| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arandkar Sharathchandra, Aanchal Katoch, Saumitra Da. IRES mediated translational regulation of p53 isoforms. Wiley interdisciplinary reviews. RNA. vol 5. issue 1. 2014-07-14. PMID:24343861. |
p53 is a well known tumor suppressor protein that plays a critical role in cell cycle arrest and apoptosis. |
2014-07-14 |
2023-08-12 |
Not clear |
| Jubina B Venghateri, Tilak Kumar Gupta, Paul J Verma, Ambarish Kunwar, Dulal Pand. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site. PloS one. vol 8. issue 10. 2014-07-11. PMID:24124473. |
subsequently, cells underwent apoptosis via p53 mediated apoptotic pathway. |
2014-07-11 |
2023-08-12 |
Not clear |
| Samuel A Jensen, Emily S Day, Caroline H Ko, Lisa A Hurley, Janina P Luciano, Fotini M Kouri, Timothy J Merkel, Andrea J Luthi, Pinal C Patel, Joshua I Cutler, Weston L Daniel, Alexander W Scott, Matthew W Rotz, Thomas J Meade, David A Giljohann, Chad A Mirkin, Alexander H Steg. Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma. Science translational medicine. vol 5. issue 209. 2014-07-11. PMID:24174328. |
snas targeting the oncoprotein bcl2like12 (bcl2l12)--an effector caspase and p53 inhibitor overexpressed in gbm relative to normal brain and low-grade astrocytomas--were effective in knocking down endogenous bcl2l12 mrna and protein levels, and sensitized glioma cells toward therapy-induced apoptosis by enhancing effector caspase and p53 activity. |
2014-07-11 |
2023-08-12 |
mouse |
| Wei Kou, Chunjiang Dou, Yongmei Lan, Qiaoling G. [Expressions and clinical significances of iASPP and caspase-9 in esophageal cancer]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 30. issue 1. 2014-07-11. PMID:24405603. |
to investigate the expressions of inhibitory member of the apoptosis stimulating protein of p53 family (iaspp) and caspase-9 in the esophageal cancer (ec) tissues and their correlations with clinical pathological parameters. |
2014-07-11 |
2023-08-12 |
Not clear |
| Yu Fan, Shenyi Yin, Yang Hao, Junyu Yang, Hanshuo Zhang, Changhong Sun, Ming Ma, Qing Chang, Jianzhong Jeff X. miR-19b promotes tumor growth and metastasis via targeting TP53. RNA (New York, N.Y.). vol 20. issue 6. 2014-07-11. PMID:24742936. |
this mir-19b-mediated p53 reduction was shown to promote cell cycle, cell migration or invasion, and repress senescence and apoptosis in vitro. |
2014-07-11 |
2023-08-13 |
human |
| M Gkotzamanidou, E Terpos, C Bamia, S A Kyrtopoulos, P P Sfikakis, M A Dimopoulos, V L Soulioti. Progressive changes in chromatin structure and DNA damage response signals in bone marrow and peripheral blood during myelomagenesis. Leukemia. vol 28. issue 5. 2014-07-10. PMID:24089038. |
following ex vivo treatment with melphalan, a gradual suppression of the apoptotic pathway occurred in samples collected at different stages of myelomagenesis, with the severity and duration of the inhibition of rna synthesis, p53 phosphorylation at serine15 and induction of apoptosis being higher in mgus than smm and lowest in mm patients (all p<0.0103). |
2014-07-10 |
2023-08-12 |
Not clear |
| L Zhang, H Sang, Y Liu, J L. Manganese activates caspase-9-dependent apoptosis in human bronchial epithelial cells. Human & experimental toxicology. vol 32. issue 11. 2014-07-08. PMID:23263852. |
taking together, our results demonstrate that caspase-9-dependent intrinsic pathway, the downregulation of c-myc and the upregulation of p53 and phosphorylated p53 might be responsible for mn-mediated apoptosis in 16hbe cells. |
2014-07-08 |
2023-08-12 |
human |
| Cheree Fitzgibbon, Saleh Ihmaid, Jasim Al-Rawi, Terri Meehan-Andrews, Christopher Bradle. Chemo-sensitisation of HeLa cells to etoposide by a benzoxazine in the absence of DNA-PK inhibition. Investigational new drugs. vol 31. issue 6. 2014-07-08. PMID:24057508. |
this results in a decrease in p53 phosphorylation and hence, restricted apoptosis. |
2014-07-08 |
2023-08-12 |
Not clear |
| Bin Yu, Xiao-Jing Shi, Yong-Fei Zheng, Yuan Fang, En Zhang, De-Quan Yu, Hong-Min Li. A novel [1,2,4] triazolo [1,5-a] pyrimidine-based phenyl-linked steroid dimer: synthesis and its cytotoxic activity. European journal of medicinal chemistry. vol 69. 2014-07-08. PMID:24077182. |
further mechanistic studies revealed that treatment of ec109 cells with compound 3 caused an obvious g2/m arrest in a concentration- and time-dependent manner and induced apoptosis probably through the mitochondrial pathway accompanied with the decrease of mitochondrial membrane potential, activations of caspase-9/-3, cleavage of mdm2 as well as up-regulation of the expressions of p53 and bax. |
2014-07-08 |
2023-08-12 |
human |
| Kan He, Xingnan Zheng, Lin Zhang, Jian Y. Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax. Molecular cancer therapeutics. vol 12. issue 11. 2014-07-07. PMID:23966620. |
deficiency in puma, bax, or p53, at lesser extent, abrogated 17-allylamino-17-demethoxygeldanamycin (17-aag)-induced apoptosis and mitochondrial dysfunction, and enhanced clonogenic cell survival. |
2014-07-07 |
2023-08-12 |
Not clear |
| Kan He, Xingnan Zheng, Lin Zhang, Jian Y. Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax. Molecular cancer therapeutics. vol 12. issue 11. 2014-07-07. PMID:23966620. |
furthermore, suppression of p53-dependent p21 induction or enhanced p53 activation synergized with 17-aag to induce puma-dependent apoptosis. |
2014-07-07 |
2023-08-12 |
Not clear |
| Manujendra N Saha, Hua Jiang, Yijun Yang, Donna Reece, Hong Chan. PRIMA-1Met/APR-246 displays high antitumor activity in multiple myeloma by induction of p73 and Noxa. Molecular cancer therapeutics. vol 12. issue 11. 2014-07-07. PMID:24030633. |
sirna-mediated silencing of p53 showed a little effect on apoptotic response of prima-1(met), whereas knockdown of p73 led to substantial attenuation of apoptotic activity in multiple myeloma cells, indicating that prima-1(met)-induced apoptosis is, at least in part, p73-dependent. |
2014-07-07 |
2023-08-12 |
mouse |
| Akechai Im-aram, Lee Farrand, Seung-Min Bae, Gwonhwa Song, Yong Sang Song, Jae Yong Han, Benjamin K Tsan. The mTORC2 component rictor contributes to cisplatin resistance in human ovarian cancer cells. PloS one. vol 8. issue 9. 2014-07-07. PMID:24086535. |
here, using sensitive wild-type p53 (ov2008 and a2780s), resistant wild-type p53 (c13* and ovcar433), and p53 compromised (a2780cp, occ1, and skov-3) ovarian cancer cells, we have demonstrated that (i) rictor is a determinant of cisplatin resistance in chemosensitive human ovarian cancer cells; (ii) cisplatin down-regulates rictor content by caspase-3 cleavage and proteasomal degradation; (iii) rictor down-regulation sensitizes chemo-resistant ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner; (iv) rictor suppresses cisplatin-induced apoptosis and confers resistance by activating and stabilizing akt. |
2014-07-07 |
2023-08-12 |
human |
| Hao Li, Xiao-Peng Zhang, Feng Li. Coordination between p21 and DDB2 in the cellular response to UV radiation. PloS one. vol 8. issue 11. 2014-07-07. PMID:24260342. |
the cyclin-dependent kinase inhibitor p21, which is induced by p53, can both arrest the cell cycle and inhibit apoptosis. |
2014-07-07 |
2023-08-12 |
Not clear |
| Hao Li, Xiao-Peng Zhang, Feng Li. Coordination between p21 and DDB2 in the cellular response to UV radiation. PloS one. vol 8. issue 11. 2014-07-07. PMID:24260342. |
we revealed that the downregulation of p21 is necessary for apoptosis induction and pten promotes apoptosis by amplifying p53 activation. |
2014-07-07 |
2023-08-12 |
Not clear |
| J Montero, C Dutta, D van Bodegom, D Weinstock, A Leta. p53 regulates a non-apoptotic death induced by ROS. Cell death and differentiation. vol 20. issue 11. 2014-07-03. PMID:23703322. |
we therefore demonstrate that p53 can regulate both necrotic and apoptotic cell death, mutations or deletions in this tumor-suppressor protein may be selected by cancer cells to provide not only their resistance to apoptosis but also to necrosis, and explain resistance to chemotherapy and radiation even when it kills via non-apoptotic mechanisms. |
2014-07-03 |
2023-08-12 |
mouse |
| Nemat Ali, Summya Rashid, Sana Nafees, Syed Kazim Hasan, Sarwat Sultan. Beneficial effects of Chrysin against Methotrexate-induced hepatotoxicity via attenuation of oxidative stress and apoptosis. Molecular and cellular biochemistry. vol 385. issue 1-2. 2014-07-02. PMID:24154663. |
histopathological alterations and apoptosis through the immunopositive staining of p53, cleaved caspases-3 and bcl-2-associated x protein in rat liver were observed. |
2014-07-02 |
2023-08-12 |
rat |
| Shabnam Enayat, Müşerref Şeyma Ceyhan, Arif Ahmet Başaran, Mayda Gürsel, Sreeparna Banerje. Anticarcinogenic effects of the ethanolic extract of Salix aegyptiaca in colon cancer cells: involvement of Akt/PKB and MAPK pathways. Nutrition and cancer. vol 65. issue 7. 2014-06-26. PMID:24168160. |
accompanying this was cell cycle arrest at g1/s independent of dna damage in the cancer cells, induction of apoptosis through a p53 dependent pathway and an inhibition of pi3k/akt and map kinase pathways at levels comparable to known commercial inhibitors. |
2014-06-26 |
2023-08-12 |
Not clear |
| Feng Zhao, Hui Yin, Jun L. Supramolecular self-assembly forming a multifunctional synergistic system for targeted co-delivery of gene and drug. Biomaterials. vol 35. issue 3. 2014-06-25. PMID:24189097. |
further, the efficient delivery of wild-type p53 gene resulted in large cell population at sub g1 and g2/m phases, inducing significant cell apoptosis. |
2014-06-25 |
2023-08-12 |
Not clear |
| Wei Cao, Ju-liang Zhang, Da-yun Feng, Xue-wu Liu, Yan Li, Li-feng Wang, Li-bo Yao, Hongxin Zhang, Jian Zhan. The effect of adenovirus-conjugated NDRG2 on p53-mediated apoptosis of hepatocarcinoma cells through attenuation of nucleotide excision repair capacity. Biomaterials. vol 35. issue 3. 2014-06-25. PMID:24383128. |
ndrg2 enhances p53-mediated apoptosis, whereas overexpression of ndrg2 suppresses tumor cell growth, regardless of whether p53 is mutated. |
2014-06-25 |
2023-08-12 |
Not clear |