| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoguang Li, Tao Chen, Sheng Lin, Jing Zhao, Peizhan Chen, Qian Ba, He Guo, Yanling Liu, Jingquan Li, Ruiai Chu, Lei Shan, Weidong Zhang, Hui Wan. Valeriana jatamansi constituent IVHD-valtrate as a novel therapeutic agent to human ovarian cancer: in vitro and in vivo activities and mechanisms. Current cancer drug targets. vol 13. issue 4. 2014-01-07. PMID:23597199. |
the detailed in vitro and in vivo study on the molecular mechanisms of this compound demonstrated that ivhd-valtrate exposure modulated the expression of numerous molecules involved in cell cycle progression and apoptosis regardless of p53 status, leading to increase the level of p53, rb, p21, p27 and decrease mdm2, e2f1, cyclin b1, cdc25c and cdc2. |
2014-01-07 |
2023-08-12 |
human |
| Zhen-Bo Wang, Xian-Zhong Peng, Shao-Shui Chen, Fang-Ling Ning, Chun-Juan Du, Kai Wang, Wei Ma, Yu-Feng Chen. High p53 and MAP1 light chain 3A co-expression predicts poor prognosis in patients with esophageal squamous cell carcinoma. Molecular medicine reports. vol 8. issue 1. 2014-01-07. PMID:23632916. |
p53 and microtubule-associated protein 1 light chain 3a (lc3a) are regulators of apoptosis and autophagy and are expressed at high levels in a number of human tumors. |
2014-01-07 |
2023-08-12 |
human |
| Haishi Qiao, Xiaoqing Chen, Lanfang Xu, Jingjing Wang, Guoyan Zhao, Yayi Hou, Hui Ming Ge, Ren-Xiang Tan, Erguang L. Antitumor effects of naturally occurring oligomeric resveratrol derivatives. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 11. 2014-01-07. PMID:23925653. |
using pauciflorol b (paub) as an example, we showed that the compound induced apoptosis p53 dependently, inducing p53 accumulation and p53-modulated gene expression in cells with wild-type p53, but not in those with nonfunctional p53. |
2014-01-07 |
2023-08-12 |
mouse |
| Jing-Ping Wang, Kai-Han Lin, Chun-Yen Liu, Ya-Chu Yu, Pei-Tsun Wu, Chien-Chih Chiu, Chun-Li Su, Kwun-Min Chen, Kang Fan. Teroxirone inhibited growth of human non-small cell lung cancer cells by activating p53. Toxicology and applied pharmacology. vol 273. issue 1. 2014-01-06. PMID:23954467. |
the onset of ultimate apoptosis is dependent on the status of p53. |
2014-01-06 |
2023-08-12 |
mouse |
| A Meijer, F A E Kruyt, A G J van der Zee, H Hollema, P Le, K A ten Hoor, G M M Groothuis, W J Quax, E G E de Vries, S de Jon. Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL. British journal of cancer. vol 109. issue 10. 2014-01-06. PMID:24136147. |
tumour cell-selective activation of apoptosis by recombinant human tnf-related apoptosis-inducing ligand (rhtrail) is enhanced through co-activation of p53 by chemotherapeutic drugs. |
2014-01-06 |
2023-08-12 |
human |
| Chuan-Dong Wei, Yan Li, Hong-Yun Zheng, Yong-Qing Tong, Wen Da. Palmitate induces H9c2 cell apoptosis by increasing reactive oxygen species generation and activation of the ERK1/2 signaling pathway. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23338747. |
in this model of treatment with palmitate, h9c2 cell apoptosis correlated with increased levels of p53 and bax expression and reduced levels of bcl-2 expression. |
2014-01-03 |
2023-08-12 |
Not clear |
| Fuling Wei, Yongmei Cao, Mengran Zhang, Rui Huang, Jun Cheng, Guoan Xiang, Jinqian Zhan. Immunosuppression induced by apoptosis of mixed lymphocyte culture is associated with p53. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23358574. |
immunosuppression induced by apoptosis of mixed lymphocyte culture is associated with p53. |
2014-01-03 |
2023-08-12 |
Not clear |
| Fuling Wei, Yongmei Cao, Mengran Zhang, Rui Huang, Jun Cheng, Guoan Xiang, Jinqian Zhan. Immunosuppression induced by apoptosis of mixed lymphocyte culture is associated with p53. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23358574. |
the suppression of recipient lymphocyte activity was due to apoptosis mediated by p53 and caspase-3, and the optimal ratio of donor and recipient lymphocytes for apoptosis was explored. |
2014-01-03 |
2023-08-12 |
Not clear |
| Fuling Wei, Yongmei Cao, Mengran Zhang, Rui Huang, Jun Cheng, Guoan Xiang, Jinqian Zhan. Immunosuppression induced by apoptosis of mixed lymphocyte culture is associated with p53. Molecular medicine reports. vol 7. issue 3. 2014-01-03. PMID:23358574. |
these data suggest that il-2 is involved in mlc-induced apoptosis of recipient lymphocytes, and that apoptosis may be associated with p53 and caspase-3 pathways. |
2014-01-03 |
2023-08-12 |
Not clear |
| Xia Ding, Fangshi Zhu, Yun Yang, Min L. Purification, antitumor activity in vitro of steroidal glycoalkaloids from black nightshade (Solanum nigrum L.). Food chemistry. vol 141. issue 2. 2014-01-03. PMID:23790901. |
the mechanism of action may be related to the decrease of mutation p53, the increase of the ratio of bax to bcl-2 and the activation of caspase-3 to induce apoptosis. |
2014-01-03 |
2023-08-12 |
Not clear |
| Jaesook Roh, Woojin P. Regulation of follicle growth and apoptosis in cultured mouse ovaries by NGF and oxygen. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 29. issue 6. 2014-01-02. PMID:23506274. |
under 20% oxygen, but not 1.5% or 5%, ngf decreased apoptosis in mouse ovaries by down-regulating the pro-apoptotic genes bax and p53. |
2014-01-02 |
2023-08-12 |
mouse |
| Wenbi Wu, Rollie J Clem, George F Rohrmann, A Lorena Passarell. The baculovirus sulfhydryl oxidase Ac92 (P33) interacts with the Spodoptera frugiperda P53 protein and oxidizes it in vitro. Virology. vol 447. issue 1-2. 2014-01-02. PMID:24210115. |
ac92 also interacts with human p53 and enhances human p53-induced apoptosis in insect cells, but it is not known whether any relationship exists between ac92 and native p53 homologs from insect hosts of acmnpv. |
2014-01-02 |
2023-08-12 |
human |
| R A Shamanna, M Hoque, T Pe'ery, M B Mathew. Induction of p53, p21 and apoptosis by silencing the NF90/NF45 complex in human papilloma virus-transformed cervical carcinoma cells. Oncogene. vol 32. issue 43. 2013-12-31. PMID:23208500. |
induction of p53, p21 and apoptosis by silencing the nf90/nf45 complex in human papilloma virus-transformed cervical carcinoma cells. |
2013-12-31 |
2023-08-12 |
human |
| R A Shamanna, M Hoque, T Pe'ery, M B Mathew. Induction of p53, p21 and apoptosis by silencing the NF90/NF45 complex in human papilloma virus-transformed cervical carcinoma cells. Oncogene. vol 32. issue 43. 2013-12-31. PMID:23208500. |
consistent with p53 derepression, nf90/nf45-depleted hela cells displayed elevated poly adp-ribose polymerase (parp) cleavage and susceptibility to camptothecin-induced apoptosis. |
2013-12-31 |
2023-08-12 |
human |
| L Wang, M Romero, P Ratajczak, C Lebœuf, S Belhadj, R Peffault de Latour, W-L Zhao, G Socié, A Jani. Increased apoptosis is linked to severe acute GVHD in patients with Fanconi anemia. Bone marrow transplantation. vol 48. issue 6. 2013-12-31. PMID:23222379. |
microrna-34 and p53 can induce apoptosis after dna damage.here we assessed epithelial cell apoptosis, and studied tp53 and mir-34a expression in the skin and gut biopsies in five non-transplanted fa patients, in 20 fa patients with agvhd and in 25 acquired aplastic anemia patients (aa). |
2013-12-31 |
2023-08-12 |
human |
| L Wang, M Romero, P Ratajczak, C Lebœuf, S Belhadj, R Peffault de Latour, W-L Zhao, G Socié, A Jani. Increased apoptosis is linked to severe acute GVHD in patients with Fanconi anemia. Bone marrow transplantation. vol 48. issue 6. 2013-12-31. PMID:23222379. |
as, among p53-independent signaling pathways of apoptosis, the microrna-34 family mimics p53 apoptotic effects in response to dna damage, we studied mir-34a expression in the same series of fa patients' gut biopsies. |
2013-12-31 |
2023-08-12 |
human |
| A Rufini, P Tucci, I Celardo, G Melin. Senescence and aging: the critical roles of p53. Oncogene. vol 32. issue 43. 2013-12-31. PMID:23416979. |
p53 functions as a transcription factor involved in cell-cycle control, dna repair, apoptosis and cellular stress responses. |
2013-12-31 |
2023-08-12 |
Not clear |
| A Rufini, P Tucci, I Celardo, G Melin. Senescence and aging: the critical roles of p53. Oncogene. vol 32. issue 43. 2013-12-31. PMID:23416979. |
however, besides inducing cell growth arrest and apoptosis, p53 activation also modulates cellular senescence and organismal aging. |
2013-12-31 |
2023-08-12 |
Not clear |
| Yang Zhao, Ming-Yang Wang, Ke Hao, Xue-Qun Chen, Ji-Zeng D. CRHR1 mediates p53 transcription induced by high altitude hypoxia through ERK 1/2 signaling in rat hepatic cells. Peptides. vol 44. 2013-12-31. PMID:23538210. |
p53 is activated by hypoxia and involved in tumorigenesis and apoptosis. |
2013-12-31 |
2023-08-12 |
rat |
| Xiaoxue Xie, Hui Wang, Hekun Jin, Shuyu Ouyang, Jumei Zhou, Jun Hu, Xuping Xi, Junming Luo, Yingying Zhang, Bingqiang H. Expression of pAkt affects p53 codon 72 polymorphism-based prediction of response to radiotherapy in nasopharyngeal carcinoma. Radiation oncology (London, England). vol 8. 2013-12-31. PMID:23663243. |
codon 72 (arg/pro), the most frequently studied single nucleotide polymorphism (snp) of p53 to date, is associated with the ability of the gene to induce cell apoptosis. |
2013-12-31 |
2023-08-12 |
Not clear |