- and -II-deficient mice display increased susceptibility to cadmium-induced fetal growth restriction. American journal of physiology. Endocrinology and metabolism. vol 305. issue 6. 2013-11-15. PMID:23880315. |
although cadmium administration did not result in any visible structural changes in the placenta, increased apoptosis was detected in mt-i/ii(-/-) placentas following cadmium exposure, with a significant increase in levels of both p53 and caspase 3 proteins. |
2013-11-15 |
2023-08-12 |
mouse |
| H-X Yan, H-P Wu, H-L Zhang, C Ashton, C Tong, J Wu, Q-J Qian, H-Y Wang, Q-L Yin. DNA damage-induced sustained p53 activation contributes to inflammation-associated hepatocarcinogenesis in rats. Oncogene. vol 32. issue 38. 2013-11-14. PMID:23069657. |
the tumor suppressor p53 has an important role in inducing cell-intrinsic responses to dna damage, including cellular senescence or apoptosis, which act to thwart tumor development. |
2013-11-14 |
2023-08-12 |
rat |
| G Can, B Akpinar, Y Baran, B Zhivotovsky, M Olsso. 5-Fluorouracil signaling through a calcium-calmodulin-dependent pathway is required for p53 activation and apoptosis in colon carcinoma cells. Oncogene. vol 32. issue 38. 2013-11-14. PMID:23108402. |
5-fluorouracil signaling through a calcium-calmodulin-dependent pathway is required for p53 activation and apoptosis in colon carcinoma cells. |
2013-11-14 |
2023-08-12 |
Not clear |
| G Can, B Akpinar, Y Baran, B Zhivotovsky, M Olsso. 5-Fluorouracil signaling through a calcium-calmodulin-dependent pathway is required for p53 activation and apoptosis in colon carcinoma cells. Oncogene. vol 32. issue 38. 2013-11-14. PMID:23108402. |
moreover, ectopic expression of p53 s15a in hct116 p53(-/-) cells confirmed the importance of a ca(2+)-cam-p53 axis in 5-fu-induced extrinsic apoptosis. |
2013-11-14 |
2023-08-12 |
Not clear |
| Peng Zhao, Juanling Fu, Biyun Yao, Entan Hu, Yanchao Song, Lan Mi, Zhenning Li, Hongtao Zhang, Yongrui Jia, Shiliang Ma, Wen Chen, Zongcan Zho. Diethyl sulfate-induced cell cycle arrest and apoptosis in human bronchial epithelial 16HBE cells. Chemico-biological interactions. vol 205. issue 2. 2013-11-14. PMID:23830811. |
down-regulation of p53 by rna interference increased 4.0mm of des-induced apoptosis but did not affect 2.0mm des-induced cell cycle arrest. |
2013-11-14 |
2023-08-12 |
human |
| Peng Zhao, Juanling Fu, Biyun Yao, Entan Hu, Yanchao Song, Lan Mi, Zhenning Li, Hongtao Zhang, Yongrui Jia, Shiliang Ma, Wen Chen, Zongcan Zho. Diethyl sulfate-induced cell cycle arrest and apoptosis in human bronchial epithelial 16HBE cells. Chemico-biological interactions. vol 205. issue 2. 2013-11-14. PMID:23830811. |
p53 might play an important role in the transition between evoking cell cycle arrest/pro-survival and apoptosis programs upon des exposure. |
2013-11-14 |
2023-08-12 |
human |
| Hai-Mei Zhao, Xiao-Ying Huang, Feng Zhou, Wen-Ting Tong, Pan-Ting Wan, Min-Fang Huang, Qing Ye, Duan-Yong Li. Si Shen Wan Inhibits mRNA Expression of Apoptosis-Related Molecules in p38 MAPK Signal Pathway in Mice with Colitis. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-11-13. PMID:24223057. |
compared with colitis mice without treatment, ssw alleviated colonic mucosal injuries and decreased apoptosis rate of colonic epithelial cell, while the mrna expressions of p38 mapk, p53, caspase-3, c-jun, c-fos, bax, and tnf- α were decreased in the colonic mucosa in colitis mice treated with ssw, and bcl-2 mrna and the ratio of bcl-2/bax were increased. |
2013-11-13 |
2023-08-12 |
mouse |
| Azhar Rasul, Chuan Ding, Xiaomeng Li, Muhammad Khan, Fei Yi, Muhammad Ali, Tonghui M. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis. Apoptosis : an international journal on programmed cell death. vol 17. issue 10. 2013-11-12. PMID:22711363. |
dracorhodin perchlorate inhibits pi3k/akt and nf-κb activation, up-regulates the expression of p53, and enhances apoptosis. |
2013-11-12 |
2023-08-12 |
human |
| Azhar Rasul, Chuan Ding, Xiaomeng Li, Muhammad Khan, Fei Yi, Muhammad Ali, Tonghui M. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis. Apoptosis : an international journal on programmed cell death. vol 17. issue 10. 2013-11-12. PMID:22711363. |
dracorhodin perchlorate-induced apoptosis is mediated via upregulation of p53, inhibiting the activation of pi3k/akt, and nf-κb, thereby decreasing the expression of the anti-apoptotic proteins, bcl-2 and bcl-xl. |
2013-11-12 |
2023-08-12 |
human |
| Shuxi Qiao, Christopher M Cabello, Sarah D Lamore, Jessica L Lesson, Georg T Wondra. D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis : an international journal on programmed cell death. vol 17. issue 10. 2013-11-12. PMID:22843330. |
focused gene expression array analysis followed by immunoblot detection revealed that dp rapidly activates the cytotoxic unfolded protein response (upr; involving phospho-perk, phospho-eif2α, grp78, chop, and hsp70) and the mitochondrial pathway of apoptosis with p53 upregulation and modulation of bcl-2 family members (involving noxa, mcl-1, and bcl-2). |
2013-11-12 |
2023-08-12 |
human |
| Lovleen Saxena, G Ravi Kumar, Shikha Saxena, Uttara Chaturvedi, Aditya Prasad Sahoo, Lakshya Veer Singh, Lakshman Santra, S K Palia, G S Desai, A K Tiwar. Apoptosis induced by NS1 gene of Canine Parvovirus-2 is caspase dependent and p53 independent. Virus research. vol 173. issue 2. 2013-11-12. PMID:23416147. |
apoptosis induced by ns1 gene of canine parvovirus-2 is caspase dependent and p53 independent. |
2013-11-12 |
2023-08-12 |
Not clear |
| Lovleen Saxena, G Ravi Kumar, Shikha Saxena, Uttara Chaturvedi, Aditya Prasad Sahoo, Lakshya Veer Singh, Lakshman Santra, S K Palia, G S Desai, A K Tiwar. Apoptosis induced by NS1 gene of Canine Parvovirus-2 is caspase dependent and p53 independent. Virus research. vol 173. issue 2. 2013-11-12. PMID:23416147. |
increase in caspase-3 activity and no change in p53 activity with time in cpv-2.ns1 expressing hela cells showed the induction of apoptosis to be caspase dependent and p53 independent. |
2013-11-12 |
2023-08-12 |
Not clear |
| Sandra Oramas-Royo, Concepción Torrejón, Irene Cuadrado, Rita Hernández-Molina, Sonsoles Hortelano, Ana Estévez-Braun, Beatriz de Las Hera. Synthesis and cytotoxic activity of metallic complexes of lawsone. Bioorganic & medicinal chemistry. vol 21. issue 9. 2013-11-12. PMID:23545136. |
compound 4 induced apoptosis by a mechanism that involves the activation of caspases 3, 8 and 9 and modulation of apoptotic-related proteins such as bax, bad, and p53. |
2013-11-12 |
2023-08-12 |
mouse |
| Ji Young Kim, Jin-Yong Chung, Seung Gee Lee, Yoon-Jae Kim, Ji-Eun Park, Jeanho Yun, Young Chul Park, Byeong Gee Kim, Young Hyun Yoo, Jong-Min Ki. p53 interferes with microtubule-stabilizing agent-induced apoptosis in prostate and colorectal cancer cells. International journal of molecular medicine. vol 31. issue 6. 2013-11-12. PMID:23563592. |
p53 interferes with microtubule-stabilizing agent-induced apoptosis in prostate and colorectal cancer cells. |
2013-11-12 |
2023-08-12 |
human |