| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuqing Zhang, Sandra J Shin, Debra Liu, Elena Ivanova, Friedrich Foerster, Haoqiang Ying, Hongwu Zheng, Yonghong Xiao, Zhengming Chen, Alexei Protopopov, Ronald A Depinho, Ji-Hye Pai. ZNF365 promotes stability of fragile sites and telomeres. Cancer discovery. vol 3. issue 7. 2014-03-21. PMID:23776040. |
critically short telomeres activate cellular senescence or apoptosis, as mediated by the tumor suppressor p53, but in the absence of this checkpoint response, telomere dysfunction engenders chromosomal aberrations and cancer. |
2014-03-21 |
2023-08-12 |
Not clear |
| V Jablonska-Mestanova, V Sisovsky, L Danisovic, S Polak, I Varg. The normal human newborns thymus. Bratislavske lekarske listy. vol 114. issue 7. 2014-03-21. PMID:23822626. |
we used a palette of seven monoclonal antibodies for exact localization of different cells creating the thymic microenvironment (cytokeratin ae1/ae3, desmin, actin, s100 protein, cd68, cd20, and cd45ro) as well as three monoclonal antibodies against proteins regulating the process of apoptosis (bcl2 oncoprotein, p53 protein, and survivin). |
2014-03-21 |
2023-08-12 |
human |
| Katharina Schlereth, Charlotte Heyl, Anna-Maria Krampitz, Marco Mernberger, Florian Finkernagel, Maren Scharfe, Michael Jarek, Ellen Leich, Andreas Rosenwald, Thorsten Stiew. Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions. PLoS genetics. vol 9. issue 8. 2014-03-21. PMID:23966881. |
there is growing evidence that the ability of p53 to bind dna in a cooperative manner prominently influences target gene selection with activation of the apoptosis program being completely dependent on dna binding cooperativity. |
2014-03-21 |
2023-08-12 |
Not clear |
| Katharina Schlereth, Charlotte Heyl, Anna-Maria Krampitz, Marco Mernberger, Florian Finkernagel, Maren Scharfe, Michael Jarek, Ellen Leich, Andreas Rosenwald, Thorsten Stiew. Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions. PLoS genetics. vol 9. issue 8. 2014-03-21. PMID:23966881. |
since both activation of apoptosis genes with non-canonical response elements and repression of pro-survival genes are crucial for p53's apoptotic activity, the cistrome analysis comprehensively explains why p53-induced apoptosis, but not cell cycle arrest, strongly depends on the intermolecular cooperation of p53 molecules as a possible safeguard mechanism protecting from accidental cell killing. |
2014-03-21 |
2023-08-12 |
Not clear |
| Alessandra Bisio, Veronica De Sanctis, Valerio Del Vescovo, Michela A Denti, Anil G Jegga, Alberto Inga, Yari Ciribill. Identification of new p53 target microRNAs by bioinformatics and functional analysis. BMC cancer. vol 13. 2014-03-21. PMID:24256616. |
the tumor suppressor p53 is a sequence-specific transcription factor that regulates an extensive network of coding genes, long non-coding rnas and micrornas, that establish intricate gene regulatory circuits influencing many cellular responses beyond the prototypical control of cell cycle, apoptosis and dna repair. |
2014-03-21 |
2023-08-12 |
Not clear |
| Xiaoyang Wu, Yunliang Wang, Hongwei Wang, Qiang Wang, Lin Wang, Jingcheng Miao, Fengmei Cui, Jinzhi Wan. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Current therapeutic research, clinical and experimental. vol 73. issue 1-2. 2014-03-21. PMID:24653512. |
in the cancer cells, qc can simultaneously suppress nuclear factor-κb and activate p53 signaling, which results in the induction of the apoptosis in these cells. |
2014-03-21 |
2023-08-12 |
mouse |
| Chun-lei Wang, Yuan-lian Wan, Yu-cun Liu, Zhi-qiang Huan. Apoptosis of human hepatoma cell lines induced by transforming growth factor beta 1 (TGF-beta1) correlates with p53 and Smad4 activation. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. vol 38. issue 2. 2014-03-20. PMID:16617361. |
apoptosis of human hepatoma cell lines induced by transforming growth factor beta 1 (tgf-beta1) correlates with p53 and smad4 activation. |
2014-03-20 |
2023-08-12 |
human |
| Laura Marcos-Villar, José V Pérez-Girón, Jéssica M Vilas, Atenea Soto, Carlos F de la Cruz-Hererra, Valerie Lang, Manuel Collado, Anxo Vidal, Manuel S Rodríguez, César Muñoz-Fontela, Carmen Riva. SUMOylation of p53 mediates interferon activities. Cell cycle (Georgetown, Tex.). vol 12. issue 17. 2014-03-20. PMID:23966171. |
the tumor suppressor p53 is a modulator of the ifn response that plays a role in virus-induced apoptosis and in ifn-induced senescence. |
2014-03-20 |
2023-08-12 |
Not clear |
| Hang Yuan, Shi-Liang Tu, Xu-Jun H. [Relationship between PUMA and BIM expression in colorectal cancer and tumor invasion, metastasis and prognosis]. Zhonghua wai ke za zhi [Chinese journal of surgery]. vol 51. issue 6. 2014-03-20. PMID:24091272. |
to study p53 up-regulated modulator of apoptosis (puma) and bcl-2 interacting mediator of cell death (bim) of the bh3-only protein family expression in colorectal cancer tissues and its relationship with colorectal cancer invasion, metastasis and prognosis. |
2014-03-20 |
2023-08-12 |
Not clear |
| Minjae Lee, Hyereen Kang, Sung-Wuk Jan. CoCl2 induces PC12 cells apoptosis through p53 stability and regulating UNC5B. Brain research bulletin. vol 96. 2014-03-19. PMID:23651544. |
cocl2 induces pc12 cells apoptosis through p53 stability and regulating unc5b. |
2014-03-19 |
2023-08-12 |
Not clear |
| Minjae Lee, Hyereen Kang, Sung-Wuk Jan. CoCl2 induces PC12 cells apoptosis through p53 stability and regulating UNC5B. Brain research bulletin. vol 96. 2014-03-19. PMID:23651544. |
the downregulation of p53 expression with specific small interfering rna (p53 sirna) in cocl2-treated pc12 cells caused reduction in apoptosis, unc5b expression, and p21 expression. |
2014-03-19 |
2023-08-12 |
Not clear |
| Minjae Lee, Hyereen Kang, Sung-Wuk Jan. CoCl2 induces PC12 cells apoptosis through p53 stability and regulating UNC5B. Brain research bulletin. vol 96. 2014-03-19. PMID:23651544. |
collectively, these results demonstrate a novel role for p53 in the control of cocl2-induced apoptosis through the regulation of unc5b. |
2014-03-19 |
2023-08-12 |
Not clear |
| Andrew G Mercader, Alicia B Pomili. Naturally-occurring dimers of flavonoids as anticarcinogens. Anti-cancer agents in medicinal chemistry. vol 13. issue 8. 2014-03-18. PMID:23796246. |
this work is focused on probably the most potentially relevant biological activity of biflavonoids, the anticancer activity and the involved mechanisms of action, such as induction of apoptosis [inhibition of cyclic nucleotide phosphodiesterases; effects on nf-κb family of transcription factors; activation of caspase(s); inhibition effects on bcl-2 expression, and upregulation of p53 and caspase-3 gene expression]; inhibition of angiogenesis [anti-proliferative effects; activation of rho-gtpases and erk signaling pathways; inhibition of fasn activity]; inhibition of pre-mrna splicing; inhibition of human dna topoisomerases i and ii-α; anti-inflammatory/ immunoregulatory effects [inhibition of xo; inhibition of proinflammatory enzymes, such as pla2 and cox; effects on cytokines mediated cox-2 and inos expression]; modulation of immune response; inhibition of protein tyrosine phosphorylation; antioxidant and analgesic activities in relation to the anticarcinogen behavior. |
2014-03-18 |
2023-08-12 |
human |
| Fang Yan, Haihong Liu, Zengrong Li. Dynamic analysis of the combinatorial regulation involving transcription factors and microRNAs in cell fate decisions. Biochimica et biophysica acta. vol 1844. issue 1 Pt B. 2014-03-18. PMID:23845991. |
p53 and e2f1 are critical transcription factors involved in the choices between different cell fates including cell differentiation, cell cycle arrest or apoptosis. |
2014-03-18 |
2023-08-12 |
Not clear |
| Petra Baresova, Jana Musilova, Paula M Pitha, Barbora Lubyov. p53 tumor suppressor protein stability and transcriptional activity are targeted by Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3. Molecular and cellular biology. vol 34. issue 3. 2014-03-18. PMID:24248600. |
virf-3 was shown to interact with p53 and inhibit p53-mediated apoptosis. |
2014-03-18 |
2023-08-12 |
Not clear |
| Lin Liu, Jie Lian, Huijuan Zhang, Hui Tian, Meng Liang, Mianmian Yin, Fei Su. MicroRNA-302a sensitizes testicular embryonal carcinoma cells to cisplatin-induced cell death. Journal of cellular physiology. vol 228. issue 12. 2014-03-14. PMID:23625774. |
mir-302a induced apoptosis was further enhanced by silencing of p53 in nt2 cells. |
2014-03-14 |
2023-08-12 |
human |
| Yanyan Wang, Yuan Ji, Zhongyi Hu, Hanming Jiang, Fanghua Zhu, Huiqing Yuan, Hongxiang Lo. Riccardin D induces cell death by activation of apoptosis and autophagy in osteosarcoma cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 27. issue 6. 2014-03-12. PMID:23810952. |
further studies revealed that the antiproliferation of rd was unaffected in the presence of p53 inhibitor but was partially reversed by a pan-inhibitor of caspases, suggesting that p53 was not required in rd-mediated apoptosis and that caspase-independent mechanisms were involved in rd-mediated cell death. |
2014-03-12 |
2023-08-12 |
Not clear |
| P Bose, S Thakur, S Thalappilly, B Y Ahn, S Satpathy, X Feng, K Suzuki, S W Kim, K Riabowo. ING1 induces apoptosis through direct effects at the mitochondria. Cell death & disease. vol 4. 2014-03-12. PMID:24008732. |
here we show that ing1 translocates to the mitochondria of primary fibroblasts and established epithelial cell lines in response to apoptosis inducing stimuli, independent of the cellular p53 status. |
2014-03-12 |
2023-08-12 |
Not clear |
| Y-H Fan, J Cheng, S A Vasudevan, J Dou, H Zhang, R H Patel, I T Ma, Y Rojas, Y Zhao, Y Yu, H Zhang, J M Shohet, J G Nuchtern, E S Kim, J Yan. USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell death & disease. vol 4. 2014-03-12. PMID:24136231. |
herein, we report that the ubiquitin-specific protease 7 (usp7) inhibitor, p22077, potently induces apoptosis in nb cells with an intact usp7-hdm2-p53 axis but not in nb cells with mutant p53 or without human homolog of mdm2 (hdm2) expression. |
2014-03-12 |
2023-08-12 |
mouse |
| X Peng, M-Q-Z Zhang, F Conserva, G Hosny, G Selivanova, V J N Bykov, E S J Arnér, K G Wima. APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase. Cell death & disease. vol 4. 2014-03-12. PMID:24157875. |
the low-molecular-weight compound apr-246 (prima-1(met)) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. |
2014-03-12 |
2023-08-12 |
Not clear |