| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marilyn Gordon, Mohamed El-Kalla, Yuewen Zhao, Yahya Fiteih, Jennifer Law, Natalia Volodko, Anwar Anwar-Mohamed, Anwar Mohamed, Ayman O S El-Kadi, Lei Liu, Jeff Odenbach, Aducio Thiesen, Christina Onyskiw, Haya Abu Ghazaleh, Jikyoung Park, Sean Bong Lee, Victor C Yu, Carlos Fernandez-Patron, R Todd Alexander, Eytan Wine, Shairaz Baks. The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PloS one. vol 8. issue 10. 2014-07-24. PMID:24146755. |
surprisingly, tyrosine phosphorylation of yap was detected which coincided with increased nuclear p73 association, bax-driven epithelial cell death and p53 accumulation resulting in enhanced apoptosis and poor survival of dss-treated rassf1a knockout mice. |
2014-07-24 |
2023-08-12 |
mouse |
| Mingzhu Li, Yang Lu, Yan Hu, Xiaohan Zhai, Wei Xu, Huirong Jing, Xiaofeng Tian, Yuan Lin, Dongyan Gao, Jihong Ya. Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats. Toxicology letters. vol 228. issue 2. 2014-07-22. PMID:24769256. |
collectively, this study indicated that salb can alleviate acute ethanol-induced hepatocyte apoptosis through sirt1-mediated deacetylation of p53 pathway. |
2014-07-22 |
2023-08-13 |
rat |
| Brendan Mulligan, Jae-Yeon Hwang, Hyung-Min Kim, Jong-Nam Oh, Kwang-Hwan Choi, Chang-Kyu Le. Pro-apoptotic Effect of Pifithrin-α on Preimplantation Porcine In vitro Fertilized Embryo Development. Asian-Australasian journal of animal sciences. vol 25. issue 12. 2014-07-22. PMID:25049533. |
treatment of pft-α was administered at both early (0 to 48 hpi), and later stages (48 to 168 hpi) of preimplantation development, and its impact upon the expression of five genes related to apoptosis (p53, bak, bcl-xl, p66shc and caspase3), was assessed in resulting d 7 blastocysts, using real-time quantitative pcr. |
2014-07-22 |
2023-08-13 |
Not clear |
| Brendan Mulligan, Jae-Yeon Hwang, Hyung-Min Kim, Jong-Nam Oh, Kwang-Hwan Choi, Chang-Kyu Le. Pro-apoptotic Effect of Pifithrin-α on Preimplantation Porcine In vitro Fertilized Embryo Development. Asian-Australasian journal of animal sciences. vol 25. issue 12. 2014-07-22. PMID:25049533. |
thus, caution should be exercised when using pft-α as a specific inhibitor of p53 mediated apoptosis, in the context of porcine ivf embryo culture systems. |
2014-07-22 |
2023-08-13 |
Not clear |
| Gilberto Jaramillo-Rangel, Marta Ortega-Martínez, Julio Sepúlveda-Saavedra, Odila Saucedo-Cárdenas, Roberto Montes-de-Oca-Lun. p53 E3 ubiquitin protein ligase homolog regulates p53 in vivo in the adult mouse eye lens. Molecular vision. vol 19. 2014-07-21. PMID:24339722. |
p53 participates in relevant aspects of cell biology, including apoptosis and cell cycle control and must be strictly regulated to maintain normal tissue homeostasis. |
2014-07-21 |
2023-08-12 |
mouse |
| Timothy M Errington, Ian G Macar. Depletion of the adaptor protein NCK increases UV-induced p53 phosphorylation and promotes apoptosis. PloS one. vol 8. issue 9. 2014-07-18. PMID:24086708. |
depletion of the adaptor protein nck increases uv-induced p53 phosphorylation and promotes apoptosis. |
2014-07-18 |
2023-08-12 |
Not clear |
| Timothy M Errington, Ian G Macar. Depletion of the adaptor protein NCK increases UV-induced p53 phosphorylation and promotes apoptosis. PloS one. vol 8. issue 9. 2014-07-18. PMID:24086708. |
this rapid, hyperactive apoptosis in nck depleted cells might be p53 dependent, because loss of nck also increased uv-induced p53 phosphorylation. |
2014-07-18 |
2023-08-12 |
Not clear |
| Timothy M Errington, Ian G Macar. Depletion of the adaptor protein NCK increases UV-induced p53 phosphorylation and promotes apoptosis. PloS one. vol 8. issue 9. 2014-07-18. PMID:24086708. |
there are two nck isoforms that have mostly redundant functions, and although nck2 appears to have a greater contribution, depletion of nck1 or nck2, led to increased p53 phosphorylation and early apoptosis after uv exposure. |
2014-07-18 |
2023-08-12 |
Not clear |
| Timothy M Errington, Ian G Macar. Depletion of the adaptor protein NCK increases UV-induced p53 phosphorylation and promotes apoptosis. PloS one. vol 8. issue 9. 2014-07-18. PMID:24086708. |
these data reveal a novel function for nck in regulating p53 phosphorylation and apoptosis, and provide evidence for interconnectedness of growth factor signaling proteins and the dna damage response. |
2014-07-18 |
2023-08-12 |
Not clear |
| Patricia Gassó, Sergi Mas, Oriol Molina, Amalia Lafuente, Miquel Bernardo, Eduard Parellad. Increased susceptibility to apoptosis in cultured fibroblasts from antipsychotic-naïve first-episode schizophrenia patients. Journal of psychiatric research. vol 48. issue 1. 2014-07-18. PMID:24128664. |
cell growth, cell viability and various apoptotic hallmarks (caspase-3 activity, translocation of phosphatidylserine, chromatin condensation and gene expression of akt1, bax, bcl2, casp3, gsk3b and p53) were measured in fibroblast cultures obtained from skin biopsies of patients (n = 11) and healthy controls (n = 8), both in basal conditions and after inducing apoptosis with staurosporine. |
2014-07-18 |
2023-08-12 |
Not clear |
| Anna Aspesi, Elisa Pavesi, Elisa Robotti, Rossella Crescitelli, Ilenia Boria, Federica Avondo, Hélène Moniz, Lydie Da Costa, Narla Mohandas, Paola Roncaglia, Ugo Ramenghi, Antonella Ronchi, Stefano Gustincich, Simone Merlin, Emilio Marengo, Steven R Ellis, Antonia Follenzi, Claudio Santoro, Irma Dianzan. Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia. Gene. vol 545. issue 2. 2014-07-18. PMID:24835311. |
several lines of evidence suggest that defects in ribosome synthesis lead to "ribosomal stress" with p53 activation and either cell cycle arrest or induction of apoptosis. |
2014-07-18 |
2023-08-13 |
Not clear |
| Ahmad Rahimi, Ying Ying Lee, Hassen Abdella, Marcel Doerflinger, Lahiru Gangoda, Rahul Srivastava, Kun Xiao, Paul G Ekert, Hamsa Puthalakat. Role of p53 in cAMP/PKA pathway mediated apoptosis. Apoptosis : an international journal on programmed cell death. vol 18. issue 12. 2014-07-15. PMID:24002658. |
role of p53 in camp/pka pathway mediated apoptosis. |
2014-07-15 |
2023-08-12 |
human |
| Omer Kacar, Zelal Adiguzel, Veysel T Yilmaz, Yuksel Cetin, Buse Cevatemre, Nazli Arda, Ahmet T Baykal, Engin Ulukaya, Ceyda Acila. Evaluation of the molecular mechanisms of a palladium(II) saccharinate complex with terpyridine as an anticancer agent. Anti-cancer drugs. vol 25. issue 1. 2014-07-15. PMID:24045367. |
other molecules that could potentially play a role in pd(ii)-induced apoptosis, such as p53 and bax, were also tested using silencing technology. |
2014-07-15 |
2023-08-12 |
human |
| Abdullah H Al-Assaf, Ali M Alqahtani, Ali A Alshatwi, Naveed A Syed, Gowhar Shafi, Tarique N Hasa. Mechanism of cadmium induced apoptosis in human peripheral blood lymphocytes: the role of p53, Fas and Caspase-3. Environmental toxicology and pharmacology. vol 36. issue 3. 2014-07-15. PMID:24100270. |
mechanism of cadmium induced apoptosis in human peripheral blood lymphocytes: the role of p53, fas and caspase-3. |
2014-07-15 |
2023-08-12 |
human |
| Abdullah H Al-Assaf, Ali M Alqahtani, Ali A Alshatwi, Naveed A Syed, Gowhar Shafi, Tarique N Hasa. Mechanism of cadmium induced apoptosis in human peripheral blood lymphocytes: the role of p53, Fas and Caspase-3. Environmental toxicology and pharmacology. vol 36. issue 3. 2014-07-15. PMID:24100270. |
data of this study compel to speculate that apoptosis may also be attributed to cd95/fas complex formation, and p53 direct apoptogenic potential at mitochondria. |
2014-07-15 |
2023-08-12 |
human |
| Abdullah H Al-Assaf, Ali M Alqahtani, Ali A Alshatwi, Naveed A Syed, Gowhar Shafi, Tarique N Hasa. Mechanism of cadmium induced apoptosis in human peripheral blood lymphocytes: the role of p53, Fas and Caspase-3. Environmental toxicology and pharmacology. vol 36. issue 3. 2014-07-15. PMID:24100270. |
although, this work does not address all the questions regarding the mechanism of cd induced apoptosis, but these findings establish an important role of p53 and mitochondrial function during apoptosis in human lymphocyte. |
2014-07-15 |
2023-08-12 |
human |
| Shenshen Zhang, Shaoping Nie, Danfei Huang, Yanling Feng, Mingyong Xi. A novel polysaccharide from Ganoderma atrum exerts antitumor activity by activating mitochondria-mediated apoptotic pathway and boosting the immune system. Journal of agricultural and food chemistry. vol 62. issue 7. 2014-07-15. PMID:24506418. |
apoptosis was associated with loss of mitochondrial membrane potential, enhancement of mitochondrial cytochrome c release and intracellular ros production, elevation of p53 and bax expression, downregulation of bcl-2, and the activation of caspase-9 and -3. |
2014-07-15 |
2023-08-12 |
mouse |
| Shaolin Shi, Liping Yu, Taoran Zhang, Haiying Qi, Sandhya Xavier, Wenjun Ju, Erwin Bottinge. Smad2-dependent downregulation of miR-30 is required for TGF-β-induced apoptosis in podocytes. PloS one. vol 8. issue 9. 2014-07-14. PMID:24086574. |
thus, we report that smad2-dependent inhibition of mir-30s in podocytes is required for the activation of p53 and the induction of apoptosis by tgf-β. |
2014-07-14 |
2023-08-12 |
mouse |
| Qian-Qian Geng, Dan-Feng Dong, Nan-Zheng Chen, Yin-Ying Wu, En-Xiao Li, Jie Wang, Shao-Meng Wan. Induction of p53 expression and apoptosis by a recombinant dual-target MDM2/MDMX inhibitory protein in wild-type p53 breast cancer cells. International journal of oncology. vol 43. issue 6. 2014-07-14. PMID:24126697. |
induction of p53 expression and apoptosis by a recombinant dual-target mdm2/mdmx inhibitory protein in wild-type p53 breast cancer cells. |
2014-07-14 |
2023-08-12 |
Not clear |
| Qian-Qian Geng, Dan-Feng Dong, Nan-Zheng Chen, Yin-Ying Wu, En-Xiao Li, Jie Wang, Shao-Meng Wan. Induction of p53 expression and apoptosis by a recombinant dual-target MDM2/MDMX inhibitory protein in wild-type p53 breast cancer cells. International journal of oncology. vol 43. issue 6. 2014-07-14. PMID:24126697. |
the data showed that this recombinant mdm2/mdmx inhibitory protein reduced the viability of mcf-7 and zr-75-30 breast cancer cell lines and promoted cell cycle arrest and apoptosis by activation and stabilization of the p53 protein. |
2014-07-14 |
2023-08-12 |
Not clear |