| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Cao, Ju-liang Zhang, Da-yun Feng, Xue-wu Liu, Yan Li, Li-feng Wang, Li-bo Yao, Hongxin Zhang, Jian Zhan. The effect of adenovirus-conjugated NDRG2 on p53-mediated apoptosis of hepatocarcinoma cells through attenuation of nucleotide excision repair capacity. Biomaterials. vol 35. issue 3. 2014-06-25. PMID:24383128. |
however, the complicated mechanism by which ndrg2 suppresses tumor cell growth and enhances apoptosis mediated by p53 is not fully understood. |
2014-06-25 |
2023-08-12 |
Not clear |
| Wei Cao, Ju-liang Zhang, Da-yun Feng, Xue-wu Liu, Yan Li, Li-feng Wang, Li-bo Yao, Hongxin Zhang, Jian Zhan. The effect of adenovirus-conjugated NDRG2 on p53-mediated apoptosis of hepatocarcinoma cells through attenuation of nucleotide excision repair capacity. Biomaterials. vol 35. issue 3. 2014-06-25. PMID:24383128. |
here, we demonstrated that ad-ndrg2 enhanced the apoptosis of hepg2 cells (wild-type p53). |
2014-06-25 |
2023-08-12 |
Not clear |
| Wei Cao, Ju-liang Zhang, Da-yun Feng, Xue-wu Liu, Yan Li, Li-feng Wang, Li-bo Yao, Hongxin Zhang, Jian Zhan. The effect of adenovirus-conjugated NDRG2 on p53-mediated apoptosis of hepatocarcinoma cells through attenuation of nucleotide excision repair capacity. Biomaterials. vol 35. issue 3. 2014-06-25. PMID:24383128. |
additionally, ad-ndrg2 combined with rad-p53 enhanced the apoptosis of huh7 cells (mutant p53) after chemotherapy, and the expression of the ercc6 gene (cockayne syndrome group b protein gene) was suppressed in this process. |
2014-06-25 |
2023-08-12 |
Not clear |
| Hongzhuan Xuan, Zhen Li, Haiyue Yan, Qing Sang, Kai Wang, Qingtao He, Yuanjun Wang, Fuliang H. Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-06-25. PMID:24963320. |
the effects of eecp on p53 level were different in mcf-7 and mda-mb-231 cells, which indicated that eecp exerted its antitumor effects in mcf-7 and mda-mb-231 cells by inducing apoptosis, regulating the levels of anxa7, p53, and nf- κ b p65, upregulating intracellular ros, and decreasing mitochondrial membrane potential. |
2014-06-25 |
2023-08-13 |
human |
| Paul Hasty, Barbara A Christ. p53 as an intervention target for cancer and aging. Pathobiology of aging & age related diseases. vol 3. 2014-06-24. PMID:24124625. |
as a transcription factor, p53 responds to a variety of stresses to either induce apoptosis (cell death) or cell cycle arrest (cell preservation) to suppress tumor development. |
2014-06-24 |
2023-08-12 |
Not clear |
| Paul Hasty, Barbara A Christ. p53 as an intervention target for cancer and aging. Pathobiology of aging & age related diseases. vol 3. 2014-06-24. PMID:24124625. |
on one side, p53 could induce cellular senescence or apoptosis to suppress cancer but as an unintended consequence enhance the aging process especially if these responses diminish stem and progenitor cell populations. |
2014-06-24 |
2023-08-12 |
Not clear |
| Kamla Kant Shukla, Woo-Sung Kwon, Md Saidur Rahman, Yoo-Jin Park, Young-Ah You, Myung-Geol Pan. Nutlin-3a decreases male fertility via UQCRC2. PloS one. vol 8. issue 10. 2014-06-24. PMID:24130818. |
simultaneously, nutlin-3a is a small molecule antagonist of mouse double minute 2 repressor (mdm2), activate p53 and induce apoptosis responsible for spermatogenesis. |
2014-06-24 |
2023-08-12 |
mouse |
| Liselotte Angus, Pauline J van der Watt, Virna D Leane. Inhibition of the nuclear transporter, Kpnβ1, results in prolonged mitotic arrest and activation of the intrinsic apoptotic pathway in cervical cancer cells. Carcinogenesis. vol 35. issue 5. 2014-06-24. PMID:24398670. |
although p53 becomes stabilized in kpnβ1 knockdown cervical cancer cells, apoptosis occurs in a p53-independent manner. |
2014-06-24 |
2023-08-12 |
Not clear |
| Yueyun Ma, Yijuan Xin, Rui Li, Zhe Wang, Qiaohong Yue, Fengjing Xiao, Xiaoke Ha. TFDP3 was expressed in coordination with E2F1 to inhibit E2F1-mediated apoptosis in prostate cancer. Gene. vol 537. issue 2. 2014-06-24. PMID:24406621. |
it has been shown to suppress e2f1-induced apoptosis dependent p53 and to play a potential role in carcinogenesis. |
2014-06-24 |
2023-08-12 |
human |
| Lindsay C Spender, Gareth J Inma. Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling. Cancer management and research. vol 6. 2014-06-24. PMID:24426788. |
both systems have been useful so far in characterizing the role of tumor suppressor genes (for example, p53), prosurvival signaling pathways, and members of the b-cell lymphoma-2 family of apoptosis regulators in determining the fate of c-myc overexpressing b-cells, and ultimately in regulating lymphoma development. |
2014-06-24 |
2023-08-12 |
mouse |
| Jennifer R Ribeiro, Lindsay A Lovasco, Barbara C Vanderhyden, Richard N Freima. Targeting TBP-Associated Factors in Ovarian Cancer. Frontiers in oncology. vol 4. 2014-06-24. PMID:24653979. |
conversely, taf9, a cofactor for p53 in regulating apoptosis, may act as a tumor suppressor in ovarian cancer, since it is downregulated or deleted in 98% of hgsc. |
2014-06-24 |
2023-08-12 |
mouse |
| Ying Chen, Shih-Hung Yang, Dueng-Yuan Hueng, Jhih-Pu Syu, Chih-Chen Liao, Ya-Chieh W. Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway. Chemico-biological interactions. vol 216. 2014-06-24. PMID:24704558. |
specific inhibitors for p53 and caspases abrogated cordycepin-induced caspase-7 and parp cleavage, and prevented cordycepin-induced apoptosis. |
2014-06-24 |
2023-08-13 |
rat |
| Ying Chen, Shih-Hung Yang, Dueng-Yuan Hueng, Jhih-Pu Syu, Chih-Chen Liao, Ya-Chieh W. Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway. Chemico-biological interactions. vol 216. 2014-06-24. PMID:24704558. |
both adenosine 2a receptor (a2ar) antagonist and small interference rna (sirna) knockdown of a2ar blocked cordycepin-induced apoptosis, p53 activation, and caspase-7 and parp cleavage. |
2014-06-24 |
2023-08-13 |
rat |
| Chunhua Wan, Junkang Jiang, Hui Mao, Jianhua Cao, Xiaohong Wu, Gang Cu. Involvement of upregulated p53-induced death domain protein (PIDD) in neuronal apoptosis after rat traumatic brain injury. Journal of molecular neuroscience : MN. vol 51. issue 3. 2014-06-23. PMID:23797734. |
recent studies indicated that p53 played a crucial role in neuronal apoptosis and regeneration following tbi. |
2014-06-23 |
2023-08-12 |
rat |
| Aihong Li, Xiaolei Sun, Yaohui Ni, Xin Chen, Aisong Gu. HIF-1α involves in neuronal apoptosis after traumatic brain injury in adult rats. Journal of molecular neuroscience : MN. vol 51. issue 3. 2014-06-23. PMID:23979836. |
in addition, glutamate excitotoxic model of primary cortex neurons was introduced to further investigate the role of hif-1α in neuronal apoptosis; the result implied hif-1α was associated with the regulation of p53 and bnip3 in the apoptotic neurons. |
2014-06-23 |
2023-08-12 |
rat |
| Li Han, Canjie Wu, Hasan Riaz, Liya Bai, Jianguo Chen, Yanhong Zhen, Aizhen Guo, Liguo Yan. Characterization of the mechanism of inhibin α-subunit gene in mouse anterior pituitary cells by RNA interference. PloS one. vol 8. issue 10. 2014-06-23. PMID:24098340. |
the results indicated that inhibin silencing significantly promoted apoptosis by up-regulating caspase-3, bax and bcl-2 genes without affecting p53 both at transcriptional and translational levels. |
2014-06-23 |
2023-08-12 |
mouse |
| Kai-hua Lu, Wei Li, Xiang-hua Liu, Ming Sun, Mei-ling Zhang, Wei-qin Wu, Wei-ping Xie, Ya-yi Ho. Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression. BMC cancer. vol 13. 2014-06-23. PMID:24098911. |
long non-coding rna meg3 inhibits nsclc cells proliferation and induces apoptosis by affecting p53 expression. |
2014-06-23 |
2023-08-12 |
human |
| Se-Jin Kim, Jae-Young Lim, Joon No Lee, Seong-Kyu Choe, Yong-Il Kim, Seung Ryel Song, Meyoung Cho, Hong-Seob So, Raekil Par. Activation of β-catenin by inhibitors of glycogen synthase kinase-3 ameliorates cisplatin-induced cytotoxicity and pro-inflammatory cytokine expression in HEI-OC1 cells. Toxicology. vol 320. 2014-06-23. PMID:24560772. |
gsk-3 inhibitors suppressed cisplatin-induced apoptosis determined by decreased p53 activity, and also decreased expression of parp and p53 target genes such as p21 and puma. |
2014-06-23 |
2023-08-12 |
Not clear |
| J Bai, M Ma, M Cai, F Xu, J Chen, G Wang, X Shuai, K Ta. Inhibition enhancer of zeste homologue 2 promotes senescence and apoptosis induced by doxorubicin in p53 mutant gastric cancer cells. Cell proliferation. vol 47. issue 3. 2014-06-23. PMID:24738879. |
inhibition enhancer of zeste homologue 2 promotes senescence and apoptosis induced by doxorubicin in p53 mutant gastric cancer cells. |
2014-06-23 |
2023-08-13 |
Not clear |
| Fan Yang, Hongyang Chen, Yanju Liu, Kun Yin, Yang Wang, Xingda Li, Guohui Wang, Siyue Wang, Xueying Tan, Chaoqian Xu, Yanjie Lu, Benzhi Ca. Doxorubicin caused apoptosis of mesenchymal stem cells via p38, JNK and p53 pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 32. issue 4. 2014-06-20. PMID:24217648. |
doxorubicin caused apoptosis of mesenchymal stem cells via p38, jnk and p53 pathway. |
2014-06-20 |
2023-08-12 |
Not clear |