| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Wu, X Lin, X Zhao, L Zheng, L Xiao, J Liu, L Ge, S Ca. MiR-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK-independent pathways. British journal of cancer. vol 109. issue 11. 2014-02-11. PMID:24169356. |
mir-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38mapk-independent pathways. |
2014-02-11 |
2023-08-12 |
Not clear |
| Takayuki Fujino, Sharifi Muhib, Nobuyuki Sato, Naoyuki Haseb. Silencing of p53 RNA through transarterial delivery ameliorates renal tubular injury and downregulates GSK-3β expression after ischemia-reperfusion injury. American journal of physiology. Renal physiology. vol 305. issue 11. 2014-02-10. PMID:24107420. |
injection of synthetic p53 shrna into the left renal artery just after ischemia improved tubular injury, apoptosis, and the swelling of mitochondria in cells of the thick ascending limb of henle (mtalh) at the outer medullary regions. |
2014-02-10 |
2023-08-12 |
mouse |
| Takayuki Fujino, Sharifi Muhib, Nobuyuki Sato, Naoyuki Haseb. Silencing of p53 RNA through transarterial delivery ameliorates renal tubular injury and downregulates GSK-3β expression after ischemia-reperfusion injury. American journal of physiology. Renal physiology. vol 305. issue 11. 2014-02-10. PMID:24107420. |
targeting sirna to p53 leads to an attenuation of apoptosis and mitochondrial damage through the downregulation of gsk-3β expression and upregulation of β-catenin. |
2014-02-10 |
2023-08-12 |
mouse |
| Jonathan Chang, Brandi N Davis-Dusenbery, Risa Kashima, Xuan Jiang, Nisha Marathe, Roberto Sessa, Justin Louie, Wei Gu, Giorgio Lagna, Akiko Hat. Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. The EMBO journal. vol 32. issue 24. 2014-02-10. PMID:24219989. |
for example, activation of p53 by genotoxic agents, such as camptothecin (cpt), triggers apoptosis, while non-genotoxic activation of p53 by nutlin-3 (nut3) leads to cell-cycle arrest without significant apoptosis. |
2014-02-10 |
2023-08-12 |
human |
| Mircea Winter, Mirjam A Moser, Dominique Meunier, Carina Fischer, Georg Machat, Katharina Mattes, Beate M Lichtenberger, Reinhard Brunmeir, Simon Weissmann, Christina Murko, Christina Humer, Tina Meischel, Gerald Brosch, Patrick Matthias, Maria Sibilia, Christian Seise. Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis. The EMBO journal. vol 32. issue 24. 2014-02-10. PMID:24240174. |
these mice display impaired sin3a co-repressor complex function, increased levels of c-myc protein, p53 expression and apoptosis in hair follicles (hfs) and misregulation of hf bulge stem cells. |
2014-02-10 |
2023-08-12 |
mouse |
| Liang Wu, You-Yong Tian, Jing-Ping Shi, Wei Xie, Jian-Quan Shi, Jie Lu, Ying-Dong Zhan. Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effects of candesartan cilexitil in the rotenone rat model of Parkinson's disease. Neuroscience letters. vol 548. 2014-02-07. PMID:23774475. |
moreover, candesartan cilexetil has been found to play a protective role via down-regulating the expression of activating transcription factor 4 (atf4), the ccaat-enhancer-binding protein (c/ebp) homologous protein (chop), and p53 upregulated modulator of apoptosis (puma). |
2014-02-07 |
2023-08-12 |
rat |
| Ryan T Pitman, Luke Wojdyla, Neelu Pur. Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma. Oncotarget. vol 4. issue 5. 2014-02-07. PMID:23800953. |
however, sirna-mediated knockdown of p53 completely blocks t-oligo induced differentiation and significantly decreases apoptosis, suggesting that p53 is an important mediator of t-oligo induced responses. |
2014-02-07 |
2023-08-12 |
Not clear |
| Kangsheng Tu, Xin Zheng, Zhenyu Zhou, Chao Li, Jing Zhang, Jie Gao, Yingmin Yao, Qingguang Li. Recombinant human adenovirus-p53 injection induced apoptosis in hepatocellular carcinoma cell lines mediated by p53-Fbxw7 pathway, which controls c-Myc and cyclin E. PloS one. vol 8. issue 7. 2014-02-07. PMID:23840897. |
here, we suggest that the activation of fbxw7 by adenoviral delivery of p53 leads to increased proteasomal degradation of c-myc and cyclin e enabling growth arrest and apoptosis. |
2014-02-07 |
2023-08-12 |
human |
| Jun-Oh Lee, Ji-Yun Kim, Dong-Kwon Rhee, Suhkneung Py. Streptococcus pneumoniae ClpP protease induces apoptosis via caspase-independent pathway in human neuroblastoma cells: cytoplasmic relocalization of p53. Toxicon : official journal of the International Society on Toxinology. vol 70. 2014-02-05. PMID:23643883. |
streptococcus pneumoniae clpp protease induces apoptosis via caspase-independent pathway in human neuroblastoma cells: cytoplasmic relocalization of p53. |
2014-02-05 |
2023-08-12 |
human |
| Emanuela Grassilli, Robert Narloch, Elena Federzoni, Leonarda Ianzano, Fabio Pisano, Roberto Giovannoni, Gabriele Romano, Laura Masiero, Biagio Eugenio Leone, Serena Bonin, Marisa Donada, Giorgio Stanta, Kristian Helin, Marialuisa Lavitran. Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 19. issue 14. 2014-02-05. PMID:23729362. |
evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug resistance. |
2014-02-05 |
2023-08-12 |
Not clear |
| Nitin Raj, Laura D Attard. Tumor suppression: p53 alters immune surveillance to restrain liver cancer. Current biology : CB. vol 23. issue 12. 2014-02-05. PMID:23787049. |
the p53 tumor suppressor governs multiple cell-intrinsic programs, including cell-cycle arrest and apoptosis, to curb neoplastic growth. |
2014-02-05 |
2023-08-12 |
Not clear |
| Linda Vuong, Daniel E Brobst, Ivana Ivanovic, David M Sherry, Muayyad R Al-Ubaid. p53 selectively regulates developmental apoptosis of rod photoreceptors. PloS one. vol 8. issue 6. 2014-02-05. PMID:23840687. |
p53 selectively regulates developmental apoptosis of rod photoreceptors. |
2014-02-05 |
2023-08-12 |
mouse |
| Linda Vuong, Daniel E Brobst, Ivana Ivanovic, David M Sherry, Muayyad R Al-Ubaid. p53 selectively regulates developmental apoptosis of rod photoreceptors. PloS one. vol 8. issue 6. 2014-02-05. PMID:23840687. |
these findings strongly support a role for p53 in regulating developmental apoptosis in the retina and suggest a potential role, either direct or indirect, for p53 in the degenerative photoreceptor loss associated with human blinding disorders. |
2014-02-05 |
2023-08-12 |
mouse |
| Biyin Cao, Jie Li, Jingyu Zhu, Mingyun Shen, Kunkun Han, Zubin Zhang, Yang Yu, Yali Wang, Depei Wu, Suning Chen, Aining Sun, Xiaowen Tang, Yun Zhao, Chunhua Qiao, Tingjun Hou, Xinliang Ma. The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity. The Journal of biological chemistry. vol 288. issue 47. 2014-02-04. PMID:24114842. |
by inhibiting hdac activity, cq induced expression of p21, p27, and p53, cell cycle arrest at g1 phase, and cell apoptosis. |
2014-02-04 |
2023-08-12 |
Not clear |
| You Ah Kim, Hojun Kim, Youngwan Se. Antiproliferative effect of flavonoids from the halophyte Vitex rotundifolia on human cancer cells. Natural product communications. vol 8. issue 10. 2014-02-04. PMID:24354186. |
compound 2 not only enhanced most remarkably the expression level of tumor suppressor genes p53 and p21, and pro-apoptotic gene bax at a concentration of 25 microm, but also suppressed the expression level of antiapoptotic gene bcl-2 to 20% at the same concentration, thus shifting the bax/bcl-2 ratio in favor of apoptosis. |
2014-02-04 |
2023-08-12 |
human |
| John Stanislav, Jan Mls, Miroslav Červinka, Emil Rudol. The role of autophagic cell death and apoptosis in irinotecan-treated p53 null colon cancer cells. Anti-cancer agents in medicinal chemistry. vol 13. issue 5. 2014-02-03. PMID:22721392. |
the role of autophagic cell death and apoptosis in irinotecan-treated p53 null colon cancer cells. |
2014-02-03 |
2023-08-12 |
Not clear |
| John Stanislav, Jan Mls, Miroslav Červinka, Emil Rudol. The role of autophagic cell death and apoptosis in irinotecan-treated p53 null colon cancer cells. Anti-cancer agents in medicinal chemistry. vol 13. issue 5. 2014-02-03. PMID:22721392. |
the roles of autophagic cell death and apoptosis induced by topoisomerase inhibitor irinotecan in colon cancer cells with deleted p53 were investigated during 48 h. we report that irinotecan-dependent cytotoxicity and proapoptotic activity were reduced in the present model while autophagy levels significantly increased. |
2014-02-03 |
2023-08-12 |
Not clear |
| John Stanislav, Jan Mls, Miroslav Červinka, Emil Rudol. The role of autophagic cell death and apoptosis in irinotecan-treated p53 null colon cancer cells. Anti-cancer agents in medicinal chemistry. vol 13. issue 5. 2014-02-03. PMID:22721392. |
upon p53 transfection, cell demise rates increased, with cells bearing the features of apoptosis and autophagic cell death. |
2014-02-03 |
2023-08-12 |
Not clear |
| Xiaoyun Zhang, Ying Jiang, Jun Yan. [p53-independent signaling pathway in DNA damage-induced cell apoptosis]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 42. issue 2. 2014-01-30. PMID:23585010. |
p53 is considered as the "master regulator" in dna damage-induced cell apoptosis. |
2014-01-30 |
2023-08-12 |
human |
| Alvaro Blanch, Fiona Robinson, Ian R Watson, Lynn S Cheng, Meredith S Irwi. Eukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity. PloS one. vol 8. issue 6. 2014-01-30. PMID:23799104. |
eukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity. |
2014-01-30 |
2023-08-12 |
Not clear |