| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Federica Polato, Paolo Rusconi, Stefano Zangrossi, Federica Morelli, Mattia Boeri, Alberto Musi, Sergio Marchini, Vittoria Castiglioni, Eugenio Scanziani, Valter Torri, Massimo Broggin. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]. Journal of the National Cancer Institute. vol 106. issue 4. 2014-06-02. PMID:24652652. |
p53 influences genomic stability, apoptosis, autophagy, response to stress, and dna damage. |
2014-06-02 |
2023-08-12 |
Not clear |
| Agata Grazia D'Amico, Soraya Scuderi, Salvatore Saccone, Alessandro Castorina, Filippo Drago, Velia D'Agat. Antiproliferative effects of PACAP and VIP in serum-starved glioma cells. Journal of molecular neuroscience : MN. vol 51. issue 2. 2014-05-30. PMID:23900722. |
cell viability, expression of proteins related to cell proliferation (cyclin d1), apoptosis (bcl2, p53, and cleaved caspase-3), and cell malignancy (gfap and nestin) were assessed by mtt assay, immunoblot, and immunolocalization, respectively. |
2014-05-30 |
2023-08-12 |
Not clear |
| Mahmoud R Gaballa, Emmanuel C Bes. Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide. Annals of hematology. vol 93. issue 5. 2014-05-29. PMID:24627193. |
subsequent to p53 activation, erythroid cell apoptosis and ineffective erythropoiesis occur. |
2014-05-29 |
2023-08-12 |
Not clear |
| Aneta Rogalska, Arkadiusz Gajek, Agnieszka Marcza. Analysis of epothilone B-induced cell death in normal ovarian cells. Cell biology international. vol 37. issue 12. 2014-05-28. PMID:23955989. |
induction of apoptosis followed an early increase in p53 levels. |
2014-05-28 |
2023-08-12 |
Not clear |
| Zhenhuan Ma, Kaiyuan Luo, Yong Yang, Guokai Yang, Jia Wan, Guojian L. Treating colon cancer with injectable PLGA-PEG-PLGA as a carrier for iodine-125. Biotechnology letters. vol 35. issue 12. 2014-05-28. PMID:24062131. |
ppp-embedded iodine-125 induced apoptosis by increasing the expression of p53, and by decreasing the levels of vegf and mvd in the colon cancer tumors (p < 0.01). |
2014-05-28 |
2023-08-12 |
mouse |
| Xian-ling Guo, Fei Hu, Shan-shan Zhang, Qiu-dong Zhao, Chen Zong, Fei Ye, Shi-wei Guo, Jian-wei Zhang, Rong Li, Meng-chao Wu, Li-xin We. Inhibition of p53 increases chemosensitivity to 5-FU in nutrient-deprived hepatocarcinoma cells by suppressing autophagy. Cancer letters. vol 346. issue 2. 2014-05-28. PMID:24462821. |
activation of p53 can induce apoptosis, cell cycle arrest, and cell senescence, although some evidence has suggested that p53 could promote cell survival. |
2014-05-28 |
2023-08-12 |
Not clear |
| Xian-ling Guo, Fei Hu, Shan-shan Zhang, Qiu-dong Zhao, Chen Zong, Fei Ye, Shi-wei Guo, Jian-wei Zhang, Rong Li, Meng-chao Wu, Li-xin We. Inhibition of p53 increases chemosensitivity to 5-FU in nutrient-deprived hepatocarcinoma cells by suppressing autophagy. Cancer letters. vol 346. issue 2. 2014-05-28. PMID:24462821. |
in this study, we show that inhibition of p53 enhanced apoptosis and increased chemosensitivity to 5-fluorouracil (5-fu) in nutrient-deprived hepatocarcinoma cells (hcc). |
2014-05-28 |
2023-08-12 |
Not clear |
| K Ito, Z Maruyama, A Sakai, S Izumi, T Moriishi, C A Yoshida, T Miyazaki, H Komori, K Takada, H Kawaguchi, T Komor. Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53-dependent apoptosis without enhancing proliferation. Oncogene. vol 33. issue 14. 2014-05-27. PMID:23624920. |
p53 deletion partially restored the size of the skeleton and almost completely rescued chondrocyte apoptosis, but failed to enhance chondrocyte proliferation in k6(h)/d1(h) mice. |
2014-05-27 |
2023-08-12 |
mouse |
| Junlian Gu, Bo Wang, Yanan Liu, Lingzhi Zhong, Yufeng Tang, Hua Guo, Tao Jiang, Liwei Wang, Yang Li, Lu Ca. Murine double minute 2 siRNA and wild-type p53 gene therapy interact positively with zinc on prostate tumours in vitro and in vivo. European journal of cancer (Oxford, England : 1990). vol 50. issue 6. 2014-05-27. PMID:24447832. |
combined treatments significantly inhibited tumour xenograft growth, retaining wild-type p53 conformation and enhancing its transcriptional regulation of p21 and bax gene expression, leading to the decreased proliferation and increased apoptosis. |
2014-05-27 |
2023-08-12 |
mouse |
| Junlian Gu, Bo Wang, Yanan Liu, Lingzhi Zhong, Yufeng Tang, Hua Guo, Tao Jiang, Liwei Wang, Yang Li, Lu Ca. Murine double minute 2 siRNA and wild-type p53 gene therapy interact positively with zinc on prostate tumours in vitro and in vivo. European journal of cancer (Oxford, England : 1990). vol 50. issue 6. 2014-05-27. PMID:24447832. |
these in vivo findings were confirmed by in vitro culture of pca pc-3 (p53 null) or du145 (mutant p53) cells and showed a positive effect of the combined therapy on cell cycle arrest and massive apoptosis. |
2014-05-27 |
2023-08-12 |
mouse |
| S Khan, G B Jen. Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat. Chemico-biological interactions. vol 213. 2014-05-27. PMID:24530320. |
plasma glucose and insulin levels, hba1c, glucose tolerance, apoptosis, and expression of proliferating cell nuclear antigen (pcna), p38, p53, caspase-3, extracellular signal-regulated kinase-1/2 (erk-1/2), forkhead box protein o1 (foxo1) and insulin receptor substrate-1 (irs-1) as well as histone acetylation were evaluated. |
2014-05-27 |
2023-08-12 |
rat |
| Wei Song, Wenyong Liu, Xufeng Niu, Qingchun Wang, Lianwen Sun, Meili Liu, Yubo Fa. Three-dimensional morphometric comparison of normal and apoptotic endothelial cells based on laser scanning confocal microscopy observation. Microscopy research and technique. vol 76. issue 11. 2014-05-26. PMID:23955846. |
the results reveal that h2 o2 can induce apoptosis effectively by regulating the activity of apoptosis-related biomolecules, including pro-apoptotic factors p53 and bax, and anti-apoptotic factor bcl-2. |
2014-05-26 |
2023-08-12 |
human |
| Giorgia Gioacchini, Luisa Dalla Valle, Francesca Benato, Gian Maria Fimia, Roberta Nardacci, Fabiola Ciccosanti, Mauro Piacentini, Andrea Borini, Oliana Carneval. Interplay between autophagy and apoptosis in the development of Danio rerio follicles and the effects of a probiotic. Reproduction, fertility, and development. vol 25. issue 8. 2014-05-22. PMID:23195281. |
the increased autophagy in preovulatory follicles from females fed the probiotic was concomitant with a decrease in the apoptotic process in the ovary, as evidenced by terminal deoxyribonucleotidyl transferase-mediated dutp-digoxigenin nick end-labelling analysis and confirmed by lower expression of genes involved in apoptosis (i.e., p53, bax, apaf and cas3) and higher expression as igfii and igf1r. |
2014-05-22 |
2023-08-12 |
zebrafish |
| Frank Louwen, Juping Yua. Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy. Oncotarget. vol 4. issue 7. 2014-05-22. PMID:23948487. |
upon treatment with plk1 inhibitors, p53 in tumor cells is activated and induces strong apoptosis, whereas tumor cells with inactive p53 arrest in mitosis with dna damage. |
2014-05-22 |
2023-08-12 |
Not clear |
| Frank Louwen, Juping Yua. Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy. Oncotarget. vol 4. issue 7. 2014-05-22. PMID:23948487. |
in addition, compared to the mono-treatment, combination of polo-like kinase 1 inhibition with anti-mitotic or dna damaging agents boosts more severe mitotic defects, effectually triggers apoptosis and strongly inhibits proliferation of cancer cells with functional p53. |
2014-05-22 |
2023-08-12 |
Not clear |
| Abood Okal, Mohanad Mossalam, Karina J Matissek, Andrew S Dixon, Philip J Moos, Carol S Li. A chimeric p53 evades mutant p53 transdominant inhibition in cancer cells. Molecular pharmaceutics. vol 10. issue 10. 2014-05-22. PMID:23964676. |
furthermore, p53-cc was found to cause apoptosis in four different cancer cell lines, regardless of endogenous p53 status. |
2014-05-22 |
2023-08-12 |
Not clear |
| Karina J Matissek, Mohanad Mossalam, Abood Okal, Carol S Li. The DNA binding domain of p53 is sufficient to trigger a potent apoptotic response at the mitochondria. Molecular pharmaceutics. vol 10. issue 10. 2014-05-22. PMID:23968395. |
the tumor suppressor p53 is one of the most studied proteins in human cancer.1-3 while nuclear p53 has been utilized for cancer gene therapy, mitochondrial targeting of p53 has not been fully exploited to date.4,5 in response to cellular stress, p53 translocates to the mitochondria and directly interacts with bcl-2 family proteins including antiapoptotic bcl-xl and bcl-2 and proapoptotic bak and bax.6 antiapoptotic bcl-xl forms inhibitory complexes with proapoptotic bak and bax preventing their homo-oligomerization.7 upon translocation to the mitochondria, p53 binds to bcl-xl, releases bak and bax from the inhibitory complex and enhances their homo-oligomerization.8 bak and bax homotetramer formation disrupts the mitochondrial outer membrane, releases antiapoptotic factors such as cytochrome c and triggers a rapid apoptotic response mediated by caspase induction.9 it is still unclear if the mdm2 binding domain (mbd), the proline-rich domain (prd) and/or dna binding domain (dbd) of p53 are the domains responsible for interaction with bcl-xl.10-17 the purpose of this work is to determine if a smaller functional domain of p53 is capable of inducing apoptosis similarly to full length p53. |
2014-05-22 |
2023-08-12 |
human |
| Karina J Matissek, Mohanad Mossalam, Abood Okal, Carol S Li. The DNA binding domain of p53 is sufficient to trigger a potent apoptotic response at the mitochondria. Molecular pharmaceutics. vol 10. issue 10. 2014-05-22. PMID:23968395. |
taken together, our data demonstrates for the first time that the dbd of p53 may be the minimally necessary domain for achieving apoptosis at the mitochondria in multiple cell lines. |
2014-05-22 |
2023-08-12 |
human |
| Larisa Pereboeva, Erik Westin, Toral Patel, Ian Flaniken, Lawrence Lamb, Aloysius Klingelhutz, Frederick Goldma. DNA damage responses and oxidative stress in dyskeratosis congenita. PloS one. vol 8. issue 10. 2014-05-22. PMID:24124565. |
apoptosis and reactive oxygen species (ros) were assessed by flow cytometry, and western blotting was used to measure expression of dna damage response (ddr) proteins, including total p53, p53s15, and p21(waf). |
2014-05-22 |
2023-08-12 |
human |
| Zhe Cheng, Huimin Tian, Hongran Chu, Jianjian Wu, Yingying Li, Yanhai Wan. The effect of tributyltin chloride on Caenorhabditis elegans germline is mediated by a conserved DNA damage checkpoint pathway. Toxicology letters. vol 225. issue 3. 2014-05-21. PMID:24445071. |
this apoptotic response was blocked in loss-of-function mutants of hus-1 (op241), mrt-2 (e2663) and p53/cep-1 (gk138), indicating that checkpoints and p53 are essential for mediating tbtcl-induced germ cell apoptosis. |
2014-05-21 |
2023-08-12 |
caenorhabditis_elegans |