| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaosheng Wan. Discovery of molecular associations among aging, stem cells, and cancer based on gene expression profiling. Chinese journal of cancer. vol 32. issue 4. 2014-04-07. PMID:23298462. |
these mechanisms are involved in cell cycle regulation, metabolic process, dna damage response, apoptosis, p53 signaling pathway, immune/inflammatory response, and other processes, suggesting that cancer is a developmental and evolutional disease that is strongly related to aging. |
2014-04-07 |
2023-08-12 |
human |
| Elwira Strozyk, Dagmar Kulm. The role of AKT/mTOR pathway in stress response to UV-irradiation: implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence. International journal of molecular sciences. vol 14. issue 8. 2014-04-07. PMID:23887651. |
besides extensive dna repair mechanisms, the damaged skin cells can be eliminated by induction of apoptosis, which is mediated through the action of tumor suppressor p53. |
2014-04-07 |
2023-08-12 |
Not clear |
| Aarthi Narayanan, Moushimi Amaya, Kelsey Voss, Myung Chung, Ashwini Benedict, Gavin Sampey, Kylene Kehn-Hall, Alessandra Luchini, Lance Liotta, Charles Bailey, Ajit Kumar, Sina Bavari, Ramin M Hakami, Fatah Kashanch. Reactive oxygen species activate NFκB (p65) and p53 and induce apoptosis in RVFV infected liver cells. Virology. vol 449. 2014-04-07. PMID:24418562. |
reactive oxygen species activate nfκb (p65) and p53 and induce apoptosis in rvfv infected liver cells. |
2014-04-07 |
2023-08-12 |
Not clear |
| O V Dolgikh, A V Krivtsov, O A Bubnova, R A Predeina, D G Dianova, O O Sinitsyna, N N Maliutina, L A Taranenk. [Immunogenetic features of apoptosis in workers engaged in methanol production]. Meditsina truda i promyshlennaia ekologiia. issue 11. 2014-04-04. PMID:24640084. |
genetic changes in the main group are associated with reliable decrease in occurrence of transcription protein p53 and tnf receptor, and with altered ratio of intracellular apoptosis factors (bax and bcl-2) towards slower programmed cellular death in chemical production. |
2014-04-04 |
2023-08-12 |
Not clear |
| Jingjie Zhang, Guangxun Gao, Liang Chen, Xu Deng, Jingxia Li, Yonghui Yu, Dongyun Zhang, Fei Li, Min Zhang, Qinshi Zhao, Chuanshu Huan. Cheliensisin A inhibits EGF-induced cell transformation with stabilization of p53 protein via a hydrogen peroxide/Chk1-dependent axis. Cancer prevention research (Philadelphia, Pa.). vol 6. issue 9. 2014-04-03. PMID:23852422. |
this notion was substantiated by the results that transfection of dominant negative mutant of chk1 (gfp-chk1 d130a) significantly attenuated the p53 protein expression, cell apoptosis, and inhibition of cell transformation by chel a. |
2014-04-03 |
2023-08-12 |
human |
| Yong-Jun Shin, Kai-Yuan Chen, Ali H Sayed, Brandon Hencey, Xiling She. Post-translational regulation enables robust p53 regulation. BMC systems biology. vol 7. 2014-04-01. PMID:23992617. |
the tumor suppressor protein p53 plays important roles in dna damage repair, cell cycle arrest and apoptosis. |
2014-04-01 |
2023-08-12 |
Not clear |
| Yung-Lin Chu, Chi-Tang Ho, Jing-Gung Chung, Rajasekaran Raghu, Yi-Chen Lo, Lee-Yan Shee. Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy. Journal of agricultural and food chemistry. vol 61. issue 41. 2014-04-01. PMID:24059278. |
allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy. |
2014-04-01 |
2023-08-12 |
human |
| Monia Lenzi, Carmela Fimognari, Patrizia Hreli. Sulforaphane as a promising molecule for fighting cancer. Cancer treatment and research. vol 159. 2014-04-01. PMID:24114482. |
cell vulnerability to sfn-mediated apoptosis was subject to regulation by cell-cycle-dependent mechanisms but was independent of a mutated p53 status. |
2014-04-01 |
2023-08-12 |
human |
| Shinji Otozai, Tomoko Ishikawa-Fujiwara, Shoji Oda, Yasuhiro Kamei, Haruko Ryo, Ayuko Sato, Taisei Nomura, Hiroshi Mitani, Tohru Tsujimura, Hidenori Inohara, Takeshi Tod. p53-Dependent suppression of genome instability in germ cells. Mutation research. vol 760. 2014-04-01. PMID:24406868. |
in the spermatogonia of the testis, radiation induced a high level of apoptosis both in wild-type and msh2(-/-) fish, but negligible levels in p53(-/-) fish. |
2014-04-01 |
2023-08-12 |
Not clear |
| N Silva, A Adamo, P Santonicola, E Martinez-Perez, A La Volp. Pro-crossover factors regulate damage-dependent apoptosis in the Caenorhabditis elegans germ line. Cell death and differentiation. vol 20. issue 9. 2014-03-31. PMID:23832114. |
although ionizing radiation fails to induce apoptosis in msh-4/5-mutant backgrounds, it induces transcriptional activation of the apoptosis-activator egl-1, which is controlled by the caenorhabditis elegans p53 orthologue cep-1. |
2014-03-31 |
2023-08-12 |
caenorhabditis_elegans |
| Masaki Kitazono, Hiroyuki Shinchi, Sumiya Ishigami, Shinichi Ueno, Shoji Natsugo. Effects of a histone deacetylase inhibitor, sodium butyrate, on 53-kDa protein expression and sensitivity to anticancer drugs of pancreatic cancer cells. Current therapeutic research, clinical and experimental. vol 71. issue 3. 2014-03-31. PMID:24683262. |
the lack of a functional p53 has been proposed to be a component of resistance to chemotherapy, resulting in the inhibition of apoptosis. |
2014-03-31 |
2023-08-12 |
Not clear |
| Yu-Li Lo, Wanjen Wang, Cheng-Ta H. 7,3',4'-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species. Toxicology. vol 302. issue 2-3. 2014-03-28. PMID:22914566. |
7,3',4'-thif and/or epi triggered apoptosis through the upregulation of p53, bax, and caspase-9. |
2014-03-28 |
2023-08-12 |
human |
| Laura Bonfili, Massimiliano Cuccioloni, Valentina Cecarini, Matteo Mozzicafreddo, Francesco Alessandro Palermo, Paolo Cocci, Mauro Angeletti, Anna Maria Eleuter. Ghrelin induces apoptosis in colon adenocarcinoma cells via proteasome inhibition and autophagy induction. Apoptosis : an international journal on programmed cell death. vol 18. issue 10. 2014-03-26. PMID:23632965. |
moreover, 1 μm ghrelin induced apoptosis in colorectal adenocarcinoma cells by inhibiting the ubiquitin-proteasome system and by activating autophagy, with p53 having an "interactive" role. |
2014-03-26 |
2023-08-12 |
human |
| Richa Tiwary, Weiping Yu, Bob G Sanders, Kimberly Klin. α-TEA cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant, triple-negative human breast cancer cells via activating p73. Breast cancer research : BCR. vol 13. issue 1. 2014-03-25. PMID:21214929. |
α-tea cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant, triple-negative human breast cancer cells via activating p73. |
2014-03-25 |
2023-08-12 |
human |
| Wen Yu, Zan Wan, Xue-Feng Qiu, Yun Chen, Yu-Tian Da. Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats. Asian journal of andrology. vol 15. issue 5. 2014-03-25. PMID:23792339. |
in contrast, resveratrol downregulated the expression of p53 and foxo3a, which regulate apoptosis and oxidative stress. |
2014-03-25 |
2023-08-12 |
rat |
| Feng Cui, Victor B Zhurki. Rotational positioning of nucleosomes facilitates selective binding of p53 to response elements associated with cell cycle arrest. Nucleic acids research. vol 42. issue 2. 2014-03-25. PMID:24153113. |
the tumor suppressor protein p53 exhibits high affinity to the response elements regulating cell cycle arrest genes (cca-sites), but relatively low affinity to the sites associated with apoptosis (apo-sites). |
2014-03-25 |
2023-08-12 |
human |
| Naoe Taira, Tomoko Yamaguchi, Junko Kimura, Zheng-Guang Lu, Shinji Fukuda, Shigeki Higashiyama, Masaya Ono, Kiyotsugu Yoshid. Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 2. 2014-03-25. PMID:24379358. |
induction of amphiregulin by p53 promotes apoptosis via control of microrna biogenesis in response to dna damage. |
2014-03-25 |
2023-08-12 |
Not clear |
| Naoe Taira, Tomoko Yamaguchi, Junko Kimura, Zheng-Guang Lu, Shinji Fukuda, Shigeki Higashiyama, Masaya Ono, Kiyotsugu Yoshid. Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 2. 2014-03-25. PMID:24379358. |
upon dna damage, tumor suppressor p53 determines cell fate by repairing dna lesions to survive or by inducing apoptosis to eliminate damaged cells. |
2014-03-25 |
2023-08-12 |
Not clear |
| Naoe Taira, Tomoko Yamaguchi, Junko Kimura, Zheng-Guang Lu, Shinji Fukuda, Shigeki Higashiyama, Masaya Ono, Kiyotsugu Yoshid. Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 2. 2014-03-25. PMID:24379358. |
however, little is known about the precise mechanism of p53 phosphorylation on the induction of apoptosis. |
2014-03-25 |
2023-08-12 |
Not clear |
| Chang-Fu Yang, Li-Xia Peng, Tie-Jun Huang, Guang-Da Yang, Qiao-Qiao Chu, Ying-Ying Liang, Xue Cao, Ping Xie, Li-Sheng Zheng, Hong-Bing Huang, Mao-De Cai, Jia-Ling Huang, Ran-Yi Liu, Zhen-Yu Zhu, Chao-Nan Qian, Bi-Jun Huan. Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway. Cancer letters. vol 344. issue 2. 2014-03-24. PMID:24262659. |
our results also demonstrated that phosphorylation of the dna damage response (ddr) proteins, atm, chk1, chk2 and p53, was inactivated in the lmp1-induced cd44(+/high) cells in response to dna damage, and this was accompanied by a downregulation of the p53-targeted proapoptotic genes, which suggested that the inactivation of the p53-mediated apoptosis pathway was responsible for the radioresistance in the cd44(+/high) cells. |
2014-03-24 |
2023-08-12 |
Not clear |