| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Judong Luo, Zhonghua Lu, Xujing Lu, Ling Chen, Jianping Cao, Shuyu Zhang, Yang Ling, Xifa Zho. OTUD5 regulates p53 stability by deubiquitinating p53. PloS one. vol 8. issue 10. 2014-06-17. PMID:24143256. |
the p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. |
2014-06-17 |
2023-08-12 |
Not clear |
| Tatiana Grohmann Ortolan, Carlos Frederico M Menc. UVB-induced cell death signaling is associated with G1-S progression and transcription inhibition in primary human fibroblasts. PloS one. vol 8. issue 10. 2014-06-17. PMID:24155908. |
thus, uvb-induced accumulation of mdm2 is critical for counteracting p53 activation and apoptosis avoidance, but its effect is limited due to transcription inhibition. |
2014-06-17 |
2023-08-12 |
human |
| Pierfausto Senec. Small molecules as pro-apoptotic anticancer agents. Pharmaceutical patent analyst. vol 1. issue 4. 2014-06-17. PMID:24236885. |
this review is chemically focused on small molecules and deals with five target families that influence caspase-dependent apoptosis: caspase-3, bcl-2 and iap protein family members, p53 and the proteasome. |
2014-06-17 |
2023-08-12 |
Not clear |
| Chengtian Zhao, Viktoria Andreeva, Yann Gibert, Melissa LaBonty, Victoria Lattanzi, Shubhangi Prabhudesai, Yi Zhou, Leonard Zon, Kathleen L McCann, Susan Baserga, Pamela C Yelic. Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development. PLoS genetics. vol 10. issue 1. 2014-06-17. PMID:24497835. |
it has been hypothesized that perturbed ribosome biogenesis and resulting p53 mediated neuroepithelial apoptosis results in ncc hypoplasia in mouse tcof1 mutants. |
2014-06-17 |
2023-08-12 |
mouse |
| Minjun Wu, Hua Zhang, Jiehua Hu, Zhiyong Weng, Chenyuan Li, Hong Li, Yan Zhao, Xifan Mei, Fu Ren, Lihua L. Isoalantolactone inhibits UM-SCC-10A cell growth via cell cycle arrest and apoptosis induction. PloS one. vol 8. issue 9. 2014-06-16. PMID:24098753. |
to explain the molecular mechanisms underlying its effects, flow cytometry and western blot analysis showed that the apoptosis was associated with cell cycle arrest during the g1 phase, up-regulation of p53 and p21, and down-regulation of cyclin d. furthermore, our results revealed that induction of apoptosis through a mitochondrial pathway led to up-regulation of pro-apoptotic protein expression (bax), down-regulation of anti-apoptotic protein expression (bcl-2), mitochondrial release of cytochrome c (cyto c), reduction of mitochondrial membrane potential (mmp) and activation of caspase-3 (casp-3). |
2014-06-16 |
2023-08-12 |
Not clear |
| Yusuke S Hori, Atsushi Kuno, Ryusuke Hosoda, Yoshiyuki Hori. Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress. PloS one. vol 8. issue 9. 2014-06-15. PMID:24040102. |
sirt1 modulates the transcription factors p53, a tumor suppressor and inducer of apoptosis, and the forkhead o (foxo) family, both of which play roles for cell survival and cell death. |
2014-06-15 |
2023-08-12 |
Not clear |
| D Sun, Y Zhang, C Wang, X Hua, X A Zhang, J Ya. Sox9-related signaling controls zebrafish juvenile ovary-testis transformation. Cell death & disease. vol 4. 2014-06-12. PMID:24263104. |
these results suggest that high levels of cytoplasmic sox9a and p-erk1/2 activity activate stromal cells and enhance the production of extracellular matrix required for testis cord formation, whereas deregulation and translocation of sox9a and p-erk1/2 induce follicle disassembly and incomplete apoptosis associated with nuclear p53. |
2014-06-12 |
2023-08-12 |
zebrafish |
| C Lv, Y Hong, L Miao, C Li, G Xu, S Wei, B Wang, C Huang, B Jia. Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway. Cell death & disease. vol 4. 2014-06-12. PMID:24309939. |
when we pre-treated cells with erk, jnk, p38, p53 inhibitor or nac followed by wa treatment, only erk and p53 inhibitors blocked wa-induced apoptosis and g2/m arrest. |
2014-06-12 |
2023-08-12 |
human |
| Sharona Tornovsky-Babeay, Daniela Dadon, Oren Ziv, Elhanan Tzipilevich, Tehila Kadosh, Rachel Schyr-Ben Haroush, Ayat Hija, Miri Stolovich-Rain, Judith Furth-Lavi, Zvi Granot, Shay Porat, Louis H Philipson, Kevan C Herold, Tricia R Bhatti, Charles Stanley, Frances M Ashcroft, Peter In't Veld, Ann Saada, Mark A Magnuson, Benjamin Glaser, Yuval Do. Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells. Cell metabolism. vol 19. issue 1. 2014-06-12. PMID:24332968. |
here, we show that genetic activation of β cell glucokinase, initially triggering replication, causes apoptosis associated with dna double-strand breaks and activation of the tumor suppressor p53. |
2014-06-12 |
2023-08-12 |
Not clear |
| L Lezina, N Purmessur, A V Antonov, T Ivanova, E Karpova, K Krishan, M Ivan, V Aksenova, D Tentler, A V Garabadgiu, G Melino, N A Barle. miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress. Cell death & disease. vol 4. 2014-06-12. PMID:24336073. |
the tumour suppressor p53 is a crucial regulator of cell cycle arrest and apoptosis by acting as a transcription factor to regulate a variety of genes. |
2014-06-12 |
2023-08-12 |
Not clear |
| J-L Roh, E H Kim, H B Park, J Y Par. The Hsp90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin increases cisplatin antitumor activity by inducing p53-mediated apoptosis in head and neck cancer. Cell death & disease. vol 4. 2014-06-12. PMID:24336076. |
the present study assessed the ability of a heat shock protein 90 (hsp90) inhibitor, 17-(allylamino)-17-demethoxygeldanamycin (17aag), to induce apoptosis in hnc by restoring p53 function. |
2014-06-12 |
2023-08-12 |
mouse |
| T Valentino, D Palmieri, M Vitiello, G M Pierantoni, A Fusco, M Fedel. PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context. Cell death & disease. vol 4. 2014-06-12. PMID:24336083. |
patz1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context. |
2014-06-12 |
2023-08-12 |
mouse |
| M Seervi, P K Sobhan, J Joseph, K Ann Mathew, T R Santhoshkuma. ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1). Cell death & disease. vol 4. 2014-06-12. PMID:24357799. |
furthermore, we identified bh3-only protein p53 upregulated modulator of apoptosis (puma) as the key molecular link that orchestrates overwhelmed er stress to mitochondria-mediated apoptosis, involving mitochondrial reactive oxygen species, in a p53-independent manner. |
2014-06-12 |
2023-08-12 |
Not clear |
| Tyler A Davis, Anna E Vilgelm, Ann Richmond, Jeffrey N Johnsto. Preparation of (-)-Nutlin-3 using enantioselective organocatalysis at decagram scale. The Journal of organic chemistry. vol 78. issue 21. 2014-06-11. PMID:24127627. |
chiral nonracemic cis-4,5-bis(aryl)imidazolines have emerged as a powerful platform for the development of cancer chemotherapeutics, stimulated by the hoffmann-la roche discovery that nutlin-3 can restore apoptosis in cells with wild-type p53. |
2014-06-11 |
2023-08-12 |
Not clear |
| Yong Fu, Dalian Ding, Lei Wei, Haiyan Jiang, Richard Salv. Ouabain-induced apoptosis in cochlear hair cells and spiral ganglion neurons in vitro. BioMed research international. vol 2013. 2014-06-11. PMID:24228256. |
the major apoptotic pathways in ouabain-induced spiral ganglion neuron apoptosis culminated in the stimulation of the p53 pathway and triggering of apoptosis by a network of proapoptotic signaling pathways. |
2014-06-11 |
2023-08-12 |
rat |
| Signe Altmäe, Jose A Martinez-Conejero, Francisco J Esteban, Maria Ruiz-Alonso, Anneli Stavreus-Evers, Jose A Horcajadas, Andres Salumet. MicroRNAs miR-30b, miR-30d, and miR-494 regulate human endometrial receptivity. Reproductive sciences (Thousand Oaks, Calif.). vol 20. issue 3. 2014-06-10. PMID:22902743. |
functional analyses of the targets using ingenuity pathways analysis and the database for annotation, visualization and integrated discovery indicated roles in transcription, cell proliferation and apoptosis, and significant involvement in several relevant pathways, such as axon guidance, wnt/β-catenin, erk/mapk, transforming growth factor β (tgf-β), p53 and leukocyte extravasation. |
2014-06-10 |
2023-08-12 |
human |
| Yiwei Wang, Jinbao Zhang, Qixia Wang, Tao Zhang, Yang Yang, Yanghua Yi, Guangxun Gao, Hongjuan Dong, Huafeng Zhu, Yue Li, Houwen Lin, Haifeng Tang, Xiequn Che. Bryostatin 5 induces apoptosis in acute monocytic leukemia cells by activating PUMA and caspases. European journal of pharmacology. vol 718. issue 1-3. 2014-06-10. PMID:24036350. |
in addition, bryostatin 5 increased the expression of p53 upregulated modulator of apoptosis (puma) and slightly increased p53 expression. |
2014-06-10 |
2023-08-12 |
Not clear |
| John R P Knight, Simon J Allison, Jo Milne. Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity. Open biology. vol 3. issue 11. 2014-06-10. PMID:24258275. |
we also demonstrate that knockdown of aros induces apoptosis in three cancer cell lines, independent of p53 activation. |
2014-06-10 |
2023-08-12 |
human |
| Yan Cheng, Lin Chen, Xin Cao, Siqimeige Ha, Xiaodong Xi. [Expression profiling and functional analysis of hsa-miR-125b and its target genes in drug-resistant cell line of human gastric cancer]. Yi chuan = Hereditas. vol 36. issue 2. 2014-06-10. PMID:24846940. |
the results revealed that hsa-mir-125b may regulate multiple biological processes and signal transduction pathways, and drug-resistant occurrence is associated with cell proliferation, cell apoptosis, cell cycle and signaling pathways including mapk, wnt and p53. |
2014-06-10 |
2023-08-13 |
human |
| Haili Huang, Keng Wu, Qiong You, Ruina Huang, Shanghai Li, Keng W. Naringin inhibits high glucose-induced cardiomyocyte apoptosis by attenuating mitochondrial dysfunction and modulating the activation of the p38 signaling pathway. International journal of molecular medicine. vol 32. issue 2. 2014-06-09. PMID:23732220. |
pre-treatment with sb203580, a p38 inhibitor, also suppressed p53 phosphorylation and prevented the loss of mmp, as well as apoptosis in the hg-treated h9c2 cells. |
2014-06-09 |
2023-08-12 |
Not clear |