| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cornelia Braicu, Valentina Pileczki, Alexandru Irimie, Ioana Berindan-Neago. p53siRNA therapy reduces cell proliferation, migration and induces apoptosis in triple negative breast cancer cells. Molecular and cellular biochemistry. vol 381. issue 1-2. 2014-02-12. PMID:23881244. |
this study is intended to investigate, the potential applications of rna interference (rnai) to block p53 expression, as well as its subsequent effect on cell growth, apoptosis and migration on a triple negative human breast cancer cell line (hs578t). |
2014-02-12 |
2023-08-12 |
human |
| Cornelia Braicu, Valentina Pileczki, Alexandru Irimie, Ioana Berindan-Neago. p53siRNA therapy reduces cell proliferation, migration and induces apoptosis in triple negative breast cancer cells. Molecular and cellular biochemistry. vol 381. issue 1-2. 2014-02-12. PMID:23881244. |
our studies indicate that the knockdown of p53 expression by sirna modulates several genes involved in cell death pathways and apoptosis, showing statistically significant gene expression differences for 22 genes, from which 18 were upregulated and 4 were downregulated. |
2014-02-12 |
2023-08-12 |
human |
| Werner W Franke, Hans Heid, Ralf Zimbelmann, Caecilia Kuhn, Stefanie Winter-Simanowski, Yvette Dörflinger, Christine Grund, Steffen Rickel. Transmembrane protein PERP is a component of tessellate junctions and of other junctional and non-junctional plasma membrane regions in diverse epithelial and epithelium-derived cells. Cell and tissue research. vol 353. issue 1. 2014-02-11. PMID:23689684. |
protein perp (p53 apoptosis effector related to pmp-22) is a small (21.4 kda) transmembrane polypeptide with an amino acid sequence indicative of a tetraspanin character. |
2014-02-11 |
2023-08-12 |
Not clear |
| Shaolong Feng, Zhaohui Cao, Xinming Wan. Role of aryl hydrocarbon receptor in cancer. Biochimica et biophysica acta. vol 1836. issue 2. 2014-02-11. PMID:23711559. |
the proposed underlying mechanisms of its actions in cancer involved multiple aspects, (a) inhibiting the functional expression of the key anti-oncogenes (such as p53 and brca1), (b) promoting stem cells transforming and angiogenesis, (c) altering cell survival, proliferation and differentiation by influencing the physiologic processes of cell-cycle, apoptosis, cell contact-inhibition, metabolism and remodel of extracellular matrix, and cell-matrix interaction, (d) cross-talking with the signaling pathways of estrogen receptor and inflammation. |
2014-02-11 |
2023-08-12 |
human |
| Bo Wang, Dongping Li, Olga Kovalchu. p53 Ser15 phosphorylation and histone modifications contribute to IR-induced miR-34a transcription in mammary epithelial cells. Cell cycle (Georgetown, Tex.). vol 12. issue 13. 2014-02-11. PMID:23759592. |
previous studies have demonstrated that mir-34a is a direct transcriptional target of tumor suppressor p53 and plays a crucial role in p53-mediated biological processes, such as cell cycle arrest, apoptosis and senescence. |
2014-02-11 |
2023-08-12 |
human |
| Isabel Cordero-Herrera, María Angeles Martín, Laura Bravo, Luis Goya, Sonia Ramo. Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells. Nutrition and cancer. vol 65. issue 5. 2014-02-11. PMID:23859040. |
in this study, the in vitro anticancer effects of ecg on sw480 colon cancer cell line was investigated by analyzing the cell cycle, apoptosis, key proteins involved in cellular survival/proliferation, namely akt/phosphatidylinositol-3-kinase (pi3k) and mitogen-activated protein kinases (mapks), and the role of p53 in these processes. |
2014-02-11 |
2023-08-12 |
human |
| Isabel Cordero-Herrera, María Angeles Martín, Laura Bravo, Luis Goya, Sonia Ramo. Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells. Nutrition and cancer. vol 65. issue 5. 2014-02-11. PMID:23859040. |
exposure of sw480 cells to ecg also led to apoptosis as determined by time-dependent changes in caspase-3 activity, mapks [extracellular regulated kinase (erk), p38, and c-jun amino-terminal kinase (jnk)], p21 and p53 activation, and akt inhibition. |
2014-02-11 |
2023-08-12 |
human |
| Isabel Cordero-Herrera, María Angeles Martín, Laura Bravo, Luis Goya, Sonia Ramo. Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells. Nutrition and cancer. vol 65. issue 5. 2014-02-11. PMID:23859040. |
the presence of pifithrin, an inhibitor of p53 function, blocked ecg-induced apoptosis as was manifested by restored cell viability and caspase-3 activity to control values and reestablished the balance among bcl-2 anti- and proapoptotic protein levels. |
2014-02-11 |
2023-08-12 |
human |
| Isabel Cordero-Herrera, María Angeles Martín, Laura Bravo, Luis Goya, Sonia Ramo. Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells. Nutrition and cancer. vol 65. issue 5. 2014-02-11. PMID:23859040. |
in addition, jnk and p38 have been identified as necessary for ecg-induced apoptosis, upon activation by p53. |
2014-02-11 |
2023-08-12 |
human |
| N Wu, X Lin, X Zhao, L Zheng, L Xiao, J Liu, L Ge, S Ca. MiR-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38MAPK-independent pathways. British journal of cancer. vol 109. issue 11. 2014-02-11. PMID:24169356. |
mir-125b acts as an oncogene in glioblastoma cells and inhibits cell apoptosis through p53 and p38mapk-independent pathways. |
2014-02-11 |
2023-08-12 |
Not clear |
| Takayuki Fujino, Sharifi Muhib, Nobuyuki Sato, Naoyuki Haseb. Silencing of p53 RNA through transarterial delivery ameliorates renal tubular injury and downregulates GSK-3β expression after ischemia-reperfusion injury. American journal of physiology. Renal physiology. vol 305. issue 11. 2014-02-10. PMID:24107420. |
injection of synthetic p53 shrna into the left renal artery just after ischemia improved tubular injury, apoptosis, and the swelling of mitochondria in cells of the thick ascending limb of henle (mtalh) at the outer medullary regions. |
2014-02-10 |
2023-08-12 |
mouse |
| Takayuki Fujino, Sharifi Muhib, Nobuyuki Sato, Naoyuki Haseb. Silencing of p53 RNA through transarterial delivery ameliorates renal tubular injury and downregulates GSK-3β expression after ischemia-reperfusion injury. American journal of physiology. Renal physiology. vol 305. issue 11. 2014-02-10. PMID:24107420. |
targeting sirna to p53 leads to an attenuation of apoptosis and mitochondrial damage through the downregulation of gsk-3β expression and upregulation of β-catenin. |
2014-02-10 |
2023-08-12 |
mouse |
| Jonathan Chang, Brandi N Davis-Dusenbery, Risa Kashima, Xuan Jiang, Nisha Marathe, Roberto Sessa, Justin Louie, Wei Gu, Giorgio Lagna, Akiko Hat. Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. The EMBO journal. vol 32. issue 24. 2014-02-10. PMID:24219989. |
for example, activation of p53 by genotoxic agents, such as camptothecin (cpt), triggers apoptosis, while non-genotoxic activation of p53 by nutlin-3 (nut3) leads to cell-cycle arrest without significant apoptosis. |
2014-02-10 |
2023-08-12 |
human |
| Mircea Winter, Mirjam A Moser, Dominique Meunier, Carina Fischer, Georg Machat, Katharina Mattes, Beate M Lichtenberger, Reinhard Brunmeir, Simon Weissmann, Christina Murko, Christina Humer, Tina Meischel, Gerald Brosch, Patrick Matthias, Maria Sibilia, Christian Seise. Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis. The EMBO journal. vol 32. issue 24. 2014-02-10. PMID:24240174. |
these mice display impaired sin3a co-repressor complex function, increased levels of c-myc protein, p53 expression and apoptosis in hair follicles (hfs) and misregulation of hf bulge stem cells. |
2014-02-10 |
2023-08-12 |
mouse |
| Liang Wu, You-Yong Tian, Jing-Ping Shi, Wei Xie, Jian-Quan Shi, Jie Lu, Ying-Dong Zhan. Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effects of candesartan cilexitil in the rotenone rat model of Parkinson's disease. Neuroscience letters. vol 548. 2014-02-07. PMID:23774475. |
moreover, candesartan cilexetil has been found to play a protective role via down-regulating the expression of activating transcription factor 4 (atf4), the ccaat-enhancer-binding protein (c/ebp) homologous protein (chop), and p53 upregulated modulator of apoptosis (puma). |
2014-02-07 |
2023-08-12 |
rat |
| Ryan T Pitman, Luke Wojdyla, Neelu Pur. Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma. Oncotarget. vol 4. issue 5. 2014-02-07. PMID:23800953. |
however, sirna-mediated knockdown of p53 completely blocks t-oligo induced differentiation and significantly decreases apoptosis, suggesting that p53 is an important mediator of t-oligo induced responses. |
2014-02-07 |
2023-08-12 |
Not clear |
| Kangsheng Tu, Xin Zheng, Zhenyu Zhou, Chao Li, Jing Zhang, Jie Gao, Yingmin Yao, Qingguang Li. Recombinant human adenovirus-p53 injection induced apoptosis in hepatocellular carcinoma cell lines mediated by p53-Fbxw7 pathway, which controls c-Myc and cyclin E. PloS one. vol 8. issue 7. 2014-02-07. PMID:23840897. |
here, we suggest that the activation of fbxw7 by adenoviral delivery of p53 leads to increased proteasomal degradation of c-myc and cyclin e enabling growth arrest and apoptosis. |
2014-02-07 |
2023-08-12 |
human |
| Jun-Oh Lee, Ji-Yun Kim, Dong-Kwon Rhee, Suhkneung Py. Streptococcus pneumoniae ClpP protease induces apoptosis via caspase-independent pathway in human neuroblastoma cells: cytoplasmic relocalization of p53. Toxicon : official journal of the International Society on Toxinology. vol 70. 2014-02-05. PMID:23643883. |
streptococcus pneumoniae clpp protease induces apoptosis via caspase-independent pathway in human neuroblastoma cells: cytoplasmic relocalization of p53. |
2014-02-05 |
2023-08-12 |
human |
| Emanuela Grassilli, Robert Narloch, Elena Federzoni, Leonarda Ianzano, Fabio Pisano, Roberto Giovannoni, Gabriele Romano, Laura Masiero, Biagio Eugenio Leone, Serena Bonin, Marisa Donada, Giorgio Stanta, Kristian Helin, Marialuisa Lavitran. Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 19. issue 14. 2014-02-05. PMID:23729362. |
evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug resistance. |
2014-02-05 |
2023-08-12 |
Not clear |
| Nitin Raj, Laura D Attard. Tumor suppression: p53 alters immune surveillance to restrain liver cancer. Current biology : CB. vol 23. issue 12. 2014-02-05. PMID:23787049. |
the p53 tumor suppressor governs multiple cell-intrinsic programs, including cell-cycle arrest and apoptosis, to curb neoplastic growth. |
2014-02-05 |
2023-08-12 |
Not clear |