| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liping Ma, Cuili Qin, Mingchun Wang, Dan Gan, Lin Cao, Hong Ye, Xiaoxiong Zen. Preparation, preliminary characterization and inhibitory effect on human colon cancer HT-29 cells of an acidic polysaccharide fraction from Stachys floridana Schuttl. ex Benth. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 60. 2014-05-05. PMID:23911803. |
these results indicated that sfpsa might induce apoptosis of ht-29 cells through regulation of apoptosis-associated gene expressions such as bcl-2, bax and p53 and the activation of caspase-3. |
2014-05-05 |
2023-08-12 |
human |
| M Janaki Ramaiah, Sreerangam N C V L Pushpavalli, A Lavanya, Kaustav Bhadra, V Haritha, Nibedita Patel, Jaki R Tamboli, Ahmed Kamal, Utpal Bhadra, Manika Pal-Bhadr. Novel anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates modulate the expression of p53-MYCN associated micro RNAs in neuroblastoma cells and cause cell cycle arrest and apoptosis. Bioorganic & medicinal chemistry letters. vol 23. issue 20. 2014-05-05. PMID:23992861. |
it has previously been shown that anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates activate p53 and cause apoptosis in cervical cancer cells such as hela and siha. |
2014-05-05 |
2023-08-12 |
Not clear |
| M Janaki Ramaiah, Sreerangam N C V L Pushpavalli, A Lavanya, Kaustav Bhadra, V Haritha, Nibedita Patel, Jaki R Tamboli, Ahmed Kamal, Utpal Bhadra, Manika Pal-Bhadr. Novel anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates modulate the expression of p53-MYCN associated micro RNAs in neuroblastoma cells and cause cell cycle arrest and apoptosis. Bioorganic & medicinal chemistry letters. vol 23. issue 20. 2014-05-05. PMID:23992861. |
our data revealed that conjugates of this nature cause cell cycle arrest and apoptosis in imr-32 cells [mycn (+) with intact wild-type p53] by activating p53 signalling and provides a lead for the development of anti-cancer therapeutics. |
2014-05-05 |
2023-08-12 |
Not clear |
| Kyung-No Son, Zhiguo Liang, Howard L Lipto. Mutation of the Theiler's virus leader protein zinc-finger domain impairs apoptotic activity in murine macrophages. Virus research. vol 177. issue 2. 2014-05-05. PMID:24036175. |
a functional l zinc-finger domain was also required for activation of p38 mapk that results in phosphorylation and activation of p53, and in turn, alteration of the conformation of the anti-apoptotic proteins puma and mcl-1, leading to the release of pro-apoptotic bax and apoptosis through the intrinsic pathway. |
2014-05-05 |
2023-08-12 |
Not clear |
| Mi-Xue Xie, Yan-Hui Xi. [Advances of studies on members of P53 family, interaction and relation with leukemia -review]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 5. 2014-05-05. PMID:24156460. |
the p53 gene has the important functions including induction of apoptosis, regulation of cell cycle, repair of dna damage. |
2014-05-05 |
2023-08-12 |
human |
| Mi-Xue Xie, Yan-Hui Xi. [Advances of studies on members of P53 family, interaction and relation with leukemia -review]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 5. 2014-05-05. PMID:24156460. |
the p73 or p63 gene, the member of the p53 family not only possesses similar to p53 activity of inducing apoptosis, activating transcription, but also plays different biological effects according to protein structural diversity, and even antagonises the function of the p53 gene. |
2014-05-05 |
2023-08-12 |
human |
| Juan Antonio Marchal, Esther Carrasco, Alberto Ramirez, Gema Jiménez, Carmen Olmedo, Macarena Peran, Ahmad Agil, Ana Conejo-García, Olga Cruz-López, Joaquin María Campos, María Ángel Garcí. Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence. Drug design, development and therapy. vol 7. 2014-05-05. PMID:24194639. |
however, p53 was not affected by bozepinib, and was not necessary for induction of apoptosis in either breast or colon cancer cells. |
2014-05-05 |
2023-08-12 |
Not clear |
| Chunyu Gu, Yeshavanth K Banasavadi-Siddegowda, Kaushal Joshi, Yuko Nakamura, Habibe Kurt, Snehalata Gupta, Ichiro Nakan. Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner. Stem cells (Dayton, Ohio). vol 31. issue 5. 2014-05-02. PMID:23339114. |
additionally, melk silencing-mediated gsc apoptosis is partially rescued by both pharmacological p53 inhibition and p53 gene silencing, indicating that melk action in gscs is p53 dependent. |
2014-05-02 |
2023-08-12 |
mouse |
| Hee Jung Park, Mingi Hong, Roderick T Bronson, Mark A Israel, Wayne N Frankel, Kyuson Yu. Elevated Id2 expression results in precocious neural stem cell depletion and abnormal brain development. Stem cells (Dayton, Ohio). vol 31. issue 5. 2014-05-02. PMID:23390122. |
deletion of p53 function from id2-transgenic brains rescues apoptosis and results in increased incidence of brain tumors. |
2014-05-02 |
2023-08-12 |
mouse |
| Yuyan Xiong, Yi Yu, Jean-Pierre Montani, Zhihong Yang, Xiu-Fen Min. Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability. Journal of the American Heart Association. vol 2. issue 4. 2014-05-02. PMID:23832324. |
arginase-ii induces vascular smooth muscle cell senescence and apoptosis through p66shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability. |
2014-05-02 |
2023-08-12 |
mouse |
| Min-Sung Lee, Ji-Hyang Ha, Ho Sup Yoon, Chong-Kil Lee, Seung-Wook Ch. Structural basis for the conserved binding mechanism of MDM2-inhibiting peptides and anti-apoptotic Bcl-2 family proteins. Biochemical and biophysical research communications. vol 445. issue 1. 2014-05-02. PMID:24491548. |
the interaction between tumor suppressor p53 and the anti-apoptotic bcl-2 family proteins serves a critical role in the transcription-independent apoptosis mechanism of p53. |
2014-05-02 |
2023-08-12 |
Not clear |
| R Voltan, P Secchiero, B Ruozi, L Caruso, F Forni, M Palomba, G Zauli, M A Vandell. Nanoparticles loaded with Nutlin-3 display cytotoxicity towards p53(wild-type) JVM-2 but not towards p53(mutated) BJAB leukemic cells. Current medicinal chemistry. vol 20. issue 21. 2014-05-01. PMID:23627936. |
np loaded with nutlin-3 (np-nutlin) were rapidly taken up by the leukemic cells and were as effective as native nutlin-3 in promoting both induction of apoptosis and cell cycle arrest in p53(wild-type) jvm-2 cells, but not in p53(mutated) bjab cells. |
2014-05-01 |
2023-08-12 |
mouse |
| Y Hadjal, O Hadadeh, C E I Yazidi, E Barruet, B Binétru. A p38MAPK-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells. Cell death & disease. vol 4. 2014-05-01. PMID:23887628. |
in addition to its well-known role in dna-damage response, apoptosis, cell cycle control and tumor suppression, p53 has also been involved in vivo in embryonic development; our results show now that p53 mediates, at least for a large part, the p38mapk control of the early commitment of escs toward mesodermal and neural lineages. |
2014-05-01 |
2023-08-12 |
mouse |
| A Ali, O Bluteau, K Messaoudi, A Palazzo, S Boukour, L Lordier, Y Lecluse, P Rameau, L Kraus-Berthier, A Jacquet-Bescond, H Lelièvre, S Depil, P Dessen, E Solary, H Raslova, W Vainchenker, I Plo, N Debil. Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms. Cell death & disease. vol 4. 2014-05-01. PMID:23887629. |
the use of a p53 shrna rescued apoptosis, and only partially the defect in ppt formation. |
2014-05-01 |
2023-08-12 |
human |
| Yong-Ming Zhou, Mei-Xia Yu, Yu-Zhen Qiu, Xiao-Lei Xing, Chun-Hong Yao, Ru-Jun Ba. [Mechanism of HL-60 cells apoptosis induced by proteasome inhibitor MG132]. Zhongguo shi yan xue ye xue za zhi. vol 21. issue 4. 2014-05-01. PMID:23998584. |
apoptosis of hl-60 cells was detected by flow cytometry, the expression of p21, p27 and p53 proteins in hl-60 cells treated with mg132 was assayed by western blot. |
2014-05-01 |
2023-08-12 |
Not clear |
| Hwa Jin Jung, Hye Lim Kim, Yeo Jin Kim, Jong-Il Weon, Young Rok Se. A novel chemopreventive mechanism of selenomethionine: enhancement of APE1 enzyme activity via a Gadd45a, PCNA and APE1 protein complex that regulates p53-mediated base excision repair. Oncology reports. vol 30. issue 4. 2014-04-29. PMID:23846616. |
our previous study showed that selenomethionine (semet) induces p53 activation without genotoxic effects including apoptosis and cell cycle arrest. |
2014-04-29 |
2023-08-12 |
human |
| Ming Sun, Rui Xia, Feiyan Jin, Tongpeng Xu, Zhijun Liu, Wei De, Xianghua Li. Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 2. 2014-04-28. PMID:24006224. |
furthermore, knockdown of meg3 expression by sirna could promote cell proliferation, while ectopic expression of meg3 inhibited cell proliferation, promoted cell apoptosis, and modulated p53 expression in gastric cancer cell lines. |
2014-04-28 |
2023-08-12 |
human |
| James A Mauro, George Blanc. Functionally distinct gene classes as bigger or smaller transcription factor traps: a possible stochastic component to sequential gene expression programs in cancer. Gene. vol 536. issue 2. 2014-04-28. PMID:24291030. |
we also applied this paradigm to the question of why p53 and interferon regulatory factor-1 (irf-1) first activate cell cycle arrest genes followed by apoptosis genes, with results indicating the cycle arrest genes are bigger p53 and irf-1 traps. |
2014-04-28 |
2023-08-12 |
Not clear |
| Vidhula Ahire, Kaushala Prasad Mishra, G R Kulkarn. On the mechanism of cellular toxicity in breast cancer by ionizing radiation and chemotherapeutic drugs. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 33. issue 1. 2014-04-28. PMID:24579811. |
both bcl-2 and p53 are linked to apoptosis pathways and are known to play a role in the outcome of radiotherapy. |
2014-04-28 |
2023-08-12 |
Not clear |
| A A Khutornenko, A A Dalina, B V Chernyak, P M Chumakov, A G Evstafiev. The Role of Dihydroorotate Dehydrogenase in Apoptosis Induction in Response to Inhibition of the Mitochondrial Respiratory Chain Complex III. Acta naturae. vol 6. issue 1. 2014-04-28. PMID:24772329. |
previously, we had found that inhibition of mitochondrial cytochrome bc1, a component of the electron transport chain complex iii, leads to activation of tumor suppressor p53, followed by apoptosis induction. |
2014-04-28 |
2023-08-13 |
human |