| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xingnan Zheng, Kan He, Lin Zhang, Jian Y. Crizotinib induces PUMA-dependent apoptosis in colon cancer cells. Molecular cancer therapeutics. vol 12. issue 5. 2013-12-10. PMID:23427294. |
the induction of puma and bim is mediated largely by p53, and deficiency in puma or p53, but not bim, blocks crizotinib-induced apoptosis. |
2013-12-10 |
2023-08-12 |
human |
| Wei-Hua Zhao, Sheng-Qi Wu, Yang-De Zhan. Downregulation of miR-124 promotes the growth and invasiveness of glioblastoma cells involving upregulation of PPP1R13L. International journal of molecular medicine. vol 32. issue 1. 2013-12-10. PMID:23624869. |
ppp1r3l, an inhibitory member of the apoptosis-stimulating protein of p53 family (iaspp), is also able to affect growth, cell cycle progression, metastasis and apoptosis of various types of cancer. |
2013-12-10 |
2023-08-12 |
human |
| Shams Reaz, Mohanad Mossalam, Abood Okal, Carol S Li. A single mutant, A276S of p53, turns the switch to apoptosis. Molecular pharmaceutics. vol 10. issue 4. 2013-12-09. PMID:23402381. |
a single mutant, a276s of p53, turns the switch to apoptosis. |
2013-12-09 |
2023-08-12 |
Not clear |
| Shams Reaz, Mohanad Mossalam, Abood Okal, Carol S Li. A single mutant, A276S of p53, turns the switch to apoptosis. Molecular pharmaceutics. vol 10. issue 4. 2013-12-09. PMID:23402381. |
the tumor suppressor protein p53 induces apoptosis, cell cycle arrest, and dna repair along with other functions in a transcription-dependent manner [vousden, k. h. cell 2000, 103(5), 691-694]. |
2013-12-09 |
2023-08-12 |
Not clear |
| Shams Reaz, Mohanad Mossalam, Abood Okal, Carol S Li. A single mutant, A276S of p53, turns the switch to apoptosis. Molecular pharmaceutics. vol 10. issue 4. 2013-12-09. PMID:23402381. |
additionally, a276s induced higher apoptosis than wild-type p53 as measured by dna segmentation and 7-aad assay. |
2013-12-09 |
2023-08-12 |
Not clear |
| Shams Reaz, Mohanad Mossalam, Abood Okal, Carol S Li. A single mutant, A276S of p53, turns the switch to apoptosis. Molecular pharmaceutics. vol 10. issue 4. 2013-12-09. PMID:23402381. |
higher induction apoptosis than wild-type p53 makes a276s an attractive candidate for therapy to eradicate cancer. |
2013-12-09 |
2023-08-12 |
Not clear |
| Diptiman Choudhury, Paulrajpillai Lourdu Xavier, Kamalesh Chaudhari, Robin John, Anjan Kumar Dasgupta, Thalappil Pradeep, Gopal Chakrabart. Unprecedented inhibition of tubulin polymerization directed by gold nanoparticles inducing cell cycle arrest and apoptosis. Nanoscale. vol 5. issue 10. 2013-12-09. PMID:23584723. |
further, western blot analysis indicated the upregulation of mitochondrial apoptosis proteins such as bax and p53, down regulation of bcl-2 and cleavage of poly(adp-ribose) polymerase (parp) confirming mitochondrial apoptosis. |
2013-12-09 |
2023-08-12 |
Not clear |
| Manabu Kurokawa, Jiyeon Kim, Joseph Geradts, Kenkyo Matsuura, Liu Liu, Xu Ran, Wenle Xia, Thomas J Ribar, Ricardo Henao, Mark W Dewhirst, Wun-Jae Kim, Joseph E Lucas, Shaomeng Wang, Neil L Spector, Sally Kornblut. A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. Science signaling. vol 6. issue 274. 2013-12-09. PMID:23652204. |
a network of substrates of the e3 ubiquitin ligases mdm2 and huwe1 control apoptosis independently of p53. |
2013-12-09 |
2023-08-12 |
human |
| Manabu Kurokawa, Jiyeon Kim, Joseph Geradts, Kenkyo Matsuura, Liu Liu, Xu Ran, Wenle Xia, Thomas J Ribar, Ricardo Henao, Mark W Dewhirst, Wun-Jae Kim, Joseph E Lucas, Shaomeng Wang, Neil L Spector, Sally Kornblut. A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. Science signaling. vol 6. issue 274. 2013-12-09. PMID:23652204. |
in contrast, in breast cancer cells that acquired resistance to lapatinib, the abundance of mdm2 was not decreased and huwe1 was degraded, which inhibited apoptosis, regardless of p53 status. |
2013-12-09 |
2023-08-12 |
human |
| Jin Boo Jeong, Xuyu Yang, Ruth Clark, Jieun Choi, Seung Joon Baek, Seong-Ho Le. A mechanistic study of the proapoptotic effect of tolfenamic acid: involvement of NF-κB activation. Carcinogenesis. vol 34. issue 10. 2013-12-09. PMID:23784084. |
ta-induced apoptosis was ameliorated by the knockout of p65 and p53 and the point mutation of p65 at ser276 residue. |
2013-12-09 |
2023-08-12 |
human |
| Lili Jiang, Jihong Chang, Qingfu Zhang, Limei Sun, Xueshan Qi. MicroRNA hsa-miR-125a-3p activates p53 and induces apoptosis in lung cancer cells. Cancer investigation. vol 31. issue 8. 2013-12-09. PMID:24044511. |
microrna hsa-mir-125a-3p activates p53 and induces apoptosis in lung cancer cells. |
2013-12-09 |
2023-08-12 |
human |
| Lili Jiang, Jihong Chang, Qingfu Zhang, Limei Sun, Xueshan Qi. MicroRNA hsa-miR-125a-3p activates p53 and induces apoptosis in lung cancer cells. Cancer investigation. vol 31. issue 8. 2013-12-09. PMID:24044511. |
moreover, blocking wild-type p53 attenuated the effect of hsa-mir-125a-3p on apoptosis but could not restore completely. |
2013-12-09 |
2023-08-12 |
human |
| Lili Jiang, Jihong Chang, Qingfu Zhang, Limei Sun, Xueshan Qi. MicroRNA hsa-miR-125a-3p activates p53 and induces apoptosis in lung cancer cells. Cancer investigation. vol 31. issue 8. 2013-12-09. PMID:24044511. |
taken together, these data suggest that hsa-mir-125a-3p induces apoptosis not only via the p53 pathway in human lung cancer cells. |
2013-12-09 |
2023-08-12 |
human |
| Changsong Wang, Chunfang Gao, Yanping Chen, Jian Yin, Ping Wang, Xuexia L. Expression pattern of the apoptosis-stimulating protein of p53 family in p53+ human breast cancer cell lines. Cancer cell international. vol 13. issue 1. 2013-12-09. PMID:24245874. |
they regulate the promotive effect of p53 on apoptosis. |
2013-12-09 |
2023-08-12 |
human |
| Yu-Ling Lin, Wen-Lin Lai, Horng-Jyh Harn, Pei-Hsiu Hung, Ming-Chang Hsieh, Kai-Fu Chang, Xiao-Fan Huang, Kuang-Wen Liao, Ming-Shih Lee, Nu-Man Tsa. The Methanol Extract of Angelica sinensis Induces Cell Apoptosis and Suppresses Tumor Growth in Human Malignant Brain Tumors. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-12-09. PMID:24319475. |
therefore, the apoptosis of cancer cells induced by as-m may be triggered through the p53 pathway. |
2013-12-09 |
2023-08-12 |
human |
| Monika Primon, Peter C Huszthy, Helena Motaln, Krishna M Talasila, Ana Torkar, Rolf Bjerkvig, Tamara Lah Turnše. Cathepsin L silencing enhances arsenic trioxide mediated in vitro cytotoxicity and apoptosis in glioblastoma U87MG spheroids. Experimental cell research. vol 319. issue 17. 2013-12-04. PMID:23968587. |
silenced catl also increased arsenite-mediated apoptosis in spheroids via elevated p53 expression, bax/bcl2 ratio and caspase 3/7 activity, though with lower efficacy than in monolayers. |
2013-12-04 |
2023-08-12 |
Not clear |
| Shahar Rotem-Bamberger, Chen Katz, Assaf Friedle. Regulation of ASPP2 interaction with p53 core domain by an intramolecular autoinhibitory mechanism. PloS one. vol 8. issue 3. 2013-12-03. PMID:23472201. |
the c-terminal part of aspp2 contains four ankyrin repeats and an sh3 domain (ank-sh3) that mediate the interactions of aspp2 with apoptosis related proteins such as p53, bcl-2 and the p65 subunit of nfκb. |
2013-12-03 |
2023-08-12 |
Not clear |
| Rakesh Kumar Gupta, Ayan Banerjee, Suajta Pathak, Chandresh Sharma, Neeta Sing. Induction of mitochondrial-mediated apoptosis by Morinda citrifolia (Noni) in human cervical cancer cells. Asian Pacific journal of cancer prevention : APJCP. vol 14. issue 1. 2013-12-03. PMID:23534730. |
the observed apoptosis appeared to be mediated particularly through the up-regulation of p53 and pro-apoptotic bax proteins, as well as down- regulation of the anti-apoptotic bcl-2, bcl-xl proteins and survivin. |
2013-12-03 |
2023-08-12 |
human |
| Arianna Giacobbe, Lucilla Bongiorno-Borbone, Francesca Bernassola, Alessandro Terrinoni, Elke Katrin Markert, Arnold J Levine, Zhaohui Feng, Massimilano Agostini, Lello Zolla, Alessandro Finazzi Agrò, Daniel A Notterman, Gerry Melino, Angelo Peschiarol. p63 regulates glutaminase 2 expression. Cell cycle (Georgetown, Tex.). vol 12. issue 9. 2013-12-03. PMID:23574722. |
sirna-mediated depletion of gls2 sensitizes cells to ros-induced apoptosis, suggesting that the tap63/gls2 axis can be functionally important as a cellular antioxidant pathway in the absence of p53. |
2013-12-03 |
2023-08-12 |
human |
| Mourad Sanhaji, Frank Louwen, Brigitte Zimmer, Nina-Naomi Kreis, Susanne Roth, Juping Yua. Polo-like kinase 1 inhibitors, mitotic stress and the tumor suppressor p53. Cell cycle (Georgetown, Tex.). vol 12. issue 9. 2013-12-03. PMID:23574746. |
in our previous study based on different cancer cell lines, we showed that cancer cells with wild type p53 were more sensitive to plk1 inhibition by inducing more apoptosis, compared with cancer cells depleted of p53. |
2013-12-03 |
2023-08-12 |
Not clear |